Principle Component Analysis (PCA) a widely used mathematical tool for high dimension data analysis. PCA has been used for face recognition[1], motion analysis and synthesis[2], clusterin[3], dimension reduction[4], e...Principle Component Analysis (PCA) a widely used mathematical tool for high dimension data analysis. PCA has been used for face recognition[1], motion analysis and synthesis[2], clusterin[3], dimension reduction[4], etc. PCA provides a guideline for how to reduce a complex dataset to one of lower dimensionality to reveal any hidden, simplified structures that may underlie it.展开更多
The heavy ions beam radiation increases the activity of the Peroxidases,an enzyme responsible for the biosynthesis of phenolic compounds,indicating significant change in the chemical composition[1].This fact explains ...The heavy ions beam radiation increases the activity of the Peroxidases,an enzyme responsible for the biosynthesis of phenolic compounds,indicating significant change in the chemical composition[1].This fact explains changes in the antioxidant activity of many herbal products exposed to radiation.展开更多
Before applying the Response surface methodology(RSM)methodology,it is first necessary to choose an experimental design that will define which experiments should be carried out in the experimental region being studied...Before applying the Response surface methodology(RSM)methodology,it is first necessary to choose an experimental design that will define which experiments should be carried out in the experimental region being studied.There are some experimental matrices for this purpose.Experimental designs for first-order models can be used when the data set does not present curvature.However,to approximate a response function to experimental data that cannot be described by linear functions,experimental designs for quadratic response surfaces should be used,such as the approach to the applications of its more frequently used second-order experimental designs is broached,as well as the optimization of procedures that generate multiple responses.展开更多
Butyric acid as a renewable resource has become an increasingly attractive alternative to petroleum based fuels.Clostridium tyrobutyricum is well documented as a fermentation strain for the production of acids. Howeve...Butyric acid as a renewable resource has become an increasingly attractive alternative to petroleum based fuels.Clostridium tyrobutyricum is well documented as a fermentation strain for the production of acids. However, it hasbeen reported that butyrate inhibits its growth, and the accumulation of acetate also inhibits biomass synthesis,making production of butyric acid from conventional fermentation processes economically challenging. The presentstudy aimed to identify whether irradiation of C. tyrobutyricum cells makes them more tolerant to butyric acidinhibition and increases the production of butyrate compared with wild type.展开更多
The world is facing severe challenges of sustainable development, which requires the joint effort of the globalscience community to solve. As China continues to grow at a very impressive pace, the state appears acutel...The world is facing severe challenges of sustainable development, which requires the joint effort of the globalscience community to solve. As China continues to grow at a very impressive pace, the state appears acutely awareof the need to expand the Chinese science and technology portfolio to help fuel its growth and keep it sustainable.China also needs to continue on the path to innovations and modernization, focusing on endogenous growth torealize full, coordinated, and sustainable development.展开更多
Artemisia annua L.is an important medicinal plant from which artemisinin was extracted to treat malaria effectively.Artemisinin is isolated from the aerial part of the A.annua harvesting from the wild is causing loss ...Artemisia annua L.is an important medicinal plant from which artemisinin was extracted to treat malaria effectively.Artemisinin is isolated from the aerial part of the A.annua harvesting from the wild is causing loss of genetic diversity and habitat destruction.The use of controlled environments can overcome cultivation difficulties and could be a means to manipulate phenotypic variation in bioactive compounds and toxins.Induced mutations have great potentials and serve as a complimentary approach in genetic improvement of crops for greater yield and quality traits[1].The generation of genetic variability by induced mutagenesis provides a base for strengthening plant improvement programs[2].For any mutation-breeding program,selection of effective and efficient mutagen is very essential to recover high frequency of desirable mutations[3].The mutagenesis approach is attractive alternate method for enhancement of artemisinin in vivo as well as in vitro.The results of many studies showed that mutation breeding has the capacity to release mutants with high artemisinin content[4].展开更多
The world’s pharmaceutical industry is facing the shrink of new drug R&D investment,reduction of the number of new product approval and listed and patent expiration,and the drug production patterns are changing.A...The world’s pharmaceutical industry is facing the shrink of new drug R&D investment,reduction of the number of new product approval and listed and patent expiration,and the drug production patterns are changing.After years of development,China has a very good accumulation on the drug production.Facing the opportunities for change,how to use and play our advantage,breaking the barriers of large foreign pharmaceutical companies,become the key to the future development of China’s pharmaceutical industry.Heavy ion irradiation drug production as a new method plays an important role both in the discovery of the structure of new drugs,high-quality traditional Chinese medicine and Resources of medicinal microorganisms.展开更多
The dry root of Scutellaria baicalensis Georgi(S.baicalensis)has the effects of clearing heat,dryness and dampness,purging re and detoxification,calming the fetus according to Chinese Pharmacopoeia^([1]).Modern resear...The dry root of Scutellaria baicalensis Georgi(S.baicalensis)has the effects of clearing heat,dryness and dampness,purging re and detoxification,calming the fetus according to Chinese Pharmacopoeia^([1]).Modern research has shown that it contains various active ingredients[2],including avonoids,phenylpropanoids,steroids,etc.,which are the material basis for its medicinal effects.展开更多
Bupleurum radix from the dried root of Bupleurum chinense(B.chinense)is one kind of commonly used Chinese medicinal materials.It has the effect of reconciling superficies and interiors,soothing the liver and promoting...Bupleurum radix from the dried root of Bupleurum chinense(B.chinense)is one kind of commonly used Chinese medicinal materials.It has the effect of reconciling superficies and interiors,soothing the liver and promoting spleen Yang,treating cold and fever,cold and heat exchange,malaria,swelling pain in the chest and ribs,etc.展开更多
利用12C^6+重离子束对黄花蒿干种子辐照后,利用发芽率、根长、下胚轴长和株高4个指标研究不同剂量12C^6+离子束辐照对黄花蒿的生物学效应。结果表明,随着辐照剂量的增加,黄花蒿的存活率和根长都呈现逐渐降低的趋势,而下胚轴长先上升后下...利用12C^6+重离子束对黄花蒿干种子辐照后,利用发芽率、根长、下胚轴长和株高4个指标研究不同剂量12C^6+离子束辐照对黄花蒿的生物学效应。结果表明,随着辐照剂量的增加,黄花蒿的存活率和根长都呈现逐渐降低的趋势,而下胚轴长先上升后下降,株高总体呈现下降的趋势,但在60和90 Gy同时存在矮化与增高的植株。利用SRAP(sequence related amplified polymorphism)技术对辐照后M1代的黄花蒿植株进行研究,结果表明对照组和处理组之间的差异体现为特异性条带的变化。综合分析表明,12C^6+的重离子辐照黄花蒿干种子可以产生显著的当代损伤效应,同时引起植物DNA的多态性变化。展开更多
文摘Principle Component Analysis (PCA) a widely used mathematical tool for high dimension data analysis. PCA has been used for face recognition[1], motion analysis and synthesis[2], clusterin[3], dimension reduction[4], etc. PCA provides a guideline for how to reduce a complex dataset to one of lower dimensionality to reveal any hidden, simplified structures that may underlie it.
基金National Major Scientific and Technological Special Project for“Significant New Drugs Development”(2017ZX09101002003001)。
文摘The heavy ions beam radiation increases the activity of the Peroxidases,an enzyme responsible for the biosynthesis of phenolic compounds,indicating significant change in the chemical composition[1].This fact explains changes in the antioxidant activity of many herbal products exposed to radiation.
基金Western Light Talent Training Program of Chinese Academy Science Ke-Fa-Ren-Zi[2015]77,Natural Science Foundation of Gansu provincial Sci.and Tech.Department(1506RJZA293).
文摘Before applying the Response surface methodology(RSM)methodology,it is first necessary to choose an experimental design that will define which experiments should be carried out in the experimental region being studied.There are some experimental matrices for this purpose.Experimental designs for first-order models can be used when the data set does not present curvature.However,to approximate a response function to experimental data that cannot be described by linear functions,experimental designs for quadratic response surfaces should be used,such as the approach to the applications of its more frequently used second-order experimental designs is broached,as well as the optimization of procedures that generate multiple responses.
文摘Butyric acid as a renewable resource has become an increasingly attractive alternative to petroleum based fuels.Clostridium tyrobutyricum is well documented as a fermentation strain for the production of acids. However, it hasbeen reported that butyrate inhibits its growth, and the accumulation of acetate also inhibits biomass synthesis,making production of butyric acid from conventional fermentation processes economically challenging. The presentstudy aimed to identify whether irradiation of C. tyrobutyricum cells makes them more tolerant to butyric acidinhibition and increases the production of butyrate compared with wild type.
文摘The world is facing severe challenges of sustainable development, which requires the joint effort of the globalscience community to solve. As China continues to grow at a very impressive pace, the state appears acutely awareof the need to expand the Chinese science and technology portfolio to help fuel its growth and keep it sustainable.China also needs to continue on the path to innovations and modernization, focusing on endogenous growth torealize full, coordinated, and sustainable development.
基金National Science and Technology Major Project(2017ZX09101002-003-001)CAS Light of West China Program(Ke-Fa-Ren-Zi[2015]No.77)Natural Science Foundation of Gansu provincial Sci.and Tech.Department(1506RJZA293)。
文摘Artemisia annua L.is an important medicinal plant from which artemisinin was extracted to treat malaria effectively.Artemisinin is isolated from the aerial part of the A.annua harvesting from the wild is causing loss of genetic diversity and habitat destruction.The use of controlled environments can overcome cultivation difficulties and could be a means to manipulate phenotypic variation in bioactive compounds and toxins.Induced mutations have great potentials and serve as a complimentary approach in genetic improvement of crops for greater yield and quality traits[1].The generation of genetic variability by induced mutagenesis provides a base for strengthening plant improvement programs[2].For any mutation-breeding program,selection of effective and efficient mutagen is very essential to recover high frequency of desirable mutations[3].The mutagenesis approach is attractive alternate method for enhancement of artemisinin in vivo as well as in vitro.The results of many studies showed that mutation breeding has the capacity to release mutants with high artemisinin content[4].
文摘The world’s pharmaceutical industry is facing the shrink of new drug R&D investment,reduction of the number of new product approval and listed and patent expiration,and the drug production patterns are changing.After years of development,China has a very good accumulation on the drug production.Facing the opportunities for change,how to use and play our advantage,breaking the barriers of large foreign pharmaceutical companies,become the key to the future development of China’s pharmaceutical industry.Heavy ion irradiation drug production as a new method plays an important role both in the discovery of the structure of new drugs,high-quality traditional Chinese medicine and Resources of medicinal microorganisms.
基金Youth Innovation Promotion Association of CAS(Y201974)Crop Varietal Improvement and Insect Pests Control by Nuclear Radiation(E11Z211GQ1)Ecological Planting and Quality Assurance Project of Daodi Medicinal Materials(China Science and Technology for Traditional Chinese Medicine(2020)153)。
文摘The dry root of Scutellaria baicalensis Georgi(S.baicalensis)has the effects of clearing heat,dryness and dampness,purging re and detoxification,calming the fetus according to Chinese Pharmacopoeia^([1]).Modern research has shown that it contains various active ingredients[2],including avonoids,phenylpropanoids,steroids,etc.,which are the material basis for its medicinal effects.
基金Crop Varietal Improvement and Insect Pests Control by Nuclear Radiation(E11Z211GQ1)Youth Innovation Promotion Association of CAS(Y201974)Dingxi Municipal Science and Technology Program(DX2021AN10)。
文摘Bupleurum radix from the dried root of Bupleurum chinense(B.chinense)is one kind of commonly used Chinese medicinal materials.It has the effect of reconciling superficies and interiors,soothing the liver and promoting spleen Yang,treating cold and fever,cold and heat exchange,malaria,swelling pain in the chest and ribs,etc.
文摘利用12C^6+重离子束对黄花蒿干种子辐照后,利用发芽率、根长、下胚轴长和株高4个指标研究不同剂量12C^6+离子束辐照对黄花蒿的生物学效应。结果表明,随着辐照剂量的增加,黄花蒿的存活率和根长都呈现逐渐降低的趋势,而下胚轴长先上升后下降,株高总体呈现下降的趋势,但在60和90 Gy同时存在矮化与增高的植株。利用SRAP(sequence related amplified polymorphism)技术对辐照后M1代的黄花蒿植株进行研究,结果表明对照组和处理组之间的差异体现为特异性条带的变化。综合分析表明,12C^6+的重离子辐照黄花蒿干种子可以产生显著的当代损伤效应,同时引起植物DNA的多态性变化。
