目的 分析卵巢癌患者血浆和组织中LincROR的表达,探讨LincROR在卵巢癌筛查中的价值。方法 收集30例健康女性、56例卵巢囊肿、23例子宫内膜异位症、38例子宫内膜癌、35例宫颈癌、42例卵巢癌、21例卵巢癌术后及26例卵巢癌化疗后患者的血...目的 分析卵巢癌患者血浆和组织中LincROR的表达,探讨LincROR在卵巢癌筛查中的价值。方法 收集30例健康女性、56例卵巢囊肿、23例子宫内膜异位症、38例子宫内膜癌、35例宫颈癌、42例卵巢癌、21例卵巢癌术后及26例卵巢癌化疗后患者的血浆样本,荧光定量PCR分析LincROR在各组样本中的表达水平,结合临床数据评估LincROR在临床妇科常见疾病中的筛查效能。结果 LincROR在卵巢癌患者血浆中的表达水平(2.90±4.42)明显高于健康人(0.23±0.28)和卵巢良性囊肿患者(0.62±0.55),差异有统计学意义( P 均<0.01)。ROC曲线分析结果表明,血浆LincROR在卵巢癌筛查中的价值优于CA125、CA199、CA153、AFP和CEA等指标, LincROR和CA125联合筛查卵巢癌的敏感性为89.7%,特异性为86.7%(AUC ROC :0.918, 95% CI :0.817~0.973)。此外,卵巢癌术后患者血浆中LincROR的表达水平明显低于未经任何治疗的卵巢癌患者( 0.50± 1.72 vs 2.90±4.42, P <0.01)。ROC曲线分析表明,血浆LincROR是比CA125更敏感的卵巢癌化疗疗效的评价指标(AUC ROC :0.866 vs 0.738)。结论 LincROR有望成为卵巢癌筛查的生物学标志物,联合CA125可提高筛查的敏感性和特异性,同时在评估卵巢癌化疗疗效中具有潜在的临床价值。展开更多
With the human space exploration activities,space life science is an emerging interdisciplinary and it covers a wide range of research.Based on our country's manned space station and recoverable satellite science ...With the human space exploration activities,space life science is an emerging interdisciplinary and it covers a wide range of research.Based on our country's manned space station and recoverable satellite science experimental platform,the development of space life science research is very important to acquire new knowledge or new innovation in technology,to give further services to the human space exploration activities,to improve the national economic and social development.Based on present situation,both theoretical and applied researches were continuously performed in2015.Here,we review and summarize the researches on space life sciences which were contributed by Chinese scientists.展开更多
In the past two years,China’s space life science has made great progress.Space biomedical and life science programs have carried out ground-based research for the first batch of projects,and are preparing to carry ou...In the past two years,China’s space life science has made great progress.Space biomedical and life science programs have carried out ground-based research for the first batch of projects,and are preparing to carry out space-based experiments along with the construction of China’s space station.And space life science payload of the space station completed the development of positive samples.Thus,with the development of lunar exploration and Mars exploration projects,astrobiology research has also made a lot of basic achievements.On the basis of summarizing the development of space life science in China,this paper mainly introduces the important progress of payload technology and life science research.展开更多
With the further advancement of China’s major manned spaceflight project,the national space laboratory was successfully built.China has also made considerable progress and breakthroughs in the field of space life sci...With the further advancement of China’s major manned spaceflight project,the national space laboratory was successfully built.China has also made considerable progress and breakthroughs in the field of space life sciences.This paper reviews the related biological effects under space flight conditions,mainly including epigenetic effects,skeleton remodeling and peripheral body fluid circulation effects,as well as the research and application of space life science related biotechnology in the field of microbial culture and biological regeneration life support system.展开更多
文摘目的 分析卵巢癌患者血浆和组织中LincROR的表达,探讨LincROR在卵巢癌筛查中的价值。方法 收集30例健康女性、56例卵巢囊肿、23例子宫内膜异位症、38例子宫内膜癌、35例宫颈癌、42例卵巢癌、21例卵巢癌术后及26例卵巢癌化疗后患者的血浆样本,荧光定量PCR分析LincROR在各组样本中的表达水平,结合临床数据评估LincROR在临床妇科常见疾病中的筛查效能。结果 LincROR在卵巢癌患者血浆中的表达水平(2.90±4.42)明显高于健康人(0.23±0.28)和卵巢良性囊肿患者(0.62±0.55),差异有统计学意义( P 均<0.01)。ROC曲线分析结果表明,血浆LincROR在卵巢癌筛查中的价值优于CA125、CA199、CA153、AFP和CEA等指标, LincROR和CA125联合筛查卵巢癌的敏感性为89.7%,特异性为86.7%(AUC ROC :0.918, 95% CI :0.817~0.973)。此外,卵巢癌术后患者血浆中LincROR的表达水平明显低于未经任何治疗的卵巢癌患者( 0.50± 1.72 vs 2.90±4.42, P <0.01)。ROC曲线分析表明,血浆LincROR是比CA125更敏感的卵巢癌化疗疗效的评价指标(AUC ROC :0.866 vs 0.738)。结论 LincROR有望成为卵巢癌筛查的生物学标志物,联合CA125可提高筛查的敏感性和特异性,同时在评估卵巢癌化疗疗效中具有潜在的临床价值。
文摘With the human space exploration activities,space life science is an emerging interdisciplinary and it covers a wide range of research.Based on our country's manned space station and recoverable satellite science experimental platform,the development of space life science research is very important to acquire new knowledge or new innovation in technology,to give further services to the human space exploration activities,to improve the national economic and social development.Based on present situation,both theoretical and applied researches were continuously performed in2015.Here,we review and summarize the researches on space life sciences which were contributed by Chinese scientists.
基金Supported by Space Medical Experiment Project of China Manned Space Program(HYZHXM02003)。
文摘In the past two years,China’s space life science has made great progress.Space biomedical and life science programs have carried out ground-based research for the first batch of projects,and are preparing to carry out space-based experiments along with the construction of China’s space station.And space life science payload of the space station completed the development of positive samples.Thus,with the development of lunar exploration and Mars exploration projects,astrobiology research has also made a lot of basic achievements.On the basis of summarizing the development of space life science in China,this paper mainly introduces the important progress of payload technology and life science research.
文摘With the further advancement of China’s major manned spaceflight project,the national space laboratory was successfully built.China has also made considerable progress and breakthroughs in the field of space life sciences.This paper reviews the related biological effects under space flight conditions,mainly including epigenetic effects,skeleton remodeling and peripheral body fluid circulation effects,as well as the research and application of space life science related biotechnology in the field of microbial culture and biological regeneration life support system.
