目的:探讨S100蛋白超家族A6(S100 family member A6,S100A6)在肝细胞癌(hepatocellular carcinoma,HCC)中的表达及临床意义。方法:利用Oncomine生物信息学在线分析网站,挖掘分析大型癌症公共数据癌症基因组图谱(TCGA)及GEO(Gene Express...目的:探讨S100蛋白超家族A6(S100 family member A6,S100A6)在肝细胞癌(hepatocellular carcinoma,HCC)中的表达及临床意义。方法:利用Oncomine生物信息学在线分析网站,挖掘分析大型癌症公共数据癌症基因组图谱(TCGA)及GEO(Gene Expression Omnibus)中肝癌S100A6 mRNA的表达信息,基于TCGA中的肝癌数据,利用GEPIA、Kaplan-Meier Plotter进行患者生存分析。结果:在Oncomine数据库中,前后共收集了337项不同类型的研究结果,关于S100A6基因表达有统计学差异的研究结果有30个,其中S100A6基因表达降低的研究有12项,表达增高的研究有18项。共有4项研究涉及S100A6在HCC癌组织和正常肝组织中的表达,与正常肝组织相比,S100A6在HCC中高表达(P=4.58E-4)。此外,S100A6表达量与HCC总体生存率存在相关性,高表达S100A6的患者总体生存率较差(P=0.048、P=0.0051)。进一步结合TNM分期进行分析发现,S100A6表达在Ⅳ期最高。S100A6表达与Ⅰ(P=0.31)、Ⅱ(P=0.2)期患者预后无相关性,在Ⅲ期患者中,高表达S100A6的患者总体生存率较差(P=0.0071)。结论:本研究通过对基因芯片数据库中肿瘤相关基因信息的深入挖掘和剖析,发现S100A6基因在肝细胞癌组织中呈现高表达,并且与肝细胞癌预后关系密切,尤其对HCCⅢ期患者有预后指导意义。展开更多
The occurrence and damage of Xylotrechus quadripes Chew were investigated in different time points and micro environments in Siman south island river coffee test demonstration field. The results showed that X. quadr/p...The occurrence and damage of Xylotrechus quadripes Chew were investigated in different time points and micro environments in Siman south island river coffee test demonstration field. The results showed that X. quadr/pes mainly damaged 5-year-old coffee trees. X. quadr/pes occurred one generation per year in Siman region, and the larval stage lasted 296 - 322 d. The adult could be found in four seasons because of different development progress and overlapping generations. In different micro environments, X. quadr/pes were mainly distributed in mixed forests and the coffee land in sunny slope. The adult enjoyed sunshine on the coffee trees at noon. The nattwal enemy Prislauacus nigripea kieff was found to parasitize in the larvae of X. quadripes, which could control the population of X. quadr/pes.展开更多
Making use of the generalized tortoise transformation,the radial part of the Klein-Gordon equation can be reduced to the standard wave equation around the event horizon in the higher dimensional Vaidya space-time.Both...Making use of the generalized tortoise transformation,the radial part of the Klein-Gordon equation can be reduced to the standard wave equation around the event horizon in the higher dimensional Vaidya space-time.Both the location of event horizon and the radiation temperature of black hole are shown automatically.展开更多
A non-stationary solution of the field equation in 1+1 dimension gravity is given with the advanced Eddington-Finkelstein coordinate.There exists a 1+1 dimensional non-stationary black hole in the space-time.The locat...A non-stationary solution of the field equation in 1+1 dimension gravity is given with the advanced Eddington-Finkelstein coordinate.There exists a 1+1 dimensional non-stationary black hole in the space-time.The location of event horizons,the Hawking temperature and the spectrum of thermal radiation are derived.展开更多
With a new method calculating the location and temperature of the event horizon of the non-static black hole,the Dirac equation is reduced and solved near the horizon in Vaidya space-time when the tortoise coordinate ...With a new method calculating the location and temperature of the event horizon of the non-static black hole,the Dirac equation is reduced and solved near the horizon in Vaidya space-time when the tortoise coordinate is adopted.The location of Vaidya event horizon,the Hawking temperature and the formula of thermal spectrum of the Dirac particles are derived.展开更多
文摘目的:探讨S100蛋白超家族A6(S100 family member A6,S100A6)在肝细胞癌(hepatocellular carcinoma,HCC)中的表达及临床意义。方法:利用Oncomine生物信息学在线分析网站,挖掘分析大型癌症公共数据癌症基因组图谱(TCGA)及GEO(Gene Expression Omnibus)中肝癌S100A6 mRNA的表达信息,基于TCGA中的肝癌数据,利用GEPIA、Kaplan-Meier Plotter进行患者生存分析。结果:在Oncomine数据库中,前后共收集了337项不同类型的研究结果,关于S100A6基因表达有统计学差异的研究结果有30个,其中S100A6基因表达降低的研究有12项,表达增高的研究有18项。共有4项研究涉及S100A6在HCC癌组织和正常肝组织中的表达,与正常肝组织相比,S100A6在HCC中高表达(P=4.58E-4)。此外,S100A6表达量与HCC总体生存率存在相关性,高表达S100A6的患者总体生存率较差(P=0.048、P=0.0051)。进一步结合TNM分期进行分析发现,S100A6表达在Ⅳ期最高。S100A6表达与Ⅰ(P=0.31)、Ⅱ(P=0.2)期患者预后无相关性,在Ⅲ期患者中,高表达S100A6的患者总体生存率较差(P=0.0071)。结论:本研究通过对基因芯片数据库中肿瘤相关基因信息的深入挖掘和剖析,发现S100A6基因在肝细胞癌组织中呈现高表达,并且与肝细胞癌预后关系密切,尤其对HCCⅢ期患者有预后指导意义。
基金Supported by Scientific Research Fund Project of Yunnan Department of Education(2014Y508)Project of Yunnan Department of Finance(YCJ[2013]212)Project of Pu’er University for Professional Gardening Talents
文摘The occurrence and damage of Xylotrechus quadripes Chew were investigated in different time points and micro environments in Siman south island river coffee test demonstration field. The results showed that X. quadr/pes mainly damaged 5-year-old coffee trees. X. quadr/pes occurred one generation per year in Siman region, and the larval stage lasted 296 - 322 d. The adult could be found in four seasons because of different development progress and overlapping generations. In different micro environments, X. quadr/pes were mainly distributed in mixed forests and the coffee land in sunny slope. The adult enjoyed sunshine on the coffee trees at noon. The nattwal enemy Prislauacus nigripea kieff was found to parasitize in the larvae of X. quadripes, which could control the population of X. quadr/pes.
文摘Making use of the generalized tortoise transformation,the radial part of the Klein-Gordon equation can be reduced to the standard wave equation around the event horizon in the higher dimensional Vaidya space-time.Both the location of event horizon and the radiation temperature of black hole are shown automatically.
文摘A non-stationary solution of the field equation in 1+1 dimension gravity is given with the advanced Eddington-Finkelstein coordinate.There exists a 1+1 dimensional non-stationary black hole in the space-time.The location of event horizons,the Hawking temperature and the spectrum of thermal radiation are derived.
基金Supported by the National Natural Science Foundation of China.
文摘With a new method calculating the location and temperature of the event horizon of the non-static black hole,the Dirac equation is reduced and solved near the horizon in Vaidya space-time when the tortoise coordinate is adopted.The location of Vaidya event horizon,the Hawking temperature and the formula of thermal spectrum of the Dirac particles are derived.
