目的探讨氨茶碱联合百令胶囊对稳定期慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者气道功能及血清气道重塑分子的影响。方法选取96例稳定期COPD患者,用随机数字表法分为3组(对照组、A组和B组),每组32例。对照组...目的探讨氨茶碱联合百令胶囊对稳定期慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者气道功能及血清气道重塑分子的影响。方法选取96例稳定期COPD患者,用随机数字表法分为3组(对照组、A组和B组),每组32例。对照组接受常规西药(硫酸沙丁胺醇吸入气雾剂联合布地奈德福莫特罗吸入粉雾剂)治疗,在对照组治疗的基础上,A组加用氨茶碱、B组加用氨茶碱和百令胶囊。观察3组治疗前后的气道功能参数、血清炎症因子、生长因子、气道重塑分子变化及生活质量评分,对比治疗效果及药物不良反应发生情况。结果治疗后,3组的第1秒用力呼气容积(forced expiratory volume in 1 second,FEV 1)、第1秒用力呼气容积与用力肺活量比值(forced expiratory volume in 1 second/forced vital capacity,FEV 1/FVC)、50%肺活量最大呼气流速(maximal expiratory flow after 50%of the FVC has been not exhaled,MEF 50)、中段呼气流速(maximal expiratory flow after 25%~75%of the FVC has been not exhaled,MEF 25~75)和25%肺活量用力呼气流速(maximal expiratory flow after 25%of the FVC has been not exhaled,MEF 25)均明显升高(P<0.05),3组治疗后的各气道功能参数比较差异有统计学意义,FEV 1、FEV 1/FVC、MEF 50、MEF 25~75和MEF 25均为B组>A组>对照组,P<0.05。3组治疗后血清白细胞介素2(interleukin-2,IL-2)、白细胞介素-18(interleukin-18,IL-18)、血管内皮生长因子(vascular endothelial growth factor,VEGF)、神经生长因子(nerve growth factor,NGF)及碱性成纤维细胞生长因子(basic fibroblast growth factor,b-FGF)水平均明显降低(P<0.05)。3组比较差异有统计学意义,且均为B组<A组<对照组(P<0.05)。3组的转化生长因子β1(transforming growth factor-β1,TGF-β1)、烟酰胺腺嘌呤二核苷酸磷酸氧化酶4(nicotinamide adenine dinucleotide phosphate oxidase 4,NOX4)、核因子-κB(nuclear factor-κB,NF-κB)及基质金属蛋白酶9(matrix metalloproteinase-9,MMP-9)水平均明显降低(P<0.05),且TGF-β1、NOX4、NF-κB及MMP-9水平均为B组<A组<对照组(P<0.05)。3组不良反应发生率比较差异无统计学意义。3组治疗后1个月的简化36医疗结局研究量表(36-item short form survey instrument,SF36)评分情况为B组>A组>对照组(P<0.05)。结论对稳定期COPD患者联用氨茶碱和百令胶囊可有效发挥抗炎作用,改善患者的气道功能,抑制气道上皮细胞增殖,减缓气道重塑进程。展开更多
On the morning of August 15, 2007,with a clear ring of gong, Wuxi Sunmart Holdings Pte Ltd officially got listed on the Singapore Stock Exchange.From this moment, a new member joined in'Jiangyin block'in Singa...On the morning of August 15, 2007,with a clear ring of gong, Wuxi Sunmart Holdings Pte Ltd officially got listed on the Singapore Stock Exchange.From this moment, a new member joined in'Jiangyin block'in Singapore.Following the successful listing of Yangtze Shipping展开更多
On the morning of August 15, 2007, with a clear ring of gong, Wuxi Sunmart Holdings Pte Ltd officially got listed on the Singa- pore Stock Exchange. From this moment, a new member joined in'Jiangyin block'in S...On the morning of August 15, 2007, with a clear ring of gong, Wuxi Sunmart Holdings Pte Ltd officially got listed on the Singa- pore Stock Exchange. From this moment, a new member joined in'Jiangyin block'in Singapore. Following the successful listing of Yangtze Shipping and Junxin Science & Technology respectively in Singapore Stock Exchange and London Stock Ex- change, Wuxi Sunmart entered the stock market full of completion as a dark horse. The major leaders of Wuxi government, Zhu Minyang, Gao Pei and Zhang Shix- ian, all attended the Wuxi Sunmart's listing ceremony.展开更多
Miracle startedA decade ago, Wuxi Sunmart was just no name. At that time, few people noticed Jiangsu Snow Leopard Atomization Pot Industry Limited Company, which was established in early 1998, as it was a small worksh...Miracle startedA decade ago, Wuxi Sunmart was just no name. At that time, few people noticed Jiangsu Snow Leopard Atomization Pot Industry Limited Company, which was established in early 1998, as it was a small workshop with a registered capital of only RMB 1.6 million. And that is where Wuxi Sunmart＇s miracle initiated and grew from.展开更多
文摘目的探讨氨茶碱联合百令胶囊对稳定期慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者气道功能及血清气道重塑分子的影响。方法选取96例稳定期COPD患者,用随机数字表法分为3组(对照组、A组和B组),每组32例。对照组接受常规西药(硫酸沙丁胺醇吸入气雾剂联合布地奈德福莫特罗吸入粉雾剂)治疗,在对照组治疗的基础上,A组加用氨茶碱、B组加用氨茶碱和百令胶囊。观察3组治疗前后的气道功能参数、血清炎症因子、生长因子、气道重塑分子变化及生活质量评分,对比治疗效果及药物不良反应发生情况。结果治疗后,3组的第1秒用力呼气容积(forced expiratory volume in 1 second,FEV 1)、第1秒用力呼气容积与用力肺活量比值(forced expiratory volume in 1 second/forced vital capacity,FEV 1/FVC)、50%肺活量最大呼气流速(maximal expiratory flow after 50%of the FVC has been not exhaled,MEF 50)、中段呼气流速(maximal expiratory flow after 25%~75%of the FVC has been not exhaled,MEF 25~75)和25%肺活量用力呼气流速(maximal expiratory flow after 25%of the FVC has been not exhaled,MEF 25)均明显升高(P<0.05),3组治疗后的各气道功能参数比较差异有统计学意义,FEV 1、FEV 1/FVC、MEF 50、MEF 25~75和MEF 25均为B组>A组>对照组,P<0.05。3组治疗后血清白细胞介素2(interleukin-2,IL-2)、白细胞介素-18(interleukin-18,IL-18)、血管内皮生长因子(vascular endothelial growth factor,VEGF)、神经生长因子(nerve growth factor,NGF)及碱性成纤维细胞生长因子(basic fibroblast growth factor,b-FGF)水平均明显降低(P<0.05)。3组比较差异有统计学意义,且均为B组<A组<对照组(P<0.05)。3组的转化生长因子β1(transforming growth factor-β1,TGF-β1)、烟酰胺腺嘌呤二核苷酸磷酸氧化酶4(nicotinamide adenine dinucleotide phosphate oxidase 4,NOX4)、核因子-κB(nuclear factor-κB,NF-κB)及基质金属蛋白酶9(matrix metalloproteinase-9,MMP-9)水平均明显降低(P<0.05),且TGF-β1、NOX4、NF-κB及MMP-9水平均为B组<A组<对照组(P<0.05)。3组不良反应发生率比较差异无统计学意义。3组治疗后1个月的简化36医疗结局研究量表(36-item short form survey instrument,SF36)评分情况为B组>A组>对照组(P<0.05)。结论对稳定期COPD患者联用氨茶碱和百令胶囊可有效发挥抗炎作用,改善患者的气道功能,抑制气道上皮细胞增殖,减缓气道重塑进程。
文摘On the morning of August 15, 2007,with a clear ring of gong, Wuxi Sunmart Holdings Pte Ltd officially got listed on the Singapore Stock Exchange.From this moment, a new member joined in'Jiangyin block'in Singapore.Following the successful listing of Yangtze Shipping
文摘On the morning of August 15, 2007, with a clear ring of gong, Wuxi Sunmart Holdings Pte Ltd officially got listed on the Singa- pore Stock Exchange. From this moment, a new member joined in'Jiangyin block'in Singapore. Following the successful listing of Yangtze Shipping and Junxin Science & Technology respectively in Singapore Stock Exchange and London Stock Ex- change, Wuxi Sunmart entered the stock market full of completion as a dark horse. The major leaders of Wuxi government, Zhu Minyang, Gao Pei and Zhang Shix- ian, all attended the Wuxi Sunmart's listing ceremony.
文摘Miracle startedA decade ago, Wuxi Sunmart was just no name. At that time, few people noticed Jiangsu Snow Leopard Atomization Pot Industry Limited Company, which was established in early 1998, as it was a small workshop with a registered capital of only RMB 1.6 million. And that is where Wuxi Sunmart＇s miracle initiated and grew from.
