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Modeling urban redevelopment:A novel approach using time-series remote sensing data and machine learning
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作者 li lin liping Di +6 位作者 Chen Zhang liying Guo Haoteng Zhao Didarul Islam Hui li Ziao liu Gavin Middleton 《Geography and Sustainability》 CSCD 2024年第2期211-219,共9页
Accurate mapping and timely monitoring of urban redevelopment are pivotal for urban studies and decisionmakers to foster sustainable urban development.Traditional mapping methods heavily depend on field surveys and su... Accurate mapping and timely monitoring of urban redevelopment are pivotal for urban studies and decisionmakers to foster sustainable urban development.Traditional mapping methods heavily depend on field surveys and subjective questionnaires,yielding less objective,reliable,and timely data.Recent advancements in Geographic Information Systems(GIS)and remote-sensing technologies have improved the identification and mapping of urban redevelopment through quantitative analysis using satellite-based observations.Nonetheless,challenges persist,particularly concerning accuracy and significant temporal delays.This study introduces a novel approach to modeling urban redevelopment,leveraging machine learning algorithms and remote-sensing data.This methodology can facilitate the accurate and timely identification of urban redevelopment activities.The study’s machine learning model can analyze time-series remote-sensing data to identify spatio-temporal and spectral patterns related to urban redevelopment.The model is thoroughly evaluated,and the results indicate that it can accurately capture the time-series patterns of urban redevelopment.This research’s findings are useful for evaluating urban demographic and economic changes,informing policymaking and urban planning,and contributing to sustainable urban development.The model can also serve as a foundation for future research on early-stage urban redevelopment detection and evaluation of the causes and impacts of urban redevelopment. 展开更多
关键词 Urban redevelopment Urban sustainability Remote sensing Time-series analysis Machine learning
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Non-contact wide-field viewing system-assisted scleral buckling surgery for retinal detachment in silicone oilfilled eyes
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作者 Su-Lan Wu Yi-Qi Chen +7 位作者 li-Jun Shen Jian-Bo Mao li lin Ji-Wei Tao Huan Chen Shi-An Zhang Jia-Feng Yu Chen-Xi Wang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第4期761-766,共6页
AIM:To evaluate scleral buckling(SB)surgery using a noncontact wide-field viewing system and 23-gauge intraocular illumination for the treatment of rhegmatogenous retinal detachment in silicone oil(SO)-filled eyes.MET... AIM:To evaluate scleral buckling(SB)surgery using a noncontact wide-field viewing system and 23-gauge intraocular illumination for the treatment of rhegmatogenous retinal detachment in silicone oil(SO)-filled eyes.METHODS:Totally 9 patients(9 eyes)with retinal detachment in SO-filled eyes were retrospectively analyzed.All patients underwent non-contact wide-field viewing system-assisted buckling surgery with 23-gauge intraocular illumination.SO was removed at an appropriate time based on recovery.The patients were followed up for at least 3mo after SO removal.Retinal reattachment,complications,visual acuity and intraocular pressure(IOP)before and after surgery were observed.RESULTS:Patients were followed up for a mean of 8.22mo(3-22mo)after SO removal.All patients had retinal reattachment.At the final follow-up,visual acuity showed improvement for 8 patients,and no change for 1 patient.The IOP was high in 3 patients before surgery,but it stabilized after treatment;it was not affected in the other patients.None of the patients had infections,hemorrhage,anterior ischemia,or any other complication.CONCLUSION:This new non-contact wide-field viewing system-assisted SB surgery with 23-gauge intraocular illumination is effective and safe for retinal detachment in SO-filled eyes. 展开更多
关键词 non-contact wide-field viewing system scleral buckling silicone oil-filled retinal detachment
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miR-17-5p调控LIMK1/cofilin1通路对子宫内膜异位症发生发展的影响
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作者 李琳 贺冰 +2 位作者 张翼 马本玲 邢敏 《吉林医学》 CAS 2023年第7期1755-1759,共5页
目的:探究微小核糖核酸-17-5p(miR-17-5p)调控LIM激酶1(LIMK1)/丝切蛋白1(cofilin1)通路对子宫内膜异位症发生发展的影响。方法:选取行子宫切除术的30例子宫内膜异位症患者作为子宫内膜异位症在位内膜组,另选取30例非雌激素依赖性疾病... 目的:探究微小核糖核酸-17-5p(miR-17-5p)调控LIM激酶1(LIMK1)/丝切蛋白1(cofilin1)通路对子宫内膜异位症发生发展的影响。方法:选取行子宫切除术的30例子宫内膜异位症患者作为子宫内膜异位症在位内膜组,另选取30例非雌激素依赖性疾病患者作为正常子宫内膜组。对两组患者的在位内膜细胞中LIMK1、cofilin1表达量采用实时荧光定量PCR法检测,对所获取的在位内膜细胞进行转染,Transwell法检测细胞的侵袭能力;CCK-8法检测细胞的增殖能力;ELISA法检测子宫内膜细胞中细胞因子ICAM-1、VEGF、MMP-9表达。结果:在位内膜组患者的miR-17-5p表达水平低于正常子宫内膜组(P<0.05);在位内膜组的LIMK1蛋白及其mRNA、cofilin1蛋白及其mRNA相对表达水平均高于正常子宫内膜组(P<0.05);在位内膜组未转染组(EC组)及转染阴性对照(EC-C组)情况下细胞侵袭能力显著高于正常子宫内膜组(NC组),但转染情况下(EC-miR-17-5p-RNAi组)细胞侵袭能力显著低于正常子宫内膜组(NC-miR-17-5p-cDNA组),两组患者细胞转染阴性对照(EC-C组、NC-C组)与未转染状态(EC组、NC组)差异无统计学意义(P>0.05);转染情况在位内膜组患者(EC-miR-17-5p-RNAi组)细胞侵袭力低于未转染状态(EC组),但正常子宫内膜组(NC-miR-17-5p-cDNA组)高于未转染组(NC组,P>0.05)。EC组细胞增殖能力在24 h、48 h、72 h、96 h均高于NC组细胞(P<0.05);EC-miR-17-5p-RNAi组各时间段细胞增殖能力与EC组相比较均升高(P<0.05);EC组与EC-C组在各时间段的细胞增殖能力比较差异无统计学意义(P>0.05);NC-miR-17-5p-cDNA组在各时间段的增殖能力均低于NC组(P<0.05);NC-C组各时间段的细胞增殖能力与NC组比较差异无统计学意义(P>0.05)。基础状态下,EC组ICAM-1、MMP-9和VEGF水平高于NC组,EC-miR-17-5p-RNAi组与EC组比较明显升高(P<0.05);EC组与EC-C组各指标比较差异无统计学意义(P>0.05);NC组ICAM-1、MMP-9和VEGF水平明显高于NC-miR-17-5p-cDNA组(P<0.05),但与NC-C组比较差异无统计学意义(P>0.05)。结论:miR-17-5p在内异症细胞中表达水平下调,通过负向调控LIMK1/cofilin1通路抑制细胞增殖、侵袭,在内异症发生及进展过程中发挥基因调节功能。 展开更多
关键词 miR-17-5p LIMK1/cofilin1通路 子宫内膜异位症
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miR-218-5p通过靶向LIN28B调控COPD时气道上皮细胞凋亡和炎症反应 被引量:5
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作者 任敏 李琳 梁向清 《西部医学》 2021年第1期27-32,共6页
目的探讨miR-218-5p通过靶向LIN28B调控慢性阻塞性肺疾病(COPD)时气道上皮细胞凋亡和炎症反应的作用及其机制。方法将人肺支气管上皮细胞BEAS-2B分为正常对照(NC)组、香烟烟雾提取物(CSE)组、miR-NC+CSE组、miR-218-5p+CSE组、si-NC+CS... 目的探讨miR-218-5p通过靶向LIN28B调控慢性阻塞性肺疾病(COPD)时气道上皮细胞凋亡和炎症反应的作用及其机制。方法将人肺支气管上皮细胞BEAS-2B分为正常对照(NC)组、香烟烟雾提取物(CSE)组、miR-NC+CSE组、miR-218-5p+CSE组、si-NC+CSE组、si-LIN28B+CSE组、miR-218-5p+pcDNA-NC+CSE组和miR-218-5p+pcDNA-LIN28B+CSE组。RT-qPCR检测miR-218-5p的表达水平;流式细胞术检测细胞凋亡;酶联免疫吸附实验(ELISA)检测白细胞介素6(IL-6)和转化生长因子-β1(TGF-β1)的表达水平;蛋白质印记(Western blot)检测LIN28B、裂解的天冬氨酸半胱氨酸蛋白酶(Cleaved-caspase-3)的表达水平;双荧光素酶报告基因实验验证miR-218-5p对LIN28B的靶向作用。结果与NC组比较,CSE组BEAS-2B细胞miR-218-5p表达降低,细胞凋亡率、LIN28B、Cleaved-caspase-3、IL-6和TGF-β1表达显著增加(均P<0.05)。与miR-NC+CSE组比较,miR-218-5p+CSE组BEAS-2B细胞凋亡率、Cleaved-caspase-3、IL-6和TGF-β1表达显著降低(均P<0.05)。与si-NC+CSE组比较,si-LIN28B+CSE组BEAS-2B细胞凋亡率、Cleaved-caspase-3、IL-6和TGF-β1表达显著降低(均P<0.05)。与miR-218-5p+pcDNA-NC+CSE组比较,miR-218-5p+pcDNA-LIN28B+CSE组BEAS-2B细胞细胞凋亡率、Cleaved-caspase-3、IL-6和TGF-β1表达显著增加(均P<0.05)。结论miR-218-5p通过靶向LIN28B可抑制CSE诱导的气道上皮细胞凋亡和炎症反应。因此,miR-218-5p可能是慢性阻塞性肺疾病的潜在治疗靶点。 展开更多
关键词 慢性阻塞性肺疾病 miR-218-5p LIN28B 气道上皮细胞 凋亡 炎症反应
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LINC00511和LINC01133诊断老年胃癌的临床价值 被引量:1
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作者 高勇 李林 +3 位作者 黄声凯 吴琦 郭红艳 孙晓杰 《中国老年学杂志》 CAS 北大核心 2023年第11期2596-2600,共5页
目的探讨老年胃癌患者血清长基因间非蛋白编码RNA(LINC)00511和LINC01133的表达及与临床特征的关系,分析二者单项及与糖类抗原(CA)72-4联合检测对老年人胃癌的临床诊断价值。方法选取老年胃癌患者100例作为实验组,再选取同期老年健康体... 目的探讨老年胃癌患者血清长基因间非蛋白编码RNA(LINC)00511和LINC01133的表达及与临床特征的关系,分析二者单项及与糖类抗原(CA)72-4联合检测对老年人胃癌的临床诊断价值。方法选取老年胃癌患者100例作为实验组,再选取同期老年健康体检者76例作为对照组,通过定量逆转录聚合酶链反应检测血清LINC00511和LINC01133的表达,分析二者血清表达水平的相关性及与肿瘤临床特征的关系;采用受试者工作特征(ROC)曲线评估其对胃癌的临床诊断效能;通过计算ROC曲线下面积(AUC)、敏感度、特异度、阳性预测值及阴性预测值,评估单项及联合检测的临床应用价值。结果实验组LINC00511和LINC01133表达量显著高于对照组(均P<0.01),实验组二者表达水平呈显著正相关(r=0.304,P<0.01)。LINC01133血清水平与性别、TNM临床分期和淋巴结转移均无统计学差异(P>0.05),但与肿瘤合并远处转移呈正相关(P<0.01)。LINC00511、LINC01133及CA72-4诊断胃癌的AUC分别为0.659、0.807和0.764,其中LINC01133诊断的敏感度(81.0%)最高,CA72-4诊断的特异度(84.2%)最高。LINC00511与LINC01133具有显著诊断互补性(P<0.05)。而LINC00511和CA72-4、LINC01133和CA72-4之间均无显著互补性(P>0.05)。LINC00511和LINC01133联合可将诊断的敏感度提高至92.0%,二者与CA72-4联合可将敏感度和阴性预测值分别提高至94.0%和85.7%。结论LINC00511和LINC01133在老年胃癌患者血清中高表达,与临床进展显著相关,可能是老年胃癌辅助诊断的潜在血清学标志物。 展开更多
关键词 长基因间非蛋白编码RNA00511 长基因间非蛋白编码RNA01133 胃癌 诊断效能
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社区获得性细菌性肺炎治疗药物lefamulin的研究进展 被引量:3
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作者 张春晓 卢芳 +2 位作者 张临 李琳 孙菲菲 《中国抗生素杂志》 CAS CSCD 北大核心 2022年第10期1020-1024,共5页
Lefamulin是首个可以用于治疗全身感染的半合成截短侧耳素类药物。目前,已经完成了lefamulin治疗社区获得性细菌性肺炎(CABP)的Ⅲ期临床试验和急性细菌性皮肤和皮肤结构感染的Ⅱ期临床试验,结果证实了其有效性和安全性,被FDA和EMA批准... Lefamulin是首个可以用于治疗全身感染的半合成截短侧耳素类药物。目前,已经完成了lefamulin治疗社区获得性细菌性肺炎(CABP)的Ⅲ期临床试验和急性细菌性皮肤和皮肤结构感染的Ⅱ期临床试验,结果证实了其有效性和安全性,被FDA和EMA批准用于治疗CABP,可经口服和静脉给药。Lefamulin对引起CABP的细菌抗菌谱广,作用机制独特,耐药性出现较慢,与其他抗生素无交叉耐药性。本文从lefamulin的药效学、药动学、临床应用、安全性及耐药机制等方面进行综述,以期为临床合理使用该抗菌素提供理论依据。 展开更多
关键词 Lefamulin 药效学 药动学 临床应用 耐药机制
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基于Energetic和改进Jiles-Atherton-Sablik模型的电工钢片动态磁致伸缩特性模拟 被引量:4
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作者 陈昊 李琳 王亚琦 《中国电机工程学报》 EI CSCD 北大核心 2024年第2期848-858,I0035,共12页
准确模拟电工钢片的动态磁致伸缩特性是电工装备铁心振动和噪声分析的关键步骤。该文提出一种基于Energetic磁滞模型和改进Jiles-Atherton-Sablik(J-A-S)模型的电工钢片动态磁致伸缩特性模拟方法。首先,基于静态Energetic磁滞模型和损... 准确模拟电工钢片的动态磁致伸缩特性是电工装备铁心振动和噪声分析的关键步骤。该文提出一种基于Energetic磁滞模型和改进Jiles-Atherton-Sablik(J-A-S)模型的电工钢片动态磁致伸缩特性模拟方法。首先,基于静态Energetic磁滞模型和损耗分离理论,考虑由励磁频率引起的动态损耗密度分量,并采用场分离技术建立动态Energetic磁滞模型。其次,将动态Energetic磁滞模型求解的动态磁场强度作为改进J-A-S模型的已知量,从而根据铁磁材料的非线性本构关系,建立以磁感应强度为输入量的动态磁致伸缩逆模型。在此基础上,设计电工钢片动态磁致伸缩曲线的模拟流程。最后,将所提方法的模拟结果与实测结果和现有方法模拟结果进行对比,可知所提方法的模拟结果与实测结果吻合更好,从而验证所提模拟方法的准确性。 展开更多
关键词 电工钢片 动态磁致伸缩特性 Energetic磁滞模型 改进Jiles-Atherton-Sablik模型
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Numerical modeling of DPSK pressure signals and their transmission characteristics in mud channels 被引量:11
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作者 Shen Yue Su Yinao +2 位作者 li Gensheng li lin Tian Shouceng 《Petroleum Science》 SCIE CAS CSCD 2009年第3期266-270,共5页
A numerical model and transmission characteristic analysis of DPSK (differential phase shift keying) pressure signals in mud channels is introduced. With the control logic analysis of the rotary valve mud telemetry,... A numerical model and transmission characteristic analysis of DPSK (differential phase shift keying) pressure signals in mud channels is introduced. With the control logic analysis of the rotary valve mud telemetry, a logical control signal is built from a Gate function sequence according to the binary symbols of transmitted data and a phase-shift function is obtained by integrating the logical control signal. A mathematical model of the DPSK pressure signal is built based on principles of communications by modulating carrier phase with the phase-shift function and a numerical simulation of the pressure wave is implemented with the mathematical model by MATLAB programming. Considering drillpipe pressure and drilling fluid temperature profile along drillpipes, the drillpipe of a vertical well is divided into a number of sections. With water-based drilling fluids, the impacts of travel distance, carrier frequency, drillpipe size, and drilling fluids on the signal transmission were studied by signal transmission characteristic analysis for all the sections. Numerical calculation results indicate that the influences of the viscosity of drilling fluids and volume fraction of gas in drilling fluids on the DPSK signal transmission are more notable than the others and the signal will distort in waveform with differential attenuations of the signal frequent component. 展开更多
关键词 Measurement while drilling (MWD) MODULATION binary symbol mathematical model numerical simulation differential phase shift keying (DPSK) signal transmission characteristics
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Lingo-1及其相关传导通路在神经系统修复中的研究进展
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作者 王天双 肖刚 +3 位作者 李林 张俭 张德新 陆莹 《中国急救医学》 CAS CSCD 北大核心 2018年第7期636-640,共5页
富含亮氨酸重复序列和免疫球蛋白结构域的Nogo受体作用蛋白-1(Lingo-1)在神经元与少突胶质细胞修复、神经突延长、轴突再生等过程中,通过NgR/p75/Lingo-1或NgR/TROY/Lingo-1、WNK1、Myt1与Myt1l等通路发挥明确的负性调节作用,阻断... 富含亮氨酸重复序列和免疫球蛋白结构域的Nogo受体作用蛋白-1(Lingo-1)在神经元与少突胶质细胞修复、神经突延长、轴突再生等过程中,通过NgR/p75/Lingo-1或NgR/TROY/Lingo-1、WNK1、Myt1与Myt1l等通路发挥明确的负性调节作用,阻断Lingo-1及其通路可促进损伤的中枢神经系统再生,提示Lingo-1有可能成为治疗神经精神系统疾病的新靶点。 展开更多
关键词 富含亮氨酸重复序列和免疫球蛋白结构域的Nogo受体作用蛋白-1(Lingo-1) 中枢神经系统损伤 神经再生 传导通路
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Nitrogen Deep Placement Combined with Straw Mulch Cultivation Enhances Physiological Traits,Grain Yield and Nitrogen Use Efficiency in Mechanical Pot-Seedling Transplanting Rice 被引量:8
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作者 li lin ZHANG Zheng +7 位作者 TIAN Hua Umair ASHRAF Yousef Alhaj HAMOUD Al Aasmi ALAA TANG Xiangru DUAN Meiyang WANG Zaiman PAN Shenggang 《Rice science》 SCIE CSCD 2022年第1期89-100,I0031,共13页
To assess the effects of straw return coupled with deep nitrogen(N)fertilization on grain yield and N use efficiency(NUE)in mechanical pot-seedling transplanting(MPST)rice,the seedlings of two rice cultivars,i.e.,Yuxi... To assess the effects of straw return coupled with deep nitrogen(N)fertilization on grain yield and N use efficiency(NUE)in mechanical pot-seedling transplanting(MPST)rice,the seedlings of two rice cultivars,i.e.,Yuxiangyouzhan and Wufengyou 615 transplanted by MPST were applied with N fertilizer at 150 kg/hm2 and straw return at 6 t/hm2 in early seasons of 2019 and 2020.The experiment comprised of following treatments:CK(no fertilizer and no straw return),MDS(deep N fertilization and straw return),MBS(broadcasting fertilizer and straw return),MD(deep N fertilization without straw return),MB(broadcasting fertilizer without straw return).Results depicted that the MDS treatment significantly increased the rice yield by 41.69%-72.22%due to total above-ground biomass,leaf area index and photosynthesis increased by 54.70%-55.80%,38.52%-52.17%and 17.89%-28.40%,respectively,compared to the MB treatment.In addition,the MDS treatment enhanced the total N accumulation by 37.74%-43.69%,N recovery efficiency by 141.45%-164.65%,N agronomic efficiency by 121.76%-134.19%,nitrate reductase by 46.46%-60.86%and glutamine synthetase by 23.56%-31.02%,compared to the MB treatment.The average grain yield and NUE in both years for Yuxiangyouzhan were higher in the MDS treatment than in the MD treatment.Hence,deep N fertilization combined with straw return can be an innovative technique with improved grain yield and NUE in MPST in South China. 展开更多
关键词 mechanical pot-seedling transplanting nitrogen deep placement nitrogen use efficiency RICE straw return
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Thermodynamic analysis of Li-Ni-Co-Mn-H2O system and synthesis of LiNi0.5Co0.2Mn0.3O2 composite oxide via aqueous process 被引量:2
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作者 li Yun-jiao li ling +6 位作者 SU Qian-ye LU Wei-sheng HAN Qiang li lin CHEN Yong-xiang DENG Shi-yi LEI Tong-xing 《Journal of Central South University》 SCIE EI CAS CSCD 2019年第10期2668-2680,共13页
The constructed potential-pH diagrams of Li-Ni(Co,Mn)-H2O system indicate that the LiNiO2,LiCoO2 and LiMnO2 are thermodynamically stable in aqueous solution within the temperature range of 25-200°C and the activi... The constructed potential-pH diagrams of Li-Ni(Co,Mn)-H2O system indicate that the LiNiO2,LiCoO2 and LiMnO2 are thermodynamically stable in aqueous solution within the temperature range of 25-200°C and the activity range of 0.01-1.00.A predominant co-region of LiNiO2,LiCoO2 and LiMnO2 oxides(Li-Ni-Co-Mncomposite oxide)is found in the Li-Ni-Co-Mn-H2O potential-pH diagrams,in which the co-precipitation region expands towards lower pH with rising temperature,indicating the enhanced possibility of synthesizing Li-Ni-Co-Mn composite oxide in aqueous solution.The experimental results prove that it is feasible to prepare the LiNi0.5Co0.2Mn0.3O2 cathode materials(NCM523)by an aqueous routine.The as-prepared lithiated precursor and NCM523 both inherit the spherical morphology of the hydroxide precursor and the obtained NCM523 has a hexagonalα-NaFeO2 structure with good crystallinity.It is reasonable to conclude that the aqueous routine for preparing NCM cathode materials is a promising method with the guidance of the reliable potential-pH diagrams to some extent. 展开更多
关键词 aqueous process potential-pH diagrams THERMODYNAMICS LiNi0.5Co0.2Mn0.3O2 cathode materials
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Ideal Cardiovascular Health is Inversely Associated with Subclinical Atherosclerosis: A Prospective Analysis 被引量:2
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作者 WANG Long NIU Jing Ya +12 位作者 ZHAO Zhi Yun li Mian XU Min LU Jie li WANG Tian Ge CHEN Yu Hong WANG Shuang Yuan DAI Meng li lin liU Shan Shan WANG Wei Qing XU Yu BI Yu Fang 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2019年第4期260-271,共12页
Objective Ideal cardiovascular health(CVH) could predict a lower risk of developing cardiovascular diseases. This study was conducted to investigate the association between ideal CVH and subclinical atherosclerosis in... Objective Ideal cardiovascular health(CVH) could predict a lower risk of developing cardiovascular diseases. This study was conducted to investigate the association between ideal CVH and subclinical atherosclerosis in a population cohort of Chinese adults aged ≥ 40 years. Methods This study was designed as a cross-sectional analysis of 8,395 participants who had complete data at baseline and a prospective analysis of 4,879 participants who had complete data at 4.3 years of follow-up. Ideal CVH metrics were defined according to the American Heart Association. Subclinical atherosclerosis was evaluated by plaques in carotid arteries, carotid intima-media thickness(CIMT), brachial-ankle pulse wave velocity(baPWV), and urinary albumin-to-creatinine ratio(UACR). Results Both the prevalence and incidence of atherosclerosis measures were found to be decreased with increasing numbers of ideal CVH metrics at baseline(all P values for trend < 0.01). The levels of CIMT and UACR at follow-up showed an inverse and significant association with the numbers of ideal CVH metrics at baseline(both P values for trend < 0.05) but a borderline significant association with baPWV(P for trend = 0.0505). Taking participants with 0-1 ideal metric as reference, we found that participants with 5-6 ideal metrics had significantly lower risks of developing carotid plaques(odds ratio, OR = 0.46; 95% confidence interval, CI 0.27-0.79), increased CIMT(OR = 0.60; 95% CI 0.42-0.84), and increased baPWV(OR = 0.57; 95% CI 0.34-0.97) after full adjustments. A significant interactive effect of age and CVH was detected on CIMT and baPWV progression(both P values for interaction < 0.05). Conclusion The numbers of ideal CVH metrics showed a significant and inverse association with the risk of developing subclinical atherosclerosis in middle-aged and elderly Chinese adults, whereas its dose-response effect was attenuated in individuals aged ≥ 60 years and partially weakened in male participants. 展开更多
关键词 CARDIOVASCULAR health SUBCLINICAL ATHEROSCLEROSIS COHORT
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A Linearly-Polarized Rubidium Vapor Laser Pumped by a Tunable Laser Diode Array with an External Cavity of a Temperature-Controlled Volume Bragg Grating 被引量:2
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作者 li Zhi-Yong TAN Rong-Qing +2 位作者 XU Cheng li lin ZHAO Zhi-Long 《Chinese Physics Letters》 SCIE CAS CSCD 2013年第3期63-65,共3页
A diode pumped alkali vapor laser has advantages in high quantum efficiency,excellent beam quality,and low thermal effect.We obtain a laser diode array(LDA)with linewidth of 0.20 nm and an external cavity of volume Br... A diode pumped alkali vapor laser has advantages in high quantum efficiency,excellent beam quality,and low thermal effect.We obtain a laser diode array(LDA)with linewidth of 0.20 nm and an external cavity of volume Bragg grating(VBG).Its central wavelength can be tuned from 779.30 nm to 780.10 nm by changing the VBG's temperature.Pumped by this LDA,a 2.1 W rubidium vapor laser is achieved with optical efficiency of 10.5%and slope efficiency of 22.7%. 展开更多
关键词 temperature. PUMPED DIODE
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Distribution,Seismic Characteristics and Controlling Factors of Carbonate Platforms on the Northwestern Margin of the South China Sea 被引量:1
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作者 li lin WANG Bin +6 位作者 YANG Taotao YANG Zhili li li LU Yintao WANG Xuefeng WU Jingwu SUN Guozhong 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2021年第1期142-152,共11页
Newly-acquired seismic data reveal widespread carbonate deposits covering a large part of the northwestern South China Sea margin.Three carbonate platforms are identified to have developed on the topographic highs inh... Newly-acquired seismic data reveal widespread carbonate deposits covering a large part of the northwestern South China Sea margin.Three carbonate platforms are identified to have developed on the topographic highs inherited from tectonic deformation and volcanic accretion.Across the carbonate platforms,the Miocene strata are characterized by high-amplitude seismic reflections and distinct platform architecture that overlaps older strata.The Guangle and Xisha carbonate platforms grew on faulted blocks due to South China Sea continental rifting,while the Zhongjian carbonate platform developed on a structural high induced by early Miocene volcanism.During the late Miocene,partial drowning resulted in the inhibition of platform growth,eventual platform drowning and termination of most carbonate deposition.The drowning of the Guangle and Zhongjian carbonate platforms is shown by the supply of siliciclastic sediments during the late Miocene and seems to be closely linked to late Neogene volcanic activity,whilst the drowning of the Xisha carbonate platform is primarily related to relative eustatic changes.Our results imply that tectonic activity,volcanism and eustasy are the dominant controls on the evolution of carbonate platforms on the northwestern margin of the South China Sea. 展开更多
关键词 seismic characteristics carbonate deposition Guangle carbonate platform Xisha carbonate platform
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Tunable and Linewidth-Reduced Laser Diode Stack for Rubidium Laser Pumping 被引量:1
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作者 li Zhi-Yong TAN Rong-Qing +1 位作者 XU Cheng li lin 《Chinese Physics Letters》 SCIE CAS CSCD 2013年第11期88-90,共3页
Linewidth of a laser diode stack with 5 bar is reduced to 0.2 nm from 1.8 nm through the use of an external volume Bragg grating(VBG)cavity.The temperature of the VBG is controlled efficiently to make the central wave... Linewidth of a laser diode stack with 5 bar is reduced to 0.2 nm from 1.8 nm through the use of an external volume Bragg grating(VBG)cavity.The temperature of the VBG is controlled efficiently to make the central wavelength tunable.The linewidth changes little in the wavelength-tuning experiments.Since the tunable range covers the rubidium D2 absorption line,the stack can be used to pump the rubidium laser efficiently. 展开更多
关键词 TUNABLE tuning PUMP
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Cornel iridoid glycoside protects against white matter lesions induced by cerebral ischemia via activation of neuregulin-1 pathway in rats
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作者 WANG Ming-yang HUA Xue-si +5 位作者 NIU Hong-mei SUN Zheng-yu ZHANG li li Ya-li ZHANG Lan li lin 《中国药理学与毒理学杂志》 CAS 北大核心 2019年第6期451-451,共1页
Ischemic stroke often elicits profound white matter lesions, which results in poor neurological outcomes and impairing the recovery in post-stroke. However, few studies have focused on white matter lesions caused by c... Ischemic stroke often elicits profound white matter lesions, which results in poor neurological outcomes and impairing the recovery in post-stroke. However, few studies have focused on white matter lesions caused by cerebral ischemia. The present study was aimed to investigate the effects of cornel iridoid glycoside(CIG), a main active component extracted from Cornus officinalis, on the white matter injury induced by ischemic stroke. CIG(60 and 120 mg·kg-1) were administered intragastrically 6 h after middle cerebral artery occlusion reperfusion(MCAO) surgery once a day for 7 d. A series of behavioral tests were carried out to evaluate the neurological function of MCAO rats. White matter structure was detected by luxol fast blue staining and transmission electron microscopy. Immunohistochemical staining was used to assess myelin loss, oligodendrocytes maturation and glial activation. Results showed that CIG remarkably decreased neurological deficit score, accelerated the recovery of somatosensory and motor functions, and ameliorated the memory deficit in MCAO rats. CIG alleviated white matter lesions and demyelination, increased myelin basic protein expression and the number of mature oligodendrocytes in the corpus callosum of MCAO rats. Besides, CIG inhibited the activation of microglia and astrocytes. Further data obtained by western blot analysis indicated that CIG increased the expression of brain-derived neurotrophic factor(BDNF)/p-Trk B, neuregulin-1/Erb B, and PI3 K p110α/p-Akt/p-m TOR in the corpus callosum of MCAO rats. Our findings demonstrated that CIG protected against white matter lesions induced by cerebral ischemia and the mechanisms were partially contributed to increasing BDNF and activating neuregulin-1/Erb B signaling and its downstream PI3 K/Akt/m TOR pathway in white matter. 展开更多
关键词 cornel IRIDOID GLYCOSIDE white matter lesions cerebral ischemia BRAIN-DERIVED NEUROTROPHIC factor NEUREGULIN-1 PATHWAY
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Preparation of Carbon-coated Tourmaline and the Degradation of Methylene Blue
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作者 WANG Yuesong CHUAN Xiuyun +1 位作者 li lin HUANG Du-bin 《矿物学报》 CAS CSCD 北大核心 2013年第S1期105-105,共1页
An attempt was made to prepare carbon coated tourmaline by mixing tourmaline powders and polyvinyl alcohol (PVA), followed by heat treatment in argon atmosphere. All samples were characterized by powder X-ray diffract... An attempt was made to prepare carbon coated tourmaline by mixing tourmaline powders and polyvinyl alcohol (PVA), followed by heat treatment in argon atmosphere. All samples were characterized by powder X-ray diffraction, high-resolution transmission electron microscopy, UV diffuse reflectance spectroscopy. Results showed that the residual carbon content was influenced by heat treatment temperature and the amount of PVA. The degradation of methylene blue by Carbon-coated tourmaline was also studied. The experiments pointed out that the carbon coated effects are best when the heating temperature was 900℃ and the weight content of PVA was 70%. And the tourmaline prepared under 900℃ in the oxidation atmosphere has the best degrade efficiency. The results also proved that the infrared radiation of tourmaline is not effect in the degrade progress. 展开更多
关键词 TOURMALINE carbon COATED METHYLENE BLUE DEGRADATION
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POINT-CONTACT TUNNELING INVESTIGATION OF THE SUPERCONDUCTORS IN Y-Ba-Cu-O SYSTEM
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作者 TAO Hongjie CHEN Yingfei +6 位作者 li ZHAO Bairu SHI Yinhuan LU Yong WANG Huisheng ZHAO Yuying li lin 《Chinese Physics Letters》 SCIE CAS 1987年第11期481-484,共4页
Point-contact tunneling measurements of the oxide superconductor Y-Ba-Cu-O were carried out with both Nb and Mo tips.An energy gap,Δ=18.5meV and 2Δ/kT_(c)=4.7 were obtained.The result is consistent with the strong-c... Point-contact tunneling measurements of the oxide superconductor Y-Ba-Cu-O were carried out with both Nb and Mo tips.An energy gap,Δ=18.5meV and 2Δ/kT_(c)=4.7 were obtained.The result is consistent with the strong-coupling theory.The tunneling conductance curves indicate a granular feature of the sample. 展开更多
关键词 THEORY TUNNELING SUPERCONDUCTOR
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Analysis of floor failure depth by using electric profiling method in longwall gangue backfill mining
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作者 Sheng-li YANG Xin-Pin DING +2 位作者 Xin WANG Xiao-Meng li li lin 《Journal of Coal Science & Engineering(China)》 2013年第3期282-289,共8页
In underground mining, floor failure depth accompanying mining phases usually results from changes in the advance abutment pressure in the coal mass, and changes in stress redistribution in the areas that have already... In underground mining, floor failure depth accompanying mining phases usually results from changes in the advance abutment pressure in the coal mass, and changes in stress redistribution in the areas that have already been mined. Although a variety of techniques have been applied to determine the failure depth, and a number of studies have provided the evidence for the decreasing of failure depth under backfilling, these methods and interactions have not been unequivocally identified. Based on the premise of one possible relation between the failure depth and filling body, which is that the filling materials (gangue) in the gob area can not only restrain the movement of the overlying strata effectively, but also can help to decrease failure depth of the floor in the coal mine. The failure depth in a specific longwall gangue backfilling mine was measured using the mine electricity profiling method. These electrode cables are arranged in a crossheading order to measure the depth and position of the destroyed floor using the DC method. After this, several different methods were used to interpret the recorded data from the field study for gaining failure depth, and the results were compared to the theoretical calculation values. And finally, the authors analyzed the reasons for failure depth form values recorded not indicating a large decrease trend when compared to the theoretical calculation. In this area, it is found that: ① The results using the mine electricity profiling method turns out to be robust and can be used in predicting floor failure depth, and the horizontal position of the maximum destroyed in working face of longwall backfilling. The maximum destroyed position and failure space of the floor can be identified by using this method. ②There is a time-delay processing between the advance of the working face and the failure of floor strata in the mining processing. ③Additionally, based on the data collected from field measurements, which includes three different test electrode spacing approaches (single, double and triple electrode spacing), and the theoretical value from theoretical calculations. The premise mentioned above cannot be supported during the specific field test, and the role of the filling body in the mined area cannot decrease the floor failure depth effectively in comparison to the theory predictions. Basically, the failure depths in the two different methods have similar results and it is possible that there will not be a direct correlation between the filling body and failure depth. ④Although the failure depth cannot decrease effectiveness when using gangue backfilling in the field testing, due to gob gangue, filling materials being able to deliver the abutment pressure from the overburden in most cases, once they were compacted and rammed by the overburden pressure, it still can make the fracture of the gob area clog and be further consolidated. In this way, it is assumed that water-bursting accidents can be prevented effectively under backfill mining. For this reason, gangue backfilling may make a significant contribution to safety mining. 展开更多
关键词 gangue backfilling floor failure depth electricity profiling method gob area
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Detection of gemcitabine-resistant genes expression in lung cancer cell lines using real-time PCR
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作者 li lin Xiaoqing liu +3 位作者 Yalan Rao Weixia Wang Shengqi Wang Santai Song 《The Chinese-German Journal of Clinical Oncology》 CAS 2008年第12期682-685,共4页
Objective: To explore the molecular mechanism of gemcitabine-resistance, the relative mRNA expression of five genes related to gemcitabine-resistance was detected in six lung cancer cell lines. Methods: The total RNA ... Objective: To explore the molecular mechanism of gemcitabine-resistance, the relative mRNA expression of five genes related to gemcitabine-resistance was detected in six lung cancer cell lines. Methods: The total RNA was extracted from six lung cancer cell lines GLC-82, NCI-H460, A549, 95-C, 95-D and QG56. Then the cDNA was amplified by real-time quantitative PCR method to quantify the gene expression of RRM1, PTEN, ERCC1, dCK and CDA. The cytotoxicity of gem- citabine to cell lines was tested by MTT method. Results: Among the detected six lung cancer cell lines, the mRNA level of RRM1, PTEN and ERCC1 in lung squamous cell line QG56 was highest, and the IC50 of gemcitabine to QG56 cell line was also highest. Conclusion: The mRNA expression of RRM1, PTEN and ERCC1 was correlated, and the high expression of RRM1 was related to gemcitabine resistance of lung cancer. 展开更多
关键词 gemcitabine-resistant real-time PCR gene expression lung cancer
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