Senegenin, an effective component of Polygala tenuifolia root extract, promotes proliferation and differentiation of neural progenitor cells in the hippocampus. However, the effects of senegenin on mesencephalon-deriv...Senegenin, an effective component of Polygala tenuifolia root extract, promotes proliferation and differentiation of neural progenitor cells in the hippocampus. However, the effects of senegenin on mesencephalon-derived neural progenitor cells remain poorly understood. Cells from a ventral mesencephalon neural progenitor cell line （ReNcell VM） were utilized as models for pharmaceutical screening. The effects of various senegenin concentrations on cell proliferation were analyzed, demonstrating that high senegenin concentrations （5, 10, 50, and 100 μmol/L）, particularly 50 μmol/L, significantly promoted proliferation of ReNcell VM cells. In the mitogen-activated protein kinase signal transduction pathway, senegenin significantly increased phosphorylation levels of extracellular signal-regulated kinases. Moreover, cell proliferation was suppressed by extracellular signal-regulated kinase inhibitors. Results suggested that senegenin contributed to in vitro proliferation of human neural progenitor cells by upregulating phosphorylation of extracellular signal-regulated kinase.展开更多
With a large reservoir as an example, a 3-D Biological Oxygen Demand (BOD) and Dissolved Oxygen (DO) model for large deep reservoirs was investigated by considering the effects of low concentration of dissolved oxygen...With a large reservoir as an example, a 3-D Biological Oxygen Demand (BOD) and Dissolved Oxygen (DO) model for large deep reservoirs was investigated by considering the effects of low concentration of dissolved oxygen and stratified temperature structure. A dissolved oxygen saturability equation was initially developed in the model. The influences of temperature on interfacial mass transfer coefficient and degradation rate coefficient and the restrained effects of low DO concentration on the degrading process were included in the model. The model is of great importance to accurate simulation of the temperature influential characteristics of water quality and the degrading law of organic pollutants in a large and deep reservoir.展开更多
基金the National Basic Research Program of China-973 Project,No. 2006CB500700the National Natural Science Foundation of China,No. 30500255the Natural Science Foundation of Beijing,No. 5102010
文摘Senegenin, an effective component of Polygala tenuifolia root extract, promotes proliferation and differentiation of neural progenitor cells in the hippocampus. However, the effects of senegenin on mesencephalon-derived neural progenitor cells remain poorly understood. Cells from a ventral mesencephalon neural progenitor cell line （ReNcell VM） were utilized as models for pharmaceutical screening. The effects of various senegenin concentrations on cell proliferation were analyzed, demonstrating that high senegenin concentrations （5, 10, 50, and 100 μmol/L）, particularly 50 μmol/L, significantly promoted proliferation of ReNcell VM cells. In the mitogen-activated protein kinase signal transduction pathway, senegenin significantly increased phosphorylation levels of extracellular signal-regulated kinases. Moreover, cell proliferation was suppressed by extracellular signal-regulated kinase inhibitors. Results suggested that senegenin contributed to in vitro proliferation of human neural progenitor cells by upregulating phosphorylation of extracellular signal-regulated kinase.
文摘With a large reservoir as an example, a 3-D Biological Oxygen Demand (BOD) and Dissolved Oxygen (DO) model for large deep reservoirs was investigated by considering the effects of low concentration of dissolved oxygen and stratified temperature structure. A dissolved oxygen saturability equation was initially developed in the model. The influences of temperature on interfacial mass transfer coefficient and degradation rate coefficient and the restrained effects of low DO concentration on the degrading process were included in the model. The model is of great importance to accurate simulation of the temperature influential characteristics of water quality and the degrading law of organic pollutants in a large and deep reservoir.
