Dengue fever （DF） is the most significant emerging arbovirus disease, which is caused by four distinct serotypes of Dengue viruses （DENY-1 to DENV-4）. Serotype-specific immunity does not confer cross-protection ag...Dengue fever （DF） is the most significant emerging arbovirus disease, which is caused by four distinct serotypes of Dengue viruses （DENY-1 to DENV-4）. Serotype-specific immunity does not confer cross-protection against secondary infec- tions from heterologous serotypes, which leads to dengue haemorrhagic fever （DHF） and dengue shock syndrome （DSS） as a result of antibody-dependent enhancement （ADE） of infection that is mediated by non-neutralizing, cross-reac- tive antibodies （Kliks et al., 1989）. The intense efforts to develop a safe and efficient DENV vaccine have involved using a variety of traditional biological technologies in the past 50 years （Durbin et al., 2005; McArthur et al., 2008）, yet no commercial DENV vaccine has been generated until now.展开更多
文摘Dengue fever （DF） is the most significant emerging arbovirus disease, which is caused by four distinct serotypes of Dengue viruses （DENY-1 to DENV-4）. Serotype-specific immunity does not confer cross-protection against secondary infec- tions from heterologous serotypes, which leads to dengue haemorrhagic fever （DHF） and dengue shock syndrome （DSS） as a result of antibody-dependent enhancement （ADE） of infection that is mediated by non-neutralizing, cross-reac- tive antibodies （Kliks et al., 1989）. The intense efforts to develop a safe and efficient DENV vaccine have involved using a variety of traditional biological technologies in the past 50 years （Durbin et al., 2005; McArthur et al., 2008）, yet no commercial DENV vaccine has been generated until now.
