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Meso-scale modeling of chloride diffusion in concrete with consideration of effects of time and temperature 被引量:4
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作者 li-cheng wang Tamon UEDA 《Water Science and Engineering》 EI CAS 2009年第3期58-70,共13页
A meso-scale truss network model was developed to predict chloride diffusion in concrete. The model regards concrete as a three-phase composite of mortar matrix, coarse aggregates, and the interfacial transition zone ... A meso-scale truss network model was developed to predict chloride diffusion in concrete. The model regards concrete as a three-phase composite of mortar matrix, coarse aggregates, and the interfacial transition zone (ITZ) between the mortar matrix and the aggregates. The diffusion coefficient of chloride in the mortar and the ITZ can be analytically determined with only the water-to-cement ratio and volume fraction of fine aggregates. Fick's second law of diffusion was used as the governing equation for chloride diffusion in a homogenous medium (e.g., mortar); it was discretized and applied to the truss network model. The solution procedure of the truss network model based on the diffusion law and the meso-scale composite structure of concrete is outlined. Additionally, the dependence of the diffusion coefficient of chloride in the mortar and the ITZ on exposure duration and temperature is taken into account to illustrate their effect on chloride diffusion coefficient. The numerical results show that the exposure duration and environmental temperature play important roles in the diffusion rate of chloride ions in concrete. It is also concluded that the meso-scale truss network model can be applied to chloride transport analysis of damaged (or cracked) concrete. 展开更多
关键词 meso-scale modeling CONCRETE chloride diffusion truss network model
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Critical chain construction with multi-resource constraints based on portfolio technology in South-to-North Water Diversion Project 被引量:3
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作者 Jing-chun FENG Lei LI +4 位作者 Nan YANG Yu-zhen HONG Min PANG Xiong YAO li-cheng wang 《Water Science and Engineering》 EI CAS 2011年第2期225-236,共12页
Recently, the critical chain study has become a hot issue in the project management research field. The construction of the critical chain with multi-resource constraints is a new research subject. According to the sy... Recently, the critical chain study has become a hot issue in the project management research field. The construction of the critical chain with multi-resource constraints is a new research subject. According to the system analysis theory and project portfolio theory, this paper discusses the creation of project portfolios based on the similarity principle and gives the definition of priority in multi-resource allocation based on quantitative analysis. A model with multi-resource constraints, which can be applied to the critical chain construction of the A-bid section in the South-to-North Water Diversion Project, was proposed. Contrast analysis with the comprehensive treatment construction method and aggressive treatment construction method was carried out. This paper also makes suggestions for further research directions and subjects, which will be useful in improving the theories in relevant research fields. 展开更多
关键词 multi-resource constraints South-to-North Water Diversion Project project portfolio critical chain
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Discovery of the Ca-Cl type brine in deep aquifers and implications for the shallow giant glauberite deposits in the Lop Nur playa, Tarim Basin, NW China 被引量:2
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作者 Hua Zhang Peng-cheng Jiao +8 位作者 Cheng-lin Liu Hui Yan Fan-kai Zhang Wen-xue Li Yong-mei Yu Lu-sha wang Yu-fei Hu li-cheng wang Li-jian Shen 《China Geology》 2021年第2期364-366,共3页
1.Objective Lop Nur is currently one of the world’s largest playa and located in the easternmost of the Tarim Basin,northwestern China.It developed unique giant glauberite deposits during the Quaternary,of which anal... 1.Objective Lop Nur is currently one of the world’s largest playa and located in the easternmost of the Tarim Basin,northwestern China.It developed unique giant glauberite deposits during the Quaternary,of which analogue with such a scale deposit is rarely seen around the world.Moreover,potassium-rich brine hosted in these glauberite intercrystalline contains a resource of KCl up to 0.25×10^(9) t. 展开更多
关键词 China. TARIM SHALLOW
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MicroRNA-381靶向调控KLF-4抗肾纤维化的机制研究 被引量:1
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作者 王立成 李现铎 +2 位作者 陈冬冬 唐冠宝 门同义 《中国现代医学杂志》 CAS 2020年第16期1-6,共6页
目的探究MicroRNA-381(miR-381)通过靶向调控KLF-4抑制肾纤维化病理进程的作用机制。方法选取2014年2月—2017年12月山东大学附属千佛山医院收治的106例肾纤维化患者;另取同期该院健康体检者100例作为对照组。采用microRNA(miRNA)靶基... 目的探究MicroRNA-381(miR-381)通过靶向调控KLF-4抑制肾纤维化病理进程的作用机制。方法选取2014年2月—2017年12月山东大学附属千佛山医院收治的106例肾纤维化患者;另取同期该院健康体检者100例作为对照组。采用microRNA(miRNA)靶基因数据库筛选出miR-381潜在靶基因KLF-4并使用荧光素酶进行验证;实时荧光定量聚合酶链反应(qRT-PCR)检测肾纤维化患者血清miR-381。将NRK49F细胞分为miR-381组、NC组、AngⅡ组及空白组。使用qRT-PCR和Western blotting检测miR-381组、NC组中KLF-4表达变化;使用qRT-PCR检测miR-381组和NC组中多种肾纤维化因子mRNA表达变化。检测AngⅡ组和空白组细胞中miR-381表达变化,miR-381组、NC组及AngⅡ组细胞中α-SMA表达变化。将小鼠随机分为单侧输卵管梗阻(UUO)组、UUO+miR-381组及假手术组,检测UUO组和假手术组小鼠肾脏组织miR-381表达变化,并使用Masson染色观察miR-381对肾纤维化的作用。结果qRT-PCR结果显示,肾纤维化患者血清miR-381相对表达量低于对照组(P<0.05)。相比NC组,miR-381组肾纤维化因子α-SMA、CTGF、COL1A1及COL3A1 mRNA相对表达量降低(P<0.05);AngⅡ刺激NRK49F细胞后,相比空白组miR-381相对表达量降低,而AngⅡ组α-SMA相对表达量升高,过表达miR-381后α-SMA相对表达量降低(P<0.05)。KLF-4是miR-381靶基因,miR-381可以负调控KLF-4 mRNA和蛋白的表达(P<0.05)。UUO组小鼠肾脏组织中miR-381相对表达量低于假手术组,相比UUO组,UUO+miR-381组肾纤维化区域减小,细胞外基质沉积变少,COL1A1和COL3A1 mRNA相对表达量降低(P<0.05)。结论miR-381通过抑制KLF-4抗肾纤维化的发展进程,可能成为肾纤维化诊断及治疗的新靶点。 展开更多
关键词 肾病 纤维化 MICRORNA 诊断 治疗
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Secondary coronary artery ostial lesions:Three case reports
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作者 Xiao-Ping Liu Hai-Jun wang +9 位作者 Jin-Liang Gao Guo-Li Ma Xin-Yun Xu Li-Na Ji Rui-Xia He Ba-Ya-Er Qi li-cheng wang Chang-Qing Li Ya-Jiang Zhang Yu-Bao Feng 《World Journal of Clinical Cases》 SCIE 2022年第20期7045-7053,共9页
BACKGROUND Atherosclerosis is one of the main causes of coronary artery ostial lesions seen clinically.Secondary coronary artery ostial lesions are rare,and cases reported previously were associated with syphilitic va... BACKGROUND Atherosclerosis is one of the main causes of coronary artery ostial lesions seen clinically.Secondary coronary artery ostial lesions are rare,and cases reported previously were associated with syphilitic vasculitis and aortic dissection.Here,we report three rare cases of secondary coronary ostial lesions.Due to their rareness,these lesions can easily be neglected,which may lead to misdiagnosis and missed diagnosis.CASE SUMMARY We present three patients with acute myocardial infarction and unstable angina caused by secondary coronary artery ostial lesions.In Case 1,coronary angiography(CAG)revealed 90%stenosis of the left main coronary ostium.Chest contrast computed tomography(CT)suggested thymic carcinoma invading the left main coronary ostium.Coronary artery bypass grafting and tumor resection were performed.In Case 2,echocardiography revealed a sinus of Valsalva aneurysm(SVA)-like dilatation.CAG showed a right coronary sinus giant aneurysm and complete obstruction of the right coronary artery(RCA)ostium.Aortic contrast CT confirmed these findings.The Bentall procedure was performed.In Case 3,CT CAG identified an anomalous origin of the right coronary artery(AORCA)from the left sinus of Valsalva coursing between the aorta and pulmonary trunk,causing severe RCA ostium stenosis by compression.Surgical correction of the AORCA was performed.CONCLUSION The cases reported here suggest that we should consider other causes of coronary ostial lesions other than atherosclerosis. 展开更多
关键词 Coronary artery Ostial lesions Thymic carcinoma Sinus of Valsalva aneurysm Anomalous origin Case report
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On-chip single-photon chirality encircling exceptional points
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作者 Zhen-Nan Tian Feng Yu +5 位作者 Xu-Lin Zhang Kai Ming Lau li-cheng wang Jensen Li C.T.Chan Qi-Dai Chen 《Chip》 EI 2023年第4期71-77,共7页
Exceptional points(EPs),which are typically defined as the degener-acy points of a non-Hermitian Hamiltonian,have been investigated in various physical systems such as photonic systems.In particular,the intriguing top... Exceptional points(EPs),which are typically defined as the degener-acy points of a non-Hermitian Hamiltonian,have been investigated in various physical systems such as photonic systems.In particular,the intriguing topological structures around EPs have given rise to novel strategies for manipulating photons and the underlying mechanism is especially useful for on-chip photonic applications.Although some on-chip experiments with the adoption of lasers have been reported,EP-based photonic chips working in the quantum regime largely re-main elusive.In the current work,a single-photon experiment was proposed to dynamically encircle an EP in on-chip photonic waveg-uides possessing passive anti-parity-time symmetry.Photon coinci-dences measurement reveals a chiral feature of transporting single photons,which can act as a building block for on-chip quantum de-vices that require asymmetric transmissions.The findings in the cur-rent work pave the way for on-chip experimental study on the physics of EPs as well as inspiring applications for on-chip non-Hermitian quantum devices. 展开更多
关键词 Non-Hermitian photonics Photonic chip Exceptional points Single photons
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