BACKGROUND Surgery is the primary curative option in patients with hepatocellular carcinoma(HCC).However,recurrence within 2 years is observed in 30%–50%of patients,being a major cause of mortality.AIM To construct a...BACKGROUND Surgery is the primary curative option in patients with hepatocellular carcinoma(HCC).However,recurrence within 2 years is observed in 30%–50%of patients,being a major cause of mortality.AIM To construct and verify a non-invasive prediction model combining contrastenhanced ultrasound(CEUS)with serology biomarkers to predict the early recurrence of HCC.METHODS Records of 744 consecutive patients undergoing first-line curative surgery for HCC in one institution from 2016–2018 were reviewed,and 292 local patients were selected for analysis.General characteristics including gender and age,CEUS liver imaging reporting and data system(LIRADS)parameters including wash-in time,wash-in type,wash-out time,and wash-out type,and serology biomarkers including alanine aminotransferase,aspartate aminotransferase,platelets,and alpha-fetoprotein(AFP)were collected.Univariate analysis and multivariate Cox proportional hazards regression model were used to evaluate the independent prognostic factors for tumor recurrence.Then a nomogram called CEUS model was constructed.The CEUS model was then used to predict recurrence at 6 mo,12 mo,and 24 mo,the cut-off value was calculate by X-tile,and each C-index was calculated.Then Kaplan-Meier curve was compared by logrank test.The calibration curves of each time were depicted.RESULTS A nomogram predicting early recurrence(ER),named CEUS model,was formulated based on the results of the multivariate Cox regression analysis.This nomogram incorporated tumor diameter,preoperative AFP level,and LIRADS,and the hazard ratio was 1.123(95%confidence interval[CI]:1.041-1.211),1.547(95%CI:1.245-1.922),and 1.428(95%CI:1.059-1.925),respectively.The cut-off value at 6 mo,12 mo,and 24 mo was 100,80,and 50,and the C-index was 0.748(95%CI:0.683-0.813),0.762(95%CI:0.704-0.820),and 0.762(95%CI:0.706-0.819),respectively.The model showed satisfactory results,and the calibration at 6 mo was desirable;however,the calibration at 12 and 24 mo should be improved.CONCLUSION The CEUS model enables the well-calibrated individualized prediction of ER before surgery and may represent a novel tool for biomarker research and individual counseling.展开更多
Chronic wound healing has long been an unmet medical need in the field of wound repair,with diabetes being one of the major etiologies.Diabetic chronic wounds(DCWs),especially diabetic foot ulcers,are one of the most ...Chronic wound healing has long been an unmet medical need in the field of wound repair,with diabetes being one of the major etiologies.Diabetic chronic wounds(DCWs),especially diabetic foot ulcers,are one of the most threatening chronic complications of diabetes.Although the treatment strategies,drugs,and dressings for DCWs have made great progress,they remain ineffective in some patients with refractory wounds.Stem cell-based therapies have achieved specific efficacy in various fields,with mesenchymal stem cells(MSCs)being the most widely used.Although MSCs have achieved good feedback in preclinical studies and clinical trials in the treatment of cutaneous wounds or other situations,the potential safety concerns associated with allogeneic/autologous stem cells and unknown long-term health effects need further attention and supervision.Recent studies have reported that stem cells mainly exert their trauma repair effects through paracrine secretion,and exosomes play an important role in intercellular communication as their main bioactive component.MSC-derived exosomes(MSC-Exos)inherit the powerful inflammation and immune modulation,angiogenesis,cell proliferation and migration promotion,oxidative stress alleviation,collagen remodeling imbalances regulation of their parental cells,and can avoid the potential risks of direct stem cell transplantation to a large extent,thus demonstrating promising performance as novel"cell-free"therapies in chronic wounds.This review aimed to elucidate the potential mechanism and update the progress of MSC-Exos in DCW healing,thereby providing new therapeutic directions for DCWs that are difficult to be cured using conventional therapy.展开更多
A dual-mode scramjet can operate in a wide range of flight conditions. Higher thrust can be generated by adopting suitable combustion modes. Based on the net thrust, an analysis and preliminary optimal design of a ker...A dual-mode scramjet can operate in a wide range of flight conditions. Higher thrust can be generated by adopting suitable combustion modes. Based on the net thrust, an analysis and preliminary optimal design of a kerosene-fueled parameterized dual-mode scramjet at a cru- cial flight Mach number of 6 were investigated by using a modified quasi-one-dimensional method and simulated annealing strategy. Engine structure and heat release distrib- utions, affecting the engine thrust, were chosen as analytical parameters for varied inlet conditions (isolator entrance Mach number: 1.5-3.5). Results show that different opti- mal heat release distributions and structural conditions can be obtained at five different inlet conditions. The highest net thrust of the parameterized dual-mode engine can be achieved by a subsonic combustion mode at an isolator entrance Mach number of 2.5. Additionally, the effects of heat release and scramjet structure on net thrust have been discussed. The present results and the developed analytical method can provide guidance for the design and optimization of high-performance dual-mode scramjets.展开更多
The navigation potential of the Arctic has improved with the rapid retreat of sea ice under continuous warming.The comprehensive evaluation of Arctic accessibility for low ice-breaking ships(civil use)in the mid-centu...The navigation potential of the Arctic has improved with the rapid retreat of sea ice under continuous warming.The comprehensive evaluation of Arctic accessibility for low ice-breaking ships(civil use)in the mid-century is important to support coordinated international decision-making.In this study,the hydrological conditions and navigation potential in key areas and crucial straits along the Northern Sea Route(NSR)and Northwest Passage(NWP)were assessed under Shared Socioeconomic Pathways(SSPs)using the Polar Operational Limit Assessment Risk Indexing System.The results showed that the most critical areas for navigation in the mid-century(2046-2055)are the waters around the New Siberian Islands and within the Parry Channel.Arctic navigability improves from SSP1-2.6 to SSP2-4.5 to SSP5-8.5,and the accessibility for PC7 ships under SSP2-4.5 is even better for OW ships under SSP5-8.5.The route on the north side of the New Siberian Islands is a relatively good choice within the NSR,and the southern route has a better navigation potential than the Parry Channel within the NWP.In addition,the accessibility of the Dmitri Laptev Strait is better than that of the Sannikov Strait at a monthly scale,although the latter has more navigable days.However,there is little difference in accessibility between the eastern and western parts of the Parry Channel.The best nav-igation potential through the above straits is in September for ordinary ships,and the optimal time window is delayed and extended for PC7 ships.The results can serve as references for policy-making and navigation planning in the Arctic.展开更多
We investigated the fatty acid profiles of muscle from large yellow croaker (Pseudosciaena crocea R.) of different age. One- and two-year-old fish were cultured in floating net cages and sampled randomly for analysis....We investigated the fatty acid profiles of muscle from large yellow croaker (Pseudosciaena crocea R.) of different age. One- and two-year-old fish were cultured in floating net cages and sampled randomly for analysis. Moisture, protein, lipid and ash contents were determined by methods of Association of Analytical Chemist (AOAC) International. Fatty acid profile was deter- mined by gas chromatography. Crude protein, fat, moisture and ash contents showed no significant differences between the two age groups. The contents of total polyunsaturated fatty acids and docosahexaenoic acid (DHA) were significantly higher and eicosapentaenoic acid (EPA) content was significantly lower in the two-year-old large yellow croaker than in the one-year-old (P<0.05). No significant differences were observed in the contents of total saturated fatty acids and monounsaturated fatty acids, or the ratio of n-3/n-6 fatty acids among the large yellow croakers of the two age groups. We conclude that large yellow croakers are good food sources of EPA and DHA.展开更多
The novel use of p-nitrophenyldiazonium tetrafluoroborate salt(GG salt)as a protectant that is electrochemically grafted onto carbon steel has been investigated in0.05 mol L-1H2SO4and 5 wt%NaCl solutions using various...The novel use of p-nitrophenyldiazonium tetrafluoroborate salt(GG salt)as a protectant that is electrochemically grafted onto carbon steel has been investigated in0.05 mol L-1H2SO4and 5 wt%NaCl solutions using various corrosion monitoring techniques,such as electrochemical impedance spectroscopy,potentiodynamic polarisation,infrared spectra and scanning electron microscopy measurements.The electrochemical study reveals that this compound is a mixed inhibitor that predominantly controls the cathodic reaction.The surface-grafted film decreases the double-layer capacitance and obviously increases the charge transfer resistance relative to a bare carbon electrode.The values of inhibition effect remain nearly unchanged with an increase in temperature range of 298–318 K.The aryl diazonium is covalently bonded on the steel surface,causing a slight decrease in the apparent activation energy.Overall,the surface-grafted films exhibit excellent inhibition performance in acid and saline solutions within the studied temperature range.展开更多
Objective:The aim of this study was to develop a reliable approach to simultaneously quantify 11 markers and explore the quality variation in honey-processed licorice.Materials and Methods:A high-performance liquid ch...Objective:The aim of this study was to develop a reliable approach to simultaneously quantify 11 markers and explore the quality variation in honey-processed licorice.Materials and Methods:A high-performance liquid chromatography-diode array detector method was developed for the simultaneous determination of 11 markers(nine flavonoids and two triterpenoid saponins)in honey-processed licorice.The changes to the 11 markers in honey-processed licorice were investigated using an orthogonal design with three input factors.Results:The established method was precise,accurate,and sensitive enough for the simultaneous quantitative evaluation of 11 markers in honey-processed licorice.Intuitive analysis and variance analysis revealed that(1)the soaking time of crude licorice,stir-frying temperature,and stir-frying time remarkably influenced the content of liquiritin apioside,signifying the decomposition of liquiritin apioside to liquiritin or transformation of liquiritin apioside to isoliquiritin apioside,(2)stir-frying temperature significantly influenced licorice-saponin G2,(3)stir-frying temperature was the most important factor of the three input factors,(4)in terms of composition,honey fried licorice had significant effects on two components,namely liquiritin apioside and licorice-saponin G2.Conclusions:Honey processing influenced the content of the 11 licorice analytes differently.This paper highlights the first report on how the quality of honey-processed licorice varies under different processing conditions and suggests the optimal levels of the investigated three factors as A2B2C3 according to the degrees of influence of these factors on the 11 components.Specifically,the soaking time of crude licorice with honey solution,stir-frying temperature,and stir-frying time were 40 min,100°C,and 20 min,respectively.展开更多
基金Startup Fund for Scientific Research,Fujian Medical University,No.2019QH1302.
文摘BACKGROUND Surgery is the primary curative option in patients with hepatocellular carcinoma(HCC).However,recurrence within 2 years is observed in 30%–50%of patients,being a major cause of mortality.AIM To construct and verify a non-invasive prediction model combining contrastenhanced ultrasound(CEUS)with serology biomarkers to predict the early recurrence of HCC.METHODS Records of 744 consecutive patients undergoing first-line curative surgery for HCC in one institution from 2016–2018 were reviewed,and 292 local patients were selected for analysis.General characteristics including gender and age,CEUS liver imaging reporting and data system(LIRADS)parameters including wash-in time,wash-in type,wash-out time,and wash-out type,and serology biomarkers including alanine aminotransferase,aspartate aminotransferase,platelets,and alpha-fetoprotein(AFP)were collected.Univariate analysis and multivariate Cox proportional hazards regression model were used to evaluate the independent prognostic factors for tumor recurrence.Then a nomogram called CEUS model was constructed.The CEUS model was then used to predict recurrence at 6 mo,12 mo,and 24 mo,the cut-off value was calculate by X-tile,and each C-index was calculated.Then Kaplan-Meier curve was compared by logrank test.The calibration curves of each time were depicted.RESULTS A nomogram predicting early recurrence(ER),named CEUS model,was formulated based on the results of the multivariate Cox regression analysis.This nomogram incorporated tumor diameter,preoperative AFP level,and LIRADS,and the hazard ratio was 1.123(95%confidence interval[CI]:1.041-1.211),1.547(95%CI:1.245-1.922),and 1.428(95%CI:1.059-1.925),respectively.The cut-off value at 6 mo,12 mo,and 24 mo was 100,80,and 50,and the C-index was 0.748(95%CI:0.683-0.813),0.762(95%CI:0.704-0.820),and 0.762(95%CI:0.706-0.819),respectively.The model showed satisfactory results,and the calibration at 6 mo was desirable;however,the calibration at 12 and 24 mo should be improved.CONCLUSION The CEUS model enables the well-calibrated individualized prediction of ER before surgery and may represent a novel tool for biomarker research and individual counseling.
基金Supported by the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University,No.ZYGD18025.
文摘Chronic wound healing has long been an unmet medical need in the field of wound repair,with diabetes being one of the major etiologies.Diabetic chronic wounds(DCWs),especially diabetic foot ulcers,are one of the most threatening chronic complications of diabetes.Although the treatment strategies,drugs,and dressings for DCWs have made great progress,they remain ineffective in some patients with refractory wounds.Stem cell-based therapies have achieved specific efficacy in various fields,with mesenchymal stem cells(MSCs)being the most widely used.Although MSCs have achieved good feedback in preclinical studies and clinical trials in the treatment of cutaneous wounds or other situations,the potential safety concerns associated with allogeneic/autologous stem cells and unknown long-term health effects need further attention and supervision.Recent studies have reported that stem cells mainly exert their trauma repair effects through paracrine secretion,and exosomes play an important role in intercellular communication as their main bioactive component.MSC-derived exosomes(MSC-Exos)inherit the powerful inflammation and immune modulation,angiogenesis,cell proliferation and migration promotion,oxidative stress alleviation,collagen remodeling imbalances regulation of their parental cells,and can avoid the potential risks of direct stem cell transplantation to a large extent,thus demonstrating promising performance as novel"cell-free"therapies in chronic wounds.This review aimed to elucidate the potential mechanism and update the progress of MSC-Exos in DCW healing,thereby providing new therapeutic directions for DCWs that are difficult to be cured using conventional therapy.
基金supported by the National Natural Science Foundation of China(Grant 11002148)
文摘A dual-mode scramjet can operate in a wide range of flight conditions. Higher thrust can be generated by adopting suitable combustion modes. Based on the net thrust, an analysis and preliminary optimal design of a kerosene-fueled parameterized dual-mode scramjet at a cru- cial flight Mach number of 6 were investigated by using a modified quasi-one-dimensional method and simulated annealing strategy. Engine structure and heat release distrib- utions, affecting the engine thrust, were chosen as analytical parameters for varied inlet conditions (isolator entrance Mach number: 1.5-3.5). Results show that different opti- mal heat release distributions and structural conditions can be obtained at five different inlet conditions. The highest net thrust of the parameterized dual-mode engine can be achieved by a subsonic combustion mode at an isolator entrance Mach number of 2.5. Additionally, the effects of heat release and scramjet structure on net thrust have been discussed. The present results and the developed analytical method can provide guidance for the design and optimization of high-performance dual-mode scramjets.
基金supported by the National Natural Science Foundation of China (42276261)the International Partnership Program of Chinese Academy of Sciences (131B62KYSB20180003)+2 种基金the National Office for Philosophy and Social Sciences as part of the project titled Strategic Competition and Cooperation in the Arctic among China,Russia,and the United States from the Perspective of Sustainable Development (20BGJ045)Gansu Provincial Science and Technology Program (22ZD6FA005)the State Key Laboratory of Cryospheric Science (SKLCS-ZZ-2023).
文摘The navigation potential of the Arctic has improved with the rapid retreat of sea ice under continuous warming.The comprehensive evaluation of Arctic accessibility for low ice-breaking ships(civil use)in the mid-century is important to support coordinated international decision-making.In this study,the hydrological conditions and navigation potential in key areas and crucial straits along the Northern Sea Route(NSR)and Northwest Passage(NWP)were assessed under Shared Socioeconomic Pathways(SSPs)using the Polar Operational Limit Assessment Risk Indexing System.The results showed that the most critical areas for navigation in the mid-century(2046-2055)are the waters around the New Siberian Islands and within the Parry Channel.Arctic navigability improves from SSP1-2.6 to SSP2-4.5 to SSP5-8.5,and the accessibility for PC7 ships under SSP2-4.5 is even better for OW ships under SSP5-8.5.The route on the north side of the New Siberian Islands is a relatively good choice within the NSR,and the southern route has a better navigation potential than the Parry Channel within the NWP.In addition,the accessibility of the Dmitri Laptev Strait is better than that of the Sannikov Strait at a monthly scale,although the latter has more navigable days.However,there is little difference in accessibility between the eastern and western parts of the Parry Channel.The best nav-igation potential through the above straits is in September for ordinary ships,and the optimal time window is delayed and extended for PC7 ships.The results can serve as references for policy-making and navigation planning in the Arctic.
基金Project supported by the National Key Research and Development Program of China(No.2018YFD0400305)the Modern Agro-industry Technology Research System of China(No.CARS-40-K26)the“One Belt and One Road”International Science and Technology Cooperation Program of Zhejiang,China(No.2019C04022)。
文摘We investigated the fatty acid profiles of muscle from large yellow croaker (Pseudosciaena crocea R.) of different age. One- and two-year-old fish were cultured in floating net cages and sampled randomly for analysis. Moisture, protein, lipid and ash contents were determined by methods of Association of Analytical Chemist (AOAC) International. Fatty acid profile was deter- mined by gas chromatography. Crude protein, fat, moisture and ash contents showed no significant differences between the two age groups. The contents of total polyunsaturated fatty acids and docosahexaenoic acid (DHA) were significantly higher and eicosapentaenoic acid (EPA) content was significantly lower in the two-year-old large yellow croaker than in the one-year-old (P<0.05). No significant differences were observed in the contents of total saturated fatty acids and monounsaturated fatty acids, or the ratio of n-3/n-6 fatty acids among the large yellow croakers of the two age groups. We conclude that large yellow croakers are good food sources of EPA and DHA.
基金supported by the National Natural Science Foundation of China(21103105)the Foundation for University Youth Teachers by the Shanghai Education Committeethe Innovation Fund of Shanghai University(50334040)
文摘The novel use of p-nitrophenyldiazonium tetrafluoroborate salt(GG salt)as a protectant that is electrochemically grafted onto carbon steel has been investigated in0.05 mol L-1H2SO4and 5 wt%NaCl solutions using various corrosion monitoring techniques,such as electrochemical impedance spectroscopy,potentiodynamic polarisation,infrared spectra and scanning electron microscopy measurements.The electrochemical study reveals that this compound is a mixed inhibitor that predominantly controls the cathodic reaction.The surface-grafted film decreases the double-layer capacitance and obviously increases the charge transfer resistance relative to a bare carbon electrode.The values of inhibition effect remain nearly unchanged with an increase in temperature range of 298–318 K.The aryl diazonium is covalently bonded on the steel surface,causing a slight decrease in the apparent activation energy.Overall,the surface-grafted films exhibit excellent inhibition performance in acid and saline solutions within the studied temperature range.
基金financially supported by the National Key R and D Program of China(2018YFC1706500 and 2018YFC1707000)。
文摘Objective:The aim of this study was to develop a reliable approach to simultaneously quantify 11 markers and explore the quality variation in honey-processed licorice.Materials and Methods:A high-performance liquid chromatography-diode array detector method was developed for the simultaneous determination of 11 markers(nine flavonoids and two triterpenoid saponins)in honey-processed licorice.The changes to the 11 markers in honey-processed licorice were investigated using an orthogonal design with three input factors.Results:The established method was precise,accurate,and sensitive enough for the simultaneous quantitative evaluation of 11 markers in honey-processed licorice.Intuitive analysis and variance analysis revealed that(1)the soaking time of crude licorice,stir-frying temperature,and stir-frying time remarkably influenced the content of liquiritin apioside,signifying the decomposition of liquiritin apioside to liquiritin or transformation of liquiritin apioside to isoliquiritin apioside,(2)stir-frying temperature significantly influenced licorice-saponin G2,(3)stir-frying temperature was the most important factor of the three input factors,(4)in terms of composition,honey fried licorice had significant effects on two components,namely liquiritin apioside and licorice-saponin G2.Conclusions:Honey processing influenced the content of the 11 licorice analytes differently.This paper highlights the first report on how the quality of honey-processed licorice varies under different processing conditions and suggests the optimal levels of the investigated three factors as A2B2C3 according to the degrees of influence of these factors on the 11 components.Specifically,the soaking time of crude licorice with honey solution,stir-frying temperature,and stir-frying time were 40 min,100°C,and 20 min,respectively.