L-T4替代治疗对妊娠期亚临床甲状腺功能减退孕妇血清抵抗素、同型半胱氨酸的影响

目的探讨左旋甲状腺激素替代治疗(L-T4)对妊娠期亚临床甲状腺功能减退(SCH)孕妇血清抵抗素(RE)、同型半胱氨酸(HCY)的影响。方法选取2014年1月-2016年1月该院收治的90例SCH患者,依据随机数字表法将其分为两组:观察组接受L-T4替代治疗,每隔4周复查甲状腺激素(TSH)水平,治疗目标为妊娠早期TSH水平在0.3~2.5 mIU/L,中期和晚期为0.3~3.0 mIU/L,直到治疗达标为止;对照组不接受治疗,每隔4周复查TSH水平。所有患者入院次日及复查TSH当日取空腹肘静脉血,测定血清HCY和RE水平,记录妊娠结局和子代发育12个月的智力情况。结果观察组治疗8周后,血清TSH达到0.3~3.0 m IU/L,达到治疗目标,故将治疗8周的时间点定义为治疗后。观察组治疗后,血清TSH、HCY水平降低(P <0.05),游离甲状腺素(FT4)、RE水平升高(P <0.05),对照组各指标无变化(P>0.05);观察组治疗后的TSH较对照组低(P <0.05),FT4指标较对照组高(P <0.05);观察组不良妊娠结局发生率(10.3%)低于对照组(28.1%)(P <0.05);两组子代发育12个月时的精细动作发育商(FMQ)、大运动发育商(GMQ)、个人社交发育商(ISBQ)及语言发育商(LQ)评分比较,差异均有统计学意义(P <0.05)。结论妊娠早期行左旋甲状腺激素替代治疗有助于降低SCH患者血清TSH、HCY水平,升高抵抗素水平,改善母体状态和妊娠结局,并促进子代智力发育,具有一定的临床意义。

Correlation of Direct Piezoelectric Effect on EAPap under Ambient Factors

Direct piezoelectricity of electro-active papers （EAPap） is analysed in this paper. The test setups for direct effect are designed and determined. Different ambient factors impacting the piezoelectricity of EAPap, such as temperature, humidity, and strain rate, are applied and analyzed. Strong piezoelectricity of EAPap is found on the basis of the test results and in comparison with polyvinylidene fluoride （PVDF） and lead zirconate titanate （PZT）-5H. The maximum piezoelectric constant is achieved to be 504 pC/N. The reason of strong piezoelectricity of EAPap is discussed in this paper. The potential of EAPap as a biomimetic actuator and sensor is also investigated.