AIM: To assess the safety and feasibility of peroral esophageal myotomy(POEM) in patients with achalasia.METHODS: From January 2012 to March 2014, 50 patients(28 men, 22 women; mean age: 42.8 years, range: 14-70 years...AIM: To assess the safety and feasibility of peroral esophageal myotomy(POEM) in patients with achalasia.METHODS: From January 2012 to March 2014, 50 patients(28 men, 22 women; mean age: 42.8 years, range: 14-70 years) underwent POEM. Pre- and postoperative symptoms were quantified using the Eckardt scoring system. Barium swallow and esophagogastroscopy were performed before and after POEM, respectively. Esophageal motility was evaluated in all patients, both preoperatively and one month after POEM treatment, using a high-resolution manometry system. Manometry data, Eckardt scores, lower esophageal sphincter pressure and barium swallow results were used to evaluate the effect of the procedure.RESULTS: POEM was successfully completed for all patients. The mean procedure time was 55.4 ± 17.3 min and the mean total length of myotomy of the circular esophagus was 10.5 ± 2.6 cm. No specific complications occurred, with the exception of two patients that developed as ymptomatic pneumomediastinum and subcutaneous emphysema. Clinical improvement in symptoms was achieved in all patients. Approximately 77.5% of patients experienced weight gain 6 mo after POEM, with an average of 4.78 kg(range: 2-15 kg). The lower esophageal sphincter resting pressure, four second integrated relaxation pressure and Eckardt scores were all significantly reduced after POEM(Ps < 0.05). A small segment of proximal esophageal peristalsis appeared postoperatively in two patients, but without normal esophageal peristalsis. The average diameter of the esophageal lumen decreased significantly from 4.39 to 3.09 cm(P < 0.01). CONCLUSION: POEM can relieve achalasia symptoms, improve gastroesophageal junction relaxation and restore esophageal body motility function, but not normal esophageal peristalsis.展开更多
目的:探讨NICD1 m RNA在乳腺组织中的表达及与临床病理特征的关系,初步评价其在乳腺癌发生、发展中的作用及其意义。方法:应用实时定量PCR法检测25例乳腺正常组织、15例非典型导管增生、20例导管原位癌和80例乳腺浸润性导管癌中NICD1 m ...目的:探讨NICD1 m RNA在乳腺组织中的表达及与临床病理特征的关系,初步评价其在乳腺癌发生、发展中的作用及其意义。方法:应用实时定量PCR法检测25例乳腺正常组织、15例非典型导管增生、20例导管原位癌和80例乳腺浸润性导管癌中NICD1 m RNA表达,分析其与乳腺癌患者临床病理特征的关系。结果:NICD1m RNA从乳腺正常组织到浸润癌的癌变过程中的表达量呈显著递增趋势(P<0.001),其中在ANBT组中的表达显著低于DCIS和IDC组(0.70±0.32 VS 2.09±0.75,2.19±0.97;P<0.01),在ADH组的表达明显低于IDC组(1.05±0.44 VS 2.19±0.97;P<0.05),其余组间差异无统计学意义(P>0.05);NICD1m RNA表达与乳腺癌组织学分级、淋巴结转移状态及TNM分期显著相关(P<0.05)。结论:NICD1分子在乳腺癌发生过程中可能发挥促癌作用,有望作为评估乳腺癌变进展的潜在生物标志物。展开更多
The width of an unresolved transition array, which was once regarded as insensitive to electron temperature by Audebert et al. [Phys. Rev. A 32 (1985) 409], is found to be a temperature-sensitive function to a certain...The width of an unresolved transition array, which was once regarded as insensitive to electron temperature by Audebert et al. [Phys. Rev. A 32 (1985) 409], is found to be a temperature-sensitive function to a certain extent and has the potential of being used in plasma diagnostics. In this letter, on the assumption that the plasma has achieved the local thermodynamical equilibrium and that each of the subarray has a Gaussian shape, the electron temperature of a gold plasma produced by laser irradiation of a microdot is obtained by comparing the experimental width with the theoretical width. The full widths at half maximum of the unresolved transition arrays are computed in the formalism of the spin-orbit-split arrays.展开更多
文摘AIM: To assess the safety and feasibility of peroral esophageal myotomy(POEM) in patients with achalasia.METHODS: From January 2012 to March 2014, 50 patients(28 men, 22 women; mean age: 42.8 years, range: 14-70 years) underwent POEM. Pre- and postoperative symptoms were quantified using the Eckardt scoring system. Barium swallow and esophagogastroscopy were performed before and after POEM, respectively. Esophageal motility was evaluated in all patients, both preoperatively and one month after POEM treatment, using a high-resolution manometry system. Manometry data, Eckardt scores, lower esophageal sphincter pressure and barium swallow results were used to evaluate the effect of the procedure.RESULTS: POEM was successfully completed for all patients. The mean procedure time was 55.4 ± 17.3 min and the mean total length of myotomy of the circular esophagus was 10.5 ± 2.6 cm. No specific complications occurred, with the exception of two patients that developed as ymptomatic pneumomediastinum and subcutaneous emphysema. Clinical improvement in symptoms was achieved in all patients. Approximately 77.5% of patients experienced weight gain 6 mo after POEM, with an average of 4.78 kg(range: 2-15 kg). The lower esophageal sphincter resting pressure, four second integrated relaxation pressure and Eckardt scores were all significantly reduced after POEM(Ps < 0.05). A small segment of proximal esophageal peristalsis appeared postoperatively in two patients, but without normal esophageal peristalsis. The average diameter of the esophageal lumen decreased significantly from 4.39 to 3.09 cm(P < 0.01). CONCLUSION: POEM can relieve achalasia symptoms, improve gastroesophageal junction relaxation and restore esophageal body motility function, but not normal esophageal peristalsis.
文摘目的:探讨NICD1 m RNA在乳腺组织中的表达及与临床病理特征的关系,初步评价其在乳腺癌发生、发展中的作用及其意义。方法:应用实时定量PCR法检测25例乳腺正常组织、15例非典型导管增生、20例导管原位癌和80例乳腺浸润性导管癌中NICD1 m RNA表达,分析其与乳腺癌患者临床病理特征的关系。结果:NICD1m RNA从乳腺正常组织到浸润癌的癌变过程中的表达量呈显著递增趋势(P<0.001),其中在ANBT组中的表达显著低于DCIS和IDC组(0.70±0.32 VS 2.09±0.75,2.19±0.97;P<0.01),在ADH组的表达明显低于IDC组(1.05±0.44 VS 2.19±0.97;P<0.05),其余组间差异无统计学意义(P>0.05);NICD1m RNA表达与乳腺癌组织学分级、淋巴结转移状态及TNM分期显著相关(P<0.05)。结论:NICD1分子在乳腺癌发生过程中可能发挥促癌作用,有望作为评估乳腺癌变进展的潜在生物标志物。
基金Supported by the Fund of Chinese Academy of Engineering Physics(Grant No.20000216)the National Natural Science Foundation of China under Grant No.19674049.
文摘The width of an unresolved transition array, which was once regarded as insensitive to electron temperature by Audebert et al. [Phys. Rev. A 32 (1985) 409], is found to be a temperature-sensitive function to a certain extent and has the potential of being used in plasma diagnostics. In this letter, on the assumption that the plasma has achieved the local thermodynamical equilibrium and that each of the subarray has a Gaussian shape, the electron temperature of a gold plasma produced by laser irradiation of a microdot is obtained by comparing the experimental width with the theoretical width. The full widths at half maximum of the unresolved transition arrays are computed in the formalism of the spin-orbit-split arrays.
