Microglia are resident immune cells in the central nervous system. During the pathogenesis of Alzheimer’s disease, stimulatory factors continuously act on the microglia causing abnormal activation and unbalanced phen...Microglia are resident immune cells in the central nervous system. During the pathogenesis of Alzheimer’s disease, stimulatory factors continuously act on the microglia causing abnormal activation and unbalanced phenotypic changes;these events have become a significant and promising area of research. In this review, we summarize the effects of microglial polarization and crosstalk with other cells in the central nervous system in the treatment of Alzheimer’s disease. Our literature search found that phenotypic changes occur continuously in Alzheimer’s disease and that microglia exhibit extensive crosstalk with astrocytes, oligodendrocytes, neurons, and penetrated peripheral innate immune cells via specific signaling pathways and cytokines. Collectively, unlike previous efforts to modulate microglial phenotypes at a single level, targeting the phenotypes of microglia and the crosstalk with other cells in the central nervous system may be more effective in reducing inflammation in the central nervous system in Alzheimer’s disease. This would establish a theoretical basis for reducing neuronal death from central nervous system inflammation and provide an appropriate environment to promote neuronal regeneration in the treatment of Alzheimer’s disease.展开更多
BACKGROUND Neuralgia is frequently noted in patients with Kummell’s disease,and its mechanism is complex,rendering it challenging to treat.Percutaneous kyphoplasty(PKP)has been widely used to treat osteoporotic verte...BACKGROUND Neuralgia is frequently noted in patients with Kummell’s disease,and its mechanism is complex,rendering it challenging to treat.Percutaneous kyphoplasty(PKP)has been widely used to treat osteoporotic vertebral compression fractures with satisfactory outcomes.However,it is not optimal for managing severely collapsed vertebrae,as cement injection may not be feasible.This report describes the use of a selective nerve block for the treatment of neuralgia caused by severely collapsed vertebrae in a patient with Kummell’s disease.CASE SUMMARY In our patient,three vertebrae were involved.The collapse of T11 was particularly severe.After managing T8 and T9 using PKP,these two segments were effectively strengthened;consequently,back pain was significantly relieved.However,the structure and strength of T11 could not be effectively restored using a minimally invasive surgical method because there was little room for cement injection.This caused obvious neuralgia according to the postoperative status of the PKP.Thus,we performed selective nerve blocks for the treatment of neuralgia,which resulted in satisfactory outcomes.CONCLUSION Selective nerve block may be a possible therapeutic strategy for neuralgia due to severely collapsed vertebrae in Kummell’s disease.展开更多
基金supported by the National Natural Science Foundation of China,Nos. 82004028 (to LJS) and 81473577 (to CGM)China Postdoctoral Science Foundation,No. 2020M680912 (to LJS)+4 种基金Shanxi Applied Basic Research Project,No. 201901D211538 (to LJS)Leading Team of Medical Science and Technology of Shanxi Province,No. 2020TD05 (to CGM)Funds for Construction of Key Disciplines from Shanxi University of Chinese Medicine,Young Scientists Cultivation Project of Shanxi University of Chinese Medicine No. 2021PYQN-09 (to LJS)Basic Research Project of the Cultivation Plan of Scientific and Technological Innovation Ability of Shanxi University of Chinese Medicine,No. 2020PY-JC-02 (to LJS)Cardiovascular Special Fund Project of National Regional Traditional Chinese Medicine Medical Center of Affiliated Hospital of Shanxi University of Chinese Medicine in 2021, No. XGZX202115 (to LJS)。
文摘Microglia are resident immune cells in the central nervous system. During the pathogenesis of Alzheimer’s disease, stimulatory factors continuously act on the microglia causing abnormal activation and unbalanced phenotypic changes;these events have become a significant and promising area of research. In this review, we summarize the effects of microglial polarization and crosstalk with other cells in the central nervous system in the treatment of Alzheimer’s disease. Our literature search found that phenotypic changes occur continuously in Alzheimer’s disease and that microglia exhibit extensive crosstalk with astrocytes, oligodendrocytes, neurons, and penetrated peripheral innate immune cells via specific signaling pathways and cytokines. Collectively, unlike previous efforts to modulate microglial phenotypes at a single level, targeting the phenotypes of microglia and the crosstalk with other cells in the central nervous system may be more effective in reducing inflammation in the central nervous system in Alzheimer’s disease. This would establish a theoretical basis for reducing neuronal death from central nervous system inflammation and provide an appropriate environment to promote neuronal regeneration in the treatment of Alzheimer’s disease.
文摘BACKGROUND Neuralgia is frequently noted in patients with Kummell’s disease,and its mechanism is complex,rendering it challenging to treat.Percutaneous kyphoplasty(PKP)has been widely used to treat osteoporotic vertebral compression fractures with satisfactory outcomes.However,it is not optimal for managing severely collapsed vertebrae,as cement injection may not be feasible.This report describes the use of a selective nerve block for the treatment of neuralgia caused by severely collapsed vertebrae in a patient with Kummell’s disease.CASE SUMMARY In our patient,three vertebrae were involved.The collapse of T11 was particularly severe.After managing T8 and T9 using PKP,these two segments were effectively strengthened;consequently,back pain was significantly relieved.However,the structure and strength of T11 could not be effectively restored using a minimally invasive surgical method because there was little room for cement injection.This caused obvious neuralgia according to the postoperative status of the PKP.Thus,we performed selective nerve blocks for the treatment of neuralgia,which resulted in satisfactory outcomes.CONCLUSION Selective nerve block may be a possible therapeutic strategy for neuralgia due to severely collapsed vertebrae in Kummell’s disease.
