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Wrinkling and Growth Mechanism of CuO Nanowires in Thermal Oxidation of Copper Foil
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作者 Fa-chun Lai Suan-zhi lin +2 位作者 Zhi-gao Chen Hai-long Hu li-mei lin 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2013年第5期585-589,I0004,共6页
我们在在铜陪衬的热氧化起皱和 CuO nanowires (NW ) 生长上报导系统的研究。有 0.5 公里的厚度的铜陪衬热地在 500 湩挠潬敶在空中被氧化吗?
关键词 生长机制 纳米线 氧化铜 热氧化 皱纹 铜箔 氧化时间 电场强度
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水线草质量控制体系构建(英文)
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作者 林艳 李洪权 +6 位作者 夏伯候 张智敏 李亚梅 张晓青 吴萍 林丽美 廖端芳 《Digital Chinese Medicine》 2018年第4期302-309,共8页
目的水线草为中国等东南亚国家的主要抗肿瘤药物,但是目前没有切实可行的质量标准对其进行有效地控制,本研究欲构建水线草全面的质量控制体系。方法采用显微鉴别法对水线草进行粉末和横切面性状鉴别;采用薄层色谱法进行定性鉴别;采用高... 目的水线草为中国等东南亚国家的主要抗肿瘤药物,但是目前没有切实可行的质量标准对其进行有效地控制,本研究欲构建水线草全面的质量控制体系。方法采用显微鉴别法对水线草进行粉末和横切面性状鉴别;采用薄层色谱法进行定性鉴别;采用高效液相色谱法建立水线草区别于易混淆品种白花蛇舌草的特征图谱,且对特征峰成分耳草酮A进行定量研究;采用2015年版中国药典规定的方法分别对水线草的水分、总灰分、酸不溶性灰分、重金属和农药残留量进行检测。结果水线草横切面内含草酸钙针晶束,偶见小油滴。薄层色谱法检出水线草样品中区别于白花蛇舌草的3个蓝色荧光斑点;高效液相色谱法(HPLC)建立了含5个特征峰的水线草特征图谱,并测定主要特征峰耳草酮A,该成分在0.0000527~0.00211 mg/mL范围内线性关系良好,线性方程为Y=3.15×10~8X+312.04(r^2=1.000),平均回收率为100.4%,RSD为0.85%,精密度(RSD 0.92%)、重复性(RSD 0.14%)、稳定性(RSD 0.85%)都达标,15批水线草中耳草酮A的质量分数在0.00017~0.00113%;水分、总灰分、酸不溶性灰分分别为8.80%~11.2%、7.00%~15.3%和0.440%~7.70%;重金属铅、砷、汞、镉、铜的含量分别为1.60~4.60、0.650~1.60、0.0300~0.100、0.240~0.690和10.1~16.6μg/g;农药残留含量低于检测限0.00100 ppm。结论此质量标准体系可有效区分水线草和易混淆品种白花蛇舌草,从而全面控制水线草质量,保证水线草的真伪优劣,为水线草临床使用提供参考。 展开更多
关键词 水线草 白花蛇舌草 耳草酮A 薄层法 高效液相色谱法(HPLC) 质量标准
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基于响应面法优化超声辅助提取山香圆叶多糖工艺(英文) 被引量:6
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作者 赵灵佳 夏伯侯 +3 位作者 林丽美 熊苏慧 唐洁 廖端芳 《Digital Chinese Medicine》 2018年第3期239-246,共8页
目的优化山香圆叶多糖提取工艺,获得最大多糖得率。方法应用响应面法联合Plackett-Burman设计、最陡爬坡法和Box-Behnken设计来获取山香圆叶多糖最佳提取工艺。利用Plackett-Burman设计筛选对多糖得率显著影响的因素,利用最陡爬坡法使... 目的优化山香圆叶多糖提取工艺,获得最大多糖得率。方法应用响应面法联合Plackett-Burman设计、最陡爬坡法和Box-Behnken设计来获取山香圆叶多糖最佳提取工艺。利用Plackett-Burman设计筛选对多糖得率显著影响的因素,利用最陡爬坡法使各因素快速逼近最佳响应区域,采用Box-Behnken设计和响应面法来进一步研究各因素之间的相互作用,并得出最优值。结果 Plackett-Burman设计筛选出三个对多糖得率显著影响的因素:酶浓度、提取时间和液固比。在进一步研究中得到最大得率的最优条件为:酶浓度2.8%、提取时间为41 min和液固比为27 mL/g。在最优条件下山香圆叶多糖得率为3.08%,与预测值3.11%接近。结论本研究优化了山香圆叶多糖的提取工艺,有利于山香圆叶多糖后续的生产和利用。 展开更多
关键词 优化 多糖 山香圆 山香圆叶 响应面法
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Effect and satisfaction of outpatient services by precision valuation reservation registration 被引量:2
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作者 Hai-Jun Jin An-Lan Cheng +2 位作者 Jin-Yan Qian li-mei lin Huan-Mei Tang 《World Journal of Clinical Cases》 SCIE 2021年第26期7750-7761,共12页
BACKGROUND Due to improvements in living standards,people are now paying more attention to their health.In China,more patients choose to go to large or well-known hospitals,which leads to constant crowding of outpatie... BACKGROUND Due to improvements in living standards,people are now paying more attention to their health.In China,more patients choose to go to large or well-known hospitals,which leads to constant crowding of outpatient clinics in these hospitals.AIM To establish precision valuation reservation registration aimed at shortening waiting time,improving patient experience and promoting the satisfaction of outpatients and medical staff.METHODS On the basis of the implementation of a conventional appointment system,more reasonable time intervals were set for different doctors by evaluating the actual capacity of each doctor to receive patients,and appointment times were made more accurate through intervention.The change in consultation waiting time of patients was then compared.Correlations between the consultation waiting time of patients and the satisfaction of patients or satisfaction of medical staff were analyzed.RESULTS After precision valuation reservation registration,the average consultation waiting time of patients reduced from 18.47 min to 10.11 min(t=8.90,P<0.001).The satisfaction score of patients increased from 91.33 to 96.27(t=-8.62,P<0.001),and the satisfaction score of medical staff increased from 90.51 to 96.04(t=-10.50,P<0.001).The consultation waiting time of patients was negatively correlated with their satisfaction scores(γ=-0.89,P<0.001).The consultation waiting time of patients was also negatively correlated with medical staff satisfaction scores(γ=-0.96,P<0.001).CONCLUSION Precision valuation reservation registration significantly shortened outpatient waiting times and improve the satisfaction of not only patients but also medical staff.This approach played an important role in improving outpatient services,provided a model that is supported by relevant evidence and could continuously improve the quality of management.Precision valuation reservation registration is worth promoting and applying in the clinic. 展开更多
关键词 Precision valuation reservation Shorten waiting time Effect on outpatient service SATISFACTION OUTPATIENTS Medical staff
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Advances in endovascular aneurysm management: coiling and adjunctive devices 被引量:6
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作者 Jessica K Campos Brian V Lien +1 位作者 Alice S Wang li-mei lin 《Stroke & Vascular Neurology》 SCIE 2020年第1期14-21,共8页
Endovascular coil embolisation continues to evolve and remains a valid modality in managing ruptured and unruptured cerebral aneurysms.Technological advances in coil properties,adjunctive devices and interventional te... Endovascular coil embolisation continues to evolve and remains a valid modality in managing ruptured and unruptured cerebral aneurysms.Technological advances in coil properties,adjunctive devices and interventional techniques continue to improve long-term aneurysm occlusion rates.This review elaborates on the latest advances in next-generation endovascular coils and adjunctive coiling techniques for treating cerebral aneurysms. 展开更多
关键词 ANEURYSM CEREBRAL ENDOVASCULAR
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Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms 被引量:2
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作者 Bowen Jiang Matthew T Bender +7 位作者 Erick M Westbroek Jessica K Campos li-mei lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon 《Stroke & Vascular Neurology》 SCIE 2018年第3期169-175,共7页
background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet funct... background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. 展开更多
关键词 P2Y12 matched BALLOON
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Cerebral aneurysm treatment: modern neurovascular techniques 被引量:7
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作者 Bowen Jiang Michelle Paff +2 位作者 Geoffrey P Colby Alexander L Coon li-mei lin 《Stroke & Vascular Neurology》 SCIE 2016年第3期93-100,共8页
Endovascular treatment of cerebral aneurysm continues to evolve with the development of new technologies.This review provides an overview of the recent major innovations in the neurointerventional space in recent years.
关键词 TREATMENT CEREBRAL NEU
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Advances in endovascular aneurysm management: flow modulation techniques with braided mesh devices 被引量:1
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作者 Jessica K Campos Barry Cheaney II +5 位作者 Brian V Lien David A Zarrin Chau D Vo Geoffrey P Colby li-mei lin Alexander L Coon 《Stroke & Vascular Neurology》 SCIE 2020年第1期1-13,共13页
Flow diverters and flow disruption technology,alongside nuanced endovascular techniques,have ushered in a new era of treating cerebral aneurysms.Here,we provide an overview of the latest flow modulation devices and hi... Flow diverters and flow disruption technology,alongside nuanced endovascular techniques,have ushered in a new era of treating cerebral aneurysms.Here,we provide an overview of the latest flow modulation devices and highlight their clinical applications and outcomes. 展开更多
关键词 FLOW braided hered
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Multimodal management of giant cerebral aneurysms: review of literature and case presentation
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作者 Jessica K Campos Benjamin Z Ball +5 位作者 Barry Cheaney II Alexander J Sweidan Bima J Hasjim Frank P K Hsu Alice S Wang li-mei lin 《Stroke & Vascular Neurology》 SCIE 2020年第1期22-28,共7页
The pathophysiology of giant cerebral aneurysms renders them difficult to treat.Advances in technology have attempted to address any shortcomings associated with open surgery or endovascular therapies.Since the introd... The pathophysiology of giant cerebral aneurysms renders them difficult to treat.Advances in technology have attempted to address any shortcomings associated with open surgery or endovascular therapies.Since the introduction of the flow diversion technique,the endovascular approach with flow diversion has become the first-line modality chosen to treat giant aneurysms.A subset of these giant aneurysms may persistent despite any treatment modality.Perhaps the best option for these recurrent and/or persistent giant aneurysms is to employ a multimodal approach-both surgical and endovascular-rather than any single technique to provide a curative result with favourable patient outcomes.This paper provides a review of the histopathology and treatment options for giant cerebral aneurysms.Additionally,an illustrative case is presented to highlight the unique challenges of a curative solution for giant cerebral aneurysms that persist despite initial treatment. 展开更多
关键词 ANEURYSM CEREBRAL GIANT
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Flow diversion covering the M1 origin as a last resort
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作者 li-mei lin Matthew T Bender +9 位作者 Geoffrey P Colby Bowen Jiang Jessica K Campos David A Zarrin Robert W C Young Risheng Xu Justin M Caplan Judy Huang Rafael J Tamargo Alexander L Coon 《Stroke & Vascular Neurology》 SCIE 2019年第3期141-147,共7页
Introduction Internal carotid artery termination(ICAT)and proximal A1 aneurysms can be challenging for open surgical clipping or endovascular coiling.Treatment with flow diversion covering the middle cerebral artery(M... Introduction Internal carotid artery termination(ICAT)and proximal A1 aneurysms can be challenging for open surgical clipping or endovascular coiling.Treatment with flow diversion covering the middle cerebral artery(MCA),an end vessel supplying a terminal circulation,has not been reported.Methods A prospective,Institutional Review Board-approved database was analysed for patients with pipeline embolisation device(PED)placement from the anterior cerebral artery(ACA)to the ICA during cerebral aneurysm treatment.Results Nine cases were identified,including five proximal A1,three posterior communicating artery and one ICAT aneurysm locations.Average aneurysm size was 8.3 mm(range 3-17),with 67%saccular and 78%right-sided.Primary indication for treatment was significant dome irregularity(44%),recurrence or enlargement(33%),underlying collagen vascular disorder(11%)and traumatic pseudoaneurysm(11%).Preservation of the ipsilateral ACA(with PED placed in A1)was performed when the anterior communicating artery(67%)or contralateral A1(33%)were absent on angiography.Adjunctive coiling was done in four cases(44%).There was one major stroke leading to mortality(11%)and one minor stroke(11%).Clinical follow-up was 27 months on average.Follow-up digital subtraction angiography(average interval 15 months)showed complete aneurysm obliteration(88%)or dome occlusion with entry remnant(12%).The jailed MCA showed minimal or mild delay(primarily anterograde flow)in 75%of cases and significant delay(reliance primarily on ACA and external carotid artery collaterals)in 25%.Conclusions Covering the MCA with a flow diverting stent should be reserved for select rare cases.Strict attention to blood pressure augmentation during the periprocedural period is necessary to minimise potential ischaemic compromise. 展开更多
关键词 primarily RESORT sided
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Tandem cervical carotid stenting for stenosis with flow diversion embolisation for the treatment of intracranial aneurysms
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作者 Jessica K Campos li-mei lin +4 位作者 Narlin B Beaty Matthew T Bender Bowen Jiang David A Zarrin Alexander L Coon 《Stroke & Vascular Neurology》 SCIE 2019年第1期43-47,共5页
Background An estimated 2%-3%of the population harbour an intracranial aneurysm.Concomitant atherosclerotic cervical carotid disease is not uncommon.The management of these two entities remains a challenge within the ... Background An estimated 2%-3%of the population harbour an intracranial aneurysm.Concomitant atherosclerotic cervical carotid disease is not uncommon.The management of these two entities remains a challenge within the field.Case presentation We report a single case of concomitant carotid stenosis and two ipsilateral unruptured intracranial aneurysms treated with a single-staged cervical carotid stenting and cerebral aneurysm embolisation with the Pipeline embolisation device.Discussion No consensus currently exists to guide endovascular treatment of intracranial aneurysms associated with asymptomatic ipsilateral stenosis.Here,we present a case of asymptomatic moderate carotid stenosis with two ipsilateral intracranial aneurysms and suggest carotid artery stenting takes procedural priority over aneurysm embolisation in single-stage treatment.The rationale for the sequence of neurointerventions is based on the tracking a robust distal access system beyond a stenotic proximal carotid lesion and stabilisation of the ulcerated plaque to avoid thromboembolic complications associated with plaque irritation during aneurysm embolisation.Additional cases and longer follow-up will be needed to further assess the efficacy of this technique. 展开更多
关键词 ANEURYSM CAROTID STENOSIS
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