Global research landscape of Peutz-Jeghers syndrome and successful endoscopic management of intestinal intussusception in patients with recurrent laparotomies

BACKGROUND Peutz-Jeghers syndrome(PJS)has brought significant physical,psychological and economic burdens on the patients and their families due to its early onset,diagnostic and therapeutic challenges and increased recurrence risk.AIM To explore the current research status and emerging hotspots of PJS.METHODS Studies on PJS published during 1994-2023 were gathered based on Web of Science Core Collection.Additionally,a case of PJS-induced intestinal intussusception,successfully treated with endoscopic methods despite three laparotomies,was highlighted.Comprehensive bibliometric and visual analysis were conducted with VOSviewer,R and CiteSpace.RESULTS Altogether 1760 studies were identified,indicating a steady increase in the publication number.The United States had the highest influence,whereas the University of Helsinki emerged as the leading institution,and Aaltonen LA from the University of Helsinki was the most prolific author.Cancer Research,Oncogene and Endoscopy were the top three journals based on H-index.Keyword burst direction analysis revealed that"cancer risk","management","surveillance"and"familial pancreatic cancer"were the potential hotspots for investigation.Additionally,"early detection","capsule endoscopy","clinical management","double-balloon endoscopy","familial pancreatic cancer"and"molecular genetic basis"were identified as the key clusters of co-cited references.Endoscopic polypectomy remained effective on resolving intestinal intussusception in patients who underwent three previous laparotomies.CONCLUSION In the last three decades,global publications related to PJS show a steadily increasing trend in number.Endoscopic management is currently a research hotspot.

Effects of BN content on the mechanical properties of nanocrystalline 3Y-TZP/Al_(2)O_(3)/BN dental ceramics

3Y-TZP/3wt%Al_(2)O_(3) powder was coated with varying amounts of BN using the urea and borate reaction sintering method,and then multiphase ceramics were prepared by hot pressing sintering.The micro-topography and the compositional analysis of synthesized ceramics were conducted through scanning electron microscopy,transmission electron microscopy and X-ray diffraction.A mechanical tester was used to analyze the Vickers hardness,fracture toughness,and bending strength of the synthesized ceramics.The results showed that the ceramic with a BN content of 12wt%showed the best processability,but had diminished mechanical properties(such as fracture toughness and bending strength).The ceramic with a BN content of 9wt%showed better processability than those with 3wt%and 6wt%BN.However,the fracture toughness was affected by the addition of 9wt%BN,making this ceramic only usable as a base material for a three-unit fixed bridge.In contrast,the ceramics with a BN content of 3wt%or 6wt%fulfilled the criteria for use in multi-unit restoration,but their low processability made them unsuitable for milling after sintering.