BACKGROUND Diffuse reduction of spleen density(DROSD)is related to cancer prognosis;however,its role in intrahepatic cholangiocarcinoma(ICC)remains unclear.AIM To assess the predictive value of DROSD in the prognosis ...BACKGROUND Diffuse reduction of spleen density(DROSD)is related to cancer prognosis;however,its role in intrahepatic cholangiocarcinoma(ICC)remains unclear.AIM To assess the predictive value of DROSD in the prognosis of ICC after curative resection.METHODS In this multicenter retrospective cohort study,we enrolled patients with ICC who underwent curative hepatectomy between 2012 and 2019.Preoperative spleen density was measured using computed tomography.Overall survival(OS)and recurrence-free survival(RFS)rates were calculated and compared utilizing the Kaplan-Meier method.Univariable and multivariable Cox regression analyses were applied to identify independent factors for OS and RFS.A nomogram was created with independent risk factors to predict prognosis of patients with ICC.RESULTS One hundred and sixty-seven ICC patients were enrolled.Based on the diagnostic cut-off values(spleen density≤45.5 Hounsfield units),55(32.9%)patients had DROSD.Kaplan-Meier analysis indicated that patients with DROSD had worse OS and RFS than those without DROSD(P<0.05).Cox regression analysis revealed that DROSD,carcinoembryonic antigen level,carbohydrate antigen 19-9 level,length of hospital stay,lymph node metastasis,and postoperative complications were independent predictors for OS(P<0.05).The nomogram created with these factors was able to predict the prognosis of patients with ICC with good reliability(OS C-index=0.733).The area under the curve for OS was 0.79.CONCLUSION ICC patients with DROSD have worse OS and RFS.The nomogram is a simple and practical method to identify high-risk ICC patients with poor prognosis.展开更多
Constructing hetero-structured catalyst is promising but still challenging to achieve overall water splitting for hydrogen production with high efficiency.Herein,we developed a sulfide-based MoS_(2)/Co_(l-x)S@C hetero...Constructing hetero-structured catalyst is promising but still challenging to achieve overall water splitting for hydrogen production with high efficiency.Herein,we developed a sulfide-based MoS_(2)/Co_(l-x)S@C hetero-structure for highly efficient electrochemical hydrogen evolution reaction(HER)and oxygen evolution reaction(OER).The carbon derived from the filter paper acts as a conducting carrier to ensure adequate exposure of the active sites guaranteed with improved catalytic stability.The unique hierarchical nano-sheets facilitate the charge and ion transfer by shortening the diffusion path during electro-catalysis.Meanwhile,the robust hetero-interfaces in MoS_(2)/Co_(1-x)S@C can expose rich electrochemical active sites and facilitate the charge transfer,which further cooperates synergistically toward electro-catalytic reactions.Consequently,the optimal MoS_(2)/Co_(1-x)S@C hetero-structures present small over-potentials toward HER(135 mV@10 mA·cm^(-2))and OER(230 mV@10 mA·cm^(-2)).The MoS_(2)/Co_(1-x)S@C electrolyzer requires an ultralow voltage of 1.6 V at the current density of 10 mA·cm^(-2)with excellent durability,outperforming the state-of-the-art electro-catalysts.This work sheds light on the design of the hetero-structured catalysts with interfacial engineering toward large-scale water splitting.展开更多
基金Supported by National Natural Science Foundation of China,No.82072685the Science and Technology Innovation Program for College Students in Zhejiang Province,No.2020R413022.
文摘BACKGROUND Diffuse reduction of spleen density(DROSD)is related to cancer prognosis;however,its role in intrahepatic cholangiocarcinoma(ICC)remains unclear.AIM To assess the predictive value of DROSD in the prognosis of ICC after curative resection.METHODS In this multicenter retrospective cohort study,we enrolled patients with ICC who underwent curative hepatectomy between 2012 and 2019.Preoperative spleen density was measured using computed tomography.Overall survival(OS)and recurrence-free survival(RFS)rates were calculated and compared utilizing the Kaplan-Meier method.Univariable and multivariable Cox regression analyses were applied to identify independent factors for OS and RFS.A nomogram was created with independent risk factors to predict prognosis of patients with ICC.RESULTS One hundred and sixty-seven ICC patients were enrolled.Based on the diagnostic cut-off values(spleen density≤45.5 Hounsfield units),55(32.9%)patients had DROSD.Kaplan-Meier analysis indicated that patients with DROSD had worse OS and RFS than those without DROSD(P<0.05).Cox regression analysis revealed that DROSD,carcinoembryonic antigen level,carbohydrate antigen 19-9 level,length of hospital stay,lymph node metastasis,and postoperative complications were independent predictors for OS(P<0.05).The nomogram created with these factors was able to predict the prognosis of patients with ICC with good reliability(OS C-index=0.733).The area under the curve for OS was 0.79.CONCLUSION ICC patients with DROSD have worse OS and RFS.The nomogram is a simple and practical method to identify high-risk ICC patients with poor prognosis.
基金supported by the National Natural Science Foundation of China(51871119,22075141,and 22101132)Scientific and Technological Innovation Special Fund for Carbon Peak and Carbon Neutrality of Jiangsu Province(BK20220039)+3 种基金Jiangsu Provincial Founds for Natural Science Foundation(BK20180015 and BK20210311)China Postdoctoral Science Foundation(2021M691561 and 2021T140319)Jiangsu Postdoctoral Research Fund(2021K547C)the Fundamental Research Funds for the Central Universities(kfjj20180605)。
文摘Constructing hetero-structured catalyst is promising but still challenging to achieve overall water splitting for hydrogen production with high efficiency.Herein,we developed a sulfide-based MoS_(2)/Co_(l-x)S@C hetero-structure for highly efficient electrochemical hydrogen evolution reaction(HER)and oxygen evolution reaction(OER).The carbon derived from the filter paper acts as a conducting carrier to ensure adequate exposure of the active sites guaranteed with improved catalytic stability.The unique hierarchical nano-sheets facilitate the charge and ion transfer by shortening the diffusion path during electro-catalysis.Meanwhile,the robust hetero-interfaces in MoS_(2)/Co_(1-x)S@C can expose rich electrochemical active sites and facilitate the charge transfer,which further cooperates synergistically toward electro-catalytic reactions.Consequently,the optimal MoS_(2)/Co_(1-x)S@C hetero-structures present small over-potentials toward HER(135 mV@10 mA·cm^(-2))and OER(230 mV@10 mA·cm^(-2)).The MoS_(2)/Co_(1-x)S@C electrolyzer requires an ultralow voltage of 1.6 V at the current density of 10 mA·cm^(-2)with excellent durability,outperforming the state-of-the-art electro-catalysts.This work sheds light on the design of the hetero-structured catalysts with interfacial engineering toward large-scale water splitting.
