AIM：To evaluate the long-term safety and efficacy of vitrectomy and internal limiting membrane（ILM）peeling with or without gas tamponade for highly myopic foveoschisis.METHODS：We performed an open-label,observerbl...AIM：To evaluate the long-term safety and efficacy of vitrectomy and internal limiting membrane（ILM）peeling with or without gas tamponade for highly myopic foveoschisis.METHODS：We performed an open-label,observerblinded clinical trial of 85 patients with myopic foveoschisis between 2000 and 2012.Patients were randomly allocated to one of two groups,those who received vitrectomy and ILM peeling without gas tamponade（no-gas group）or those who with gas tamponade（gas group）and follow up at least 5y.RESULTS：Visual acuity of gas group improved from0.82±0.33 to 0.79±0.73 in 6mo,improved to 0.71±0.67 in 1y and within this range in the following 4y.Visual acuity of no-gas group improved from 0.81±0.46 to 0.78±0.66 in 6mo,improved to 0.70±0.65 in 1y.The finial visual acuity of two groups were significantly increased compared with the baseline（P〈0.05）.The visual acuity was improved in 35 of40 eyes（87.5%）in gas group and 29 of 33 eyes（87.9%）in no-gas group,while there were no significant differences between gas group and no-gas group in the visual acuity.The foveoschisis on optical coherence tomography（OCT）completely resolved in 5 of 40 eyes in 1mo,14 eyes in 6mo and 40 eyes in 1y in the gas group.While the foveoschisis completely resolved in 4 of 33 eyes in 1mo,10 eyes in 6mo and 33 eyes in 1y in the no-gas group.CONCLUSION：Vitrectomy and ILM peeling without gas tamponade appears to be as effective in the treatment of myopic foveoschisis as vitrectomy and ILM with gas tamponade.However,eyes treated with no-gas tamponade showed more rapid resolution of myopic foveoschisis.展开更多
文摘AIM：To evaluate the long-term safety and efficacy of vitrectomy and internal limiting membrane（ILM）peeling with or without gas tamponade for highly myopic foveoschisis.METHODS：We performed an open-label,observerblinded clinical trial of 85 patients with myopic foveoschisis between 2000 and 2012.Patients were randomly allocated to one of two groups,those who received vitrectomy and ILM peeling without gas tamponade（no-gas group）or those who with gas tamponade（gas group）and follow up at least 5y.RESULTS：Visual acuity of gas group improved from0.82±0.33 to 0.79±0.73 in 6mo,improved to 0.71±0.67 in 1y and within this range in the following 4y.Visual acuity of no-gas group improved from 0.81±0.46 to 0.78±0.66 in 6mo,improved to 0.70±0.65 in 1y.The finial visual acuity of two groups were significantly increased compared with the baseline（P〈0.05）.The visual acuity was improved in 35 of40 eyes（87.5%）in gas group and 29 of 33 eyes（87.9%）in no-gas group,while there were no significant differences between gas group and no-gas group in the visual acuity.The foveoschisis on optical coherence tomography（OCT）completely resolved in 5 of 40 eyes in 1mo,14 eyes in 6mo and 40 eyes in 1y in the gas group.While the foveoschisis completely resolved in 4 of 33 eyes in 1mo,10 eyes in 6mo and 33 eyes in 1y in the no-gas group.CONCLUSION：Vitrectomy and ILM peeling without gas tamponade appears to be as effective in the treatment of myopic foveoschisis as vitrectomy and ILM with gas tamponade.However,eyes treated with no-gas tamponade showed more rapid resolution of myopic foveoschisis.
