BACKGROUND High-grade B-cell lymphoma(HGBL)is an unusual malignancy that includes myelocytomatosis viral oncogene(MYC),B-cell lymphoma-2(BCL-2),and/or BCL-6 rearrangements,termed double-hit or triple-hit lymphomas,and...BACKGROUND High-grade B-cell lymphoma(HGBL)is an unusual malignancy that includes myelocytomatosis viral oncogene(MYC),B-cell lymphoma-2(BCL-2),and/or BCL-6 rearrangements,termed double-hit or triple-hit lymphomas,and HGBL-not otherwise specific(HGBL-NOS),which are morphologically characteristic of HGBL but lack MYC,BCL-2,or BCL-6 rearrangements.HGBL is partially transformed by follicular lymphoma and other indolent lymphoma,with few cases of marginal zone lymphoma(MZL)transformation.HGBL often has a poor prognosis and intensive therapy is currently mainly advocated,but there is no good treatment for these patients who cannot tolerate chemotherapy.CASE SUMMARY We reported a case of MZL transformed into HGBL-NOS with TP53 mutation and terminal deoxynucleotidyl transferase expression.Gene analysis revealed the gene expression profile was identical in the pre-and post-transformed tissues,suggesting that the two diseases are homologous,not secondary tumors.The chemotherapy was ineffective and the side effect was severe,so we tried combination therapy including venetoclax and obinutuzumab.The patient tolerated treatment well,and reached partial response.The patient had recurrence of hepatocellular carcinoma and died of multifunctional organ failure.He survived for 12 months after diagnosis.CONCLUSION Venetoclax combined with obinutuzumab might improve the survival in some HGBL patients,who are unsuitable for chemotherapy.展开更多
For the past decades,networked control systems(NCSs),as an interdisciplinary subject,have been one of the main research highlights and many fruitful results from different aspects have been achieved.With these growing...For the past decades,networked control systems(NCSs),as an interdisciplinary subject,have been one of the main research highlights and many fruitful results from different aspects have been achieved.With these growing research trends,it is significant to consolidate the latest knowledge and information to keep up with the research needs.In this paper,the results of different aspects of NCSs,such as quantization,estimation,fault detection and networked predictive control,are summarized.In addition,with the development of cloud technique,cloud control systems are proposed for the further development of NCSs.展开更多
基金Supported by The Lishui Science and Technology Planing Projects,No.2020SJZC048.
文摘BACKGROUND High-grade B-cell lymphoma(HGBL)is an unusual malignancy that includes myelocytomatosis viral oncogene(MYC),B-cell lymphoma-2(BCL-2),and/or BCL-6 rearrangements,termed double-hit or triple-hit lymphomas,and HGBL-not otherwise specific(HGBL-NOS),which are morphologically characteristic of HGBL but lack MYC,BCL-2,or BCL-6 rearrangements.HGBL is partially transformed by follicular lymphoma and other indolent lymphoma,with few cases of marginal zone lymphoma(MZL)transformation.HGBL often has a poor prognosis and intensive therapy is currently mainly advocated,but there is no good treatment for these patients who cannot tolerate chemotherapy.CASE SUMMARY We reported a case of MZL transformed into HGBL-NOS with TP53 mutation and terminal deoxynucleotidyl transferase expression.Gene analysis revealed the gene expression profile was identical in the pre-and post-transformed tissues,suggesting that the two diseases are homologous,not secondary tumors.The chemotherapy was ineffective and the side effect was severe,so we tried combination therapy including venetoclax and obinutuzumab.The patient tolerated treatment well,and reached partial response.The patient had recurrence of hepatocellular carcinoma and died of multifunctional organ failure.He survived for 12 months after diagnosis.CONCLUSION Venetoclax combined with obinutuzumab might improve the survival in some HGBL patients,who are unsuitable for chemotherapy.
基金supported by National Basic Research Program of China(973 Program)(No.2012CB720000)National Natural Science Foundation of China(Nos.61225015 and 60974011)+3 种基金Foundation for Innovative Research Groups of the National Natural Science Foundation of China(No.61321002)Beijing Municipal Natural Science Foundation(Nos.4102053 and 4101001)Beijing Natural Science Foundation(Nos.4132042)Beijing Higher Education Young Elite Teacher Project(No.YETP1212)
文摘For the past decades,networked control systems(NCSs),as an interdisciplinary subject,have been one of the main research highlights and many fruitful results from different aspects have been achieved.With these growing research trends,it is significant to consolidate the latest knowledge and information to keep up with the research needs.In this paper,the results of different aspects of NCSs,such as quantization,estimation,fault detection and networked predictive control,are summarized.In addition,with the development of cloud technique,cloud control systems are proposed for the further development of NCSs.
