Treatment of oral lichen planus by surgical excision and acellular dermal matrix grafting:Eleven case reports and review of literature

BACKGROUND Oral lichen planus(OLP)is a chronic inflammatory disorder,and it can affect normal oral function.The conventional treatments for OLP are not always effective,and relapse easily occurs.Therefore,treatment of OLP is difficult and challenging.In this study,we evaluated over a long period the clinical efficacy of surgical excision and acellular dermal matrix(ADM)grafting in patients with refractory OLP.CASE SUMMARY Eleven patients with refractory OLP underwent a standardized protocol of surgical excision and ADM grafting.The condition of the area of the grafted wound,the intraoperative maximum mouth opening,pain,and clinical healing were assessed at postoperative follow-up visits.All patients had a flat surgical area with similar mucosal tissue coverage and local scar formation.Patients had no irritation and pain in their mucous membranes when eating acidic and spicy food.All patients’mouth openings returned to normal within 2-6 mo after surgery.During follow-up,none of the patients had recurrence of OLP after surgery.The longest follow-up was 11 yr and the shortest was 6 mo,and none of the patients relapsed during follow-up.CONCLUSION Surgical excision and ADM grafting could be an effective method to treat refractory OLP.

Influence of S Contents on the Hydrogen Blistering and Hydrogen Induced Cracking of A350LF2 Steel

In the present work, the effects of chemical compositions on the hydrogen blistering and hydrogen induced cracking of A350LF2 steel with different S contents were studied. Four types of A350LF2 steels were evaluated by immersing samples in H2S-saturated NACE solution. The hydrogen blistering, crack length rate(CLR), crack thickness rate(CTR) and crack sensitivity rate(CSR) were evaluated. The results show that there are many hydrogen blisters on the sample surface with S content of 0.021%, a few on the sample surface with S content of 0.019% and 0.012% and no one on the surface with S content of 0.002%. There were 12, 2 and 1 strips of cracks of longer than 0.3 mm on the evaluated cross sections with S content of 0.021%, 0.019% and 0.012%, respectively. There was no any crack in the sample with 0.002% S. The corrosion rate was also evaluated. The S content has no obvious influence on the corrosion rate.

Protective effect of dietary nitrate on stress-induced gastric mucosal injury via enhancing blood perfusion in Mongolian gerbils

To the Editor:Gastric ulceration caused by stress is one example of stress-induced organ injuries.Stress-induced ulcer is commonly seen in critically ill patients and can result in significant upper gastrointestinal bleeding associated with a highly increased mortality.Water immersion and restraint stress(WIRS),which is a complex of physical and psychological stressors,causes damage that mimics the gastric lesions caused by sepsis,trauma,or surgery.[1]Notably,it is well established that adequate mucosal blood flow plays an important role in protecting the gastric mucosa from injuries.Inorganic nitrate exists in everyday diet especially in some vegetables.Dietary nitrate can be rapidly converted to nitrite by oral bacteria,and further reduced to nitric oxide(NO)in the acidic stomach.It has been reported that nitrate serves as biological reservoirs for NO in hypoxia or acidic conditions.[2]Dietary nitrate,as NO donor,has the potential to prevent cardiovascular disease,vascular damage,and high blood pressure in animal models and humans.[3,4]Our previous study has showed that dietary nitrate enhances blood flow in ischemic skin flap.[5]Here,we explore the role of nitrate therapy in stressinduced gastric mucosal injury in Mongolian gerbils.