INTRODUCTION Autoimmunity is defined as, a condition characterized by a specific humoral or cell-mediated immune response against the constituents of the body＇s own tissues （autoantigens）. In numerous autoimmune di...INTRODUCTION Autoimmunity is defined as, a condition characterized by a specific humoral or cell-mediated immune response against the constituents of the body＇s own tissues （autoantigens）. In numerous autoimmune diseases, such an immune response is well recognized that causes damage to the self-constituents of body tissues by the products of the immune system. Graves＇ hyperthyroidism occurs after the loss of tolerance to the thyroid stimulating hormone receptor （TSHR） and the generation of thyroid stimulatory antibodies that mimic the action of thyroid-stimulating hormone （TSH）.展开更多
基金Financial support and sponsorship This study was supported by the grants from National Natural Science Foundation of China （No. 81170729 and No. 81200574）.
文摘INTRODUCTION Autoimmunity is defined as, a condition characterized by a specific humoral or cell-mediated immune response against the constituents of the body＇s own tissues （autoantigens）. In numerous autoimmune diseases, such an immune response is well recognized that causes damage to the self-constituents of body tissues by the products of the immune system. Graves＇ hyperthyroidism occurs after the loss of tolerance to the thyroid stimulating hormone receptor （TSHR） and the generation of thyroid stimulatory antibodies that mimic the action of thyroid-stimulating hormone （TSH）.
