Asymmetric construction of quinuclidine derivatives has been realized by an iridium-catalyzed allylic dearomatization reaction.The catalytic system,derived from[Ir(cod)Cl]2 and the Feringa ligand,tolerates a broad ran...Asymmetric construction of quinuclidine derivatives has been realized by an iridium-catalyzed allylic dearomatization reaction.The catalytic system,derived from[Ir(cod)Cl]2 and the Feringa ligand,tolerates a broad range of substrates.A large array of quinuclidine derivatives can be obtained under mild conditions in good to excellent yields(68%–96%),diastereoselectivity(up to>20/1 dr),and enantioselectivity(up to>99%ee).These pro-ducts feature versatile functional group diversity and can undergo diverse transformations.A model that accounts for the origin of the stereoselectivity has been proposed based on density functional theory(DFT)calculations.展开更多
文摘Asymmetric construction of quinuclidine derivatives has been realized by an iridium-catalyzed allylic dearomatization reaction.The catalytic system,derived from[Ir(cod)Cl]2 and the Feringa ligand,tolerates a broad range of substrates.A large array of quinuclidine derivatives can be obtained under mild conditions in good to excellent yields(68%–96%),diastereoselectivity(up to>20/1 dr),and enantioselectivity(up to>99%ee).These pro-ducts feature versatile functional group diversity and can undergo diverse transformations.A model that accounts for the origin of the stereoselectivity has been proposed based on density functional theory(DFT)calculations.
