Research trends of uveal melanoma: a bibliometric study and visualization analysis

Background:Uveal melanoma is the most prevalent intraocular malignancy.In preceding decades,many studies have been published on uveal melanoma.However,so far,uveal melanoma-related bibliometric studies have not been reported.Methods:Uveal melanoma-related articles and reviews published between 2005 and 2019 were retrieved in the Web of Science Core Collection on March 15,2020.Three bibliometric tools(HistCite,VOSviewer,and CiteSpace)were employed to conduct the current study.Results:A total of 3,404 publications related to uveal melanoma were identified,involving 3015 articles(88.57%)and 389 reviews(11.43%)with 65,429 co-cited references in 9 languages,which were published by 2,875 institutions in 66 countries/regions.The United States contributed to most publications(n=1427,41.92%),and the Thomas Jefferson University was involved in most of the studies(n=160,5.56%).Investigative Ophthalmology&Visual Science published the majority of the papers(n=175,5.14%),whereas Ophthalmology received the most co-citations(n=7050).Shields CL owned the most publications and co-citations(n=122 and 2151,respectively).Gene and molecular biology aspects,prevalence,the main prognosis factor,and treatment were the intellectual foundations of uveal melanoma research.In the field of uveal melanoma,emerging hotspots of uveal melanoma include epidemiologic characteristics,prognosis factors,mechanisms of uveal melanoma development,the use of novel predictive tools,and clinical applications of novel targeted drugs.Conclusion:This first bibliometric study focused on the integral tendency of the past 15 years,identified landmark items,and revealed current research hotspots in the field of uveal melanoma,which will provide references for clinicians and researchers,as well as an example of visualization analysis to explore research hotspots in other fields.

Reporting and methodological quality of meta-analyses of acupuncture for patients with migraine:A methodological investigation with evidence map

Background:Acupuncture has been widely used to relieve migraine-related symptoms.However,the findings of previous systematic reviews(SRs)and meta-analyses(MAs)are still not completely consistent.Their quality is also unknown,so a comprehensive study is needed.Objective:To evaluate the reporting and methodological quality of these MAs concerning acupuncture for migraine,and summarize evidence about the efficacy and safety of acupuncture for migraine.Search strategy:Pub Med,Embase,Cochrane Library,China National Knowledge Infrastructure,Chinese Biomedical Databases,Wanfang Data,and VIP databases were searched from inception to September 2020,with a comprehensive search strategy.Inclusion criteria:The pairwise MAs of randomized controlled trials(RCTs)concerning migraine treated by acupuncture or acupuncture-based therapies,with a control group that received sham acupuncture,medication,no treatment,or acupuncture at different acupoints were included.Data extraction and analysis:Two independent investigators screened studies,extracted relevant data,and assessed reporting and methodological quality using Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)2009 and A Measurement Tool to Assess Systematic Reviews 2(AMSTAR 2),then all results were cross-checked.Spearman correlation test was used to evaluate the correlation between reporting and methodological quality scores.Results:A total of 20 MAs were included in this study.The included MAs indicated that acupuncture was efficacious and safe in preventing and treating migraine when compared with control intervention.There was a high correlation between reporting and methodological quality scores(rs=0.87,P<0.001).The quality of the included SRs needs to be improved mainly with regard to protocol and prospective registration,using a comprehensive search strategy,summarizing the strength of evidence body for key outcomes,a full list of excluded studies with reasons for exclusion,reporting of RCTs’funding sources,and assessing the potential impact of risk of bias in RCTs on MA results.Conclusion:Acupuncture is an effective and safe intervention for preventing and treating migraine,and could be considered as a good option for patients with migraine.However,the reporting and methodological quality of MAs included in this overview is suboptimal.In the future,AMSTAR 2 and PRISMA tools should be followed when making and reporting an SR with MA.