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Reversal of multidrug resistance in vincristine-resistant human gastric cancer cell line SGC7901/VCR by LY980503 被引量:3
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作者 Da-Long Wu ying Xu +1 位作者 li-xin yin Huan-Zhang Lu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第15期2234-2237,共4页
瞄准:调查 LY980503 的颠倒效果, benflumetol 衍生物,在上多在长春新碱(VCR ) 的药抵抗抵抗的人的胃的癌房间线 SGC7901/VCR。方法:一根人的胃的癌症房间线, SGC7901,和它的 VCR- 抵抗变体的房间, SGC7901/VCR,与 LY980503 和 ... 瞄准:调查 LY980503 的颠倒效果, benflumetol 衍生物,在上多在长春新碱(VCR ) 的药抵抗抵抗的人的胃的癌房间线 SGC7901/VCR。方法:一根人的胃的癌症房间线, SGC7901,和它的 VCR- 抵抗变体的房间, SGC7901/VCR,与 LY980503 和 /or doxorubicin (纪录影片) 被栽培。药在试管内的细胞毒性是由 MTT 方法的 assayed。基于流动 cytometric 技术,纪录影片的举起被测量联系纪录影片的吝啬的荧光紧张(MFI ) 在这些房间检测。结果:SGC7901/VCR 房间是对与 SGC7901 房间比较的纪录影片更抵抗的 23.5 次。在 2.0 mumol/L -10 mumol/L 的集中的 LY980503 没有明显的细胞毒性到 SGC7901 和 SGC7901/VCR 房间。在有在 2.0 , 4.0 和 10 mumol/L 的集中的 LY980503 的同时的治疗以后,到 SGC7901/VCR 房间的纪录影片的 IC50 从 1.6 +/-减少了 0.12 mumol/L 到 0.55 +/- 0.024 , 0.25 +/- 0.032 和 0.11 +/- 0.015 mumol/L ,分别地这样,由2.9褶层增加 DOX 敏感( P 【 0 。05 ) , 6.4 褶层(P 【 0。01 ) 并且 14.5 褶层(P 【 0。01 ) 分别地。在纪录影片的举起学习,有 LY980503 的 SGC7901/VCR 房间的同时的孵化显著地增加了 DOX 在 SGC7901/VCR 房间的联系 MFI。没有如此的结果在父母 SGC7901 房间被发现。结论:在非细胞毒素的集中的 LY980503 能有效地由增加细胞内部的纪录影片累积围绕 SGC7901/VCR 房间的抵抗到纪录影片。 展开更多
关键词 长春新碱 多药耐药 胃癌细胞系 LY980503 逆转
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Necrotizing fasciitis of cryptoglandular infection treated with multiple incisions and thread-dragging therapy:A case report 被引量:1
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作者 Xiao-Chun Tao De-Chang Hu +2 位作者 li-xin yin Chen Wang Jin-Gen Lu 《World Journal of Clinical Cases》 SCIE 2021年第28期8537-8544,共8页
BACKGROUND Necrotizing fasciitis is a fulminant necrotizing soft tissue disease with a high fatality rate.It always starts with impact on the deep fascia rapidly and might result in secondary necrosis of the subcutane... BACKGROUND Necrotizing fasciitis is a fulminant necrotizing soft tissue disease with a high fatality rate.It always starts with impact on the deep fascia rapidly and might result in secondary necrosis of the subcutaneous tissue,fascia,and muscle.Thus,timely and multiple surgical operations are needed for the treatment.Meanwhile,the damage of skin and soft tissue caused by multiple surgical operations may require dermatoplasty and other treatments as a consequence.CASE SUMMARY Here,we report a case of 50-year-old male patient who was admitted to our hospital with symptoms of necrotizing fasciitis caused by cryptoglandular infection in the perianal and perineal region.The symptoms of necrotizing fasciitis,also known as the cardinal features,include hyperpyrexia,excruciatingly painful lesions,demonstration gas in the tissue,an obnoxious foul odor and uroschesis.The results of postoperative pathology met the diagnosis.Based on the premise of complete debridement,multiple incisions combined with thread-dragging therapy(a traditional Chinese medicine therapy)and intensive supportive therapies including comprising antibiotics,nutrition and fluids were given.The outcome of the treatment was satisfactory.The patient recovered quickly and achieved ideal anal function and morphology.CONCLUSION Timely and effective debridement and multiple incisions combined with thread-dragging therapy are an integrated treatment for necrotizing fasciitis. 展开更多
关键词 Necrotizing fasciitis Cryptoglandular infection Traditional Chinese medicine Multiple incisions and thread-dragging therapy Integrated treatment Case report
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