BACKGROUND Sarcomatoid carcinoma of the pancreas(SCP) is a rare and aggressive epithelial tumor that has both epithelial and mesenchymal features. It is characterized by sarcomatous elements with evidence of epithelia...BACKGROUND Sarcomatoid carcinoma of the pancreas(SCP) is a rare and aggressive epithelial tumor that has both epithelial and mesenchymal features. It is characterized by sarcomatous elements with evidence of epithelial differentiation. And the term"sarcomatoid carcinoma" is often confused with "carcinosarcoma".CASE SUMMARY We present a case of SCP with lymph node metastasis in a 59-year-old male patient. He had experienced darkening of the urine, scleral icterus, and fatigue for 4 weeks. Computed tomography and magnetic resonance imaging revealed a mass in the pancreatic head, and laboratory tests revealed elevated serum bilirubin levels. The patient underwent pancreaticoduodenectomy after biliary decompression. Histologically, spindle cells with marked nuclear atypia and brisk mitotic activity arranged in a storiform or fascicular pattern were present in the bulk of the tumor. Immunohistochemical analysis found that the spindle cells exhibited strong diffuse positivity for epithelial markers, indicative of epithelial differentiation. Accordingly, the pathologic diagnosis of the pancreatic neoplasm was SCP.CONCLUSION Although sarcomatoid carcinomas and carcinosarcomas have different pathologic features, both have epithelial origin.展开更多
A 67-year-old man was admitted to our hospital for a space-occupying lesion in his liver found 1 week earlier.There were no obvious complaints in this patient and no obvious abnormalities were founded during the physi...A 67-year-old man was admitted to our hospital for a space-occupying lesion in his liver found 1 week earlier.There were no obvious complaints in this patient and no obvious abnormalities were founded during the physical examination.He presented with a habit of heavy drinking(500 mL/day)for more than 40 years.There was no history of other neoplasms,no other history of past illness or any family illness in this patient.展开更多
基金Supported by National Natural Science Foundation of China,No.81572307 and No.81773096Major Project of Medical and Health Technology Development Program in Zhejiang Province,No.7211902Science and Technology Major Project of Zhejiang Province,No.2014C13G2010059 and No.2014C03041-2
文摘BACKGROUND Sarcomatoid carcinoma of the pancreas(SCP) is a rare and aggressive epithelial tumor that has both epithelial and mesenchymal features. It is characterized by sarcomatous elements with evidence of epithelial differentiation. And the term"sarcomatoid carcinoma" is often confused with "carcinosarcoma".CASE SUMMARY We present a case of SCP with lymph node metastasis in a 59-year-old male patient. He had experienced darkening of the urine, scleral icterus, and fatigue for 4 weeks. Computed tomography and magnetic resonance imaging revealed a mass in the pancreatic head, and laboratory tests revealed elevated serum bilirubin levels. The patient underwent pancreaticoduodenectomy after biliary decompression. Histologically, spindle cells with marked nuclear atypia and brisk mitotic activity arranged in a storiform or fascicular pattern were present in the bulk of the tumor. Immunohistochemical analysis found that the spindle cells exhibited strong diffuse positivity for epithelial markers, indicative of epithelial differentiation. Accordingly, the pathologic diagnosis of the pancreatic neoplasm was SCP.CONCLUSION Although sarcomatoid carcinomas and carcinosarcomas have different pathologic features, both have epithelial origin.
文摘A 67-year-old man was admitted to our hospital for a space-occupying lesion in his liver found 1 week earlier.There were no obvious complaints in this patient and no obvious abnormalities were founded during the physical examination.He presented with a habit of heavy drinking(500 mL/day)for more than 40 years.There was no history of other neoplasms,no other history of past illness or any family illness in this patient.
