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丙酸氟替卡松吸入气雾剂联合ACEI/ARB治疗IgA肾病的临床观察 被引量:2
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作者 袁湘宁 杨敬华 +6 位作者 唐家乐 廖中华 罗丽颖 肖湘成 许辉 周巧玲 李晓照 《中国现代医学杂志》 CAS 2020年第18期57-61,共5页
目的探讨丙酸氟替卡松吸入气雾剂联合血管紧张素转化酶抑制剂或血管紧张素受体阻断剂(ACEI/ARB)治疗IgA肾病的有效性和安全性。方法采用前瞻性随机对照研究方法,将经3个月足量ACEI/ARB治疗,尿蛋白仍>0.5g/d的原发性IgA肾病患者随机... 目的探讨丙酸氟替卡松吸入气雾剂联合血管紧张素转化酶抑制剂或血管紧张素受体阻断剂(ACEI/ARB)治疗IgA肾病的有效性和安全性。方法采用前瞻性随机对照研究方法,将经3个月足量ACEI/ARB治疗,尿蛋白仍>0.5g/d的原发性IgA肾病患者随机分为治疗组和对照组,每组17例。治疗组给予丙酸氟替卡松吸入气雾剂250μg/次,2次/d,同时联合ACEI/ARB治疗;对照组仅给予ACEI/ARB治疗。入组后第3、6和9月各随访1次。结果治疗组与对照组0、3、6和9个月的的尿总蛋白/尿肌酐比值在不同组间有差别(P<0.05),在不同时间、变化趋势上无差别(P>0.05)。治疗组与对照组0、3、6和9个月的的eGFR在不同时间、不同组间、变化趋势上无差别(P<0.05)。治疗组与对照组0、3、6和9个月的尿总蛋白/尿肌酐比值变化率、eGFR变化率在不同时间、不同组间、下降趋势上有差别(P<0.05)。所有患者未发生严重不良反应。结论丙酸氟替卡松吸入气雾剂联合ACEI/ARB治疗IgA肾病可有效降低患者的蛋白尿水平,延缓eGFR下降。 展开更多
关键词 IgA肾病/肾小球肾炎IgA 丙酸氟替卡松/糖皮质激素类 血管紧张素转换酶抑制药 血管紧张素受体阻断剂 蛋白尿
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Flotation evaluation and adsorption mechanism of medialan collector to wolframite 被引量:3
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作者 Xian-Ping luo li-ying luo +1 位作者 Li Gao Xue-Kun Tang 《Rare Metals》 SCIE EI CAS CSCD 2013年第6期636-641,共6页
Medialan has preferable flotation performance to wolframite,under the conditions of the best flotation pH value 7.0 and low dosage,wolframite recovery is up to80%.Medialan shows poor flotation performance to quartz,bu... Medialan has preferable flotation performance to wolframite,under the conditions of the best flotation pH value 7.0 and low dosage,wolframite recovery is up to80%.Medialan shows poor flotation performance to quartz,but better to fluorite and calcite.However,fluorite and calcite are inhibited in a certain degree by adding medialan mixed with sodium silicate.Adsorption mechanism of medialan collector on wolfram surface was also studied by using infrared(IR)radiation spectrum,adsorption volume,and zeta potential.The results show that medialan can adsorb on wolfram surface in the form of chemistry adsorption,and as medialan collector dosage changes,change law of adsorption volume is similar with that of wolfram pure mineral flotation.Zeta potential results prove that zeta potential of wolfram surface moves negatively after adsorbing medialan collector. 展开更多
关键词 Medialan WOLFRAMITE Flotation performance IR spectrum measurement Adsorbance Zeta potential
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Reduced choroidal peripapillary capillaries in thyroid-associated ophthalmopathy with early stage of dysthyroid optic neuropathy 被引量:1
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作者 Jia-Hui Wu li-ying luo +3 位作者 Hao Zhou Ying Wu Jian Zhang Jin-Wei Cheng 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2022年第7期1135-1141,共7页
AIM: To investigate whether the subtle change of choroidal/retinal vessel densities and volumes in thyroidassociated ophthalmopathy(TAO) could be an early sign to detect dysthyroid optic neuropathy(DON). METHODS: This... AIM: To investigate whether the subtle change of choroidal/retinal vessel densities and volumes in thyroidassociated ophthalmopathy(TAO) could be an early sign to detect dysthyroid optic neuropathy(DON). METHODS: This was a retrospective cross-sectional study, and a total of 98 eyes from 50 subjects were enrolled under certain criteria. Thirty-four eyes of normal controls and 64 eyes of TAO, including 39 eyes of DON and 25 eyes of TAO without DON, underwent optical coherence tomography angiography(OCTA) scanning. All the tested parameters of OCTA scanning including choroid radial peripapillary capillaries(RPC), retinal nerve fiber layer(RNFL), and macular ganglion cell complex(GCC) were compared among groups, and the correlation between OCTA parameters and visual function parameters was also investigated. RESULTS: Whole choroidal RPC was significantly reduced in DON(48.24%±0.4978%) compared to normal(50.33%±0.3173%) and TAO without DON(49.16%±0.5463%;P=0.0041). The reduction of whole choroidal RPC was also correlated with visual field(VF) defect in DON(r=0.5422, n=39). Although vision acuity and VF were improved in all the patients with DON after being treated with medical and surgical decompression, the reduction of RPC density were not reversed.CONCLUSION: There is a notable reduction in choroidal RPC in DON, which is correlated with VF defect. The reduction of RPC density could not be reversed immediately by medical and surgical decompression even when vision and VF were improved. These findings suggest that choroidal RPC could be a useful parameter to diagnose and monitor early stage of DON. 展开更多
关键词 dysthyroid optic neuropathy thyroid-associated ophthalmopathy choroidal radial peripapillary capillaries optical coherence tomography angiography optic nerve
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