AIM To evaluate the effects of hydrotalcite combined with esomeprazole on gastric ulcer healing quality. METHODS Forty-eight patients diagnosed with gastric ulcer between June 2014 and February 2016 were randomly allo...AIM To evaluate the effects of hydrotalcite combined with esomeprazole on gastric ulcer healing quality. METHODS Forty-eight patients diagnosed with gastric ulcer between June 2014 and February 2016 were randomly alloc at e d t o t he c ombinat ion t he r apy gr oup or monotherapy group. The former received hydrotalcite combined with esomeprazole, and the latter received esomeprazole alone, for 8 wk. Twenty-four healthy volunteers were recruited and acted as the healthy control group. Endoscopic ulcer healing was observed using white light endoscopy and narrow band imaging magnifying endoscopy. The composition of collagen fibers, amount of collagen deposition, expression of factor Ⅷ and TGF-β1, and hydroxyproline content were analyzed by Masson staining, immunohistochemistry, immunofluorescent imaging and ELISA. RESULTS Following treatment, changes in the gastric microvascular network were statistically different between the combination therapy group and the monotherapy group(P < 0.05). There were significant differences(P < 0.05) in collagen deposition, expression level of Factor Ⅷ and TGF-β1, and hydroxyproline content in the two treatment groups compared with the healthy control group. These parameters in the combination therapy group were significantly higher than in the monotherapy group(P < 0.05). The ratio of collagen?Ⅰ?to collagen Ⅲ was statistically different among the three groups, and was significantly higher in the combination therapy group than in the monotherapy group(P < 0.05). CONCLUSION Hydrotalcite combined with esomeprazole is superior to esomeprazole alone in improving gastric ulcer healing quality in terms of improving microvascular morphology, degree of structure maturity and function of regenerated mucosa.展开更多
Objective To detect the values of NT-proBNP and evaluate its relationship with liver function,cardiac structure,and cardiac function which was evaluated by echocardiography in patients with liver cirrhosis.Methods A t...Objective To detect the values of NT-proBNP and evaluate its relationship with liver function,cardiac structure,and cardiac function which was evaluated by echocardiography in patients with liver cirrhosis.Methods A total of 50 liver cirrhotic patients and 11 healthy controls were studied by two dimensional Doppler echocardiography.Liver cirrhotic patients were divided into group A,B and C according to the Child-Pugh score.Cardiac dimensions and left and right ventricular functions were also evaluated.At the same time,the serum NTproBNP of liver cirrhotic patients and healthy controls were detected,respectively.Results By Comparison between two groups,we found that the values of LVd,LAs,LVPW,AAO,A Wave,RVOTs,PV and NT-proBNP in liver cirrhosis group were higher than those in control group,whereas the value of E/A decreased.As for the value of LAs and serum NT-proBNP,A and B group were all lower than C group.With LAs>35 mm,the number of cases in liver cirrhosis group was higher than that in control group.So did that With E/A<1.Conclusions The cardiac dysfunction confirmed the existence of cirrhotic cardiomyopathy.More clinical implications were found in liver cirrhotic patients with increased values of serum NT-proBNP.展开更多
文摘AIM To evaluate the effects of hydrotalcite combined with esomeprazole on gastric ulcer healing quality. METHODS Forty-eight patients diagnosed with gastric ulcer between June 2014 and February 2016 were randomly alloc at e d t o t he c ombinat ion t he r apy gr oup or monotherapy group. The former received hydrotalcite combined with esomeprazole, and the latter received esomeprazole alone, for 8 wk. Twenty-four healthy volunteers were recruited and acted as the healthy control group. Endoscopic ulcer healing was observed using white light endoscopy and narrow band imaging magnifying endoscopy. The composition of collagen fibers, amount of collagen deposition, expression of factor Ⅷ and TGF-β1, and hydroxyproline content were analyzed by Masson staining, immunohistochemistry, immunofluorescent imaging and ELISA. RESULTS Following treatment, changes in the gastric microvascular network were statistically different between the combination therapy group and the monotherapy group(P < 0.05). There were significant differences(P < 0.05) in collagen deposition, expression level of Factor Ⅷ and TGF-β1, and hydroxyproline content in the two treatment groups compared with the healthy control group. These parameters in the combination therapy group were significantly higher than in the monotherapy group(P < 0.05). The ratio of collagen?Ⅰ?to collagen Ⅲ was statistically different among the three groups, and was significantly higher in the combination therapy group than in the monotherapy group(P < 0.05). CONCLUSION Hydrotalcite combined with esomeprazole is superior to esomeprazole alone in improving gastric ulcer healing quality in terms of improving microvascular morphology, degree of structure maturity and function of regenerated mucosa.
文摘Objective To detect the values of NT-proBNP and evaluate its relationship with liver function,cardiac structure,and cardiac function which was evaluated by echocardiography in patients with liver cirrhosis.Methods A total of 50 liver cirrhotic patients and 11 healthy controls were studied by two dimensional Doppler echocardiography.Liver cirrhotic patients were divided into group A,B and C according to the Child-Pugh score.Cardiac dimensions and left and right ventricular functions were also evaluated.At the same time,the serum NTproBNP of liver cirrhotic patients and healthy controls were detected,respectively.Results By Comparison between two groups,we found that the values of LVd,LAs,LVPW,AAO,A Wave,RVOTs,PV and NT-proBNP in liver cirrhosis group were higher than those in control group,whereas the value of E/A decreased.As for the value of LAs and serum NT-proBNP,A and B group were all lower than C group.With LAs>35 mm,the number of cases in liver cirrhosis group was higher than that in control group.So did that With E/A<1.Conclusions The cardiac dysfunction confirmed the existence of cirrhotic cardiomyopathy.More clinical implications were found in liver cirrhotic patients with increased values of serum NT-proBNP.
