Ischemic heart diseases are one of the major causes of death worldwide. Effective restoration of blood flow can significantly improve patients’ quality of life and reduce mortality. However, reperfusion injury cannot...Ischemic heart diseases are one of the major causes of death worldwide. Effective restoration of blood flow can significantly improve patients’ quality of life and reduce mortality. However, reperfusion injury cannot be ignored. Flavonoids possess well-established antioxidant properties;They also have other benefits that may be relevant for ameliorating myocardial ischemia-reperfusion injury(MIRI). In this review,we focus on flavonoids with cardiovascular-protection function and emphasize their pharmacological effects. The main mechanisms of flavonoid pharmacological activities against MIRI involve the following aspects: a) antioxidant, b) anti-inflammatory, c) anti-platelet aggregation, d) anti-apoptosis, and e)myocardial-function regulation activities. We also summarized the effectiveness of flavonoids for MIRI.展开更多
Non-Camellia Tea, as an integral part of Chinese tea culture for several centuries, is important to prevent chronic metabolic diseases. However, it was not systematically studied until academician Pei-gen Xiao defined...Non-Camellia Tea, as an integral part of Chinese tea culture for several centuries, is important to prevent chronic metabolic diseases. However, it was not systematically studied until academician Pei-gen Xiao defined it. Hereby, Non-Camellia Tea was reviewed systematically in definition, classification, traditional functions, chemical compositions, and pharmacology.展开更多
基金financial supports from the National Natural Science Foundation of China (No. 81874336, 81303306)Tianjin Applied Basic and Frontier Technology Research Plan (15JCQNJC13400)The National Natural Science Foundation of Inner Mongolia (2018ZD13)。
文摘Ischemic heart diseases are one of the major causes of death worldwide. Effective restoration of blood flow can significantly improve patients’ quality of life and reduce mortality. However, reperfusion injury cannot be ignored. Flavonoids possess well-established antioxidant properties;They also have other benefits that may be relevant for ameliorating myocardial ischemia-reperfusion injury(MIRI). In this review,we focus on flavonoids with cardiovascular-protection function and emphasize their pharmacological effects. The main mechanisms of flavonoid pharmacological activities against MIRI involve the following aspects: a) antioxidant, b) anti-inflammatory, c) anti-platelet aggregation, d) anti-apoptosis, and e)myocardial-function regulation activities. We also summarized the effectiveness of flavonoids for MIRI.
基金financially supported by National Natural Science Foundation of China (Grant No. 81874336)National Natural Science Foundation of China (Grant No. 81760776)+2 种基金Natural Science Foundation of Inner Mongolia Autonomous Region (2018ZD13)The Fourth National Traditional Chinese Medicine Resources Survey Project (No. Caishe [2017] 66)Tianjin Applied Foundation and Frontier Technology Research Program (15JCQNJC13400)
文摘Non-Camellia Tea, as an integral part of Chinese tea culture for several centuries, is important to prevent chronic metabolic diseases. However, it was not systematically studied until academician Pei-gen Xiao defined it. Hereby, Non-Camellia Tea was reviewed systematically in definition, classification, traditional functions, chemical compositions, and pharmacology.
