AIM:To analyze and compare the differences among ocular biometric parameters in Han and Uyghur populations undergoing cataract surgery.METHODS:In this hospital-based prospective study,410 patients undergoing cataract ...AIM:To analyze and compare the differences among ocular biometric parameters in Han and Uyghur populations undergoing cataract surgery.METHODS:In this hospital-based prospective study,410 patients undergoing cataract surgery(226 Han patients in Tianjin and 184 Uyghur patients in Xinjiang)were enrolled.The differences in axial length(AL),anterior chamber depth(ACD),keratometry[steep K(Ks)and flat K(Kf)],and corneal astigmatism(CA)measured using IOL Master 700 were compared between Han and Uyghur patients.RESULTS:The average age of Han patients was higher than that of Uyghur patients(70.22±8.54 vs 63.04±9.56y,P<0.001).After adjusting for age factors,Han patients had longer AL(23.51±1.05 vs 22.86±0.92 mm,P<0.001),deeper ACD(3.06±0.44 vs 2.97±0.37 mm,P=0.001),greater Kf(43.95±1.40 vs 43.42±1.69 D,P=0.001),steeper Ks(45.00±1.47 vs 44.26±1.71 D,P=0.001),and higher CA(1.04±0.68 vs 0.79±0.65,P=0.025)than Uyghur patients.Intra-ethnic male patients had longer AL,deeper ACD,and lower keratometry than female patients;however,CA between the sexes was almost similar.In the correlation analysis,we observed a positive correlation between AL and ACD in patients of both ethnicities(rHan=0.48,rUyghur=0.44,P<0.001),while AL was negatively correlated with Kf(rHan=-0.42,rUyghur=-0.64,P<0.001)and Ks(rHan=-0.38,rUyghur=-0.66,P<0.001).Additionally,Kf was positively correlated with Ks(rHan=0.89,rUyghur=0.93,P<0.001).CONCLUSION:There are differences in ocular biometric parameters between individuals of Han ethnicity in Tianjin and those of Uyghur ethnicity in Xinjiang undergoing cataract surgery.These ethnic variances can enhance our understanding of ocular diseases related to these parameters and provide guidance for surgical procedures.展开更多
AIM: To describe a three-dimensional model(3DM) to accurately reconstruct anatomic relationships of centrally located hepatocellular carcinomas(HCCs).METHODS: From March 2013 to July 2014, reconstructions and visual s...AIM: To describe a three-dimensional model(3DM) to accurately reconstruct anatomic relationships of centrally located hepatocellular carcinomas(HCCs).METHODS: From March 2013 to July 2014, reconstructions and visual simulations of centrally located HCCs were performed in 39 patients using a 3D subject-based computed tomography(CT) model with customdeveloped software. CT images were used for the 3D reconstruction of Couinaud's pedicles and hepatic veins, and the calculation of corresponding tumor territories and hepatic segments was performed using Yorktal DMIT software. The respective volume, surgical margin, and simulated virtual resection of tumors were also estimated by this model preoperatively. All patients were treated surgically and the results were retrospectively assessed. Clinical characteristics, imaging data, procedure variables, pathologic features, and postoperative data were recorded and compared to determine the reliability of the model.RESULTS: 3D reconstruction allowed stereoscopic identification of the spatial relationships between physiologic and pathologic structures, and offered quantifiable liver resection proposals based on individualized liver anatomy. The predicted values were consistent with the actual values for tumor mass volume(82.4 ± 109.1 m L vs 84.1 ± 108.9 m L, P = 0.910), surgical margin(10.1 ± 6.2 mm vs 9.1 ± 5.9 mm, P = 0.488), and maximum tumor diameter(4.61 ± 2.16 cm vs 4.53 ± 2.14 cm, P = 0.871). In addition,the number and extent of portal venous ramifications, as well as their relation to hepatic veins, were visualized. Preoperative planning based on simulated resection facilitated complete resection of large tumors located in the confluence of major vessels. And most of the predicted data were correlated with intraoperative findings.CONCLUSION: This 3DM provides quantitative morphometry of tumor masses and a stereo-relationship with adjacent structures, thus providing a promising technique for the management of centrally located HCCs.展开更多
In this paper, uniaxial compression tests were carried out on a series of composite rock specimens with different dip angles, which were made from two types of rock-like material with different strength. The acoustic ...In this paper, uniaxial compression tests were carried out on a series of composite rock specimens with different dip angles, which were made from two types of rock-like material with different strength. The acoustic emission technique was used to monitor the acoustic signal characteristics of composite rock specimens during the entire loading process. At the same time, an optical non-contact 3 D digital image correlation technique was used to study the evolution of axial strain field and the maximal strain field before and after the peak strength at different stress levels during the loading process. The effect of bedding plane inclination on the deformation and strength during uniaxial loading was analyzed. The methods of solving the elastic constants of hard and weak rock were described. The damage evolution process, deformation and failure mechanism, and failure mode during uniaxial loading were fully determined. The experimental results show that the θ = 0?–45?specimens had obvious plastic deformation during loading, and the brittleness of the θ = 60?–90?specimens gradually increased during the loading process. When the anisotropic angle θincreased from 0?to 90?, the peak strength, peak strain,and apparent elastic modulus all decreased initially and then increased. The failure mode of the composite rock specimen during uniaxial loading can be divided into three categories:tensile fracture across the discontinuities(θ = 0?–30?), slid-ing failure along the discontinuities(θ = 45?–75?), and tensile-split along the discontinuities(θ = 90?). The axial strain of the weak and hard rock layers in the composite rock specimen during the loading process was significantly different from that of the θ = 0?–45?specimens and was almost the same as that of the θ = 60?–90?specimens. As for the strain localization highlighted in the maximum principal strain field, the θ = 0?–30?specimens appeared in the rock matrix approximately parallel to the loading direction,while in the θ = 45?–90?specimens it appeared at the hard and weak rock layer interface.展开更多
During the condition monitoring of a planetary gearbox, features are extracted from raw data for a fault diagnosis.However, different features have different sensitivity for identifying different fault types, and thus...During the condition monitoring of a planetary gearbox, features are extracted from raw data for a fault diagnosis.However, different features have different sensitivity for identifying different fault types, and thus, the selection of a sensitive feature subset from an entire feature set and retaining as much of the class discriminatory information as possible has a directly effect on the accuracy of the classification results. In this paper, an improved hybrid feature selection technique(IHFST) that combines a distance evaluation technique(DET), Pearson’s correlation analysis, and an ad hoc technique is proposed. In IHFST, a temporary feature subset without irrelevant features is first selected according to the distance evaluation criterion of DET, and the Pearson’s correlation analysis and ad hoc technique are then employed to find and remove redundant features in the temporary feature subset, respectively, and hence,a sensitive feature subset without irrelevant or redundant features is selected from the entire feature set. Further, the k-means clustering method is applied to classify the different kinds of health conditions. The effectiveness of the proposed method was validated through several experiments carried out on a planetary gearbox with incipient cracks seeded in the tooth root of the sun gear, planet gear, and ring gear. The results show that the proposed method can successfully distinguish the different health conditions of a planetary gearbox, and achieves a better classification performance than other methods. This study proposes a sensitive feature subset selection method that achieves an obvious improvement in terms of the accuracy of the fault classification.展开更多
Introduction:Hepatocellular adenomas(HCAs),with a risk of malignant transformation into hepatocellular carcinoma(HCQ,classically develop in young women who are taking oral contraceptives.It is now clear that HCAs may ...Introduction:Hepatocellular adenomas(HCAs),with a risk of malignant transformation into hepatocellular carcinoma(HCQ,classically develop in young women who are taking oral contraceptives.It is now clear that HCAs may also occur in men.However,it is rarely reported that HCAs with malignant transformation occur in male patients with non-cirrhotic livers.This study aimed to characterize the malignancy of HCAs occurring in male patients.Methods:All patients with HCAs with malignant transformation who underwent hepatectomy at the Cancer Institute and Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College between January 1,1999 and December 31,2011 were enrolled in the study.The clinical characteristics as well as radiologic and pathologic data were reviewed.Results:HCAs with malignant transformation were observed in 5 male patients with non-cirrhotic livers,but not in female patients.The alpha-fetoprotein(AFP) levels were higher in patients with HCAs with malignant transformation than in patients with HCAs without malignant transformation.The diameters of the tumors with malignant transformation were larger than 5 cm in 3 cases and smaller than 5 cm in 2 cases.The 5 patients were all alive without recurrence by the end of the study period.The disease-free survival times of the 5 patients were 26,48,69,69,and 92 months.Conclusion:Our results indicate that resection would be advised even if the presumptive diagnosis is adenoma smaller than 5 cm in diameter,especially in male patients.展开更多
AIM:To investigate the possible protective effects of carnosol on liver injury induced by intestinal ischemia reperfusion (I/R). METHODS: Rats were divided randomly into three experimental groups:sham, intestinal I/R ...AIM:To investigate the possible protective effects of carnosol on liver injury induced by intestinal ischemia reperfusion (I/R). METHODS: Rats were divided randomly into three experimental groups:sham, intestinal I/R and carnosol treatment (n=18 each). The intestinal I/R model was established by clamping the superior mesenteric artery for 1h. In the carnosol treatment group, surgery was performed as in the intestinal I/R group, with intraperitoneal administration of 3 mg/kg carnosol 1h before the operation. At 2, 4 and 6h after reperfusion, rats were killed and blood, intestine and liver tissue samples were obtained. Intestine and liverhistology was investigated. Serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and interleukin (IL)-6 were measured. Liver tissue superoxide dismutase (SOD) and myeloperoxidase (MPO) activity were assayed. The liver intercellular adhesion molecule-1 (ICAM-1) and nuclear factor κB (NF-κB) were determined by immunohistochemical analysis and western blot analysis. RESULTS: Intestinal I/R induced intestine and liver injury, characterized byhistological changes, as well as a significant increase in serum AST and ALT levels. The activity of SOD in the liver tissue decreased after I/R, which was enhanced by carnosol pretreatment. In addition, compared with the control group, carnosol markedly reduced liver tissue MPO activity and serum IL-6 level, which was in parallel with the decreased level of liver ICAM-1 and NF-κB expression. CONCLUSION: Our results indicate that carnosol pretreatment attenuates liver injury induced by intestinal I/R, attributable to the antioxidant effect and inhibition of the NF-κB pathway.展开更多
OBJECTIVE: To investigate the expression and the role of iNOS expression in hepatic ischemia-reperfusion (L/R) injury. METHODS: Male Wistar rats were subjected to 30-minute hepatic ischemia, then iNOS protein and iNOS...OBJECTIVE: To investigate the expression and the role of iNOS expression in hepatic ischemia-reperfusion (L/R) injury. METHODS: Male Wistar rats were subjected to 30-minute hepatic ischemia, then iNOS protein and iNOS mRNA expression in liver tissue was assessed by Western blot and RT-PCR analysis respectively at different time points after reperfusion. The effects of L-NAME (Nω-nitro-L-arginine methyl ester, a nonselective NOS inhibitor) or AE-ITU (aminoethytl-isothiourea, a relative selective inhibitor of iNOS) treatment were also evaluated. RESULTS: High levels of iNOS protein and mRNA expression were detected in the liver tissue subjected to I/R, but not in the sham-operated rats. iNOS protein and iNOS mRNA expression reached a maximum on the first day after reperfusion and decreased later. The levels of iNOS protein and iNOS mRNA disappeared on 7th, 3rd day after reperfusion respectively. The high iNOS expression was correlated with hepatic dysfunction. L-NAME administration worsened hepatic dysfunction induced by hepatic I/R. In contrast, AE-ITU administration showed mild protective effects against hepatic dysfunction induced by hepatic I/R. CONCLUSION: Ischemia-reperfusion may induce or up-regulate the expression of iNOS protein and iNOS mRNA, which is detrimental to hepatic I/R injury.展开更多
BACKGROUND Hepatocellular carcinoma(HCC)with inferior vena cava and right atrium thrombus is rare,accounting for approximately 1.4%-4.9%of cases.These patients are rarely reported,but the condition is being increasing...BACKGROUND Hepatocellular carcinoma(HCC)with inferior vena cava and right atrium thrombus is rare,accounting for approximately 1.4%-4.9%of cases.These patients are rarely reported,but the condition is being increasingly discovered with advances in imaging techniques,and their prognosis is extremely pessimistic with no current effective treatment.This condition is further associated with unexpected sudden death by cardiac arrest and acute large area pulmonary embolism.CASE SUMMARY A 34-year-old man with advanced HCC with a hepatic vein thrombus extending into the right atrium had a long-term,disease-free survival following 5-mo sequential treatment combined with transcatheter arterial chemoembolization and curative liver resection.No severe adverse effects were encountered,such as massive hemorrhage or pulmonary embolism.The proper selection of operative method is an important factor.CONCLUSION HCC with a tumor thrombus extending into the right atrium has a significant impact on the survival of patients.Thrombectomy combined with adjuvant therapy may be beneficial for these patients.展开更多
In the original publication of this article,Table 2 is incorrectly published due to the negligence of the author's proofreading.The correct version of Table 2 is provided below.
Objective:To explore the effect of sodium ferulate in combined with atorvastatin on the renal interstitial fibrosis and inflammatory cytokines in patients with diabetic nephropathy (DN). Methods: A total of 111 patien...Objective:To explore the effect of sodium ferulate in combined with atorvastatin on the renal interstitial fibrosis and inflammatory cytokines in patients with diabetic nephropathy (DN). Methods: A total of 111 patients with DN who were admitted in our hospital from January, 2016 to April, 2017 were included in the study and randomized into the observation group and the control 1 and 2 group with 37 cases in each group. The patients in the control group were given routine blood sugar reducing, blood pressure reducing, and high quality low protein diet. On the above basis, the patients in the control 2 group were orally administrated with atorvastatin before sleep (20 mg). On the basis of treatments in the control 1 group, the patients in the observation group were given sodium ferulate (0.3 g) + 0.9% NaCl (250 mL), ivdrip, 1 time/d, and administrated with atorvastatin before sleep (20 mg). The fasting peripheral venous blood before and after treatment in the three groups was collected. The glycse oxidase (GOD) method was used to detect FPG. ELISA was used to detect SCr, TGF-β, AngⅡ, CTGF, hs-CRP, TNF-α, and IL-6. RIA was used to detect BUN and 24hUAER. The strengthened chemiluminescence immunoassay was used to detect CⅣ and PCⅢ. MAP was recorded. Results: FPG, MAP, BUN, 24hUAER, and SCr after treatment in the control 2 group were significantly lower than those in the control 1 group. FPG, MAP, BUN, 24hUAER, and SCr after treatment in the observation group were significantly lower than those in the control 2 group. AngⅡ, TGF-β, CTGF, PCⅢ, and CⅣ after treatment in the control 2 group were significantly lower than those in the control 1 group. AngⅡ, TGF-β, CTGF, PCⅢ, and CⅣ after treatment in the observation group were significantly lower than those in the control 2 group. TNF-α, IL-6, and hs-CRP after treatments in the control 2 group were significantly lower than those in the control 1 group. TNF-α, IL-6, and hs-CRP after treatment in the observation group were significantly lower than those in the control 2 group.Conclusions:The sodium ferulate in combined with atorvastatin can effectively improve the renal function in patients with DN, alleviate the systemic inflammatory reaction, and delay the renal interstitial fibrosis speed.展开更多
The conversion of perhydropolysilazane(PHPS)to silica at low temperature is beneficial for its application on thermally vulnerable substrates.In this work,it is demonstrated that(3-aminopropyl)triethoxysilane(APTES)ha...The conversion of perhydropolysilazane(PHPS)to silica at low temperature is beneficial for its application on thermally vulnerable substrates.In this work,it is demonstrated that(3-aminopropyl)triethoxysilane(APTES)has high catalytic efficiency for the low temperature conversion of PHPS and the catalytic mechanism of APTES was suggested.The influence of temperatu re and humidity on the catalytic conversion process was investigated,and it was found that PHPS can be rapidly converted to silica in 10 min at 80℃with relative humidity of 90%.The achieved silica is mainly composed of SiNO_(3)/SiO_(3)OH and SiO_(4)structure with O/Si of 1.74 and N content of 1%.As an approach to prepare inorganic coating,the low-temperature conversion method achieves a silica coating with low volume shrinkage of 0.86%,low roughness of R_(a)=0.293 nm,high nanoindentation hardness of 3.62 GPa and modulus of 30.06 GPa,which exhibits high potentials as protective coating for va rious materials even those vulnerable to high temperature.展开更多
Over last decades,the development of new organic materials has contributed to the rapid increase of high-power conversion efficiency of photovoltaic cells.At this stage,to understand the structure and the dynamic of m...Over last decades,the development of new organic materials has contributed to the rapid increase of high-power conversion efficiency of photovoltaic cells.At this stage,to understand the structure and the dynamic of materials is of significant importance for designing novel low-cost photovoltaic cells with superior performance.Neutron scattering is a powerful tool to provide unique and non-destructive information for the organic photovoltaic materials with particular advantages of addressing different parts of organic system by deuterium or tritium substitution.In addition,by employing several neutron scattering methods together,it is possible to further access the static structure and dynamic relaxation of the materials.With this perspective review,we introduce three neutron scattering techniques,including neutron reflectivity,small angle neutron scattering,grazing incidence small angle neutron scattering and quasi-elastic neutron scattering,and their applications on the organic photovoltaic materials.展开更多
背景如何保证呼吸科重症监护室(intensive care unit,ICU)患者肠内营养治疗安全性及有效性成为研究热点.胃残余量为肠内营养重要评估指标,可指导后续干预但近年来临床对胃残余量的评估准确性、科学性存在一定争议.目的探讨腹内压联合24 ...背景如何保证呼吸科重症监护室(intensive care unit,ICU)患者肠内营养治疗安全性及有效性成为研究热点.胃残余量为肠内营养重要评估指标,可指导后续干预但近年来临床对胃残余量的评估准确性、科学性存在一定争议.目的探讨腹内压联合24 h胃残余量监测调适的肠内营养方案在呼吸科ICU鼻饲患者中的应用效果.方法选取2019-02/2020-12我院呼吸科ICU鼻饲患者82例,依据随机数字表法分为研究组(n=41)及对照组(n=41).对照组采取常规营养支持,研究组采取腹内压联合24 h胃残余量监测调适的肠内营养方案干预.统计两组治疗情况、干预前后营养状态指标[转铁蛋白(transferrin,TF)、前白蛋白(prealbumin,PA)、白蛋白(albumin,ALB)]水平、T细胞亚群指标(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))水平、不良事件发生情况.结果(1)研究组达目标喂养用时、ICU住院时间短于对照组(P<0.05);(2)干预后两组TF、PA、ALB水平较干预前增高(P<0.05),但研究组干预后TF、PA、ALB水平虽略高于对照组,但二者比较无显著差异;(3)两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)干预后水平增高(P<0.05),但研究组干预后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平虽略高于对照组,但二者比较无显著差异;(4)研究组营养达标率较对照组高,营养支持中断发生率较对照组低(P<0.05);(5)研究组腹胀、呕吐的发生率(4.88%)明显低于对照组(21.95%)(P<0.05).但两组吸入性肺炎及腹泻的发生率比较无显著差异.结论腹内压联合24 h胃残余量监测调适的肠内营养方案在呼吸科ICU鼻饲患者中具有较高应用价值,可改善患者机体营养状态及免疫功能,提高生存质量,减少不良事件发生.展开更多
Background：Hyperglycemia is associated with poor clinical outcomes and mortality in several patients.However,studies evaluating hyperglycemia variation in tumor patients receiving total parenteral nutrition （TPN） a...Background：Hyperglycemia is associated with poor clinical outcomes and mortality in several patients.However,studies evaluating hyperglycemia variation in tumor patients receiving total parenteral nutrition （TPN） are scarce.The aim of this study was to assess the relationship between glycemia and tumor kinds with TPN by monitoring glycemic variation in tumor patients.Methods：This retrospective clinical trial selected 312 patients with various cancer types,whose unique nutrition treatment was TPN during the monitoring period.All patients had blood glucose （BG） values assessed at least six times daily during the TPN infusion.The glycemic variation before and after TPN was set as the indicator to evaluate the factors influencing BG.Results：The clinical trial lasted 7.5 ± 3.0 days adjusted for age,gender,family cancer history and blood types.There were six cancer types：Hepatic carcinoma （HC,21.8%）,rectal carcinoma （17.3%）,colon carcinoma （CC,14.7%）,gastric carcinoma （29.8%）,pancreatic carcinoma （11.5%）,and duodenal carcinoma （DC,4.8%）.The patients were divided into diabetes and nondiabetes groups.No statistical differences in TPN glucose content between diabetes and nondiabetes groups were found;however,the tumor types affected by BG values were obvious.With increasing BG values,DC,HC and CC were more represented than other tumor types in this sequence in diabetic individuals,as well as in the nondiabetic group.BG was inclined to be more easily influenced in the nondiabetes group.Other factors did not impact BG values,includiug gender,body mass index,and TPN infusion duration time.Conclusions：When tumor patients are treated with TPN,BG levels should be monitored according to different types of tumors,besides differentiating diabetes or nondiabetes patients.Special BG control is needed for DC,HC and CC in both diabetic and nondiabetic patients.If BG overtly increases,positive measurements are needed to control BG values.The ClinicalTrials.gov ID is NCT02024321.展开更多
基金Supported by Tianjin Higher Education Commission Science and Technology Development Fund Project(No.2022ZD057)Tianjin Binhai New Area Health Commission Science and Technology Project(No.2022BWKZ003)+4 种基金Tianjin Key Laboratory of Retinal Function and Disease Open Project(No.2021tjswmm002)Tianjin Health Researh(No.TJWJ2023ZD002)General Project of Natural Science Foundation of Xinjiang Uygur Autonomous Region(No.2020D01A06)Special Fund for Youth of Clinical Research Center in Tianjin Medical University Eye Hospital(No.2020QN02)Tianjin Key Medical Discipline(Specialty)Construction Project(No.TJYXZDXK-037A)。
文摘AIM:To analyze and compare the differences among ocular biometric parameters in Han and Uyghur populations undergoing cataract surgery.METHODS:In this hospital-based prospective study,410 patients undergoing cataract surgery(226 Han patients in Tianjin and 184 Uyghur patients in Xinjiang)were enrolled.The differences in axial length(AL),anterior chamber depth(ACD),keratometry[steep K(Ks)and flat K(Kf)],and corneal astigmatism(CA)measured using IOL Master 700 were compared between Han and Uyghur patients.RESULTS:The average age of Han patients was higher than that of Uyghur patients(70.22±8.54 vs 63.04±9.56y,P<0.001).After adjusting for age factors,Han patients had longer AL(23.51±1.05 vs 22.86±0.92 mm,P<0.001),deeper ACD(3.06±0.44 vs 2.97±0.37 mm,P=0.001),greater Kf(43.95±1.40 vs 43.42±1.69 D,P=0.001),steeper Ks(45.00±1.47 vs 44.26±1.71 D,P=0.001),and higher CA(1.04±0.68 vs 0.79±0.65,P=0.025)than Uyghur patients.Intra-ethnic male patients had longer AL,deeper ACD,and lower keratometry than female patients;however,CA between the sexes was almost similar.In the correlation analysis,we observed a positive correlation between AL and ACD in patients of both ethnicities(rHan=0.48,rUyghur=0.44,P<0.001),while AL was negatively correlated with Kf(rHan=-0.42,rUyghur=-0.64,P<0.001)and Ks(rHan=-0.38,rUyghur=-0.66,P<0.001).Additionally,Kf was positively correlated with Ks(rHan=0.89,rUyghur=0.93,P<0.001).CONCLUSION:There are differences in ocular biometric parameters between individuals of Han ethnicity in Tianjin and those of Uyghur ethnicity in Xinjiang undergoing cataract surgery.These ethnic variances can enhance our understanding of ocular diseases related to these parameters and provide guidance for surgical procedures.
文摘AIM: To describe a three-dimensional model(3DM) to accurately reconstruct anatomic relationships of centrally located hepatocellular carcinomas(HCCs).METHODS: From March 2013 to July 2014, reconstructions and visual simulations of centrally located HCCs were performed in 39 patients using a 3D subject-based computed tomography(CT) model with customdeveloped software. CT images were used for the 3D reconstruction of Couinaud's pedicles and hepatic veins, and the calculation of corresponding tumor territories and hepatic segments was performed using Yorktal DMIT software. The respective volume, surgical margin, and simulated virtual resection of tumors were also estimated by this model preoperatively. All patients were treated surgically and the results were retrospectively assessed. Clinical characteristics, imaging data, procedure variables, pathologic features, and postoperative data were recorded and compared to determine the reliability of the model.RESULTS: 3D reconstruction allowed stereoscopic identification of the spatial relationships between physiologic and pathologic structures, and offered quantifiable liver resection proposals based on individualized liver anatomy. The predicted values were consistent with the actual values for tumor mass volume(82.4 ± 109.1 m L vs 84.1 ± 108.9 m L, P = 0.910), surgical margin(10.1 ± 6.2 mm vs 9.1 ± 5.9 mm, P = 0.488), and maximum tumor diameter(4.61 ± 2.16 cm vs 4.53 ± 2.14 cm, P = 0.871). In addition,the number and extent of portal venous ramifications, as well as their relation to hepatic veins, were visualized. Preoperative planning based on simulated resection facilitated complete resection of large tumors located in the confluence of major vessels. And most of the predicted data were correlated with intraoperative findings.CONCLUSION: This 3DM provides quantitative morphometry of tumor masses and a stereo-relationship with adjacent structures, thus providing a promising technique for the management of centrally located HCCs.
基金supported by the National Basic Research 973 Program of China (Grant 2014CB046905)the Natural Science Foundation of Jiangsu Province for Distinguished Young Scholars (Grant BK20150005)+1 种基金the Fundamental Research Funds for the Central Universities (China University of Mining and Technology) (Grant 2014XT03)the innovation research project for academic graduate of Jiangsu Province (Grant KYLX16_0536)
文摘In this paper, uniaxial compression tests were carried out on a series of composite rock specimens with different dip angles, which were made from two types of rock-like material with different strength. The acoustic emission technique was used to monitor the acoustic signal characteristics of composite rock specimens during the entire loading process. At the same time, an optical non-contact 3 D digital image correlation technique was used to study the evolution of axial strain field and the maximal strain field before and after the peak strength at different stress levels during the loading process. The effect of bedding plane inclination on the deformation and strength during uniaxial loading was analyzed. The methods of solving the elastic constants of hard and weak rock were described. The damage evolution process, deformation and failure mechanism, and failure mode during uniaxial loading were fully determined. The experimental results show that the θ = 0?–45?specimens had obvious plastic deformation during loading, and the brittleness of the θ = 60?–90?specimens gradually increased during the loading process. When the anisotropic angle θincreased from 0?to 90?, the peak strength, peak strain,and apparent elastic modulus all decreased initially and then increased. The failure mode of the composite rock specimen during uniaxial loading can be divided into three categories:tensile fracture across the discontinuities(θ = 0?–30?), slid-ing failure along the discontinuities(θ = 45?–75?), and tensile-split along the discontinuities(θ = 90?). The axial strain of the weak and hard rock layers in the composite rock specimen during the loading process was significantly different from that of the θ = 0?–45?specimens and was almost the same as that of the θ = 60?–90?specimens. As for the strain localization highlighted in the maximum principal strain field, the θ = 0?–30?specimens appeared in the rock matrix approximately parallel to the loading direction,while in the θ = 45?–90?specimens it appeared at the hard and weak rock layer interface.
基金Supported by National Natural Science Foundation of China(Grant No.51475053)
文摘During the condition monitoring of a planetary gearbox, features are extracted from raw data for a fault diagnosis.However, different features have different sensitivity for identifying different fault types, and thus, the selection of a sensitive feature subset from an entire feature set and retaining as much of the class discriminatory information as possible has a directly effect on the accuracy of the classification results. In this paper, an improved hybrid feature selection technique(IHFST) that combines a distance evaluation technique(DET), Pearson’s correlation analysis, and an ad hoc technique is proposed. In IHFST, a temporary feature subset without irrelevant features is first selected according to the distance evaluation criterion of DET, and the Pearson’s correlation analysis and ad hoc technique are then employed to find and remove redundant features in the temporary feature subset, respectively, and hence,a sensitive feature subset without irrelevant or redundant features is selected from the entire feature set. Further, the k-means clustering method is applied to classify the different kinds of health conditions. The effectiveness of the proposed method was validated through several experiments carried out on a planetary gearbox with incipient cracks seeded in the tooth root of the sun gear, planet gear, and ring gear. The results show that the proposed method can successfully distinguish the different health conditions of a planetary gearbox, and achieves a better classification performance than other methods. This study proposes a sensitive feature subset selection method that achieves an obvious improvement in terms of the accuracy of the fault classification.
基金supported by the Peking Union Medical College Youth Fundthe Fundamental Research Funds for the Central Universities(No.33320140163)
文摘Introduction:Hepatocellular adenomas(HCAs),with a risk of malignant transformation into hepatocellular carcinoma(HCQ,classically develop in young women who are taking oral contraceptives.It is now clear that HCAs may also occur in men.However,it is rarely reported that HCAs with malignant transformation occur in male patients with non-cirrhotic livers.This study aimed to characterize the malignancy of HCAs occurring in male patients.Methods:All patients with HCAs with malignant transformation who underwent hepatectomy at the Cancer Institute and Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College between January 1,1999 and December 31,2011 were enrolled in the study.The clinical characteristics as well as radiologic and pathologic data were reviewed.Results:HCAs with malignant transformation were observed in 5 male patients with non-cirrhotic livers,but not in female patients.The alpha-fetoprotein(AFP) levels were higher in patients with HCAs with malignant transformation than in patients with HCAs without malignant transformation.The diameters of the tumors with malignant transformation were larger than 5 cm in 3 cases and smaller than 5 cm in 2 cases.The 5 patients were all alive without recurrence by the end of the study period.The disease-free survival times of the 5 patients were 26,48,69,69,and 92 months.Conclusion:Our results indicate that resection would be advised even if the presumptive diagnosis is adenoma smaller than 5 cm in diameter,especially in male patients.
基金This work was supported by the National Natural Science Foundation of China （No.21177041 and No.21107026）, the Fundamental Research Funds for the Central Universities （No.2013ZZ0073）, and the Scientific Research Foundation for Returned Overseas Chinese Scholars, State Education Ministry.
基金Supported by The grants from the Dalian Scientific Research Foundation,No.2004 B3SF 143,No.2007 J21JH006National Natural Science Foundation,No.30872449
文摘AIM:To investigate the possible protective effects of carnosol on liver injury induced by intestinal ischemia reperfusion (I/R). METHODS: Rats were divided randomly into three experimental groups:sham, intestinal I/R and carnosol treatment (n=18 each). The intestinal I/R model was established by clamping the superior mesenteric artery for 1h. In the carnosol treatment group, surgery was performed as in the intestinal I/R group, with intraperitoneal administration of 3 mg/kg carnosol 1h before the operation. At 2, 4 and 6h after reperfusion, rats were killed and blood, intestine and liver tissue samples were obtained. Intestine and liverhistology was investigated. Serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and interleukin (IL)-6 were measured. Liver tissue superoxide dismutase (SOD) and myeloperoxidase (MPO) activity were assayed. The liver intercellular adhesion molecule-1 (ICAM-1) and nuclear factor κB (NF-κB) were determined by immunohistochemical analysis and western blot analysis. RESULTS: Intestinal I/R induced intestine and liver injury, characterized byhistological changes, as well as a significant increase in serum AST and ALT levels. The activity of SOD in the liver tissue decreased after I/R, which was enhanced by carnosol pretreatment. In addition, compared with the control group, carnosol markedly reduced liver tissue MPO activity and serum IL-6 level, which was in parallel with the decreased level of liver ICAM-1 and NF-κB expression. CONCLUSION: Our results indicate that carnosol pretreatment attenuates liver injury induced by intestinal I/R, attributable to the antioxidant effect and inhibition of the NF-κB pathway.
基金This study was supported partly by the Grant-In-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan (No. 11470334) to M.Takeda.
文摘OBJECTIVE: To investigate the expression and the role of iNOS expression in hepatic ischemia-reperfusion (L/R) injury. METHODS: Male Wistar rats were subjected to 30-minute hepatic ischemia, then iNOS protein and iNOS mRNA expression in liver tissue was assessed by Western blot and RT-PCR analysis respectively at different time points after reperfusion. The effects of L-NAME (Nω-nitro-L-arginine methyl ester, a nonselective NOS inhibitor) or AE-ITU (aminoethytl-isothiourea, a relative selective inhibitor of iNOS) treatment were also evaluated. RESULTS: High levels of iNOS protein and mRNA expression were detected in the liver tissue subjected to I/R, but not in the sham-operated rats. iNOS protein and iNOS mRNA expression reached a maximum on the first day after reperfusion and decreased later. The levels of iNOS protein and iNOS mRNA disappeared on 7th, 3rd day after reperfusion respectively. The high iNOS expression was correlated with hepatic dysfunction. L-NAME administration worsened hepatic dysfunction induced by hepatic I/R. In contrast, AE-ITU administration showed mild protective effects against hepatic dysfunction induced by hepatic I/R. CONCLUSION: Ischemia-reperfusion may induce or up-regulate the expression of iNOS protein and iNOS mRNA, which is detrimental to hepatic I/R injury.
基金Supported by the National Natural Science Foundation of China,No.81972749 and No.81471755Education Department of Liaoning Province,No.XLYC1802011。
文摘BACKGROUND Hepatocellular carcinoma(HCC)with inferior vena cava and right atrium thrombus is rare,accounting for approximately 1.4%-4.9%of cases.These patients are rarely reported,but the condition is being increasingly discovered with advances in imaging techniques,and their prognosis is extremely pessimistic with no current effective treatment.This condition is further associated with unexpected sudden death by cardiac arrest and acute large area pulmonary embolism.CASE SUMMARY A 34-year-old man with advanced HCC with a hepatic vein thrombus extending into the right atrium had a long-term,disease-free survival following 5-mo sequential treatment combined with transcatheter arterial chemoembolization and curative liver resection.No severe adverse effects were encountered,such as massive hemorrhage or pulmonary embolism.The proper selection of operative method is an important factor.CONCLUSION HCC with a tumor thrombus extending into the right atrium has a significant impact on the survival of patients.Thrombectomy combined with adjuvant therapy may be beneficial for these patients.
文摘In the original publication of this article,Table 2 is incorrectly published due to the negligence of the author's proofreading.The correct version of Table 2 is provided below.
文摘Objective:To explore the effect of sodium ferulate in combined with atorvastatin on the renal interstitial fibrosis and inflammatory cytokines in patients with diabetic nephropathy (DN). Methods: A total of 111 patients with DN who were admitted in our hospital from January, 2016 to April, 2017 were included in the study and randomized into the observation group and the control 1 and 2 group with 37 cases in each group. The patients in the control group were given routine blood sugar reducing, blood pressure reducing, and high quality low protein diet. On the above basis, the patients in the control 2 group were orally administrated with atorvastatin before sleep (20 mg). On the basis of treatments in the control 1 group, the patients in the observation group were given sodium ferulate (0.3 g) + 0.9% NaCl (250 mL), ivdrip, 1 time/d, and administrated with atorvastatin before sleep (20 mg). The fasting peripheral venous blood before and after treatment in the three groups was collected. The glycse oxidase (GOD) method was used to detect FPG. ELISA was used to detect SCr, TGF-β, AngⅡ, CTGF, hs-CRP, TNF-α, and IL-6. RIA was used to detect BUN and 24hUAER. The strengthened chemiluminescence immunoassay was used to detect CⅣ and PCⅢ. MAP was recorded. Results: FPG, MAP, BUN, 24hUAER, and SCr after treatment in the control 2 group were significantly lower than those in the control 1 group. FPG, MAP, BUN, 24hUAER, and SCr after treatment in the observation group were significantly lower than those in the control 2 group. AngⅡ, TGF-β, CTGF, PCⅢ, and CⅣ after treatment in the control 2 group were significantly lower than those in the control 1 group. AngⅡ, TGF-β, CTGF, PCⅢ, and CⅣ after treatment in the observation group were significantly lower than those in the control 2 group. TNF-α, IL-6, and hs-CRP after treatments in the control 2 group were significantly lower than those in the control 1 group. TNF-α, IL-6, and hs-CRP after treatment in the observation group were significantly lower than those in the control 2 group.Conclusions:The sodium ferulate in combined with atorvastatin can effectively improve the renal function in patients with DN, alleviate the systemic inflammatory reaction, and delay the renal interstitial fibrosis speed.
基金financially supported by the National Natural Science Foundation of China(No.21872152)Guangdong Natural Science Foundation(No.2019A1515111028)Xiejialin Foundation in the Institute of High Energy Physics(No.E15466U210)。
文摘The conversion of perhydropolysilazane(PHPS)to silica at low temperature is beneficial for its application on thermally vulnerable substrates.In this work,it is demonstrated that(3-aminopropyl)triethoxysilane(APTES)has high catalytic efficiency for the low temperature conversion of PHPS and the catalytic mechanism of APTES was suggested.The influence of temperatu re and humidity on the catalytic conversion process was investigated,and it was found that PHPS can be rapidly converted to silica in 10 min at 80℃with relative humidity of 90%.The achieved silica is mainly composed of SiNO_(3)/SiO_(3)OH and SiO_(4)structure with O/Si of 1.74 and N content of 1%.As an approach to prepare inorganic coating,the low-temperature conversion method achieves a silica coating with low volume shrinkage of 0.86%,low roughness of R_(a)=0.293 nm,high nanoindentation hardness of 3.62 GPa and modulus of 30.06 GPa,which exhibits high potentials as protective coating for va rious materials even those vulnerable to high temperature.
基金supported by the National Natural Science Foundation of China(No.12105306,52072008 and U2032167)Guangdong Natural Science Foundation(No.2019A1515111028)+1 种基金Xiejialin Foundation in the Institute of High Energy Physics(No.E15466U210)National Key R&D Projects(2022YFA1604103 and 2020YFA0406203).
文摘Over last decades,the development of new organic materials has contributed to the rapid increase of high-power conversion efficiency of photovoltaic cells.At this stage,to understand the structure and the dynamic of materials is of significant importance for designing novel low-cost photovoltaic cells with superior performance.Neutron scattering is a powerful tool to provide unique and non-destructive information for the organic photovoltaic materials with particular advantages of addressing different parts of organic system by deuterium or tritium substitution.In addition,by employing several neutron scattering methods together,it is possible to further access the static structure and dynamic relaxation of the materials.With this perspective review,we introduce three neutron scattering techniques,including neutron reflectivity,small angle neutron scattering,grazing incidence small angle neutron scattering and quasi-elastic neutron scattering,and their applications on the organic photovoltaic materials.
文摘Background：Hyperglycemia is associated with poor clinical outcomes and mortality in several patients.However,studies evaluating hyperglycemia variation in tumor patients receiving total parenteral nutrition （TPN） are scarce.The aim of this study was to assess the relationship between glycemia and tumor kinds with TPN by monitoring glycemic variation in tumor patients.Methods：This retrospective clinical trial selected 312 patients with various cancer types,whose unique nutrition treatment was TPN during the monitoring period.All patients had blood glucose （BG） values assessed at least six times daily during the TPN infusion.The glycemic variation before and after TPN was set as the indicator to evaluate the factors influencing BG.Results：The clinical trial lasted 7.5 ± 3.0 days adjusted for age,gender,family cancer history and blood types.There were six cancer types：Hepatic carcinoma （HC,21.8%）,rectal carcinoma （17.3%）,colon carcinoma （CC,14.7%）,gastric carcinoma （29.8%）,pancreatic carcinoma （11.5%）,and duodenal carcinoma （DC,4.8%）.The patients were divided into diabetes and nondiabetes groups.No statistical differences in TPN glucose content between diabetes and nondiabetes groups were found;however,the tumor types affected by BG values were obvious.With increasing BG values,DC,HC and CC were more represented than other tumor types in this sequence in diabetic individuals,as well as in the nondiabetic group.BG was inclined to be more easily influenced in the nondiabetes group.Other factors did not impact BG values,includiug gender,body mass index,and TPN infusion duration time.Conclusions：When tumor patients are treated with TPN,BG levels should be monitored according to different types of tumors,besides differentiating diabetes or nondiabetes patients.Special BG control is needed for DC,HC and CC in both diabetic and nondiabetic patients.If BG overtly increases,positive measurements are needed to control BG values.The ClinicalTrials.gov ID is NCT02024321.
基金Project supported by the National Natural Science Foundation of China(No.31522026)the Fundamental Research Funds for the Zhejiang Provincial Universities(No.2019XZZX003-12),China
