Bioremediation plays an increasingly important role in the remediation of chromium-contaminated soil because it is an environmentally friendly technology. To investigate the Cr(Ⅵ)reduction process by indigenous micro...Bioremediation plays an increasingly important role in the remediation of chromium-contaminated soil because it is an environmentally friendly technology. To investigate the Cr(Ⅵ)reduction process by indigenous microorganisms in soil, a batch of incubation experiments were carried out in a bioreactor under aerobic conditions. The results showed that in the presence of indigenous microorganisms, the Cr(Ⅵ) concentration in the chromium-contaminated soil decreased from 1521.9 to 199.2 mg/kg within 66 h with culture medium addition, while a slight decrease in the Cr(Ⅵ) concentration was found in the sterilized soil,implying that the indigenous microorganisms contributed to the Cr(Ⅵ) reduction. In the microbial remediation process, Cr(Ⅵ)microbial reduction occurred after the reduction of NO3-, Mn4+ and Fe3+ and,before SO42- reduction. The reduction process of Cr(Ⅵ) can be divided into two phases, characterized by the exponential equation model of microbial reduction and the linear equation model of the combined effect of the major ions. It can be concluded that indigenous Cr(Ⅵ)-reducing bacteria have a potential application for in-situ remediation of Cr(Ⅵ)-contaminated soil.展开更多
Background and Aims:The study aimed to create a new staging model for radiotherapy-based treatment for prognostic hepatocellular carcinoma(HCC)classification.Methods:The training cohort comprised 658 patients receivin...Background and Aims:The study aimed to create a new staging model for radiotherapy-based treatment for prognostic hepatocellular carcinoma(HCC)classification.Methods:The training cohort comprised 658 patients receiving stereotactic body radiotherapy and external validation cohort comprised 533 patients receiving three-dimensional conformal radiotherapy and intensity-modulated radiotherapy.We established a modified staging system as follows:stage I,solitary nodule without macrovascular invasion,or 2–3 nodules no more than 3.0 cm apart,and performance status(PS)0–2(Ia:ALBI-1 grade;Ib:ALBI-2 or 3 grade);stage II:2–3 nodules with any one nodule more than 3.0-cm apart,or≥4 nodules,and performance status 0–2(IIa:ALBI-1 grade;IIb:ALBI-2 grade);stage III:macrovascular invasion,regional lymph node metastasis or distant metastasis,and performance status 0–2(IIIa:ALBI-1 grade;IIIb:ALBI-2 grade);stage IV:performance status 3–4,or performance status 0–2 with ALBI-3 grade.We analyzed longterm overall survival based on different stages.Results:The staging model showed an excellent ability to discriminate patients according to four stages and seven substages with notably different curves in the training and validation cohort.The median survival decreased from stages I to IV with 63.0 months in stage I(not reached in Ia,and 53.0 months in Ib),24.0 months in stage II(28.0 months in IIa,and 22.0 months in IIb),11.0 months in stage III(18.0 months in IIIa,and 9.0 months in IIIb),and less than 9.0 months in stage IV in the training cohort.Conclusions:The modified staging model may provide an alternative for clinical radiation oncologists.展开更多
基金financially supported by the National Key Research and Development Project of China (Nos. 2021YFC2902802, 2021YFC2902805, 2021YFC2902602, 2021YFC2902604)the Natural Science Foundation of Guangdong Province,China (No. 2023A1515030145)Guangdong Academy of Science Special Funds,China (Nos. 2020GDASYL-0104027, 2022GDASZH-2022010104, 2021GDASYL-20210302004)。
基金Project(2018SK2044)supported by the Innovation Program of Science&Technology of Hunan Province,ChinaProject(51304250)supported by the National Natural Science Foundation of China
文摘Bioremediation plays an increasingly important role in the remediation of chromium-contaminated soil because it is an environmentally friendly technology. To investigate the Cr(Ⅵ)reduction process by indigenous microorganisms in soil, a batch of incubation experiments were carried out in a bioreactor under aerobic conditions. The results showed that in the presence of indigenous microorganisms, the Cr(Ⅵ) concentration in the chromium-contaminated soil decreased from 1521.9 to 199.2 mg/kg within 66 h with culture medium addition, while a slight decrease in the Cr(Ⅵ) concentration was found in the sterilized soil,implying that the indigenous microorganisms contributed to the Cr(Ⅵ) reduction. In the microbial remediation process, Cr(Ⅵ)microbial reduction occurred after the reduction of NO3-, Mn4+ and Fe3+ and,before SO42- reduction. The reduction process of Cr(Ⅵ) can be divided into two phases, characterized by the exponential equation model of microbial reduction and the linear equation model of the combined effect of the major ions. It can be concluded that indigenous Cr(Ⅵ)-reducing bacteria have a potential application for in-situ remediation of Cr(Ⅵ)-contaminated soil.
基金supported by National Natural Science Foundation of China (81903257)Cancer Precision Radiotherapy Spark Program of China International Medical Foundation (2019-N-11-01)+4 种基金Guangxi Natural Science Foundation (2020GXNSFAA297171)Guangxi BaGui Scholars’Special FundGuangxi Medical University Training Program for Distinguished Young ScholarsHigh-level innovation team and outstanding scholar program in Guangxi Colleges and Universitiesthe Cultivation Project of the“139”Program for Medicine High-level Key Talents of Guangxi.
文摘Background and Aims:The study aimed to create a new staging model for radiotherapy-based treatment for prognostic hepatocellular carcinoma(HCC)classification.Methods:The training cohort comprised 658 patients receiving stereotactic body radiotherapy and external validation cohort comprised 533 patients receiving three-dimensional conformal radiotherapy and intensity-modulated radiotherapy.We established a modified staging system as follows:stage I,solitary nodule without macrovascular invasion,or 2–3 nodules no more than 3.0 cm apart,and performance status(PS)0–2(Ia:ALBI-1 grade;Ib:ALBI-2 or 3 grade);stage II:2–3 nodules with any one nodule more than 3.0-cm apart,or≥4 nodules,and performance status 0–2(IIa:ALBI-1 grade;IIb:ALBI-2 grade);stage III:macrovascular invasion,regional lymph node metastasis or distant metastasis,and performance status 0–2(IIIa:ALBI-1 grade;IIIb:ALBI-2 grade);stage IV:performance status 3–4,or performance status 0–2 with ALBI-3 grade.We analyzed longterm overall survival based on different stages.Results:The staging model showed an excellent ability to discriminate patients according to four stages and seven substages with notably different curves in the training and validation cohort.The median survival decreased from stages I to IV with 63.0 months in stage I(not reached in Ia,and 53.0 months in Ib),24.0 months in stage II(28.0 months in IIa,and 22.0 months in IIb),11.0 months in stage III(18.0 months in IIIa,and 9.0 months in IIIb),and less than 9.0 months in stage IV in the training cohort.Conclusions:The modified staging model may provide an alternative for clinical radiation oncologists.
