Clinical analysis of Wernicke encephalopathy after liver transplantation

Background:Wernicke encephalopathy(WE)is an acute neurological disease resulting from vitamin B1 deficiency,and there are only very few case reports of WE after liver transplantation.The present study aimed to investigate the clinical characteristics,etiology,magnetic resonance imaging(MRI)features,treatment and prognosis of patients with WE after liver transplantation.Methods:Twenty-three patients with WE after liver transplantation from the First Affiliated Hospital,Zhejiang University School of Medicine and Jiangxi Provincial People’s Hospital between January 2011 and December 2021 were retrospectively analyzed.Results:Among the 23 patients diagnosed with WE after liver transplantation,6(26%)had a classic triad of impaired consciousness,oculomotor palsy and ataxia,and 17(74%)had two features.The misdiagno-sis rate was 65%.After treatment with high-dose vitamin B1,19(83%)patients showed improvement,whereas 4(17%)showed no improvement,including 3 with residual short-term memory impairments and 1 with residual spatial and temporal disorientation and ataxia.Conclusions:The misdiagnosis rate is high in the early stage of WE,and the prognosis is closely asso-ciated with whether WE is diagnosed early and treated timely.High-dose glucose or glucocorticoids can trigger WE and cannot be administered before vitamin B1 treatment.Vitamin B1 is suggested to be used as a prophylactic treatment for patients with WE after liver transplantation.

Quasi-angle-preserving mesh deformation using the least-squares approach

We propose an angle-based mesh representation, which is invariant under translation, rotation, and uniform scaling, to encode the geometric details of a triangular mesh. Angle-based mesh representation consists of angle quantities defined on the mesh, from which the mesh can be reconstructed uniquely up to translation, rotation,and uniform scaling. The reconstruction process requires solving three sparse linear systems: the first system encodes the length of edges between vertices on the mesh, the second system encodes the relationship of local frames between two adjacent vertices on the mesh, and the third system defines the position of the vertices via the edge length and the local frames. From this angle-based mesh representation, we propose a quasi-angle-preserving mesh deformation system with the least-squares approach via handle translation, rotation, and uniform scaling. Several detail-preserving mesh editing examples are presented to demonstrate the effectiveness of the proposed method.