目的研究缬沙坦氨氯地平片在健康受试者体内的人体药动学和生物等效性。方法采用随机、开放、四周期、两序列完全重复交叉设计,72例受试者(空腹和餐后实验各36例)单次口服受试制剂(T)或参比制剂(R)(含缬沙坦:80 mg;氨氯地平:5 mg)后,采...目的研究缬沙坦氨氯地平片在健康受试者体内的人体药动学和生物等效性。方法采用随机、开放、四周期、两序列完全重复交叉设计,72例受试者(空腹和餐后实验各36例)单次口服受试制剂(T)或参比制剂(R)(含缬沙坦:80 mg;氨氯地平:5 mg)后,采用液相色谱-串联质谱技术(liquid chromatography tandem mass spectrometry,LC-MS/MS)测定人血浆中缬沙坦和氨氯地平浓度。选择Phoenix WinNonlin 8.2计算药动学参数,采用参比制剂校正的平均生物等效性(reference-scaled average bioequivalence,RSABE)或平均生物等效性(average bioequivalence,ABE)方法评价缬沙坦的生物等效性,ABE方法评价氨氯地平的生物等效性。结果空腹和餐后受试者单剂量口服缬沙坦氨氯地平片受试制剂和参比制剂后的平均血药浓度-时间曲线表明本研究受试制剂与参比制剂中缬沙坦、氨氯地平的食物影响与原研药说明书一致。空腹实验缬沙坦C_(max)和AUC_(0-t)的个体内变异系数(coefficient of variation within individuals,CVW)≥30%,用RSABE方法评价两参数的生物等效性,缬沙坦受试制剂和参比制剂C_(max)和AUC_(0-t)的几何均值比(geometric mean ratio,GMR)分别为101.03%、101.86%,且单侧95%置信区间(confidence interval,CI)上限均<0;空腹实验缬沙坦AUC_(0-∞)和氨氯地平C_(max)、AUC_(0-72)以及餐后实验缬沙坦C_(max)、AUC_(0-t)、AUC_(0-∞)和氨氯地平C_(max)、AUC_(0-72)的CVW均<30%,用ABE方法评价各药动学参数的生物等效性,各参数的GMR的90%CI均在80.00%~125.00%等效范围,说明两制剂具有生物等效性。结论缬沙坦氨氯地平片受试制剂和参比制剂药动学参数无明显差异,两制剂生物等效。展开更多
By studying the properties of Chebyshev polynomials, some specific and mean-ingful identities for the calculation of square of Chebyshev polynomials, Fibonacci numbersand Lucas numbers are obtained.
Sudan Khartoum Refinery Co. has selected a unique route featuring delayed coking of crude in connection with the highly sour and high-calcium heavy crude extracted from Sudanese oil block No. 6.The crude oil after pre...Sudan Khartoum Refinery Co. has selected a unique route featuring delayed coking of crude in connection with the highly sour and high-calcium heavy crude extracted from Sudanese oil block No. 6.The crude oil after pretreatment for calcium removal is subjected to coking for removal of acids and metals with the coker products being further processed. The crude oil extracted from Sudanese oil block No. 6contains as high as 13 mg KOH/g of crude in addition to a calcium content of 1600 ppm. This article makes an analysis on problems related with the operation of commercial delayed coking unit for processing of highly sour crude and bring forth measures to solve these problems. The liquid yield resulted from coking of crude oil can reach 82m%, and the petroleum coke can meet the quality requirement for class 3B petroleum coke.展开更多
Based on the theory of exponential sums an d quadratic forms over finite field, the crosscorrelation function values betwee n two maximal linear recursive sequences are determined under some conditions.
Mathematical model for hyperboloid grinding of twist drill and relationships between drill design and grinding parameters are introduced.Point angles at outer corner and chisel edge corner are proposed to be used as t...Mathematical model for hyperboloid grinding of twist drill and relationships between drill design and grinding parameters are introduced.Point angles at outer corner and chisel edge corner are proposed to be used as the drill design parameters to determine the type uniquely and the relicf andgle is used as a supplement parameter.Function relations between the twist drill design and the grinding parameters are derived.Hence a theeoretical basis is estab-lised for design and grinding of the hyperboloid twist drill.展开更多
A newly transparent approach for determining energy eigenvalues is proposed, which is finding the ‘eigen-operator' of the square of the Schroedinger operator. As three examples, we discuss the energy level of a n...A newly transparent approach for determining energy eigenvalues is proposed, which is finding the ‘eigen-operator' of the square of the Schroedinger operator. As three examples, we discuss the energy level of a nondegenerate parametric amplifier, an angular momentum system and a ring shape of coupled oscillators.展开更多
We establish the path integral formalism for nondegenerate parametric amplifiers in the entangled state representations. Its advantage in obtaining the energy level gap of this system is analyzed.
We extend the approach of solving master equations for density matrices by projecting it onto the thermal entangled state representation(Hong-Yi Fan and Jun-Hua Chen,J.Phys.A35(2002)6873)to two-mode case.In this appro...We extend the approach of solving master equations for density matrices by projecting it onto the thermal entangled state representation(Hong-Yi Fan and Jun-Hua Chen,J.Phys.A35(2002)6873)to two-mode case.In this approach the two-photon master equations can be directly and conveniently converted into c-number partial differential equations.As an example,we solve the typical master equation for two-photon process in some limiting cases.展开更多
文摘目的研究缬沙坦氨氯地平片在健康受试者体内的人体药动学和生物等效性。方法采用随机、开放、四周期、两序列完全重复交叉设计,72例受试者(空腹和餐后实验各36例)单次口服受试制剂(T)或参比制剂(R)(含缬沙坦:80 mg;氨氯地平:5 mg)后,采用液相色谱-串联质谱技术(liquid chromatography tandem mass spectrometry,LC-MS/MS)测定人血浆中缬沙坦和氨氯地平浓度。选择Phoenix WinNonlin 8.2计算药动学参数,采用参比制剂校正的平均生物等效性(reference-scaled average bioequivalence,RSABE)或平均生物等效性(average bioequivalence,ABE)方法评价缬沙坦的生物等效性,ABE方法评价氨氯地平的生物等效性。结果空腹和餐后受试者单剂量口服缬沙坦氨氯地平片受试制剂和参比制剂后的平均血药浓度-时间曲线表明本研究受试制剂与参比制剂中缬沙坦、氨氯地平的食物影响与原研药说明书一致。空腹实验缬沙坦C_(max)和AUC_(0-t)的个体内变异系数(coefficient of variation within individuals,CVW)≥30%,用RSABE方法评价两参数的生物等效性,缬沙坦受试制剂和参比制剂C_(max)和AUC_(0-t)的几何均值比(geometric mean ratio,GMR)分别为101.03%、101.86%,且单侧95%置信区间(confidence interval,CI)上限均<0;空腹实验缬沙坦AUC_(0-∞)和氨氯地平C_(max)、AUC_(0-72)以及餐后实验缬沙坦C_(max)、AUC_(0-t)、AUC_(0-∞)和氨氯地平C_(max)、AUC_(0-72)的CVW均<30%,用ABE方法评价各药动学参数的生物等效性,各参数的GMR的90%CI均在80.00%~125.00%等效范围,说明两制剂具有生物等效性。结论缬沙坦氨氯地平片受试制剂和参比制剂药动学参数无明显差异,两制剂生物等效。
基金Supported by the Natural Science Foundation of Shaanxi Province(2002A11)Supported by the Shangluo Teacher's College Research Foundation(SKY2106)
文摘By studying the properties of Chebyshev polynomials, some specific and mean-ingful identities for the calculation of square of Chebyshev polynomials, Fibonacci numbersand Lucas numbers are obtained.
文摘Sudan Khartoum Refinery Co. has selected a unique route featuring delayed coking of crude in connection with the highly sour and high-calcium heavy crude extracted from Sudanese oil block No. 6.The crude oil after pretreatment for calcium removal is subjected to coking for removal of acids and metals with the coker products being further processed. The crude oil extracted from Sudanese oil block No. 6contains as high as 13 mg KOH/g of crude in addition to a calcium content of 1600 ppm. This article makes an analysis on problems related with the operation of commercial delayed coking unit for processing of highly sour crude and bring forth measures to solve these problems. The liquid yield resulted from coking of crude oil can reach 82m%, and the petroleum coke can meet the quality requirement for class 3B petroleum coke.
文摘Based on the theory of exponential sums an d quadratic forms over finite field, the crosscorrelation function values betwee n two maximal linear recursive sequences are determined under some conditions.
文摘Mathematical model for hyperboloid grinding of twist drill and relationships between drill design and grinding parameters are introduced.Point angles at outer corner and chisel edge corner are proposed to be used as the drill design parameters to determine the type uniquely and the relicf andgle is used as a supplement parameter.Function relations between the twist drill design and the grinding parameters are derived.Hence a theeoretical basis is estab-lised for design and grinding of the hyperboloid twist drill.
文摘A newly transparent approach for determining energy eigenvalues is proposed, which is finding the ‘eigen-operator' of the square of the Schroedinger operator. As three examples, we discuss the energy level of a nondegenerate parametric amplifier, an angular momentum system and a ring shape of coupled oscillators.
文摘We establish the path integral formalism for nondegenerate parametric amplifiers in the entangled state representations. Its advantage in obtaining the energy level gap of this system is analyzed.
基金The project supported by National Natural Science Foundation of China under Grant No.10175057the President Foundation of the Chinese Academy of Sciences
文摘We extend the approach of solving master equations for density matrices by projecting it onto the thermal entangled state representation(Hong-Yi Fan and Jun-Hua Chen,J.Phys.A35(2002)6873)to two-mode case.In this approach the two-photon master equations can be directly and conveniently converted into c-number partial differential equations.As an example,we solve the typical master equation for two-photon process in some limiting cases.
