Objective:The heightened prevalence of pulmonary nodules(PN)has escalated its significance as a public health concern.While the precise identification of high-risk PN carriers for malignancy remains an ongoing challen...Objective:The heightened prevalence of pulmonary nodules(PN)has escalated its significance as a public health concern.While the precise identification of high-risk PN carriers for malignancy remains an ongoing challenge,genetic variants hold potentials as determinants of disease susceptibility that can aid in diagnosis.Yet,current understanding of the genetic loci associated with malignant PN(MPN)risk is limited.Methods:A frequency-matched case-control study was performed,comprising 247 MPN cases and 412 benign NP(BNP)controls.We genotyped 11 established susceptibility loci for lung cancer in a Chinese cohort.Loci associated with MPN risk were utilized to compute a polygenic risk score(PRS).This PRS was subsequently incorporated into the diagnostic evaluation of MPNs,with emphasis on serum tumor biomarkers.Results:Loci rs10429489G>A,rs17038564A>G,and rs12265047A>G were identified as being associated with an increased risk of MPNs.The PRS,formulated from the cumulative risk effects of these loci,correlated with the malignant risk of PNs in a dose-dependent fashion.A high PRS was found to amplify the MPN risk by 156%in comparison to a low PRS[odds ratio(OR)=2.56,95%confidence interval(95%CI),1.40−4.67].Notably,the PRS was observed to enhance the diagnostic accuracy of serum carcinoembryonic antigen(CEA)in distinguishing MPNs from BPNs,with diagnostic values rising from 0.716 to 0.861 across low-to high-PRS categories.Further bioinformatics investigations pinpointed rs10429489G>A as an expression quantitative trait locus.Conclusions:Loci rs10429489G>A,rs17038564A>G,and rs12265047A>G contribute to MPN risk and augment the diagnostic precision for MPNs based on serum CEA concentrations.展开更多
Objective: To confirm whether self-administered AVNA treatment is effective in improving emotional distressunder the COVID-19 pandemic.Methods: A smartphone-based online, randomized, controlled trial was designed from...Objective: To confirm whether self-administered AVNA treatment is effective in improving emotional distressunder the COVID-19 pandemic.Methods: A smartphone-based online, randomized, controlled trial was designed from 26 February 2020 to 28April 2020 in four study sites, including Wuhan, Beijing, Shenyang, and Guangzhou of China. Local residentswho had considerable emotional distress with a score of the Hospital Anxiety and Depression Scale (HADS) ≥9 were recruited. Participants were randomly assigned to three times of AVNA (n = 191) per day, in morning,around noon, and in evening or usual care (UC, n = 215) once daily for 14 days. The primary outcome was theresponse rate, which was the proportion of participants whose Hospital Anxiety and Depression Scale (HADS)score reduced from baseline by ≥ 50%. The assessment was conducted at baseline, 3 days, and 14 days.Results: The AVNA group had a markedly higher response rate than the UC group at 3 days (35.6% vs. 24.9%,P = 0.02) and at 14 days (70.7% vs. 60.6%, P = 0.02). The AVNA group showed significantly greater reductionin scores of HADS at the two measurement points and BAI at 3 days (P ≤ 0.03), with average respective effectsize of 0.217 and 0.195. Participants with AVNA spent less time falling asleep and rated their sleep qualitybeing remarkably higher than those with UC at endpoint.Conclusion: During COVID-19 pandemic period, treatment with self-administrated AVNA was more effectivethan UC in reducing emotional distress of isolated populations. These findings support self-administered AVNAas a treatment option for patients with emotional distress under the COVID-19 pandemic or other emergentevents.展开更多
Based on new rolling-sliding compound bearings,the wear between the one-way spiral hollow cylindrical roller and the ribs of the inner and outer ring of rolling-sliding compound bearings is reduced by innovational str...Based on new rolling-sliding compound bearings,the wear between the one-way spiral hollow cylindrical roller and the ribs of the inner and outer ring of rolling-sliding compound bearings is reduced by innovational structural design. A new left-right spiral hollow cylindrical roller is proposed to replace the one-way spiral hollow cylindrical roller. The finite element analysis models of ordinary cylindrical rollers,one-way spiral hollow cylindrical rollers and left-right spiral hollow cylindrical rollers are respectively established by ABAQUS.The axial displacement of their center mass and the stress distribution of left-right spiral hollow cylindrical rollers are compared and analyzed. Theoretical study results show that this new left-right spiral hollow cylindrical roller not only inherits the advantages of one-way spiral hollow cylindrical rollers,but also avoids the axial offset and the serious wear of the one-way spiral hollow cylindrical roller. And the theory research conclusion is verified by the experiment. The left-right spiral hollow cylindrical roller has the advantages to overcome boundary stress concentration like logarithmic convex roller. The rolling-sliding compound bearings equipped with the new rollers can be better to adapt to the impact of vibration load.展开更多
The innovation of organizational model of tobacco production is the key to realization of sustainable development of tobacco production in China. From the perspective of sustainable development, we analyze the necessi...The innovation of organizational model of tobacco production is the key to realization of sustainable development of tobacco production in China. From the perspective of sustainable development, we analyze the necessity of innovation of organizational model of tobacco production, put forward the principles on innovation of organizational model of tobacco production, and offer corresponding recommendations for the ways of innovation of organizational model of tobacco production.展开更多
One of the main purposes of heavy-ion collisions over a wide range of beam energy is to study the bulk properties of strong interaction matter and understand the Quantum Chromo Dy- namics （QCD） phase diagram, which ...One of the main purposes of heavy-ion collisions over a wide range of beam energy is to study the bulk properties of strong interaction matter and understand the Quantum Chromo Dy- namics （QCD） phase diagram, which carries wealth of infor- mation of the phase transition and the possibly existing criti- cal point of the strongly interacting system [1]. Such system exists as hadron gases at lower temperature and low baryon density. By increasing the temperature or density, the bound- ary of the hadrons disappears and the confined quarks move freely in the whole system.展开更多
Studies have demonstrated estrogen replacement therapy can improve the life quality of surgically menopausal women. However, the mechanisms in this process remain poorly defined. Here we show the effect of transdermal...Studies have demonstrated estrogen replacement therapy can improve the life quality of surgically menopausal women. However, the mechanisms in this process remain poorly defined. Here we show the effect of transdermal estrogen therapy on expressions of estrogen receptors and T-lymphocyte apoptosis in surgically postmenopausal women. Fifteen surgically menopausal women, 15 naturally menopausal women and 15 young women were chosen in our studies. Peripheral vein blood was collected and serum E2 and FSH levels were assessed using ACCESS. T-lymphocyte apoptosis and the expressions of Fas, FasL and ER subtypes α and β were determined. The serum E2 levels of surgically menopausal woman were significantly higher, and the ＂Improved Kupperman Index＂ and the scores of ＂Menopause Specific Quality of Life Questionnaire＂ in surgically menopausal women were significantly low after ERT. The rates of T-lymphocyte apoptosis and FasL expression in surgically menopausal women were decreased after ERT, but the difference was not significant. The expressions of ERa and ERβ in two menopausal groups were significantly lower than those of the young group. They were both significantly up-regulated after 3 months of ERT. Transdermal ERT could significantly upregulate the serum E2 level, could improve menopausal symptoms and life quality of surgically menopausal women and upregulate ERa and ERβ expressions on T lymphocytes, especially ERp. Thus, the low dose of transdermal ERT may have a protective effect on menopausal women＇s immune function and aging.展开更多
基金supported by the National Natural Science Foundation of China(No.82073628,81871876 and 82173609).
文摘Objective:The heightened prevalence of pulmonary nodules(PN)has escalated its significance as a public health concern.While the precise identification of high-risk PN carriers for malignancy remains an ongoing challenge,genetic variants hold potentials as determinants of disease susceptibility that can aid in diagnosis.Yet,current understanding of the genetic loci associated with malignant PN(MPN)risk is limited.Methods:A frequency-matched case-control study was performed,comprising 247 MPN cases and 412 benign NP(BNP)controls.We genotyped 11 established susceptibility loci for lung cancer in a Chinese cohort.Loci associated with MPN risk were utilized to compute a polygenic risk score(PRS).This PRS was subsequently incorporated into the diagnostic evaluation of MPNs,with emphasis on serum tumor biomarkers.Results:Loci rs10429489G>A,rs17038564A>G,and rs12265047A>G were identified as being associated with an increased risk of MPNs.The PRS,formulated from the cumulative risk effects of these loci,correlated with the malignant risk of PNs in a dose-dependent fashion.A high PRS was found to amplify the MPN risk by 156%in comparison to a low PRS[odds ratio(OR)=2.56,95%confidence interval(95%CI),1.40−4.67].Notably,the PRS was observed to enhance the diagnostic accuracy of serum carcinoembryonic antigen(CEA)in distinguishing MPNs from BPNs,with diagnostic values rising from 0.716 to 0.861 across low-to high-PRS categories.Further bioinformatics investigations pinpointed rs10429489G>A as an expression quantitative trait locus.Conclusions:Loci rs10429489G>A,rs17038564A>G,and rs12265047A>G contribute to MPN risk and augment the diagnostic precision for MPNs based on serum CEA concentrations.
基金the National Key R&D Program of China(No.2018YFC1705800 and No.2018YFC1705801)the Fundamental Research Funds for the Central public welfare research institutes(No.ZZ202017009)General Research Fund(GRF)of Research Grant Council of HKSAR(No.17115017).
文摘Objective: To confirm whether self-administered AVNA treatment is effective in improving emotional distressunder the COVID-19 pandemic.Methods: A smartphone-based online, randomized, controlled trial was designed from 26 February 2020 to 28April 2020 in four study sites, including Wuhan, Beijing, Shenyang, and Guangzhou of China. Local residentswho had considerable emotional distress with a score of the Hospital Anxiety and Depression Scale (HADS) ≥9 were recruited. Participants were randomly assigned to three times of AVNA (n = 191) per day, in morning,around noon, and in evening or usual care (UC, n = 215) once daily for 14 days. The primary outcome was theresponse rate, which was the proportion of participants whose Hospital Anxiety and Depression Scale (HADS)score reduced from baseline by ≥ 50%. The assessment was conducted at baseline, 3 days, and 14 days.Results: The AVNA group had a markedly higher response rate than the UC group at 3 days (35.6% vs. 24.9%,P = 0.02) and at 14 days (70.7% vs. 60.6%, P = 0.02). The AVNA group showed significantly greater reductionin scores of HADS at the two measurement points and BAI at 3 days (P ≤ 0.03), with average respective effectsize of 0.217 and 0.195. Participants with AVNA spent less time falling asleep and rated their sleep qualitybeing remarkably higher than those with UC at endpoint.Conclusion: During COVID-19 pandemic period, treatment with self-administrated AVNA was more effectivethan UC in reducing emotional distress of isolated populations. These findings support self-administered AVNAas a treatment option for patients with emotional distress under the COVID-19 pandemic or other emergentevents.
基金Sponsored by the National Natural Science Foundation of China(Grant No.51065009)the Science Foundation of Jiangxi Province Education Department of China(Grant No.GJJ14392GJJ14360)
文摘Based on new rolling-sliding compound bearings,the wear between the one-way spiral hollow cylindrical roller and the ribs of the inner and outer ring of rolling-sliding compound bearings is reduced by innovational structural design. A new left-right spiral hollow cylindrical roller is proposed to replace the one-way spiral hollow cylindrical roller. The finite element analysis models of ordinary cylindrical rollers,one-way spiral hollow cylindrical rollers and left-right spiral hollow cylindrical rollers are respectively established by ABAQUS.The axial displacement of their center mass and the stress distribution of left-right spiral hollow cylindrical rollers are compared and analyzed. Theoretical study results show that this new left-right spiral hollow cylindrical roller not only inherits the advantages of one-way spiral hollow cylindrical rollers,but also avoids the axial offset and the serious wear of the one-way spiral hollow cylindrical roller. And the theory research conclusion is verified by the experiment. The left-right spiral hollow cylindrical roller has the advantages to overcome boundary stress concentration like logarithmic convex roller. The rolling-sliding compound bearings equipped with the new rollers can be better to adapt to the impact of vibration load.
基金Supported by Technology Project of Sichuan Tobacco Monopoly Administration(201102014)
文摘The innovation of organizational model of tobacco production is the key to realization of sustainable development of tobacco production in China. From the perspective of sustainable development, we analyze the necessity of innovation of organizational model of tobacco production, put forward the principles on innovation of organizational model of tobacco production, and offer corresponding recommendations for the ways of innovation of organizational model of tobacco production.
基金supported by National Program on Key Basic Research Project(Grant No.2015CB856903)National Natural Science Foundation of China(Grant No.U1332207)
文摘One of the main purposes of heavy-ion collisions over a wide range of beam energy is to study the bulk properties of strong interaction matter and understand the Quantum Chromo Dy- namics （QCD） phase diagram, which carries wealth of infor- mation of the phase transition and the possibly existing criti- cal point of the strongly interacting system [1]. Such system exists as hadron gases at lower temperature and low baryon density. By increasing the temperature or density, the bound- ary of the hadrons disappears and the confined quarks move freely in the whole system.
文摘Studies have demonstrated estrogen replacement therapy can improve the life quality of surgically menopausal women. However, the mechanisms in this process remain poorly defined. Here we show the effect of transdermal estrogen therapy on expressions of estrogen receptors and T-lymphocyte apoptosis in surgically postmenopausal women. Fifteen surgically menopausal women, 15 naturally menopausal women and 15 young women were chosen in our studies. Peripheral vein blood was collected and serum E2 and FSH levels were assessed using ACCESS. T-lymphocyte apoptosis and the expressions of Fas, FasL and ER subtypes α and β were determined. The serum E2 levels of surgically menopausal woman were significantly higher, and the ＂Improved Kupperman Index＂ and the scores of ＂Menopause Specific Quality of Life Questionnaire＂ in surgically menopausal women were significantly low after ERT. The rates of T-lymphocyte apoptosis and FasL expression in surgically menopausal women were decreased after ERT, but the difference was not significant. The expressions of ERa and ERβ in two menopausal groups were significantly lower than those of the young group. They were both significantly up-regulated after 3 months of ERT. Transdermal ERT could significantly upregulate the serum E2 level, could improve menopausal symptoms and life quality of surgically menopausal women and upregulate ERa and ERβ expressions on T lymphocytes, especially ERp. Thus, the low dose of transdermal ERT may have a protective effect on menopausal women＇s immune function and aging.
