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锚注联合支护技术在失修巷道中的应用 被引量:2
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作者 牛飞 李强 +1 位作者 都琨 王青海 《煤矿现代化》 2023年第4期82-85,共4页
针对济宁二号煤矿93下10运输顺槽在返修时的实际情况,探讨并在实践中采用锚注联合支护技术对失修段进行加固治理,取得了良好的支护效果,保证了矿井正常接续。
关键词 巷道失修 施工工艺 锚注联合支护
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rs3804100、rs3804099及rs2295080基因多态性与黑龙江省2型糖尿病患者并发肺结核关系的研究
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作者 陈海军 薄璐 +4 位作者 郭鑫 张堃 赫丽杰 李强 李雨泽 《结核病与肺部健康杂志》 2020年第1期49-54,共6页
目的探究Toll样受体2(Toll-like receptor 2,TLR2)rs3804100、rs3804099位点和哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)rs2295080位点基因多态性与2型糖尿病并发肺结核的关系。方法选择2017年1-9月黑龙江省传染病... 目的探究Toll样受体2(Toll-like receptor 2,TLR2)rs3804100、rs3804099位点和哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)rs2295080位点基因多态性与2型糖尿病并发肺结核的关系。方法选择2017年1-9月黑龙江省传染病防治院收治的300例2型糖尿病并发肺结核患者作为观察组,以及同时期在哈尔滨医科大学附属第四医院内分泌科就诊的300例2型糖尿病患者作为对照组。所有患者收集血液提取DNA,用PCR技术对TLR2的rs3804100、rs3804099位点及mTOR的rs2295080位点进行基因多态性检测,并对这3个基因位点多态性与2型糖尿病并发肺结核的关系进行单因素和logistic多因素分析。结果单因素分析结果显示,TLR2的rs3804100位点TT、TC、CC(T:胸腺嘧啶;C:胞嘧啶)基因型在观察组和对照组分布构成比分别为51.3%(154/300)、25.7%(77/300)、23.0%(69/300)和47.0%(141/300)、31.3%(94/300)、21.7%(65/300),差异无统计学意义(χ^2=2.382,P=0.304);TLR2的rs3804099位点TT、TC、CC基因型在观察组和对照组分布构成比分别为53.0%(159/300)、29.7%(89/300)、17.3%(52/300)和54.3%(163/300)、33.0%(99/300)、12.7%(38/300),差异无统计学意义(χ^2=2.759,P=0.252);mTOR的rs2295080位点TT、TG、GG(G:鸟嘌呤)基因型在观察组和对照组分布构成比分别为26.7%(80/300)、67.3%(202/300)、6.0%(18/300)和24.3%(73/300)、66.0%(198/300)、9.7%(29/300),差异无统计学意义(χ^2=2.935,P=0.231)。logistic多因素分析结果显示,TLR2的rs3804100位点TC、CC基因型的OR(95%CI)值分别为1.261(0.591~2.689)和1.284(0.542~3.042),P值分别为0.549和0.569;TLR2的rs3804099位点TC、CC基因型的OR(95%CI)值分别为0.752(0.461~1.227)和0.729(0.430~1.235),P值分别为0.254和0.240;mTOR的rs2295080位点TG、GG基因型的OR(95%CI)值分别为1.789(0.890~3.596)和1.603(0.839~3.063),P值分别为0.103和0.153。结论 TLR2基因rs3804100、rs3804099位点及mTOR的rs2295080位点多态性与黑龙江省2型糖尿病并发肺结核均无相关性。 展开更多
关键词 结核 糖尿病 2型 糖尿病并发症 扩增片段长度多态性分析 因素分析 统计学
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喉癌、喉良性病变及声带息肉组织HPV-DNA及P16蛋白的表达差异 被引量:7
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作者 李强 秦雪梅 +2 位作者 叶宣光 顾立新 朱小平 《中国临床医学》 2017年第5期744-747,共4页
目的:检测喉癌、喉良性病变组织及声带息肉组织中HPV-DNA及P16蛋白的表达水平,探讨HPV感染与喉癌发生的相关性。方法:收集2011年5月至2015年7月就诊于复旦大学附属金山医院耳鼻咽喉-头颈外科的256例患者,其中喉鳞状细胞癌34例、喉良性病... 目的:检测喉癌、喉良性病变组织及声带息肉组织中HPV-DNA及P16蛋白的表达水平,探讨HPV感染与喉癌发生的相关性。方法:收集2011年5月至2015年7月就诊于复旦大学附属金山医院耳鼻咽喉-头颈外科的256例患者,其中喉鳞状细胞癌34例、喉良性病变(非声带息肉)15例、声带息肉207例,男性184例、女性72例,中位年龄56岁。采用实时荧光PCR法检测喉鳞状细胞癌组织和喉良性病变组织HPV-DNA水平。采用免疫组化法观察喉癌组织、喉良性病变及声带息肉中P16蛋白的表达。结果:实时荧光PCR检测发现34例喉鳞状细胞癌组织中HPV-DNA阳性率为8.8%(3/34),喉良性病变均为阴性(0/15),两组间HPV-DNA阳性率差异无统计学意义。免疫组化染色显示喉鳞状细胞癌、喉良性病变、声带息肉组织P16蛋白阳性表达率分别为32.4%(11/34)、46.7%(7/15)和47.8%(99/207),其中声带息肉组织P16蛋白阳性率高于喉癌组织,差异有统计学意义(P=0.046)。结论:喉癌组织HPV-DNA阳性率略高于喉良性病变;P16蛋白在喉癌组织的表达略低于喉良性病变,明显低于声带息肉。 展开更多
关键词 喉癌 喉良性病变 声带息肉 人乳头状瘤病毒(HPV) 实时荧光PCR
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SWIM技术在大脑中动脉急性闭塞治疗中的应用 被引量:12
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作者 李强 朱良付 +4 位作者 周腾飞 管民 吴立恒 贺迎坤 李天晓 《介入放射学杂志》 CSCD 北大核心 2019年第8期717-720,共4页
目的探讨颅内支撑导管辅助Solitaire FR支架机械取栓术(SWIM)治疗大脑中动脉急性闭塞的临床效果。方法选取2016年5月至2017年12月收治的急性大脑中动脉闭塞患者53例,根据治疗方案最终选择,分为观察组(n=32,给予SWIM术)和对照组(n=21,给... 目的探讨颅内支撑导管辅助Solitaire FR支架机械取栓术(SWIM)治疗大脑中动脉急性闭塞的临床效果。方法选取2016年5月至2017年12月收治的急性大脑中动脉闭塞患者53例,根据治疗方案最终选择,分为观察组(n=32,给予SWIM术)和对照组(n=21,给予单纯支架机械取栓术)。对比观察两组患者穿刺至血管再通时间和术中术后并发症发生情况。根据脑梗死溶栓(TICI)治疗后血流分级标准评价术后即刻血管再通率,根据美国国立卫生研究院卒中量表(NIHSS)评分评价术前和术后1周神经功能情况,根据改良Rankin量表(mRS)评分评价术后90d预后。结果观察组穿刺至血管再通时间为(70.12±24.16)min,明显短于对照组(95.57±30.41)min(P<0.05);术后1周NIHSS评分为(3.30±1.01)分,明显低于对照组(5.76±0.97)分(P<0.05);术后即刻血管再通率、术后90d预后良好率分别为93.8%(30/32)、81.3%(26/32),明显高于对照组66.7%(14/21)、47.6%(10/21)(P<0.05)。两组术后并发症比较,差异无统计学意义(P>0.05)。结论5FNavien导管辅助Solitaire支架机械取栓术治疗急性大脑中动脉闭塞效果良好,可提高血管再通率,改善患者预后。 展开更多
关键词 Solitaire支架 Navien导管 大脑中动脉 急性闭塞
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Study on Properties of Magnesia-Hercynite Brick 被引量:4
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作者 LIUHuilin LINing liqiang 《China's Refractories》 CAS 2005年第2期23-26,共4页
Using magnesia and hercynite as materials, we researched the magnesia hercynite brick in order to solve the problem of chrome free brick used in the burning zone of cement rotary kiln. Effect of different firing tempe... Using magnesia and hercynite as materials, we researched the magnesia hercynite brick in order to solve the problem of chrome free brick used in the burning zone of cement rotary kiln. Effect of different firing temperature and different content of hercynite on properties of the brick were studied. The results show that the magnesia hercynite specimen fired at 1600℃ was densified and when the hercynite content is 7%, the cold crushing strength and the adhesive strength of rupture of the specimen have the highest value. 展开更多
关键词 MAGNESIA hercynite brick HERCYNITE PROPERTY Cement kiln
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Production of radioactive ~9C ion beam and its optimization 被引量:3
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作者 WEIZeng-Quan liqiang +5 位作者 A.KITAGAWA T.KANAI M.KANAZAWA E.URAKABE XIEHong-Mei ZHOUGuang-Ming 《Nuclear Science and Techniques》 SCIE CAS CSCD 2005年第2期95-98,共4页
To explore the medical use of a radioactive 9C-ion beam in tumor treatment, which is a double radiation source coming from the external beam itself and the delayed particles emitted internally, some physical experimen... To explore the medical use of a radioactive 9C-ion beam in tumor treatment, which is a double radiation source coming from the external beam itself and the delayed particles emitted internally, some physical experiments are performed at the Secondary Beam Line (SBL) of Heavy Ion Medical Accelerator, Chiba (HIMAC) in Japan be- fore radiobiological research for exhibiting therapeutic value of the 9C beam. Intention of the experiments is for pro- ducing a radioactive 9C-ion beam with higher production rate and purity by means of optimizing the beam line pa- rameters. Finally, a produced 9C beam with the production rate of 9.07×10-6 and purity of 82.88% at full momentum acceptance has been obtained under the optimal conditions of 40 mm-thick beryllium target and 10 mm-thick alumi- num degrader. Both momentum distribution and contaminations for the produced 9C beam under the optimal condi- tions are measured. In order to execute further biological experiments of the 9C beam project, a uniform irradiation field is made with the wobbling magnets and its homogeneity is up to 93.8% inside central area of 20mm in diameter. 展开更多
关键词 放射性离子束 参数优化 肿瘤治疗 放射医学
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Numerical Simulation of Dendrite Evolution during Solidification Process 被引量:2
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作者 liqiang GUOQiao-yi RENChuan-fu 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2005年第1期28-33,共6页
The effect of manganese on the as-cast structure and hardening behavior of high chromium white cast iron subjected to sub-critical treatment was studied. The results indicate that the fraction of retained austenite an... The effect of manganese on the as-cast structure and hardening behavior of high chromium white cast iron subjected to sub-critical treatment was studied. The results indicate that the fraction of retained austenite and the manganese distribution in as-cast alloys are controlled by manganese content. The manganese distribution in as-cast alloys is not homogeneous. The manganese content in carbide is higher than that in matrix. Whether the secondary hardening occurs or not and the peak hardness of secondary hardening is controlled by manganese content in retained austenite in as-cast structure. Higher manganese content can cause more retained austenite. The secondary hardening occurs in sub-critical treating process if the fraction of retained austenite is high. 展开更多
关键词 white cast iron high chromium MICROSTRUCTURE hardening behavior MANGANESE sub-critical treatment
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猕猴桃果园种草试验 被引量:2
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作者 白立强 刘存寿 +3 位作者 宣世荣 刘少波 赵晓娥 程敏 《防护林科技》 2020年第12期3-8,共6页
在降雨比较充沛的地区,果园种草对控制杂草、调节小气候、保持果园生态平衡均有益处。通过在猕猴桃果园进行种草试验,结果表明:果园种草能够有效降低林下温度、提高湿度、增加土壤含水率,可为果树生长提供更优质的环境。而不同的种草模... 在降雨比较充沛的地区,果园种草对控制杂草、调节小气候、保持果园生态平衡均有益处。通过在猕猴桃果园进行种草试验,结果表明:果园种草能够有效降低林下温度、提高湿度、增加土壤含水率,可为果树生长提供更优质的环境。而不同的种草模式,在不同月份对土壤含水率的影响也不同。建议选择高羊茅(Festuca elata)作为猕猴桃果园主要种植品种。 展开更多
关键词 猕猴桃 果园 种草
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Extending Bragg peak of heavy ion beam and melanoma cell inactivation measurement
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作者 liqiang WeiZeng-Quan 《Nuclear Science and Techniques》 SCIE CAS CSCD 1998年第1期8-10,共3页
ExtendingBraggpeakofheavyionbeamandmelanomacelinactivationmeasurementLiQiang,WeiZengQuan,LiWenJian,ZhouGuang... ExtendingBraggpeakofheavyionbeamandmelanomacelinactivationmeasurementLiQiang,WeiZengQuan,LiWenJian,ZhouGuangMing,DangBing... 展开更多
关键词 重离子束 黑素瘤细胞 钝化作用
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I Live by the Songhua River
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作者 liqiang 《China Today》 2004年第4期32-33,共2页
HAVING worked in the television industry for 15 years, I've been to various Chinese, European and American cities, but of all of them I like my hometown, Harbin in Northeast China's Heilongjiang Province, the ... HAVING worked in the television industry for 15 years, I've been to various Chinese, European and American cities, but of all of them I like my hometown, Harbin in Northeast China's Heilongjiang Province, the best. My affection stems neither from Harbin's beauty nor my nostalgia, but from the city's distinctive glamour.Harbin's unique culture came into being because of two major events: the Niizhen, ancestors of the Manchu ethnic group, establishing their capital in what is now Harbin 800 years ago, and the influx of foreign immigrants in the 20th century. Both of these groups introduced distinct cultural elements to Harbin. 展开更多
关键词 松花江 黑龙江省 历史文化 经济建设 哈尔滨市
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An Improved New Cultivar of Spring Wheat Bred by Heavy Ion Beams with Medium Energy-"Longfu 2"
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作者 XieHongmei WeiZengquan +7 位作者 WangHaohan LiuQin ZhaoLianzhi LiWenjian liqiang WangJufang ZhouGuangming DangBingron 《近代物理研究所和兰州重离子加速器实验室年报:英文版》 2003年第1期86-86,共1页
75 MeV/u oxygen ion (^16O+8) beams supplied by HIRFL were used to irradiate 14615 of spring wheat dry seeds of stable multi-generation. Range of the ions in the seeds is about 11 mm. They can enter the seed from its e... 75 MeV/u oxygen ion (^16O+8) beams supplied by HIRFL were used to irradiate 14615 of spring wheat dry seeds of stable multi-generation. Range of the ions in the seeds is about 11 mm. They can enter the seed from its embryo, come out from its top, and penetrate through an entire grain of wheat, length of which is about 6~7 mm. The seeds were vertically inserted in a sample plate of 4 cm in diameter, which can contain about 100 grain of the seeds. During irradiation, the embryo of the seeds faced to ion beams and was irradiated at normal temperature and atmosphere. Irradiation dose was arranged in 1×10^7, 5×10^7, 1×10^8, 2×10^8 and 5×10^8 ions/cm^2 with dose rate of about 3 Gy/min. A part of the irradiated seeds was employed for cytology examination in laboratory, the others were used for breeding in the fields. 展开更多
关键词 氧离子 能量束 HIRFL 小麦种子 辐射伤害 细胞学
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小剂量螺内酯对老年难治性高血压患者的治疗效果观察 被引量:1
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作者 李强 韩雪 《首都食品与医药》 2023年第3期65-67,共3页
目的观察应用小剂量螺内酯治疗老年难治性高血压的疗效及安全性.方法将天津市河西区陈塘庄街社区卫生服务中心180例老年难治性高血压患者随机均等分成两组,常规组给予三种常规降压药联合治疗,实验组在此基础上联合20mg小剂量螺内酯治疗... 目的观察应用小剂量螺内酯治疗老年难治性高血压的疗效及安全性.方法将天津市河西区陈塘庄街社区卫生服务中心180例老年难治性高血压患者随机均等分成两组,常规组给予三种常规降压药联合治疗,实验组在此基础上联合20mg小剂量螺内酯治疗,均连续给药4周后对两组疗效指标和不良反应出现情况予以评估.结果两组治疗前后血压监测值均有明显变化,且实验组血压改善程度优于常规组(P<0.01);实验组临床疗效明显优于常规组(P<0.01);两组均无严重不良反应发生.结论小剂量螺内酯对老年难治性高血压患者的治疗效果显著,安全性较高. 展开更多
关键词 小剂量 螺内酯 难治性高血压 老年 治疗效果
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刺血疗法联合蛇伤外敷散对蝮蛇咬伤大鼠HAase、PLA_2的影响研究 被引量:6
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作者 陈平 颜纯钏 +6 位作者 董德刚 严张仁 张艳晖 王秀琴 李强 陈琦 王万春 《时珍国医国药》 CAS CSCD 北大核心 2019年第1期241-244,共4页
目的观察八风穴位刺血疗法联合蛇伤外敷散对蝮蛇咬伤大鼠血清HAase、PLA_2的水平及症状积分的干预作用。方法将40只大鼠随机分成刺血加中药组、中药组、对照组、模型组。通过在大鼠左下肢皮下注射蝮蛇毒的方法造模,刺血加中药组、中药... 目的观察八风穴位刺血疗法联合蛇伤外敷散对蝮蛇咬伤大鼠血清HAase、PLA_2的水平及症状积分的干预作用。方法将40只大鼠随机分成刺血加中药组、中药组、对照组、模型组。通过在大鼠左下肢皮下注射蝮蛇毒的方法造模,刺血加中药组、中药组、对照组三组干预治疗后,从大鼠的球后静脉采血,通过ELISA法检测各组大鼠血清HAase、PLA_2的水平和观察各组症状积分。结果造模后各组HAase、PLA_2含量及症状积分显著超过造模前(P<0.05),刺血治疗和给药后各组HAase、PLA_2含量显著降低(P<0.05),症状积分降低(P<0.05)。其中以刺血加中药组对HAase、PLA_2含量及症状积分降低效果最佳,与中药组比较,差异有统计学意义(P<0.05)。结论八风穴位刺血疗法联合蛇伤外敷散可以显著降低蝮蛇咬伤大鼠血清HAase、PLA_2含量及症状积分。 展开更多
关键词 穴位刺血疗法 蛇伤外敷散 蝮蛇咬伤 HAase PLA2
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Biological effects of radioactive ~9C-ion beams on cells 被引量:2
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作者 WEIZengquan liqiang +6 位作者 A.Kitagawa T.Kanai M.Kanazawa Y.Furusawa E.Urakabe XIEHongmei ZHOUGuangming 《Chinese Science Bulletin》 SCIE EI CAS 2005年第11期1070-1075,共6页
The distinguishing feature and current technique progress of tumor treatment with heavy-ion beams is introduced in the paper. Additional superiority to tumor treatment from a radioactive ion beam (RIB) is emphatically... The distinguishing feature and current technique progress of tumor treatment with heavy-ion beams is introduced in the paper. Additional superiority to tumor treatment from a radioactive ion beam (RIB) is emphatically discussed. The experimental research of the radioactive 9C-ion beams aimed at tumor treatment at Heavy Ion Medical Accelerator in Chiba (HIMAC), National Institute of Radiological Sciences (NIRS), Japan is described in detail, La-eluding production of the beams, optimization of parameters, distribution of depth dose, survival effect of cell and comparison of RBE between 9C- and 12C-beams. Results show that under 40 mm thick Beryllium target and 10 mm thick aluminum degrader at full (5%) momentum acceptance, the production rate and purity of the produced 9C-beams are 9.07×10-6 and 82.88% respectively with the primary 12C-beams of 430 MeV/u and 1.8×109 pps. A uniform irradiation field with homogeneity up to 89.6% inside central area 10 mm in diameter is obtained by using spot scanning. In this case, the dose rate at the entrance is 0.5 Gy/h. In survival experiment of cells, the average relative biological effectiveness (RBE) of 9C-beams is 5.28 and 2.93 for 12C-beams in the region around Bragg peak. The RBE of 9C-beams is 1.8 times higher than that of 12C-beams. It indicates that cell-killing efficiency of 9C-beams is stronger than that of 12C-beams. 9C-beams are more efficacious for tumor treatment than 12C-beams. 展开更多
关键词 生物学 放射性粒子束 参数优化 生存能力 肿瘤细胞 治疗方法
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Special Issue: Peasant Workers'' Migration to China's Cities 被引量:2
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作者 liqiang 《Social Sciences in China》 2003年第4期80-83,共4页
关键词 中国 农村劳动力 城市 就业
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Policy Issues Concerning the Informal Employment of Rural-Urban Migrants in China 被引量:1
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作者 liqiang 《Social Sciences in China》 2003年第4期126-137,共12页
本文利用各种最新的实证数据,考察了流入城市的农民工的非正规就业及其在中国经济中的作用。作者预测,在未来的几十年里非正规部门和非正规就业将在中国的城市就业中发挥重要功能。文章肯定了流入城市的农民工非正规就业的积极贡献。... 本文利用各种最新的实证数据,考察了流入城市的农民工的非正规就业及其在中国经济中的作用。作者预测,在未来的几十年里非正规部门和非正规就业将在中国的城市就业中发挥重要功能。文章肯定了流入城市的农民工非正规就业的积极贡献。不能把非正规就业与地下活动或非法活动等同起来。文章指出,目前对非正规就业的政策牺牲了农民工的利益,必须予以纠正。本文所使用的数据来源于两次对城市流动人口的问卷调查,一次是2002年在北京朝阳区进行的调查,有效问卷307份;另一次是2000年在丰台区进行的调查,有效问卷493份。 展开更多
关键词 农村劳动力 城市 流动人口 非正规就业
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醇基压裂液在强水敏储层改造中的应用 被引量:1
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作者 常学伟 李强 +1 位作者 胡毅 钟兵 《江汉石油职工大学学报》 2022年第5期42-44,共3页
通过室内实验,对改性乙二醇防膨压裂液体系进行性能测定及配方优化,该工艺可满足压裂工艺和现场施工的要求。压后产量评估显示增产效果显著。
关键词 无水压裂 醇基压裂液 改性乙二醇 强水敏储层
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Relationship between IRS-2G1057D variant and type 2 diabetes mellitus in Han population in Liaoning Province, China
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作者 KONGLing-fang QIANCong +3 位作者 ZHENGXiao-min HOUYong-sheng liqiang LIUGuo-liang 《Chinese Medical Journal》 SCIE CAS CSCD 2005年第5期415-417,共3页
The two major pathogeneses of type 2 diabetes mellitus (T2DM) are insulin resistance and insulin secretion deficiency. During recent years, researches on the molecular target sites of insulin resistance and the mechan... The two major pathogeneses of type 2 diabetes mellitus (T2DM) are insulin resistance and insulin secretion deficiency. During recent years, researches on the molecular target sites of insulin resistance and the mechanism of the signal transduction has made great progress: especially, the study of insulin receptor substrate-2 (IRS-2). Human IRS-2 gene is located at 13q8.6. IRS-2G1057D is a replacement of G (glycine) by D (aspartic acid) at site 1057 of insulin receptor substrate-2, which is caused by simple nucleotide polymorphism. The role of this variant is still not clear. We detected IRS-2G1057D variant in Han population in Liaoning Province by measuring body mass index (BMI), waistline/hip ratio (WHR) and other parameters of insulin secretion, as well as insulin action to explore the relationship between IRS-2G1057D variant and T2DM. 展开更多
关键词 insulin receptor substrate-2 type 2 diabetes mellitus OBESITY insulin resistance
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