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燥湿苦参汤联合NB-UVB治疗寻常性银屑病及对Th17和Treg及其相关因子表达的影响 被引量:13
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作者 张连云 谭晓慧 +1 位作者 赵敏 朱蓓蓓 《中国现代医学杂志》 CAS 2018年第31期25-31,共7页
目的探讨燥湿苦参汤联合窄谱中波紫外线(NB-UVB)治疗寻常性银屑病的临床疗效及其对Th17、Treg细胞相关的转录、分泌因子的影响。方法选取2014年6月-2015年12月该院收治的寻常型银屑病患者126例。按照就诊顺序随机分为中医对照组、NB-UV... 目的探讨燥湿苦参汤联合窄谱中波紫外线(NB-UVB)治疗寻常性银屑病的临床疗效及其对Th17、Treg细胞相关的转录、分泌因子的影响。方法选取2014年6月-2015年12月该院收治的寻常型银屑病患者126例。按照就诊顺序随机分为中医对照组、NB-UVB对照组和研究组,每组42例。中医对照组内服燥湿苦参汤,NB-UVB对照组进行NB-UVB照射治疗,研究组内服燥湿苦参汤加用NB-UVB局部照射。另选择40例体检正常者为健康对照组。3组均治疗12周,评价其综合疗效,对比治疗前后的外周血Th17细胞比例及其特异性转录因子—孤儿受体转录因子(RORγt mRNA)、分泌因子—白细胞介素17(IL-17),Treg细胞的比例及其特异性转录因子—叉头状转录因子(Foxp3 mRNA)、分泌因子—转化生长因子(TGF-β)的表达水平。结果 (1)治疗12周后,3组的严重程度评分(PASI)均下降,且研究组评分低于中医对照组与NB-UVB对照组,总有效率也高于中医对照组与NB-UVB对照组,差异有统计学意义(P <0.05)。(2)与健康对照组比较,3组治疗前外周血Th17细胞比例及RORγt mRNA与IL-17均升高,而Treg细胞的比例及Foxp3 mRNA与TGF-β降低,差异有统计学意义(P <0.05)。治疗后,3组Th17细胞的相关因子表达均较治疗前下降,Treg细胞相关因子表达较治疗前升高,差异有统计学意义(P <0.05)。结论燥湿苦参汤联合NB-UVB局部照射可抑制Th17细胞及其相关因子的表达,恢复Treg/Th17细胞的动态平衡,增强Treg细胞的免疫抑制功能,从而降低外周血及皮损处的炎症细胞因子,达到改善寻常性银屑病临床症状的理想疗效。 展开更多
关键词 寻常性银屑病 燥湿苦参汤 Th17细胞 TREG细胞 NB-UVB
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Corrosion resistance and antibacterial activity of different zones in TA2 weldment by TIG welding 被引量:4
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作者 Yan-Ping Zhu Chang-Yi Li lian-yun zhang 《Rare Metals》 SCIE EI CAS CSCD 2020年第12期1449-1456,共8页
The corrosion resistance behavior of TA2 pure titanium processed by tungsten inert gas(TIG)welding was investigated in artificial saliva solution at 37℃.By metallographic examination,electrochemical measurement techn... The corrosion resistance behavior of TA2 pure titanium processed by tungsten inert gas(TIG)welding was investigated in artificial saliva solution at 37℃.By metallographic examination,electrochemical measurement technology,and electrochemical impedance spectroscopy(EIS),the corrosion resistance of the base metal(BM),heat-affected zone(HAZ),and weld metal(WM)were investigated.Metallographic examination experiments show that welding process would cause the growth of grain size.In addition,phase change happens in the HAZ and WM.The change of grain size and phase would influence the generation of the original passive film.The electrochemical tests show that the BM,HAZ,and WM are all equipped with good corrosion resistance.The welded joint shows a better corrosion resistance than the original TA2.It is shown that the BM with the lowest corrosion potential and the biggest corrosion current has a worse corrosion resistance than WM as well as HAZ.Silver(Ag)nanoparticles can be distributed on the WM zone of Ti uniformly.The WM zone of Ti with Ag coating considerably enhances the antibacterial activity of Ti implants. 展开更多
关键词 TITANIUM Tungsten inert gas welding Corrosion resistance Artificial saliva solution Antibacterial activity
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