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GLP-1类似物利拉鲁肽联合门冬胰岛素30对2型糖尿病患者认知功能障碍的影响 被引量:23
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作者 李伟 王梅 +3 位作者 董雪 吕梁 付兴根 王德忠 《中国现代医学杂志》 CAS 2018年第31期108-112,共5页
目的探究GLP-1类似物利拉鲁肽联合门冬胰岛素30治疗2型糖尿病患者认知功能障碍的临床疗效。方法连续入选2014年9月-2016年1月山东省滕州市中心人民医院内住院的2型糖尿病患者132例,将患者随机分成门冬胰岛素30治疗组(对照组,66例)和利... 目的探究GLP-1类似物利拉鲁肽联合门冬胰岛素30治疗2型糖尿病患者认知功能障碍的临床疗效。方法连续入选2014年9月-2016年1月山东省滕州市中心人民医院内住院的2型糖尿病患者132例,将患者随机分成门冬胰岛素30治疗组(对照组,66例)和利拉鲁肽联合门冬胰岛素30治疗组(实验组,66例),治疗1年后随访结果,比较分析治疗前后两组患者血糖、血脂、体重指数及认知功能的变化情况。结果治疗1年后随访,实验组的血糖、体重指数较对照组改善,认知功能量表MMSE、MoCA、CMS总分均高于对照组(P<0.05)。结论利拉鲁肽联合门冬胰岛素30在控制血糖、降血脂、改善体重指数方面的临床疗效优于单纯的门冬胰岛素30,且有效改善糖尿病患者认知功能。 展开更多
关键词 利拉鲁肽 门冬胰岛素30 认知功能障碍 2型糖尿病
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Numerical investigation of the interactions between a laser-generated bubble and a particle near a solid wall 被引量:5
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作者 Jian-yong Yin Yong-xue Zhang +2 位作者 Jian-jun Zhu liang lü Shi-da li 《Journal of Hydrodynamics》 SCIE EI CSCD 2021年第2期311-322,共12页
The interactions between the bubbles and the particles near structures are important issues for the applications of the cavitation in the fluid machinery.To study the hidden microscopic mechanisms,a numerical method f... The interactions between the bubbles and the particles near structures are important issues for the applications of the cavitation in the fluid machinery.To study the hidden microscopic mechanisms,a numerical method for simulating the laser-generated bubble between the solid wall and a particle is developed in this paper with considerations of the viscosities and the compressibility of the gas and the liquid phases,as well as the surface tension between them.The gas-liquid interface is tracked by the coupling level set and the volume of fluid(CLSVOF)method.The numerical results clearly reveal that the particle can influence the cavitation bubble behaviors.The potential damage of the nearby structures is numerically quantified in terms of the wall pressure,which helps better understand the synergetic effects of the particle on the cavitation.The effects of three dimensionless parameters on the wall pressure are also investigated,especially,on the peak pressure,namely,γ1(defined as L_(1)/R_(max),where L_(1)is the distance from the center of the initial bubble to the solid wall and R_(max)is the maximum bubble radius),γ_(2)(defined as L_(2)/R_(max),where L_(2)is the distance from the lower surface of the spherical particle to the initial bubble center)andθ(defined as Rp/R_(max),where Rp is the spherical particle radius).Further numerical results show that these parameters play a dominant role in determining the peak pressure.When y_(1)<1.00,the peak pressure on the solid wall during the bubble collapse is mainly resulted from the liquid jet.Whenγ1>1.00,the peak pressure is caused by the shock wave.With the increase ofθor decrease ofγ_(2),the peak pressure increases.Whenγ_(2)>2.00,the effect of the particle on the bubble behavior can be neglected. 展开更多
关键词 CAVITATION BUBBLE spherical PARTICLE coupling level set and the volume of fluid(CLSVOF) solid wall OPENFOAM
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