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Identification of candidate genes for early-maturity traits by combining BSA-seq and QTL mapping in upland cotton(Gossypium hirsutum L.) 被引量:1
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作者 liang ma Tingli Hu +7 位作者 Meng Kang Xiaokang Fu Pengyun Chen Fei Wei Hongliang Jian Xiaoyan Lü Meng Zhang Yonglin Yang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第10期3472-3486,共15页
Cotton breeding for the development of early-maturing varieties is an effective way to improve multiple cropping indexes and alleviate the conflict between grains and cotton in the cultivated fields in China.In the pr... Cotton breeding for the development of early-maturing varieties is an effective way to improve multiple cropping indexes and alleviate the conflict between grains and cotton in the cultivated fields in China.In the present study,we aimed to identify upland cotton quantitative trait loci(QTLs)and candidate genes related to early-maturity traits,including whole growth period(WGP),flowering timing(FT),node of the first fruiting branch(NFFB),height of the node of the first fruiting branch(HNFFB),and plant height(PH).An early-maturing variety,CCRI50,and a latematuring variety,Guoxinmian 11,were crossed to obtain biparental populations.These populations were used to map QTLs for the early-maturity traits for two years(2020 and 2021).With BSA-seq analysis based on the data of population 2020,the candidate regions related to early maturity were found to be located on chromosome D03.We then developed 22 polymorphic insertions or deletions(InDel)markers to further narrow down the candidate regions,resulting in the detection of five and four QTLs in the 2020 and 2021 populations,respectively.According to the results of QTL mapping,two candidate regions(InDel_G286-InDel_G144 and InDel_G24-InDel_G43)were detected.In these regions,three genes(GH_D03G0451,GH_D03G0649,and GH_D03G1180)have nonsynonymous mutations in their exons and one gene(GH_D03G0450)has SNP variations in the upstream sequence between CCRI50 and Guoxinmian 11.These four genes also showed dominant expression in the floral organs.The expression levels of GH_D03G0451,GH_D03G0649 and GH_D03G1180 were significantly higher in CCRI50 than in Guoxinmian 11 during the bud differentiation stages,while GH_D03G0450 showed the opposite trend.Further functional verification of GH_D03G0451 indicated that the GH_D03G0451-silenced plants showed a delay in the flowering time.The results suggest that these are the candidate genes for cotton early maturity,and they may be used for breeding early-maturity cotton varieties. 展开更多
关键词 cotton genomics early-maturity traits BSA-seq QTL mapping molecular breeding
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Accurate and efficient remaining useful life prediction of batteries enabled by physics-informed machine learning 被引量:1
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作者 liang ma Jinpeng Tian +2 位作者 Tieling Zhang Qinghua Guo Chunsheng Hu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第4期512-521,共10页
The safe and reliable operation of lithium-ion batteries necessitates the accurate prediction of remaining useful life(RUL).However,this task is challenging due to the diverse ageing mechanisms,various operating condi... The safe and reliable operation of lithium-ion batteries necessitates the accurate prediction of remaining useful life(RUL).However,this task is challenging due to the diverse ageing mechanisms,various operating conditions,and limited measured signals.Although data-driven methods are perceived as a promising solution,they ignore intrinsic battery physics,leading to compromised accuracy,low efficiency,and low interpretability.In response,this study integrates domain knowledge into deep learning to enhance the RUL prediction performance.We demonstrate accurate RUL prediction using only a single charging curve.First,a generalisable physics-based model is developed to extract ageing-correlated parameters that can describe and explain battery degradation from battery charging data.The parameters inform a deep neural network(DNN)to predict RUL with high accuracy and efficiency.The trained model is validated under 3 types of batteries working under 7 conditions,considering fully charged and partially charged cases.Using data from one cycle only,the proposed method achieves a root mean squared error(RMSE)of 11.42 cycles and a mean absolute relative error(MARE)of 3.19%on average,which are over45%and 44%lower compared to the two state-of-the-art data-driven methods,respectively.Besides its accuracy,the proposed method also outperforms existing methods in terms of efficiency,input burden,and robustness.The inherent relationship between the model parameters and the battery degradation mechanism is further revealed,substantiating the intrinsic superiority of the proposed method. 展开更多
关键词 Lithium-ion batteries Remaining useful life Physics-informed machine learning
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Animal Model of Aortic Valve Calcification: Their Methodology Helps Us Understand Aortic Valve Calcification
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作者 Yinze Wei Zhen Wang +1 位作者 Miao Chen liang ma 《Advances in Bioscience and Biotechnology》 CAS 2024年第4期235-268,共34页
Aortic valve calcification disease (CAVD) is the most prevalent degenerative valve disease in humans, leading to significant morbidity and mortality. Despite its common occurrence, our understanding of the underlying ... Aortic valve calcification disease (CAVD) is the most prevalent degenerative valve disease in humans, leading to significant morbidity and mortality. Despite its common occurrence, our understanding of the underlying mechanisms remains incomplete, and available treatment options are limited and risky. A more comprehensive understanding of the biology of CAVD is essential to identify new therapeutic strategies. Animal models have played a crucial role in advancing our knowledge of CAVD and exploring potential treatments. However, these models have inherent limitations as they cannot fully replicate the complex physiological mechanisms of human CAVD. In this review, we examine various CAVD models ranging from pigs to mice, highlighting the unique characteristics of each model to enhance our understanding of CAVD. While these models offer valuable insights, they also have limitations and shortcomings. We propose that the guide wire model shows promise for future CAVD research, and streamlining the methodology could enhance our understanding and expand the research scope in this field. 展开更多
关键词 Animal Model Aortic Valve Stenosis CALCIFICATION CARDIOVASCULAR
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Deep learning-based battery state of charge estimation:Enhancing estimation performance with unlabelled training samples
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作者 liang ma Tieling Zhang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第5期48-57,I0002,共11页
The estimation of state of charge(SOC)using deep neural networks(DNN)generally requires a considerable number of labelled samples for training,which refer to the current and voltage pieces with knowing their correspon... The estimation of state of charge(SOC)using deep neural networks(DNN)generally requires a considerable number of labelled samples for training,which refer to the current and voltage pieces with knowing their corresponding SOCs.However,the collection of labelled samples is costly and time-consuming.In contrast,the unlabelled training samples,which consist of the current and voltage data with unknown SOCs,are easy to obtain.In view of this,this paper proposes an improved DNN for SOC estimation by effectively using both a pool of unlabelled samples and a limited number of labelled samples.Besides the traditional supervised network,the proposed method uses an input reconstruction network to reformulate the time dependency features of the voltage and current.In this way,the developed network can extract useful information from the unlabelled samples.The proposed method is validated under different drive cycles and temperature conditions.The results reveal that the SOC estimation accuracy of the DNN trained with both labelled and unlabelled samples outperforms that of only using a limited number of labelled samples.In addition,when the dataset with reduced number of labelled samples to some extent is used to test the developed network,it is found that the proposed method performs well and is robust in producing the model outputs with the required accuracy when the unlabelled samples are involved in the model training.Furthermore,the proposed method is evaluated with different recurrent neural networks(RNNs)applied to the input reconstruction module.The results indicate that the proposed method is feasible for various RNN algorithms,and it could be flexibly applied to other conditions as required. 展开更多
关键词 Deep learning State of charge estimation Data-driven methods Battery management system Recurrent neural networks
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Band engineering of valleytronics WSe_(2)–MoS_(2)heterostructures via stacking form,magnetic moment and thickness
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作者 吴彦玮 张宗源 +5 位作者 马亮 刘涛 郝宁 吕文刚 龙明生 单磊 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第10期45-49,共5页
Spin-valley polarization and bandgap regulation are critical in the developing of quantum devices.Here,by employing the density functional theory,we investigate the effects of stacking form,thickness and magnetic mome... Spin-valley polarization and bandgap regulation are critical in the developing of quantum devices.Here,by employing the density functional theory,we investigate the effects of stacking form,thickness and magnetic moment in the electronic structures of WSe_(2)–MoS_(2)heterostructures.Calculations show that spin-valley polarization maintains in all situations.Increasing thickness of 2H-MoS_(2)not only tunes the bandgap but also changes the degeneracy of the conduction band minimums(CBM)at K/K_(1) points.Gradual increase of micro magnetic moment tunes the bandgap and raises the valence band maximums(VBM)atΓpoint.In addition,the regulation of band gap by the thickness of 2H-MoS_(2)and introduced magnetic moment depends on the stacking type.Results suggest that WSe_(2)–MoS_(2)heterostructure supports an ideal platform for valleytronics applications.Our methods also give new ways of optical absorption regulation in spin-valley devices. 展开更多
关键词 valleytronics thickness STACKING magnetic moment
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What’s next toward the bio-design and manufacturing field?Academic and humanistic interactions echo each other in BDMC2023
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作者 liang ma Huayong Yang 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2023年第6期735-741,共7页
This report provides a highlight of the third International Conference on Biomaterials,Bio-Design and Manufacturing(BDMC2023).BDMC2023,based on the journal of Bio-Design and Manufacturing(BDM)founded by Zhejiang Unive... This report provides a highlight of the third International Conference on Biomaterials,Bio-Design and Manufacturing(BDMC2023).BDMC2023,based on the journal of Bio-Design and Manufacturing(BDM)founded by Zhejiang University,was successfully held in Singapore on August 6–8,2023. 展开更多
关键词 journal BDM SINGAPORE
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Bio-manufacturing innovation lights up the future Report from the Second Bio-Design & Manufacturing Youth Forum
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作者 liang ma Huayong Yang 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2023年第2期204-215,共12页
Bio-manufacturing,a frontier interdisciplinary subject,is a promising field full of creative thinking and innovation[1].In order to create a platform for young scientists and students in the bio-manufacturing field to... Bio-manufacturing,a frontier interdisciplinary subject,is a promising field full of creative thinking and innovation[1].In order to create a platform for young scientists and students in the bio-manufacturing field to have a good chance of communication and discussion,based on the success of First Bio-Design&Manufacturing Youth Forum in 2021[2],the Second Bio-Design&Manufacturing Youth Forum chaired by the editor-in-chief Academician Huayong Yang and jointly sponsored by the journal of Bio-Design and Manufacturing,School of Mechanical Engineering,Zhejiang University and the State Key Laboratory of Fluid Power and Mechatronic Systems was successfully held in Hangzhou on November 19,2022.Ten prestigious young scientists were invited to deliver a speech on their own research both onsite and online。 展开更多
关键词 ACADEMICIAN lights jointly
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Revealing the key role of non-solvating diluents for fast-charging and low temperature Li-ion batteries 被引量:1
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作者 Yuping Zhang Siyin Li +8 位作者 Junkai Shi Jiawei Lai Ziyue Zhuang Jingwen Liu Wenming Yang liang ma Yue-Peng Cai Jijian Xu Qifeng Zheng 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第7期171-180,共10页
Fast-charging and low temperature operation are of vital importance for the further development of lithium-ion batteries(LIBs),which is hindered by the utilization of conventional carbonate-based electrolytes due to t... Fast-charging and low temperature operation are of vital importance for the further development of lithium-ion batteries(LIBs),which is hindered by the utilization of conventional carbonate-based electrolytes due to their slow kinetics,narrow operating temperature and voltage range.Herein,an acetonitrile(AN)-based localized high-concentration electrolyte(LHCE)is proposed to retain liquid state and high ionic conductivity at ultra-low temperatures while possessing high oxidation stability.We originally reveal the excellent thermal shielding effect of non-solvating diluent to prevent the aggregation of Li^(+) solvates as temperature drops,maintaining the merits of fast Li transport and facile desolvation as at room temperature,which bestows the graphite electrode with remarkable low temperature performance(264 mA h g^(-1) at-20 C).Remarkably,an extremely high capacity retention of 97%is achieved for high-voltage high-energy graphite||NCM batteries after 250 cycles at-20 C,and a high capacity of 110 mA h g^(-1)(71%of its room-temperature capacity)is retained at-30°C.The study unveils the key role of the non-solvating diluents and provides instructive guidance in designing electrolytes towards fast-charging and low temperature LIBs. 展开更多
关键词 Li-ion battery Fast-charging Low temperature Non-solvating diluent Shielding effect
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Calcium-chelating peptides from rabbit bone collagen:characterization,identification and mechanism elucidation 被引量:1
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作者 Fuhuan Yuan Yu Fu +8 位作者 liang ma Hankun Zhu Yong Yu Xin Feng Yi Sun Hongjie Dai Xin Liu Zhengfang Liu Yuhao Zhang 《Food Science and Human Wellness》 SCIE CSCD 2024年第3期1485-1493,共9页
This study aimed to characterize and identify calcium-chelating peptides from rabbit bone collagen and explore the underlying chelating mechanism.Collagen peptides and calcium were extracted from rabbit bone by instan... This study aimed to characterize and identify calcium-chelating peptides from rabbit bone collagen and explore the underlying chelating mechanism.Collagen peptides and calcium were extracted from rabbit bone by instant ejection steam explosion(ICSE)combined with enzymatic hydrolysis,followed by chelation reaction to prepare rabbit bone peptide-calcium chelate(RBCP-Ca).The chelating sites were further analyzed by liquid chromatography-tandem mass(LC-MS/MS)spectrometry while the chelating mechanism and binding modes were investigated.The structural characterization revealed that RBCP successfully chelated with calcium ions.Furthermore,LC-MS/MS analysis indicated that the binding sites included both acidic amino acids(Asp and Glu)and basic amino acids(Lys and Arg),Interestingly,three binding modes,namely Inter-Linking,Loop-Linking and Mono-Linking were for the first time found,while Inter-Linking mode accounted for the highest proportion(75.1%),suggesting that chelation of calcium ions frequently occurred between two peptides.Overall,this study provides a theoretical basis for the elucidation of chelation mechanism of calcium-chelating peptides. 展开更多
关键词 Rabbit bone Collagen peptide Peptide-calcium chelate Chelation mechanism Liquid chromatography-tandem mass(LC-MS/MS)
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Cracking on a nickel-based superalloy fabricated by direct energy deposition
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作者 Xue Zhang Ya-hang Mu +4 位作者 liang ma Jing-jing liang Yi-zhou Zhou Xiao-feng Sun Jin-guo Li 《China Foundry》 SCIE EI CAS CSCD 2024年第4期311-318,共8页
Cracks have consistently been a significant challenge limiting the development of additive manufactured nickel-based superalloys.It is essential to investigate the location of cracks and their forming mechanism.This s... Cracks have consistently been a significant challenge limiting the development of additive manufactured nickel-based superalloys.It is essential to investigate the location of cracks and their forming mechanism.This study extensively examines the impact of solidification process,microstructural evolution,and stress concentration on crack initiation during direct energy deposition(DED).The results emphasize that the crack formation is significantly related to large-angle grain boundaries,rapid cooling rates.Cracks caused by large-angle grain boundaries and a fast-cooling rate predominantly appear near the edge of the deposited samples.Liquation cracks are more likely to form near the top of the deposited sample,due to the presence ofγ/γ'eutectics.The secondary dendritic arm and the carbides in the interdendritic regions can obstruct liquid flow during the final stage of solidification,which results in the formation of solidification cracks and voids.This work paves the way to avoid cracks in nickel-based superalloys fabricated by DED,thereby enhancing the performance of superalloys. 展开更多
关键词 LOCATION cracks direct energy deposition nickel-based superalloys
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Appropriate treatment strategies improve survival of hepatocellular carcinoma patients with portal vein tumor thrombus 被引量:34
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作者 Jia-Zhou Ye Yong-Quan Zhang +4 位作者 Hai-Hong Ye Tao Bai liang ma Bang-De Xiang Le-Qun Li 《World Journal of Gastroenterology》 SCIE CAS 2014年第45期17141-17147,共7页
AIM: To evaluate the survival benefits of different treatment strategies for hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) and to determine the prognosis factors.
关键词 Hepatocellular carcinoma Portal vein tumor thrombosis Conservative treatment Transarterial chemoembolization Surgical resection Postoperative transarterial chemoembolization
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Comprehensive treatments for hepatocellular carcinoma with tumor thrombus in major portal vein 被引量:16
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作者 Hai-Hong Ye Jia-Zhou Ye +9 位作者 Zhi-Bo Xie Yu-Chong Peng Jie Chen liang ma Tao Bai Jun-Ze Chen Zhan Lu Hong-Gui Qin Bang-De Xiang Le-Qun Li 《World Journal of Gastroenterology》 SCIE CAS 2016年第13期3632-3643,共12页
AIM: To evaluate the efficacy of transcatheter arterial chemoembolisation (TACE) compared with surgical intervention and sorafenib for treatment of hepatocellular carcinoma (HCC) in patients with tumor thrombus extend... AIM: To evaluate the efficacy of transcatheter arterial chemoembolisation (TACE) compared with surgical intervention and sorafenib for treatment of hepatocellular carcinoma (HCC) in patients with tumor thrombus extending to the main portal vein.METHODS: From 2009 to 2013, a total of 418 HCC patients with tumor thrombus extending to the main portal vein were enrolled in this study and divided into four groups. These groups underwent different treatments as follows: TACE (n = 307), surgical intervention (n = 54), sorafenib (n = 15) and palliative treatment (n = 42). Overall survival rates were determined by Kaplan-Meier method, and differences between the groups were identified through log-rank analysis. Cox&#x02019;s proportional hazard model was used to identify the risk factors for survival.RESULTS: The mean survival periods for patients in the TACE, surgical intervention, sorafenib and palliative treatment groups were 10.39, 4.13, 5.54 and 2.82 mo, respectively. For the TACE group, the 3-, 6-, 12- and 24-mo survival rates were 94.1%, 85.9%, 51.5% and 0.0%, respectively. The corresponding rates were 60.3%, 22.2%, 0.0% and 0.0% for the surgical intervention group and 50.9%, 29.5%, 0.0% and 0.0% for the sorafenib group. Evidently, the results in the TACE group were significantly higher than those in the other groups (P &#x0003c; 0.0001). Furthermore, no significant difference among survival rates was observed between TACE with/without sorafenib (10.22 mo vs 10.52 mo, P = 0.615). No significant difference in survival rates was also found among the surgical intervention, sorafenib and palliative treatment groups (P &#x0003e; 0.05). These values significantly increased after TACE with/without sorafenib compared with other treatments (P &#x0003c; 0.05).CONCLUSION: For HCC patients with tumor thrombus extending to the main portal vein, TACE can yield a higher survival rate than surgical intervention or sorafenib treatment. 展开更多
关键词 Hepatocellular carcinoma Portal vein Tumor thrombus SORAFENIB Transcatheter arterial chemoembolisation Surgery
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3D Bioprinting:A Novel Avenue for Manufacturing Tissues and Organs 被引量:10
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作者 Bin Zhang Lei Gao +3 位作者 liang ma Yichen Luo Huayong Yang Zhanfeng Cui 《Engineering》 SCIE EI 2019年第4期777-794,共18页
Three-dimensional(3D)bioprinting is a rapidly growing technology that has been widely used in tissue engineering,disease studies,and drug screening.It provides the unprecedented capacity of depositing various types of... Three-dimensional(3D)bioprinting is a rapidly growing technology that has been widely used in tissue engineering,disease studies,and drug screening.It provides the unprecedented capacity of depositing various types of biomaterials,cells,and biomolecules in a layer-by-layer fashion,with precisely controlled spatial distribution.This technology is expected to address the organ-shortage issue in the future.In this review,we first introduce three categories of 3D bioprinting strategies:inkjet-based printing(IBP),extrusion-based printing(EBP),and light-based printing(LBP).Biomaterials and cells,which are normally referred to as“bioinks,”are then discussed.We also systematically describe the recent advancements of 3D bioprinting in fabricating cell-laden artificial tissues and organs with solid or hollow structures,including cartilage,bone,skin,muscle,vascular network,and so on.The development of organs-onchips utilizing 3D bioprinting technology for drug discovery and toxicity testing is reviewed as well.Finally,the main challenges in current studies and an outlook of the future research of 3D bioprinting are discussed. 展开更多
关键词 Three-dimensional BIOPRINTING Solid TISSUES HOLLOW TISSUES Organs-on-chips Tissue engineering Drug screening
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Antiviral therapy for hepatitis B virus-related hepatocellular carcinoma after radical hepatectomy 被引量:11
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作者 Yang Ke liang ma +4 位作者 Xue-Mei You Sheng-Xin Huang Yong-Rong liang Bang-De Xiang Le-Qun Li 《Cancer Biology & Medicine》 SCIE CAS CSCD 2013年第3期158-164,共7页
Objective: To assess the effect of antiviral therapy for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after radical hepatectomy. Methods: A total of 478 HBV-related HCC patients treated by radi... Objective: To assess the effect of antiviral therapy for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after radical hepatectomy. Methods: A total of 478 HBV-related HCC patients treated by radical hepatectomy were retrospectively collected. Patients in the treatment group (n=141) received postoperative lamivudine treatment (100 rag/d), whereas patients in the control group (n=337) did not. Recurrence-free survival (RFS) rates, overall survival (OS) rates, treatments for recurrent HCC and cause of death were compared between the two groups. Propensity score matching (PSM) analysis was also conducted to reduce confounding bias between the two groups. Results: The 1-, 3-, and 5-year RFS rates didn't significantly differ between the two groups (P=0.778); however, the 1-, 3-, and 5-year OS rates in the treatment group were significantly higher than those in the control group (P=0.002). Similar results were observed in the matched data. Subgroup analysis showed that antiviral treatment conferred a significant survival benefit for Barcelona Clinical Liver Cancer stage A/B patients. Following HCC recurrence, more people in the treatment group were able to choose curative treatments than those in the control group (P=0.031). For cause of death, fewer people in the treatment group died of liver failure than those in the control group (P=0.041). Conclusion: Postoperative antiviral therapy increases chances of receiving curative treatments for recurrent HCC and prevents death because of liver failure, thereby significantly prolonging OS, especially in early- or intermedian-stage tumors. 展开更多
关键词 Antiviral therapy hepatocellular carcinoma propensity score matching recurrence-free survival rate
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Single-Crystalline In Ga As Nanowires for Room-Temperature High-Performance Near-Infrared Photodetectors 被引量:7
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作者 Huang Tan Chao Fan +8 位作者 liang ma Xuehong Zhang Peng Fan Yankun Yang Wei Hu Hong Zhou Xiujuan Zhuang Xiaoli Zhu Anlian Pan 《Nano-Micro Letters》 SCIE EI CAS 2016年第1期29-35,共7页
In Ga As is an important bandgap-variable ternary semiconductor which has wide applications in electronics and optoelectronics. In this work, single-crystal In Ga As nanowires were synthesized by a chemical vapor depo... In Ga As is an important bandgap-variable ternary semiconductor which has wide applications in electronics and optoelectronics. In this work, single-crystal In Ga As nanowires were synthesized by a chemical vapor deposition method.Photoluminescence measurements indicate the In Ga As nanowires have strong light emission in near-infrared region. For the first time, photodetector based on as-grown In Ga As nanowires was also constructed. It shows good light response over a broad spectral range in infrared region with responsivity of 6.5×10~3 AW^(-1) and external quantum efficiency of 5.04×10~5%. This photodetector may have potential applications in integrated optoelectronic devices and systems. 展开更多
关键词 INGAAS NANOWIRE NEAR-INFRARED PHOTODETECTOR
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Efficacy of hepatic resection vs transarterial chemoembolization for solitary huge hepatocellular carcinoma 被引量:6
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作者 Shao-liang Zhu Jian-Hong Zhong +3 位作者 Yang Ke liang ma Xue-Mei You Le-Qun Li 《World Journal of Gastroenterology》 SCIE CAS 2015年第32期9630-9637,共8页
AIM: To compare the efficacy of hepatic resection(HR) and transarterial chemoembolization(TACE) for patients with solitary huge(≥ 10 cm) hepatocellular carcinoma(HCC).METHODS: Records were retrospectively analyzed of... AIM: To compare the efficacy of hepatic resection(HR) and transarterial chemoembolization(TACE) for patients with solitary huge(≥ 10 cm) hepatocellular carcinoma(HCC).METHODS: Records were retrospectively analyzed of 247 patients with solitary huge HCC, comprising 180 treated by HR and 67 by TACE. Long-term overall survival(OS) was compared between the two groups using the Kaplan-Meier method, and independent predictors of survival were identified by multivariate analysis. These analyses were performed using all patients in both groups and/or 61 pairs of propensity score-matched patients from the two groups. RESULTS: OS at 5 years was significantly higher in the HR group than the TACE group, across all patients(P = 0.002) and across propensity score-matchedpairs(36.4% vs 18.2%, P = 0.039). The two groups showed similar postoperative mortality and morbidity. Multivariate analysis identified alpha-fetoprotein ≥ 400 ng/m L, presence of vascular invasion and TACE treatment as independent predictors of poor OS.CONCLUSION: Our findings suggest that HR can be safe and more effective than TACE for patients with solitary huge HCC. 展开更多
关键词 HEPATIC RESECTION Transarterial CHEMOEMBOLIZATION
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One-dimensional microstructure-assisted intradermal and intracellular delivery 被引量:4
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作者 Wensen Jiang liang ma Xiaobin Xu 《Bio-Design and Manufacturing》 SCIE CSCD 2019年第1期24-30,共7页
The advancement in the materials manufacturing at micrometer and nanometer scales has already enabled numerous applications in electronics, optics, chemistry, biology and medicine. Biomedical devices carrying micro-/n... The advancement in the materials manufacturing at micrometer and nanometer scales has already enabled numerous applications in electronics, optics, chemistry, biology and medicine. Biomedical devices carrying micro-/nanostructures are currently being widely used in drug delivery, drug release, biosensing and therapy. New clinical methods for disease diagnosis and treatments are being developed enabled by nanotech no logy. One-dimensional (ID) structures are playi ng an importa nt role in the direct drug delivery both in vivo and ex vivo among various micro-/nanostructures. Here, in this paper, we reviewed recent progresses made on next-generation intradermal and intracellular delivery strategies and applications with focus on ID microstructure-based approaches. 展开更多
关键词 BIOMEDICAL devices INTRADERMAL INTRACELLULAR ID NANOSTRUCTURE DRUG delivery
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The Phoebe genome sheds light on the evolution of magnoliids 被引量:4
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作者 Shi-Pin Chen Wei-Hong Sun +17 位作者 Yuan-Fang Xiong Yu-Ting Jiang Xue-Die Liu Xing-Yu Liao Di-Yang Zhang Shu-Zhen Jiang Yu Li Bin Liu liang ma Xia Yu Li He Bao Liu Jin-Lin Feng Li-Zhen Feng Zhi-Wen Wang Shuang-Quan Zou Si-Ren Lan Zhong-Jian Liu 《Horticulture Research》 SCIE 2020年第1期876-888,共13页
Lauraceae includes the genus Phoebe,and the family is linked to the evolution of magnoliids.We sequenced the genome of Phoebe bournei Nanmu.The assembled genome size was 989.19 Mb,with a contig N50 value of 2.05 Mb.A ... Lauraceae includes the genus Phoebe,and the family is linked to the evolution of magnoliids.We sequenced the genome of Phoebe bournei Nanmu.The assembled genome size was 989.19 Mb,with a contig N50 value of 2.05 Mb.A total of 28,198 protein-coding genes were annotated in P.bournei.Whole-genome duplication(WGD)analysis showed that Lauraceae has experienced two WGD events;the older WGD event occurred just before the divergence of Lauraceae and Magnoliales,and the more recent WGD was shared by all lineages of Lauraceae.The phylogenetic tree showed that magnoliids form a sister clade to monocots and eudicots.We also identified 63 MADS-box genes,including AGL12-like genes that may be related to the regulation of P.bournei roots and FIN219-like genes encoding GH3 proteins,which are involved in photomorphogenesis.SAUR50-like genes involved in light signal-mediated pedicel or stem development were also identified.Four ATMYB46-and three PtrEPSP-homologous genes related to lignin biosynthesis were identified.These genes may be associated with the formation of straight trunks in P.bournei.Overall,the P.bournei reference genome provides insight into the origin,evolution,and diversification of Phoebe and other magnoliids. 展开更多
关键词 WHOLE EVOLUTION LIGHT
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Antiviral therapy for hepatitis B virus-related hepatocellular carcinoma after surgery: A comment for moving forward 被引量:2
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作者 Jian-Hong Zhong Tian Yang +2 位作者 Bang-De Xiang Le-Qun Li liang ma 《World Journal of Hepatology》 CAS 2016年第13期605-606,共2页
Recurrence rate of hepatocellular carcinoma remains quite high even after surgery,and no postoperative therapies have been definitively shown to prevent hepatocellular carcinoma recurrence.A previous study showed that... Recurrence rate of hepatocellular carcinoma remains quite high even after surgery,and no postoperative therapies have been definitively shown to prevent hepatocellular carcinoma recurrence.A previous study showed that therapy with nucleos(t)ide analogues given to such patients after surgery significantly improved survival.However,many questions still exist about the usage of nucleos(t)ide analogues for patients with hepatocellular carcinoma after surgery. 展开更多
关键词 ANTIVIRAL therapy HEPATOCELLULAR carcinoma HEPATITIS B virus Unanswered QUESTION
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Manipulating Interfacial Stability Via Absorption-Competition Mechanism for Long-Lifespan Zn Anode 被引量:2
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作者 Meijia Qiu liang ma +3 位作者 Peng Sun Zilong Wang Guofeng Cui Wenjie mai 《Nano-Micro Letters》 SCIE EI CAS CSCD 2022年第2期161-173,共13页
The stability of Zn anode in various Znbased energy storage devices is the key problem to be solved.Herein,aromatic aldehyde additives are selected to modulate the interface reactions between the Zn anode and electrol... The stability of Zn anode in various Znbased energy storage devices is the key problem to be solved.Herein,aromatic aldehyde additives are selected to modulate the interface reactions between the Zn anode and electrolyte.Through comprehensively considering electrochemical measurements,DFT calculations and FEA simulations,novel mechanisms of one kind of aromatic aldehyde,veratraldehyde in inhibiting Zn dendrite/by-products can be obtained.This additive prefers to absorb on the Zn surface than H_(2)O molecules and Zn^(2+),while competes with hydrogen evolution reaction and Zn plating/stripping proces s via redox reactions,thus preventing the decomposition of active H_(2)O near the interface and uncontrollable Zn dendrite growth via a synactic absorption-competition mechanism.As a result,Zn-Zn symmetric cells with the veratraldehyde additive realize an excellent cycling life of 3200 h under 1 mA cm^(-2)/1 mAh cm^(-2)and over 800 h even under 5 mA cm^(-2)/5 mAh cm^(-2).Moreover,Zn-Ti and Zn-MnO_(2)cells with the veratraldehyde additive both obtain elevated performance than that with pure ZnSO_(4)electrolyte.Finally,two more aromatic aldehyde additives are chosen to prove their universality in stabilizing Zn anodes. 展开更多
关键词 Aromatic aldehyde Absorption-competition mechanism Zn anode Interfacial stability
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