目的对成年癌症患者决策辅助工具应用体验进行系统整合,为开发我国本土化决策辅助工具、实现共享决策提供循证指导。方法计算机检索PubMed、Cochrane Library、CINAHL、Embase、Web of Science、ProQuest、中国知网、万方数据库、维普...目的对成年癌症患者决策辅助工具应用体验进行系统整合,为开发我国本土化决策辅助工具、实现共享决策提供循证指导。方法计算机检索PubMed、Cochrane Library、CINAHL、Embase、Web of Science、ProQuest、中国知网、万方数据库、维普网、中国生物医学文献数据库中关于癌症患者决策辅助工具应用体验的质性研究,检索时限为建库至2023年7月。采用JBI循证卫生保健中心质性研究质量评价标准(2020)进行文献质量评价,以Meta整合方法对文献研究结果进行整合。结果纳入17篇文献,提炼出50个研究结果,归纳出7个类别,最终形成3个整合结果:患者对决策辅助工具总体满意度较高、增强患者决策参与体验、阻碍因素。结论决策辅助工具可以帮助癌症患者了解治疗方案并积极参与决策,满足患者的决策需求,缓解决策冲突,从而改善患者的临床结局。展开更多
导管相关性血栓形成是外周置入中心静脉导管(peripherally inserted central catheter,PICC)留置期间最常见的并发症之一,严重时可导致非计划性拔管而影响患者的治疗进程,甚至威胁患者的生命安全。握力训练作为预防PICC相关性血栓形成...导管相关性血栓形成是外周置入中心静脉导管(peripherally inserted central catheter,PICC)留置期间最常见的并发症之一,严重时可导致非计划性拔管而影响患者的治疗进程,甚至威胁患者的生命安全。握力训练作为预防PICC相关性血栓形成的常用干预方法之一,具有有效性和实用性,但在临床实践中由于缺乏科学化、规范化、精准化训练方案的指导,患者训练依从性及其干预效果参差不齐。该文对PICC相关性血栓形成的发生机制、常用握力训练方法及局限性进行总结分析,以期为临床更好地实施握力训练干预提供参考。展开更多
目的对系统性红斑狼疮患者疾病体验进行系统整合,为制订以系统性红斑狼疮患者心理体验为导向的健康管理方案提供循证依据。方法计算机检索PubMed、Cochrane Library、CINAHL、Embase、Web of Science、ProQuest、中国知网、万方数据库...目的对系统性红斑狼疮患者疾病体验进行系统整合,为制订以系统性红斑狼疮患者心理体验为导向的健康管理方案提供循证依据。方法计算机检索PubMed、Cochrane Library、CINAHL、Embase、Web of Science、ProQuest、中国知网、万方数据库、维普网、中国生物医学文献数据库中关于系统性红斑狼疮患者心理体验的质性研究,检索时限为自建库至2023年7月。采用澳大利亚乔安娜布里格斯研究所循证卫生保健中心质性研究质量评价标准(2020)进行文献质量评价,以Meta整合方法对文献研究结果进行整合。结果共纳入13篇文献,提炼出48个研究结果,归纳出8个类别,最终形成"负性心理体验""疾病需求增加""主动调节策略"3个整合结果。结论医护人员应重视系统性红斑狼疮患者在患病过程中的身心感受,在临床实践中针对性地给予患者科学、有效的干预策略,缓解其负性情绪,改善患者生活质量。展开更多
OBJECTIVE:To observe the effect of pressing auricular points on myopia in children.METHODS:Myopic children aged 8-9 years were divided into two groups.The Chinese herb Semen Vaccariae was used to stimulate the auricul...OBJECTIVE:To observe the effect of pressing auricular points on myopia in children.METHODS:Myopic children aged 8-9 years were divided into two groups.The Chinese herb Semen Vaccariae was used to stimulate the auricular points of CO_(10),LO_5,TF_4,CO_(15),CO_(12),and CO_(13) for three treatment courses for the experimental group(n =39),while the same therapy was not given to the control group(n = 33).Binocular naked vision of the experimental group and the control group before and after the intervention was measured using a standard E visual acuity chart.RESULTS:There was no difference in the binocular naked vision between the experimental group and the control group before the intervention.In contrast,there was significant improvement in binocular naked vision in the experimental group after the intervention compared with the control group(P <0.05).CONCLUSION:When combined with external medical application,non-invasive auricular therapy could improve the function of myopia in children.Auricular pressing was well received by the children.展开更多
OBJECTIVE: We wished to study the impact of Chaihushugan San(CSS) on the behavior of perimenopausal rats with liver-Qi stagnation(LQS) and to investigate the effect of CSS on signal transduction of the Raf/mitogen-act...OBJECTIVE: We wished to study the impact of Chaihushugan San(CSS) on the behavior of perimenopausal rats with liver-Qi stagnation(LQS) and to investigate the effect of CSS on signal transduction of the Raf/mitogen-activated protein kinase(MEK)/extracellular signal-regulated kinase(ERK) cascade in the hippocampi of rats induced by immobilization.METHODS: Twenty 52-week-old female rats were divided into two groups by the random number table method: model control group(MCG) and CSS group(CSSG), with 10 rats in each group.Ten-week-old female rats were used as the normal control group(NCG). CSS effects were assessed using rats exposed to immobilization stress by measuring body weight and sucrose consumption, serum hormone levels, and observing performance in the open field test(OFT). Molecular mechanisms were examined by measuring the effect of CSS on expression of Raf1, MEK1/2 and ERK1/2 m RNA in hippocampi using quantitative real-time polymerase chain reaction and by measuring levels of these proteins and related phospho-proteins using Western blotting.RESULTS: Perimenopausal rats with LQS had decreased locomotor activity; reduced sucrose consumption; and increased serum levels of corticotropin releasing hormone(CRH) and corticosterone(CORT). Activation of hippocampal Raf/MEK/ERK cascade was suppressed significantly in the MCG,and activation was increased after 21 days of CSS treatment.CONCLUSION: CSS has significant effects upon relief of the symptoms of LQS in immobilization-induced rats. The mechanism underlying this action might(at least in part) be mediated by reversal of disruption of the Raf/MEK/ERK pathway.展开更多
文摘目的对成年癌症患者决策辅助工具应用体验进行系统整合,为开发我国本土化决策辅助工具、实现共享决策提供循证指导。方法计算机检索PubMed、Cochrane Library、CINAHL、Embase、Web of Science、ProQuest、中国知网、万方数据库、维普网、中国生物医学文献数据库中关于癌症患者决策辅助工具应用体验的质性研究,检索时限为建库至2023年7月。采用JBI循证卫生保健中心质性研究质量评价标准(2020)进行文献质量评价,以Meta整合方法对文献研究结果进行整合。结果纳入17篇文献,提炼出50个研究结果,归纳出7个类别,最终形成3个整合结果:患者对决策辅助工具总体满意度较高、增强患者决策参与体验、阻碍因素。结论决策辅助工具可以帮助癌症患者了解治疗方案并积极参与决策,满足患者的决策需求,缓解决策冲突,从而改善患者的临床结局。
文摘导管相关性血栓形成是外周置入中心静脉导管(peripherally inserted central catheter,PICC)留置期间最常见的并发症之一,严重时可导致非计划性拔管而影响患者的治疗进程,甚至威胁患者的生命安全。握力训练作为预防PICC相关性血栓形成的常用干预方法之一,具有有效性和实用性,但在临床实践中由于缺乏科学化、规范化、精准化训练方案的指导,患者训练依从性及其干预效果参差不齐。该文对PICC相关性血栓形成的发生机制、常用握力训练方法及局限性进行总结分析,以期为临床更好地实施握力训练干预提供参考。
文摘目的对系统性红斑狼疮患者疾病体验进行系统整合,为制订以系统性红斑狼疮患者心理体验为导向的健康管理方案提供循证依据。方法计算机检索PubMed、Cochrane Library、CINAHL、Embase、Web of Science、ProQuest、中国知网、万方数据库、维普网、中国生物医学文献数据库中关于系统性红斑狼疮患者心理体验的质性研究,检索时限为自建库至2023年7月。采用澳大利亚乔安娜布里格斯研究所循证卫生保健中心质性研究质量评价标准(2020)进行文献质量评价,以Meta整合方法对文献研究结果进行整合。结果共纳入13篇文献,提炼出48个研究结果,归纳出8个类别,最终形成"负性心理体验""疾病需求增加""主动调节策略"3个整合结果。结论医护人员应重视系统性红斑狼疮患者在患病过程中的身心感受,在临床实践中针对性地给予患者科学、有效的干预策略,缓解其负性情绪,改善患者生活质量。
基金the Research Project of the State Administration of Traditional Chinese Medicine(Evaluation on Treatment of Teenagers with Four-section Therapy,No.ZZ03116)
文摘OBJECTIVE:To observe the effect of pressing auricular points on myopia in children.METHODS:Myopic children aged 8-9 years were divided into two groups.The Chinese herb Semen Vaccariae was used to stimulate the auricular points of CO_(10),LO_5,TF_4,CO_(15),CO_(12),and CO_(13) for three treatment courses for the experimental group(n =39),while the same therapy was not given to the control group(n = 33).Binocular naked vision of the experimental group and the control group before and after the intervention was measured using a standard E visual acuity chart.RESULTS:There was no difference in the binocular naked vision between the experimental group and the control group before the intervention.In contrast,there was significant improvement in binocular naked vision in the experimental group after the intervention compared with the control group(P <0.05).CONCLUSION:When combined with external medical application,non-invasive auricular therapy could improve the function of myopia in children.Auricular pressing was well received by the children.
基金Supported by the National Natural Sciences Foundations of China(Study on the Molecular Mechanism of Formation of Liver-Qi Stagnation in Perimenopausal Syndrome Based on the Neuroendocrine Axis and Ras/Raf/MEK/ERK Pathway,No.81302889Study on the Mechanism of Liver-Qi Stagnation in Perimenopausal Syndrome Based on "Women Easily Qi-Stagnated" and Ca2+/Camp Pathway Mediated by the Estrogen Receptor,No.81173203)
文摘OBJECTIVE: We wished to study the impact of Chaihushugan San(CSS) on the behavior of perimenopausal rats with liver-Qi stagnation(LQS) and to investigate the effect of CSS on signal transduction of the Raf/mitogen-activated protein kinase(MEK)/extracellular signal-regulated kinase(ERK) cascade in the hippocampi of rats induced by immobilization.METHODS: Twenty 52-week-old female rats were divided into two groups by the random number table method: model control group(MCG) and CSS group(CSSG), with 10 rats in each group.Ten-week-old female rats were used as the normal control group(NCG). CSS effects were assessed using rats exposed to immobilization stress by measuring body weight and sucrose consumption, serum hormone levels, and observing performance in the open field test(OFT). Molecular mechanisms were examined by measuring the effect of CSS on expression of Raf1, MEK1/2 and ERK1/2 m RNA in hippocampi using quantitative real-time polymerase chain reaction and by measuring levels of these proteins and related phospho-proteins using Western blotting.RESULTS: Perimenopausal rats with LQS had decreased locomotor activity; reduced sucrose consumption; and increased serum levels of corticotropin releasing hormone(CRH) and corticosterone(CORT). Activation of hippocampal Raf/MEK/ERK cascade was suppressed significantly in the MCG,and activation was increased after 21 days of CSS treatment.CONCLUSION: CSS has significant effects upon relief of the symptoms of LQS in immobilization-induced rats. The mechanism underlying this action might(at least in part) be mediated by reversal of disruption of the Raf/MEK/ERK pathway.
