Programmed cell death(PCD)is mediated by specific genes that encode signals.It can balance cell survival and death.Pyroptosis is a type of inflammatory,caspase-dependent PCD mediated by gasdermin proteins,which functi...Programmed cell death(PCD)is mediated by specific genes that encode signals.It can balance cell survival and death.Pyroptosis is a type of inflammatory,caspase-dependent PCD mediated by gasdermin proteins,which function in pore formation,cell expansion,and plasma membrane rupture,followed by the release of intracellular contents.Pyroptosis is mediated by caspase-1/3/4/5/11 and is primarily divided into the classical pathway,which is dependent on caspase-1,and the non-classical pathway,which is dependent on caspase-4/5/11.Inflam-masomes play a vital role in these processes.The various components of the pyroptosis pathway are related to the occurrence,invasion,and metastasis of tumors.Research on pyroptosis has revealed new options for tumor treatment.This article summarizes the recent research progress on the molecular mechanism of pyroptosis,the relationship between the various components of the pyroptosis pathway and cancer,and the applications and prospects of pyroptosis in anticancer therapy.展开更多
Natural gas hydrate is estimated to have huge reserves. Its exploitation can solve the global oil and gas shortage problem. Hydrates decompose into water and methane, and methane molecules are supersaturated to form n...Natural gas hydrate is estimated to have huge reserves. Its exploitation can solve the global oil and gas shortage problem. Hydrates decompose into water and methane, and methane molecules are supersaturated to form nanobubbles.Methane nanobubbles can affect the decomposition efficiency of hydrates. They can provide abundant methane sources for the re-nucleation of hydrates. Molecular dynamics is employed in this study to investigate the decomposition process of type I methane hydrate and the formation of methane nanobubbles generated during decomposition under different methane mole fraction, pressures, and temperatures. The results indicate that external pressure inhibits the diffusion of methane molecules, thereby preventing the formation of nanobubbles. A higher mole fraction of methane molecules in the system requires a higher external pressure to generate stable nanobubbles after the decomposition of the hydrate structure.At 330 K, it is easy to form a nanobubble structure. Results of this study can help provide ideas for the study of efficient extraction and secondary nucleation of hydrates.展开更多
Intelligent reflecting surface(IRS)has been widely regarded as a promising technology for configuring wireless propagation environments.In this paper,we utilize IRS to assist transmission of a secondary user(SU)in a c...Intelligent reflecting surface(IRS)has been widely regarded as a promising technology for configuring wireless propagation environments.In this paper,we utilize IRS to assist transmission of a secondary user(SU)in a cognitive radio-inspired rate-splitting multiple access(CR-RSMA)system in which a primary user's(PU's)quality of service(QoS)requirements must be guaranteed.Without introducing intolerable interference to deteriorate the PU's outage performance,the SU conducts rate-splitting to transmit its signal to the base-station through the direct link and IRS reflecting channels.For the IRS-assisted CR-RSMA(IRS-CR-RSMA)scheme,we derive the optimal transmit power allocation,target rate allocation,and successive interference cancellation decoding order to enhance the outage performance of the SU.The closed-form expression for the SU's outage probability achieved by the IRS-CR-RSMA scheme is derived.Various simulation results are presented to clarify the enhanced outage performance achieved by the proposed IRS-CR-RSMA scheme over the CR-RSMA scheme.展开更多
The VOF method is used to simulate the dynamics of a droplet interacting with a structure consisting of an array of microcolumns mounted on a flat surface.Such a specific configuration is intended to mimic the typical...The VOF method is used to simulate the dynamics of a droplet interacting with a structure consisting of an array of microcolumns mounted on a flat surface.Such a specific configuration is intended to mimic the typical properties of lotus leaves,which typically display regularly arranged micron-scale papillary structures.After setting the initial velocity of the simulated droplet on the basis of practical considerations,an analysis is conducted about the effect of the characteristic size of the microstructure on the apparent contact angle.The pressure variation in the microstructure caves is also examined.The simulation results show that the change of the contact angle of the droplet in the quasi-static state is consistent with theoretical calculations and the contact angle in the dynamic state is smaller than that in the quasi-static state.Moreover,under dynamic conditions,the pressure fluctuation in the microstructure cave depends essentially on the characteristic size of the microstructure.展开更多
Duplicated inferior vena cava with bilateral iliac vein compression is extremely rare.We report a case of an 87-year-old man presented with bilateral lower extremity swelling,who was noted to have duplicated inferior ...Duplicated inferior vena cava with bilateral iliac vein compression is extremely rare.We report a case of an 87-year-old man presented with bilateral lower extremity swelling,who was noted to have duplicated inferior vena cava,as revealed by computed tomography angiography(CTA).This revealed bilateral iliac vein compression caused by surrounding structures.Anticoagulant treatment combined with stent implantation completely alleviated this chronic debilitating condition during the follow-up of 2 months with no recurrence.展开更多
基金supported by the National Natural Science Foundation of China (Nos. 52071278, 51827801)the National Key Research and Development Program of China (No. 2018YFA0703603)。
文摘Programmed cell death(PCD)is mediated by specific genes that encode signals.It can balance cell survival and death.Pyroptosis is a type of inflammatory,caspase-dependent PCD mediated by gasdermin proteins,which function in pore formation,cell expansion,and plasma membrane rupture,followed by the release of intracellular contents.Pyroptosis is mediated by caspase-1/3/4/5/11 and is primarily divided into the classical pathway,which is dependent on caspase-1,and the non-classical pathway,which is dependent on caspase-4/5/11.Inflam-masomes play a vital role in these processes.The various components of the pyroptosis pathway are related to the occurrence,invasion,and metastasis of tumors.Research on pyroptosis has revealed new options for tumor treatment.This article summarizes the recent research progress on the molecular mechanism of pyroptosis,the relationship between the various components of the pyroptosis pathway and cancer,and the applications and prospects of pyroptosis in anticancer therapy.
基金supported by the specific research fund of the Innovation Platform for Academicians of Hainan Province of China and the Hainan Provincial Natural Science Foundation of China (Grant No. 519MS025)。
文摘Natural gas hydrate is estimated to have huge reserves. Its exploitation can solve the global oil and gas shortage problem. Hydrates decompose into water and methane, and methane molecules are supersaturated to form nanobubbles.Methane nanobubbles can affect the decomposition efficiency of hydrates. They can provide abundant methane sources for the re-nucleation of hydrates. Molecular dynamics is employed in this study to investigate the decomposition process of type I methane hydrate and the formation of methane nanobubbles generated during decomposition under different methane mole fraction, pressures, and temperatures. The results indicate that external pressure inhibits the diffusion of methane molecules, thereby preventing the formation of nanobubbles. A higher mole fraction of methane molecules in the system requires a higher external pressure to generate stable nanobubbles after the decomposition of the hydrate structure.At 330 K, it is easy to form a nanobubble structure. Results of this study can help provide ideas for the study of efficient extraction and secondary nucleation of hydrates.
基金supported in part by National Natural Science Foundation of China under Grant 62071202in part by Shandong Provincial Natural Science Foundation under Grants ZR2020MF009,ZR2020MF075in part by Shandong Key Laboratory of Intelligent Buildings Technology undert Grant SDIBT202004.
文摘Intelligent reflecting surface(IRS)has been widely regarded as a promising technology for configuring wireless propagation environments.In this paper,we utilize IRS to assist transmission of a secondary user(SU)in a cognitive radio-inspired rate-splitting multiple access(CR-RSMA)system in which a primary user's(PU's)quality of service(QoS)requirements must be guaranteed.Without introducing intolerable interference to deteriorate the PU's outage performance,the SU conducts rate-splitting to transmit its signal to the base-station through the direct link and IRS reflecting channels.For the IRS-assisted CR-RSMA(IRS-CR-RSMA)scheme,we derive the optimal transmit power allocation,target rate allocation,and successive interference cancellation decoding order to enhance the outage performance of the SU.The closed-form expression for the SU's outage probability achieved by the IRS-CR-RSMA scheme is derived.Various simulation results are presented to clarify the enhanced outage performance achieved by the proposed IRS-CR-RSMA scheme over the CR-RSMA scheme.
基金funding from the China Scholarship Council(CSC)and Basic Scientific Research Projects of Liaoning Provincial Department of Education:‘Design and manufacture of bionic antifogging surface of optical glass lens based on nanosecond laser’(LJKMZ20220827).Y received the grant.
文摘The VOF method is used to simulate the dynamics of a droplet interacting with a structure consisting of an array of microcolumns mounted on a flat surface.Such a specific configuration is intended to mimic the typical properties of lotus leaves,which typically display regularly arranged micron-scale papillary structures.After setting the initial velocity of the simulated droplet on the basis of practical considerations,an analysis is conducted about the effect of the characteristic size of the microstructure on the apparent contact angle.The pressure variation in the microstructure caves is also examined.The simulation results show that the change of the contact angle of the droplet in the quasi-static state is consistent with theoretical calculations and the contact angle in the dynamic state is smaller than that in the quasi-static state.Moreover,under dynamic conditions,the pressure fluctuation in the microstructure cave depends essentially on the characteristic size of the microstructure.
文摘Duplicated inferior vena cava with bilateral iliac vein compression is extremely rare.We report a case of an 87-year-old man presented with bilateral lower extremity swelling,who was noted to have duplicated inferior vena cava,as revealed by computed tomography angiography(CTA).This revealed bilateral iliac vein compression caused by surrounding structures.Anticoagulant treatment combined with stent implantation completely alleviated this chronic debilitating condition during the follow-up of 2 months with no recurrence.
