Fluoxetine Ameliorates the Aggravation of UC Symptoms in C57BL/6 Mice Induced by CUMS

Objective Patients with chronic ulcerative colitis(UC)often have mental symptoms such as depression and anxiety,and stress can lead to gastrointestinal diseases.However,the correlation between mental stress and UC is unclear.In this paper,chronic unpredictable mild stress(CUMS)was utilized to evaluate the involvement of mental factors in the pathogenesis of UC.Methods The CUMS model was used to evaluate the direct/indirect involvement of mental factors in the pathogenesis of UC.The behavior was evaluated by the open field,forced swimming,and tail suspension tests.Body weight,the disease activity index(DAI)score,colon length,and HE staining of colon tissue were used to evaluate the action of CUMS and fluoxetine.Results The results showed that weight loss and the DAI score increased in CUMS mice,but they had no meaningful effect on colon length and morphological structure of colon tissue.However,CUMS aggravated dextran sulfate sodium(DSS)-induced colon length shortening and colon morphological structure damage.Fluoxetine significantly improved the DAI score,shortened colon length,and damaged morphology and structure of the colons induced by CUMS combined with DSS in mice.Fluoxetine also decreased the level of IL-6 in the serum and the TNF-αand IFN-γlevels of colon tissue.Fluoxetine simultaneously improved behavioral abnormalities induced by CUMS combined with DSS in mice.Conclusion CUMS aggravated the UC symptoms induced by DSS,and fluoxetine could improve the UC symptoms due to its improvement in the inflammatory level and behavioral abnormalities.

Numerical simulation and optimized design of cased telescoped ammunition interior ballistic

In order to achieve the optimized design of a cased telescoped ammunition(CTA) interior ballistic design,a genetic algorithm was introduced into the optimal design of CTA interior ballistics with coupling the CTA interior ballistic model. Aiming at the interior ballistic characteristics of a CTA gun, the goal of CTA interior ballistic design is to obtain a projectile velocity as large as possible. The optimal design of CTA interior ballistic is carried out using a genetic algorithm by setting peak pressure, changing the chamber volume and gun powder charge density. A numerical simulation of interior ballistics based on a 35 mm CTA firing experimental scheme was conducted and then the genetic algorithm was used for numerical optimization. The projectile muzzle velocity of the optimized scheme is increased from 1168 m/s for the initial experimental scheme to 1182 m/s. Then four optimization schemes were obtained with several independent optimization processes. The schemes were compared with each other and the difference between these schemes is small. The peak pressure and muzzle velocity of these schemes are almost the same. The result shows that the genetic algorithm is effective in the optimal design of the CTA interior ballistics. This work will be lay the foundation for further CTA interior ballistic design.

Microstructure and properties of W-4.9Ni-2.1Fe heavy alloy with Dy2O3 addition

The W-4.9 Ni-2.1 Fe-xDy2 O3 heavy alloy was fabricated by high-energy ball milling and spark plasma sintering(SPS)technique,and the microstructure,mechanical and friction behavior and anti-corrosion ability were investigated by scanning electron microscope(SEM),Rockwell hardness tester,X-ray diffraction(XRD),reciprocating friction and wear tester,electrochemical station,etc.The results show that the trace Dy2 O3 particles,which mainly distributes in the W-M(tungsten-matrix)interface and the tungsten matrix phase,can dramatically decrease the tungsten grain size and the amount of O and P impurities aggregating in the interface,promote the γ-(Ni,Fe)bonding phase and tungsten particles uniform distribution,and increase the relative density,hardness,and wear and corrosion resistance properties.But the excessive Dy2 O3 addition can make the inhibition effect weaken,resulting in the decrease in the comprehensive performances of the alloy.So,the amount of Dy2 O3 should be appropriate.When the adding amount of Dy2 O3 particles is 0.7 wt%,the comprehensive performances of the heavy alloy are the best.