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Antioxidant and antiaging effect of traditional Thai rejuvenation medicines in Caenorhabditis elegans 被引量:1
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作者 Sutticha Ruangchuay Qiang-qiang wang +6 位作者 liang-yi wang Jing Lin Yong-chao wang Guo-huan Zhong Katesarin Maneenoon Ze-bo Huang Sasitorn Chusri 《Journal of Integrative Medicine》 SCIE CAS CSCD 2021年第4期362-373,共12页
Objective: This study explored the rejuvenation mechanisms of Thai polyherbal medicines using different approaches, including in vitro methods, as well as a well-defined nematode model, Caenorhabditis elegans.Methods:... Objective: This study explored the rejuvenation mechanisms of Thai polyherbal medicines using different approaches, including in vitro methods, as well as a well-defined nematode model, Caenorhabditis elegans.Methods: THP-R-SR012 decoction was selected from 23 polyherbal medicines, based on metal-chelating and chain-breaking antioxidant capacities. The influences of this extract on the survival and some stress biomarkers of C. elegans under paraquat-induced oxidative stress were evaluated. Furthermore, lifespan analysis and levels of lipofuscin accumulation were examined in senescent nematodes. The phytochemical profile of THP-R-SR012 was analyzed.Results: Supplementation with THP-R-SR012 decoction significantly increased the mean lifespan and reduced the oxidative damage to C. elegans under oxidative stress conditions. Further, THP-R-SR012 supplementation slightly influenced the lifespan and the level of lipofuscin accumulation during adulthood.Antioxidant-related phytochemical constituents of THP-R-SR012 decoction were rutin, naringenin, 3,4-dihydroxybenzoic acid, gallic acid, glycyrrhizic acid, demethoxycurcumin and 18 a-glycyrrhetinic acid.Conclusion: The antioxidant potential of THP-R-SR012 was due to its scavenging properties, its enhancement of antioxidant-related enzyme activities, and the presence of the antioxidant-related compound.These results support the traditional use of THP-R-SR012 decoction as a tonic for nourishing and strengthening the whole body. 展开更多
关键词 Antioxidants Caenorhabditis elegans Herbal formula Lifespan extension Rejuvenation medicine
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