阿帕替尼治疗难治性鼻咽癌的疗效和生存分析

目的:评价阿帕替尼治疗难治性鼻咽癌的疗效及安全性并探索预后不良因素。方法:回顾性分析2016年9月至2019年4月郑州大学第一附属医院接受阿帕替尼治疗66例难治性鼻咽癌患者资料,采用Kaplan-Meier法及Cox模型分析疗效及影响生存的相关因素。结果:阿帕替尼治疗难治性鼻咽癌的客观缓解率为33.33%,疾病控制率为54.55%。中位无进展生存时间(progression-free survival time,PFS)为7个月(95%CI:2.816~11.184),中位总生存时间(overall survival,OS)为20个月(95%CI:11.496~28.504)。评价66例患者不良反应,最常见的不良反应为蛋白尿40.90%(27/66)、高血压45.45%(30/66)、手足综合征37.88%(25/66),无4级不良反应发生;Cox单因素分析显示乳酸脱氢酶水平是PFS的影响因素,WHO病理类型是OS的影响因素。结论:难治性鼻咽癌应用阿帕替尼治疗可能具有一定疗效,不良反应可控制,对于依从性好、无其他有效治疗方案的难治性鼻咽癌患者可考虑选择,但仍需大样本前瞻性研究证实。

Aerodynamic Analysis and Simulation of Flapping Wing Aerial Vehicles on Hovering

In order to design and verify control algorithms for flapping wing aerial vehicles(FWAVs),calculation models of the translational force,rotational force and virtual mass force were established with the basis on the modified quasi-steady aerodynamic theory and high lift mechanisms of insect flight.The simulation results show that the rotational force and virtual mass force can be ignored in the hovering FWAVs with simple harmonic motions in a cycle.The effects of the wing deformation on aerodynamic forces were investigated by regarding the maximum rotational angle of wingtip as a reference variable.The simulation results also show that the average lift coefficient increases and drag coefficient decreases with the increase of the maximum rotational angle of wingtip in the range of 0-90°.