Charles Morris constructs his semiotics on the basis of scientific empiricism. The latter is the combination of three schools of thought, namely, formalism, empiricism and pragmatism. The former similarly consists of ...Charles Morris constructs his semiotics on the basis of scientific empiricism. The latter is the combination of three schools of thought, namely, formalism, empiricism and pragmatism. The former similarly consists of three parts, i.e., syntactics, semantics and pragmatics. The three philosophical schools of thought contribute to the three major components of Morris' s semiotics.展开更多
To repair the blood–brain barrier(BBB)after traumatic brain injury(TBI)remains a multidisciplinary challenge.No first-line drugs are available.Here,we reported a novel and non-toxic functional negative-charged carbon...To repair the blood–brain barrier(BBB)after traumatic brain injury(TBI)remains a multidisciplinary challenge.No first-line drugs are available.Here,we reported a novel and non-toxic functional negative-charged carbon dots(CDs)generated from green Semen pruni persicae and Carthamus tinctorius L.(TH-CDs)through a hydrothermal synthesis without any organic solvent.The surface of TH-CDs retained part functional groups of active pharmacophores from both drugs.TH-CDs could improve the neurological function,brain edema,neuronal damage,and the BBB permeability by tail vein injection of mice models without systemic toxicity.Furthermore,higher expression of tight junction proteins claudin 5 and ZO-1 was observed after TH-CDs administration,which may be due to the electrostatic interaction between TH-CDs and claudin 5.Our study highlights an inexpensive,green,non-toxic,and intravenous functional TH-CD,which represents a potential TBI treatment strategy.展开更多
文摘Charles Morris constructs his semiotics on the basis of scientific empiricism. The latter is the combination of three schools of thought, namely, formalism, empiricism and pragmatism. The former similarly consists of three parts, i.e., syntactics, semantics and pragmatics. The three philosophical schools of thought contribute to the three major components of Morris' s semiotics.
基金supported by the National Natural Science Foundation of China(No.81973665)the Science and Technology Innovation Program of Hunan Province(No.2021RC3030)+1 种基金the Fundamental Research Funds for the Central Universities of Central South University(No.2021zzts1028)the InnovationDriven Project of Central South University(No.2020CX047).
文摘To repair the blood–brain barrier(BBB)after traumatic brain injury(TBI)remains a multidisciplinary challenge.No first-line drugs are available.Here,we reported a novel and non-toxic functional negative-charged carbon dots(CDs)generated from green Semen pruni persicae and Carthamus tinctorius L.(TH-CDs)through a hydrothermal synthesis without any organic solvent.The surface of TH-CDs retained part functional groups of active pharmacophores from both drugs.TH-CDs could improve the neurological function,brain edema,neuronal damage,and the BBB permeability by tail vein injection of mice models without systemic toxicity.Furthermore,higher expression of tight junction proteins claudin 5 and ZO-1 was observed after TH-CDs administration,which may be due to the electrostatic interaction between TH-CDs and claudin 5.Our study highlights an inexpensive,green,non-toxic,and intravenous functional TH-CD,which represents a potential TBI treatment strategy.
