Photodynamic therapy(PDT)is a novel therapy that combines photosensitizers,light,and oxygen molecules to treat diseases such as joint lesions and microbial infections through photodynamic reactions.The photosensitizer...Photodynamic therapy(PDT)is a novel therapy that combines photosensitizers,light,and oxygen molecules to treat diseases such as joint lesions and microbial infections through photodynamic reactions.The photosensitizers are activated under specific wavelengths of laser radiation to generate reactive oxygen species,which alter the microenvironment of the diseased tissue,cause ischemia and target cell death,and thus effectively treat cancer.Now that there is growing evidence that nonlethal doses of PDT reduce inflammation and treat infections in multiple animal models of arthritis,PDT should be considered as a new option for the treatment of arthritis.This article presents a literature review of published original articles and review articles concerning photodynamic therapy and arthritis.We conducted a comprehensive literature search in PubMed,Web of Science and Google Scholar databases,excluding duplicated and irrelevant studies.In cases of duplicated research,we selected articles with higher impact factors for the review.In this review,we summarize the application and progress of PDT in the treatment of rheumatoid arthritis,osteoarthritis,psoriatic arthritis,and infectious arthritis,and clarify the advantages and limitations of PDT for arthritis.PDT offers therapeutic value for patients with inflammatory and infectious arthritis through promoting vascular occlusion,cell death,and antibacterial therapy.展开更多
Antiphospholipid syndrome(APS)is a systemic autoimmune disease characterized by thrombotic or obstetric events caused by persistent antiphospholipid antibodies(aPLs),namely lupus anticoagulant,anticardiolipin antibodi...Antiphospholipid syndrome(APS)is a systemic autoimmune disease characterized by thrombotic or obstetric events caused by persistent antiphospholipid antibodies(aPLs),namely lupus anticoagulant,anticardiolipin antibodies,or anti-β2 glycoprotein I(anti-β2GPI)antibodies.^([1])The main target antigen in APS isβ2GPI,through which aPL binds to the cell membrane and subsequently activates membrane receptors and down-stream signal transducers.This may activate natural killer(NK)cells,leading to obstetric complications.展开更多
基金Fundamental Research Program of Shanxi Province,Grant/Award Number:202303021211218Four“Batches”Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province,Grant/Award Number:2023XM002+2 种基金Shanxi Province Postgraduate Practice Innovation Project,Grant/Award Number:2023SJ135National Natural Science Foundation of China,Grant/Award Number:81871292Shanxi Province Postgraduate Practice Innovation,Grant/Award Number:2020BY080。
文摘Photodynamic therapy(PDT)is a novel therapy that combines photosensitizers,light,and oxygen molecules to treat diseases such as joint lesions and microbial infections through photodynamic reactions.The photosensitizers are activated under specific wavelengths of laser radiation to generate reactive oxygen species,which alter the microenvironment of the diseased tissue,cause ischemia and target cell death,and thus effectively treat cancer.Now that there is growing evidence that nonlethal doses of PDT reduce inflammation and treat infections in multiple animal models of arthritis,PDT should be considered as a new option for the treatment of arthritis.This article presents a literature review of published original articles and review articles concerning photodynamic therapy and arthritis.We conducted a comprehensive literature search in PubMed,Web of Science and Google Scholar databases,excluding duplicated and irrelevant studies.In cases of duplicated research,we selected articles with higher impact factors for the review.In this review,we summarize the application and progress of PDT in the treatment of rheumatoid arthritis,osteoarthritis,psoriatic arthritis,and infectious arthritis,and clarify the advantages and limitations of PDT for arthritis.PDT offers therapeutic value for patients with inflammatory and infectious arthritis through promoting vascular occlusion,cell death,and antibacterial therapy.
基金the National Natural Science Foundation of China(No.81871292)the Key Research and Development(R&D)Projects of Shanxi Province(No.201803D31136)。
文摘Antiphospholipid syndrome(APS)is a systemic autoimmune disease characterized by thrombotic or obstetric events caused by persistent antiphospholipid antibodies(aPLs),namely lupus anticoagulant,anticardiolipin antibodies,or anti-β2 glycoprotein I(anti-β2GPI)antibodies.^([1])The main target antigen in APS isβ2GPI,through which aPL binds to the cell membrane and subsequently activates membrane receptors and down-stream signal transducers.This may activate natural killer(NK)cells,leading to obstetric complications.
