Background To explore the clinical,radiological,and surgical characteristics of anterior perforated substance(APS)gliomas.Methods Twenty patients with APS glioma who were treated with surgery between March 2019 and Ja...Background To explore the clinical,radiological,and surgical characteristics of anterior perforated substance(APS)gliomas.Methods Twenty patients with APS glioma who were treated with surgery between March 2019 and January 2022 from Tiantan hospital were retrospectively reviewed.The clinical,histological and radiological data were collected.Results Twenty patients,including 7 males(55%)and 13 females(45%),with a mean age at diagnosis of 37.9 years(range,28-53 years)underwent operative intervention for APS.Headaches and dizziness were the most common preoperative symptoms in the majority patients(14,70%).Based on radiological features of MRI,the APS was classified into two subtypes,type A and type B.Seven patients(40%)in type A indicated a clear tumor margin,while 13 patients(60%)in type B showed an ill-defined margin.The surgical approach including frontal,temporal,and coronal frontal incisions for type A and type B tumors,respectively.Three patients in type A received total resection,while one patient in type B were total resected.Pathologically,12 cases(60%,12/20)were diagnosed as astrocytoma and 8 cases(20%,8/20)were oligodendroglioma.Meanwhile,17 cases(85%,17/20)had MGMT promotor methylation.Conclusion In this study,we performed the first systematic research of patients with APS glioma.Most of patients with APS presented headaches and dizziness symptoms.The APS glioma was further divided into two major radiological subtypes with relevant different surgical approaches.The APS glioma in type A were more likely to receive total resection.展开更多
New discoveries based on genetic and epigenetic evidence have significantly expanded the understanding of diffuse gliomas.Molecular biomarkers detected in diffuse gliomas are not only potential targets for radiotherap...New discoveries based on genetic and epigenetic evidence have significantly expanded the understanding of diffuse gliomas.Molecular biomarkers detected in diffuse gliomas are not only potential targets for radiotherapy,chemotherapy,and immunotherapy,but are also able to guide surgical treatment.Previous studies have suggested that the optimal extent of resection of diffuse gliomas varies according to the expression of specific molecular biomarkers.However,the specific guiding role of these biomarkers in the resection of diffuse gliomas has not been systemically analyzed.This review summarizes several critical molecular biomarkers of tumorigenesis and progression in diffuse gliomas and discusses different strategies of tumor resection in the context of varying genetic expression.With ongoing study and advances in technology,molecular biomarkers will play a more important role in glioma resection and maximize the survival benefit from surgery for diffuse gliomas.展开更多
Glioma of the brain is a kind of tumor originating from neuroglial cells.It is the most common primary intracranial tumor,accounting for~30%of all central nervous system tumors and 80% of malignant brain tumors.Glioma...Glioma of the brain is a kind of tumor originating from neuroglial cells.It is the most common primary intracranial tumor,accounting for~30%of all central nervous system tumors and 80% of malignant brain tumors.Glioma is characterized by high disability and recurrence rates.The disease seriously threatens the life of patients,afects their quality of life,and brings a heavy economic and psychological burden to patients,families,and society.With the progression of molecular genetic testing technology and the completion of various clinical trials,the classifcation scheme for glioma is increasingly well established.Diagnosis and treatment regimens,including traditional and new regimens,are becoming increasingly specialized and standardized.The purpose is to develop a clinical diagnosis and treatment guideline for glioma in the Chinese population suitable for Chinese doctors and the general population based on domestic and international glioma research progress.Thus,domestic practitioners in the feld can obtain current information and provide better service to patients with glioma,promoting the development of domestic clinical medicine and basic research on glioma.展开更多
基金funding by the National Natural Science Foundation of China(No.81772005,No.82102764)the collaborative innovative major special project supported by Beijing Municipal Science&Technology Commission(No.Z191100006619088)
文摘Background To explore the clinical,radiological,and surgical characteristics of anterior perforated substance(APS)gliomas.Methods Twenty patients with APS glioma who were treated with surgery between March 2019 and January 2022 from Tiantan hospital were retrospectively reviewed.The clinical,histological and radiological data were collected.Results Twenty patients,including 7 males(55%)and 13 females(45%),with a mean age at diagnosis of 37.9 years(range,28-53 years)underwent operative intervention for APS.Headaches and dizziness were the most common preoperative symptoms in the majority patients(14,70%).Based on radiological features of MRI,the APS was classified into two subtypes,type A and type B.Seven patients(40%)in type A indicated a clear tumor margin,while 13 patients(60%)in type B showed an ill-defined margin.The surgical approach including frontal,temporal,and coronal frontal incisions for type A and type B tumors,respectively.Three patients in type A received total resection,while one patient in type B were total resected.Pathologically,12 cases(60%,12/20)were diagnosed as astrocytoma and 8 cases(20%,8/20)were oligodendroglioma.Meanwhile,17 cases(85%,17/20)had MGMT promotor methylation.Conclusion In this study,we performed the first systematic research of patients with APS glioma.Most of patients with APS presented headaches and dizziness symptoms.The APS glioma was further divided into two major radiological subtypes with relevant different surgical approaches.The APS glioma in type A were more likely to receive total resection.
基金This work was supported by the Public welfare development and reform pilot project of Beijing Medical Research Institute(JYY 2019-5)Beijing Nova Program(Z181100006218064).
文摘New discoveries based on genetic and epigenetic evidence have significantly expanded the understanding of diffuse gliomas.Molecular biomarkers detected in diffuse gliomas are not only potential targets for radiotherapy,chemotherapy,and immunotherapy,but are also able to guide surgical treatment.Previous studies have suggested that the optimal extent of resection of diffuse gliomas varies according to the expression of specific molecular biomarkers.However,the specific guiding role of these biomarkers in the resection of diffuse gliomas has not been systemically analyzed.This review summarizes several critical molecular biomarkers of tumorigenesis and progression in diffuse gliomas and discusses different strategies of tumor resection in the context of varying genetic expression.With ongoing study and advances in technology,molecular biomarkers will play a more important role in glioma resection and maximize the survival benefit from surgery for diffuse gliomas.
基金supported by China Anti-Cancer Association (CACA).
文摘Glioma of the brain is a kind of tumor originating from neuroglial cells.It is the most common primary intracranial tumor,accounting for~30%of all central nervous system tumors and 80% of malignant brain tumors.Glioma is characterized by high disability and recurrence rates.The disease seriously threatens the life of patients,afects their quality of life,and brings a heavy economic and psychological burden to patients,families,and society.With the progression of molecular genetic testing technology and the completion of various clinical trials,the classifcation scheme for glioma is increasingly well established.Diagnosis and treatment regimens,including traditional and new regimens,are becoming increasingly specialized and standardized.The purpose is to develop a clinical diagnosis and treatment guideline for glioma in the Chinese population suitable for Chinese doctors and the general population based on domestic and international glioma research progress.Thus,domestic practitioners in the feld can obtain current information and provide better service to patients with glioma,promoting the development of domestic clinical medicine and basic research on glioma.
