[Objective] The paper was clear the effects of ferulic sesquiterpene compounds on enzyme activity of schistosomulum.[Method]Mice infected with schistosome cercariae were orally administrated with ferulic sesquiterpene...[Objective] The paper was clear the effects of ferulic sesquiterpene compounds on enzyme activity of schistosomulum.[Method]Mice infected with schistosome cercariae were orally administrated with ferulic sesquiterpene compounds at the dose of 300 mg/kg on the 6 thday post infection once a week for 4 weeks.Schistosomula were collected and ground into homogenate on the 3 rdand 5 thday after every time of administration.Thin layer starch gel electrophoresis was used to observe the activity of enzymes in the homogenate.Control group was also designed（drug free mice）.[Result] The activities of malic dehydrogenase,6-phophate mannosease and acid phosphatase were obviously inhibited in the drug group,but the activity of phosphoglucoisomerase was not inhibited.[Conclusion] Ferulic sesquiterpene compounds have inhibitory effect on energy metabolism of schistosomulum and digestion of red blood cells.展开更多
基金Supported by National Innovation Experiment Program for University Students in Yangtze River University(091048926)
文摘[Objective] The paper was clear the effects of ferulic sesquiterpene compounds on enzyme activity of schistosomulum.[Method]Mice infected with schistosome cercariae were orally administrated with ferulic sesquiterpene compounds at the dose of 300 mg/kg on the 6 thday post infection once a week for 4 weeks.Schistosomula were collected and ground into homogenate on the 3 rdand 5 thday after every time of administration.Thin layer starch gel electrophoresis was used to observe the activity of enzymes in the homogenate.Control group was also designed（drug free mice）.[Result] The activities of malic dehydrogenase,6-phophate mannosease and acid phosphatase were obviously inhibited in the drug group,but the activity of phosphoglucoisomerase was not inhibited.[Conclusion] Ferulic sesquiterpene compounds have inhibitory effect on energy metabolism of schistosomulum and digestion of red blood cells.
