An organic visible-photocatalytic-adsorbence mechanism to high-efficient removal of heavy metal antimony ions

Purification of emerging heavy metal antimony contaminated water based on advanced ingenious strategies.An activated modified coconut shell charcoal(CSC)was synthesized and evaluated as a substrate-supported loaded organic photovoltaic material,PM6:PYIT:PM6-b-PYIT,to prepare a surprisingly highly efficient,stable,environmentally friendly,and recyclable organic photocatalyst(CSC–N–P.P.P),which showed excellent effects on the simultaneous removal of Sb(Ⅲ)and Sb(Ⅴ).The removal efficiency of CSC-N-P.P.P on Sb(Ⅲ)and Sb(Ⅴ)reached an amazing 99.9%in quite a short duration of 15 min.At the same time,under ppb level and indoor visible light(~1 W m^(2)),it can be treated to meet the drinking water standards set by the European Union and the U.S.National Environmental Protection Agency in 5 min,and even after 25 cycles of recycling,the efficiency is still maintained at about 80%,in addition to the removal of As(Ⅲ),Cd(Ⅱ),Cr(Ⅵ),and Pb(Ⅱ)can also be realized.The catalyst not only solves the problems of low reuse rate,difficult structure adjustment and high energy consumption of traditional photocatalysts but also has strong applicability and practical significance.The pioneering approach provides a much-needed solution strategy for removing highly toxic heavy metal antimony pollution from the environment.

Research on College Network Information Security Protection in the Digital Economy Era

In the era of the digital economy,the informatization degree of various industries is getting deeper and deeper,and network information security has also come into people’s eyes.Colleges and universities are in the position of training applied talents,because of the needs of teaching and education,as well as the requirements of teaching reform,the information construction of colleges and universities has been gradually improved,but the problem of network information security is also worth causing people to ponder.The low security of the network environment will cause college network information security leaks,and even hackers will attack the official website of the university and leak the personal information of teachers and students.To solve such problems,this paper studies the protection of college network information security against the background of the digital economy era.This paper first analyzes the significance of network information security protection,then points out the current and moral problems,and finally puts forward specific countermeasures,hoping to create a safe learning environment for teachers and students for reference.

青海都兰沟里金矿整装勘查区1:100000地质矿产数据集

青海都兰沟里金矿整装勘查区1:100 000地质矿产数据集由系统库、建造构造图、地质矿产图、地磁ΔT平面等值线图、地磁ΔT化极平面等值线图、化探综合异常图、矿产预测成果图及附表组成;每张图文件夹内有对应的编图说明。沟里整装勘查区总体被新元古代-早古生代东昆中缝合带(Pt3-P2末)、中-晚古生代兴海-苦海缝合带(D-P3)、晚古生代-早中生代(C-T2末)阿尼玛卿缝合带分割为4个二级构造单元。区内岩浆活动以奥陶纪-泥盆纪和二叠纪-三叠纪为主,分别代表了两期不同的造山旋回,成矿期可能在晚三叠世-早侏罗世。此次工作在整装勘查区内共圈定了1:50 000磁异常21处、化探综合异常80处;划分4个三级成矿带(区)、7个四级成矿亚带、8个五级矿带(矿田)、17个六级有利找矿区块;在有利找矿区块中筛选并提交找矿靶区14处;通过后续投入,区内相继发现了那更康切尔大型银矿、德龙金矿、迈龙金矿点、浪木日铜镍矿点、龙什更铜钴矿点等一批有找矿潜力的矿床(点);估算区内金资源总量588.04吨、银资源总量3 197.85吨、铅-锌资源总量235.83万吨,铜-钴资源总量121.49万吨。

Refinement of four major QTL for oil content in Brassica napus by integration of genome resequencing and transcriptomics

Rapeseed(Brassica napus)supplies about half of the vegetable oil in China.Increasing oil production and searching for genes that control oil content in the crop are research goals.In our previous studies,four major QTL for oil content located on A08,A09,C03 and C06 in the Ken C-8×N53-2(KN DH)mapping population were detected.The parental lines were resequenced to identify structural variations and candidate genes affecting oil content in these four major QTL regions.Insertion-deletion(In Del)markers were developed and used to narrow the regions.Differentially expressed genes located in the regions were investigated.GO and KEGG analysis showed that several genes were associated with lipid metabolism.Several transcription factors with higher expression in N53-2 than in Ken C-8 were identified.These results shed light on the genetic control of oil content and may be helpful for the development of highoil-content cultivars.

MiRNA identification,characterization and integrated network analysis for flavonoid biosynthesis in Brassicacoraphanus

Brassica rapa(AA,2n=20)and Raphanus sativus(RR,2n=18)are popular vegetables containing multiple secondary metabolites,such as flavonoids and anthocyanins.Nevertheless,fewstudies on miRNA expression profiles and potential regulatory network of flavonoid metabolism have been reported in the intergeneric hybrid of B.rapa and R.sativus(Brassicacoraphanus,AARR,2n=38).Here,themiRNAs of Brassicacoraphanus and its parents were first identified by small RNA sequencing.It was revealed that 315 conserved miRNAs and 193 novel miRNAs were found in Brassicacoraphanus and its parents.Moreover,the miRNA expression profiles were characterized and 204 miRNAs with differential expression were obtained.Further analysis showed that 184 miRNAs were non-additively expressed in Brassicacoraphanus.At last,the potential regulatory network of flavonoid metabolism in Brassicacoraphanus was analyzed by multi-omics data,suggesting possible roles of miR858a and miR157a in regulating flavonoid synthesis pathway in Brassicacoraphanus.Taken together,this study provides useful resources for probing globalmiRNA expression patterns in Brassicacoraphanus,which facilitates regulatory mechanism research on the biosynthesis pathway of secondary metabolites in Brassicacoraphanus.

The clinical effects of DC-CIK cells combined with chemotherapy in the treatment of advanced NSCLC

Objective: The aim of the study was to evaluate the safety and therapeutic effects of autologous dendritic cells co-cultured with cytokine-induced killer cells (DC-CIK) combined with chemotherapy in advanced non-small cell lung cancer (NSCLC) patients. Methods: Fifty patients with advanced NSCLC (stages III to IV), who had received therapies in our Center (Department of Biotherapy, Affiliated to Cancer Hospital of Shanxi Medical University, Taiyuan, China) from August 2008 to January 2010, were treated by DC-CIK + chemotherapy as the combined treatment group; fifty advanced NSCLC patients treated with chemotherapy at the same time served as controls. The immunologic function, short-term therapeutic effects, the 1-year survival rate, the life quality, the chemotherapy side effects were compared between the two groups, the safety and therapeutic effects of DC-CIK cells therapy were observed too. Results: There was no obvious change of subsets of T cells in peripheral blood before and after therapy in DC-CIK + chemotherapy group, and IFN-γ was improved after therapy in this group (P < 0.05); in chemotherapy alone group, the ratios of CD3+CD4+, CD3+CD8+, CD3-CD56+ cells and the secretion of IL-2, TNF-α decreased significantly after therapy (P < 0.05); the ratios of CD3+CD8+, CD3+CD56+ were improved after cell culture (P < 0.05). The disease control rate (DCR) of DC-CIK + chemotherapy group was higher than that in the chemotherapy alone group (78.0% vs 56.0%, P < 0.05); the 1-year survival rates of DC-CIK + chemotherapy group and chemotherapy alone group were 50% and 44% respectively, had no significant difference. Compared with chemotherapy alone group, the occurrence of chemotherapy side effects (including bone marrow suppression, nausea and vomiting, peripheral nerve toxicity) was less in the DC-CIK + chemotherapy group (P < 0.05). The physical and appetite were better in DC-CIK + chemotherapy group after therapy. Conclusion: To compare with simple chemotherapy, DC-CIK + chemotherapy for advanced NSCLC is safe and effective, and it can improve patients' life quality and remission rate, and prolong their survival time.

Genome-wide unbalanced expression bias and expression level dominance toward Brassica oleracea in artificially synthesized intergeneric hybrids of Raphanobrassica

Raphanobrassica(R^(r)R^(r)C^(r)C^(r),2n=4x=36),which is generated by distant hybridization between the maternal parent Raphanus sativus(R s R s,2n=2x=18)and the paternal parent Brassica oleracea(C°C°,2n=2x=18),displays intermediate silique phenotypes compared to diploid progenitors.However,the hybrid shares much more similarities in silique phenotypes with those of B.oleracea than those of R.sativus.Strikingly,the silique of Raphanobrassica is obviously split into two parts.To investigate the gene expression patterns behind these phenomena,transcriptome analysis was performed on the upper,middle,and lower sections of pods(RCsiu,RCsim,and RCsil),seeds in the upper and lower sections of siliques(RCseu and RCsel)from Raphanobrassica,whole pods(Rsi and Csi)and all seeds in the siliques(Rse and Cse)from R.sativus and B.oleracea.Transcriptome shock was observed in all five aforementioned tissues of Raphanobrassica.Genome-wide unbalanced biased expression and expression level dominance were also discovered,and both of them were toward B.oleracea in Raphanobrassica,which is consistent with the observed phenotypes.The present results reveal the global gene expression patterns of different sections of siliques of Raphanobrassica,pods,and seeds of B.oleracea and R.sativus,unraveling the tight correlation between global gene expression patterns and phenotypes of the hybrid and its parents.

Protective Effects of Tetramethylpyrazine on Glutamate-Induced Neurotoxicity in Mice

The aim of this study was to investigate the potential protective effect of tetramethylpyrazine (TMP), one of available blood-activating and stasis-eliminating components from traditional Chinese medicines, on glutamate-induced neurotoxicity in mice and its possible mechanism. Mice, except for controls, received simultaneously intragastric (ig) administration of monosodium glutamate [MSG, 4.0 g/(kg·d)] or/and intraperitoneal (ip) administration of TMP [10, 20, 40 mg/(kg·d)] for 10 d, and then behavioral tests, as well as histopathological and immunohistochemical examination of hippocampi were performed to analyze the glutamate-induced functional and morphological changes and the possible protective effect of TMP. The results showed that ip administration of TMP countered the effects of ig administration of MSG on behavior and histopathology, suggesting that TMP was a neuroprotective agent. This study provides evidence that TMP possesses obviously neuroprotection against glutamate-induced neurotoxicity, and the neuroprotection effect may result from its inhibiting expression of NMDARs, consequently blocking-up Ca2+ influx through the receptor’s associated ion channel, which can be neurotoxic.

Investigation and Analysis of Crop Germplasm Resources in Coastal Areas of Shandong Province

This study focused on the investigation of crop germplasm resources in coastal areas of Shandong Province, including 132 villages in 82 towns of 34 counties. The survey collected local varieties and wild resources of grain crops, economic crops, vegetables and fruit trees, and a total of 848 samples were collected, belonging to 54 species of 39 genera in 15 families. In this study, the current situation and growth and decline conditions of crop germplasm resources were investigated, and their botanical classification and utilization importance were analyzed. Furthermore, the conservation, development and utilization of crop germplasrp resources in coastal areas of Shandong Province were also discussed in this paper.

Recognition and Visualization of Lithography Defects based on Transfer Learning

Yield control in the integrated circuit manufacturing process is very important,and defects are one of the main factors affecting chip yield.As the process control becomes more and more critical and the critical dimension becomes smaller and smaller,the identification and location of defects is particularly important.This paper uses a machine learning algorithm based on transfer learning and two fine-tuned neural network models to realize the autonomous recognition and classification of defects even the data set is small,which achieves 94.6%and 91.7%classification accuracy.The influence of network complexity on classification result is studied at the same time.This paper also establishes a visual display algorithm of defects,shows the process of extracting the deep-level features of the defective image by the network,and then analyze the defect features.Finally,the Gradient-weighted Class Activation Mapping technology is used to generate defect heat maps,which locate the defect positions and probability intensity effects.This paper greatly expands the application of transfer learning in the field of integrated circuit lithography defect recognition,and greatly improves the friendliness of defect display.

A collaborative assembly for low-voltage electrical apparatuses

Low-voltage electrical apparatuses(LVEAs)have many workpieces and intricate geometric structures,and the assembly process is rigid and labor-intensive,and has little balance.The assembly process cannot readily adapt to changes in assembly situations.To address these issues,a collaborative assembly is proposed.Based on the requirements of collaborative assembly,a colored Petri net(CPN)model is proposed to analyze the performance of the interaction and self-government of robots in collaborative assembly.Also,an artificial potential field based planning algorithm(AFPA)is presented to realize the assembly planning and dynamic interaction of robots in the collaborative assembly of LVEAs.Then an adaptive quantum genetic algorithm(AQGA)is developed to optimize the assembly process.Lastly,taking a two-pole circuit-breaker controller with leakage protection(TPCLP)as an assembly instance,comparative results show that the collaborative assembly is cost-effective and flexible in LVEA assembly.The distribution of resources can also be optimized in the assembly.The assembly robots can interact dynamically with each other to accommodate changes that may occur in the LVEA assembly.

Multifunctional all-polymer photovoltaic blend with simultaneously improved efficiency(18.04%),stability and mechanical durability

One of the most appealing material systems for solar energy conversion is allpolymer blend.Presently,the three key merits(power conversion efficiency,operation stability and mechanical robustness)exhibited a trade-off in a particular all-polymer blend system,which greatly limit its commercial application.Diverting the classic ternary tactic of organic solar cells based on polymer,nonfullerene small molecule and fullerene,herein we demonstrate that the three merits of a benchmark all-polymer blend PM6:PY-IT can be simultaneously maximized via the introduction of a polymerized fullerene derivative PPCBMB.Importantly,the addition of the guest component promoted the power conversion efficiency of PM6:PY-IT blend from 16.59%to 18.04%.Meanwhile,the device stability and film ductility are also improved due to the addition of this polymerized fullerene material.Morphology and device physics analyses reveal that optimal ternary system contains well-maintained molecular packing and crystallinity,being beneficial to keeping favorable charge transport and the reduced domain size contributed to charge generation and ductility improvement.Furthermore,the ternary photovoltaic blend was successfully used as photocatalysts,and an excellent heavy metal removal from water was demonstrated.This study showcases the multi-functions of all-polymer blends via the use of polymerized fullerenes.

装配式弦支钢-混凝土组合楼盖中槽型板单元力学性能有限元研究

装配式弦支钢-混凝土组合楼盖是一种新型大跨度预应力组合结构,为了探究该组合楼盖中楼板部分的力学性能,从装配式弦支钢-混凝土组合楼盖中选取由4块槽型叠合板通过板间连接件连接组合形成的标准楼板单元,以此为研究对象,对其在正常使用阶段的受力性能进行有限元模拟分析。模拟结果显示,该组合楼板单元由于肋梁及后浇带的存在,在加载初期,单块槽型叠合板单元率先发生双向弯曲变形且跨中挠度最大,随着荷载的不断增加,组合楼板单元发生整体弯曲变形,跨中位置的挠度变形最大,当加载结束时,跨中挠度值为59 mm。在外荷载作用下,组合楼板单元沿跨度方向混凝土出现明显的塑性损伤,这表明两端简支组合楼板单元整体的抗弯刚度与垂直于跨度方向的截面有关。为详细探究混凝土强度、叠合层厚度、肋梁高度以及板间连接件的高度等参数对组合楼板抗弯刚度等力学性能的影响,建立13个有限元模型,对槽型钢筋桁架叠合板及板间连接件进行变参数分析,通过对比相同荷载与边界条件作用下跨中荷载-位移曲线,探究了不同因素对组合楼板抗弯性能的影响。结果表明:在保持其他条件不变的情况下,随着肋梁高度的增加,抗弯刚度急剧增大而位移迅速减小,肋梁高度从400 mm增大到700 mm,抗弯刚度增加322.6%,位移减小99%;随着叠合层厚度的增加,抗弯刚度增大而跨中位移减小,叠合层厚度从40 mm增大到70 mm时,抗弯刚度增加24.2%,位移减小54.7%;随着混凝土强度等级的增加,抗弯刚度略有增加而跨中位移未见明显变化,混凝土强度等级从C25增大到C40,抗弯刚度最大增加10.1%,位移在55~60 mm间波动;仅改变板间连接件高度并不改变其中心作用位置时,对抗弯刚度及位移影响不大,板间连接件高度从300 mm增大到360 mm,抗弯刚度增加8.0%,位移减小未超过10%。综上,对组合楼板整体的抗弯刚度及跨中位移影响最大的是肋梁高度,其次是叠合层厚度,混凝土强度及板间连接件高度影响较小。

基于衍射谱分析的全芯片光源掩模联合优化关键图形筛选

提出了一种全芯片光源掩模联合优化的关键图形筛选方法,用图形的主要频率表征图形的特征,用主要频率的位置和轮廓信息描述主要频率在频域上的分布特征。设计了相应的主要频率提取方法、覆盖规则、聚类方法以及关键图形筛选方法,实现了全芯片光源掩模联合优化的关键图形筛选。采用荷兰ASML公司的商用计算光刻软件Tachyon进行了仿真验证,与ASML公司同类技术的对比结果表明,本方法获得的工艺窗口优于ASML Tachyon方法。

Coupled biodegradation of p-nitrophenol and p-aminophenol in bioelectrochemical system:Mechanism and microbial functional diversity

Biodegradation mechanisms and microbial functional diversity during coupled pnitrophenol(PNP)and p-aminophenol(PAP)degradation were studied in a bioelectrochemical system.PNP in the biocathode and PAP in the bioanode were almost completely removed within 28 hr and 68 hr respectively.The degradation followed the steps including hydrating hydroxyalkylation,dehydrogenating carbonylation,and hydrolating ring cleavage,etc.Metagemomic analysis based on the KEGG and egg NOG database annotations revealed the microbial composition and functional genes/enzymes related to phenol degradation in the system.The predominant bacteria genera were Lautropia,Pandoraea,Thiobacillus,Ignavibacterium,Truepera and Hyphomicrobium.The recognized biodegradation genes/enzymes related to pollutant degradation were as follows:pmo,hbd,&ppo for phenol degradation,nzba,amie,&badh for aromatic degradation,and CYP&p450 for xenobiotics degradation,etc.The co-occurrence of ARGs(antibiotic resistant genes),such as ade F,Mex J,Erm F,PDC-93 and Escherichiacolimdf A,etc.,were annotated in CARD database during the biodegradation process.The Proteobacteria&Actinobacteria phylum was the primary host of both the biodegradation genes&ARGs in this system.The microbial functional diversity ensured the effective biodegradation of the phenol pollutants in the bioelectrochemical system.

Synergistic effects of plant hormones on spontaneous late-ripening mutant of'Jinghong'peach detected by transcriptome analysis

Objectives:Peach(Prunus persica L.)is an ancient fruit tree that originated from China.It is the climacteric fruit belonging to genus Prunus in family Rosaceae.Ethylene,which is produced during ripening,accelerates fruit softening,and therefore peaches cannot be stored for a long time.Materials and Methods:To study the mechanism of fruit late ripening,transcriptome analysis of the fruit of a late-ripening mutant of'Jinghong'peach was performed to identify genes and pathways involved in fruit late ripening.Results:A total of 1805,1511,and 2309 genes were found to be differentially expressed in W2_vs_M1,W3_vs_M2,and W3_vs_M3,respectively.Functional enrichment analysis of the differentially expressed genes showed they were related to carotenoid biosynthesis,starch and sucrose metabolism plant hormone signal transduction,flavonoid biosynthesis,and photosynthesis.The expression trends of ripening-related genes that encode transcription factors and plant hormone signal transduction-related genes that encode enzymes were similar.Conclusions:It will help to elucidate the transcriptional regulatory network of fruit development in the spontaneous late-ripening mutant of‘Jinghong’peach and provide a theoretical basis for understanding the molecular regulatory mechanism of fruit ripening.

3D genome structural variations play important roles in regulating seed oil content of Brassica napus

Dissecting the complex regulatory mechanism of seed oil content(SOC)is one of the main research goals in Brassica napus.Increasing evidence suggests that genome architecture is linked to multiple biological functions.However,the effect of genome architecture on SOC regulation remains unclear.Here,we used high-throughput chromatin conformation capture to characterize differences in the three-dimen-sional(3D)landscape of genome architecture of seeds from two B.napus lines,N53-2(with high SOC)and Ken-C8(with low SOC).Bioinformatics analysis demonstrated that differentially accessible regions and differentially expressed genes between N53-2 and Ken-C8 were preferentially enriched in regions with quantitative trait loci(QTLs)/associated genomic regions(AGRs)for SOC.A multi-omics analysis demonstrated that expression of SOC-related genes was tightly correlated with genome structural varia-tions in QTLs/AGRs of B.napus.The candidate gene BnaA09g48250D,which showed structural variation in a QTL/AGR on chrA09,was identified byfine-mapping of a KN double-haploid population derived from hybridization of N53-2 and Ken-C8.Overexpression and knockout of BnaA09g48250D led to significant in-creases and decreases in SOC,respectively,in the transgenic lines.Taken together,our results reveal the 3D genome architecture of B.napus seeds and the roles of genome structural variations in SOC regulation,enriching our understanding of the molecular mechanisms of SOC regulation from the perspective of spatial chromatin structure.