We described a case of hemiconvulsion-hemiplegia-epilepsy syndrome treated by anatomical hemispherectomy. A 9-year-old boy who suffered from frequent convulsions at 1 month old, left hemiparesis, free of fever, follow...We described a case of hemiconvulsion-hemiplegia-epilepsy syndrome treated by anatomical hemispherectomy. A 9-year-old boy who suffered from frequent convulsions at 1 month old, left hemiparesis, free of fever, followed by epileptic seizure at 4 years of age, and was diagnosed with hemiconvulsion-hemiplegia-epilepsy syndrome. Clinical manifestations and Wada test results confirmed that the impaired function of the affected cerebral hemisphere had been compensated by the normal hemisphere. The patient was treated by anatomic hemispherectomy. After the operation, the patient was seizure-free, but did not take any anti-epileptic drugs, and the hemiplegia was not aggravated. These findings demonstrated that the cortex controlling sensory and motor function has transferred.展开更多
Cancer was gradually regarded as a metabolic disease,which might be linked to impairment of mitochondrial function.There are really some essential differences between the mitochondria of normal and cancer cells,which ...Cancer was gradually regarded as a metabolic disease,which might be linked to impairment of mitochondrial function.There are really some essential differences between the mitochondria of normal and cancer cells,which might become promising target for cancer chemotherapy.According to western pharmacology,a known target was needed for drug development.Unfortunately,the number of therapeutic agents relating to the mitochondrion are severely limited because of lacking of knowledge about mitochondrial biology.Unlike the“Western Medicine”,some traditional Chinese herbal medicine(TCHM)might be prone to targeting mitochondria despite the lack of precise molecular mechanisms.If it is the case,we might be able to screen and identify active anti-cancer drugs from traditional Chinese therapeutics by using mitochondrial functional assay.In this review,we would give an overview of the effect of TCHM on the mitochondrion,and the challenges and breakthroughs remaining in cancer treatment.展开更多
Rational design and construction of chiral-achiral hybrid structures are of great importance to realize the multifunctional complex chiral structures toward emerging technological applications. However, significant ch...Rational design and construction of chiral-achiral hybrid structures are of great importance to realize the multifunctional complex chiral structures toward emerging technological applications. However, significant challenges remain due to the lack of fine control over the heterostructure. Here, we have developed a general bottom-up synthetic strategy for the site-selective growth of Cu nanodomains on intrinsically chiral Au nanocrystals. Chiral AuCu heterostructures with three distinct architectures were achieved by controlling the overgrowth of Cu nanodomains in a site-specific manner. The geometry-dependent plasmonic chirality of the heterostructures was demonstrated experimentally by circular dichroism spectroscopy and theoretically through finite-difference time-domain simulations. The site-specific geometric control of chiral AuCu heterostructures was also extended to employ anisotropic chiral Au nanoplates and nanorods as the building blocks. By virtue of the galvanic replacement reactions between metal ions and Cu atoms, chiral heterostructures with increasing architectural complexity and compositional diversity can be further achieved. The current work not only opens up a promising strategy to synthesize complex chiral hybrid nanostructures but also provides an important knowledge framework that guides the rational design of multifunctional chiral hybrid nanostructures toward chiroptical applications.展开更多
Background:The transforming growth factor-β(TGF-β)pathway plays a pivotal role in inducing epithelial-mesenchymal transition(EMT),which is a key step in cancer invasion and metastasis.However,the regulatory mechanis...Background:The transforming growth factor-β(TGF-β)pathway plays a pivotal role in inducing epithelial-mesenchymal transition(EMT),which is a key step in cancer invasion and metastasis.However,the regulatory mechanism of TGF-βin inducing EMT in colorectal cancer(CRC)has not been fully elucidated.In previous studies,it was found that S100A8 may regulate EMT.This study aimed to clarify the role of S100A8 in TGF-β-induced EMT and explore the underlying mechanism in CRC.Methods:S100A8 and upstream transcription factor 2(USF2)expression was detected by immunohistochemistry in 412 CRC tissues.Kaplan-Meier survival analysis was performed.In vitro,Western blot,and migration and invasion assays were performed to investigate the effects of S100A8 and USF2 on TGF-β-induced EMT.Mouse metastasis models were used to determine in vivo metastasis ability.Luciferase reporter and chromatin immunoprecipitation assay were used to explore the role of USF2 on S100A8 transcription.Results:During TGF-β-induced EMT in CRC cells,S100A8 and the transcription factor USF2 were upregulated.S100A8 promoted cell migration and invasion and EMT.USF2 transcriptionally regulated S100A8 expression by directly binding to its promoter region.Furthermore,TGF-βenhanced the USF2/S100A8 signaling axis of CRC cells whereas extracellular S100A8 inhibited the USF2/S100A8 axis of CRC cells.S100A8 expression in tumor cells was associated with poor overall survival in CRC.USF2 expression was positively related to S100A8 expression in tumor cells but negatively related to S100A8-positive stromal cells.Conclusions:TGF-βwas found to promote EMT and metastasis through the USF2/S100A8 axis in CRC while extracellular S100A8 suppressed the USF2/S100A8 axis.USF2 was identified as an important switch on the intracellular and extracellular S100A8 feedback loop.展开更多
When exposing to environmental stress or internal damage,such as genotoxic stress,oxidative stress,and heat stress,cells produce a series of adaptive responses called cellular stress responses[1].The major proteins in...When exposing to environmental stress or internal damage,such as genotoxic stress,oxidative stress,and heat stress,cells produce a series of adaptive responses called cellular stress responses[1].The major proteins involved in cellular stress are heat shock proteins(HSPs).HSPs remain in a low expression level and display a diffused distribution in the nucleoplasm and cytoplasm under basal conditions.In response to various stress conditions。展开更多
1 INTRODUCTION Association between aberrant metabolism and tumor progression has been discovered and studied for a long period of time,and reprogramming of metabolism has become one of the key characteristics of cance...1 INTRODUCTION Association between aberrant metabolism and tumor progression has been discovered and studied for a long period of time,and reprogramming of metabolism has become one of the key characteristics of cancer cells[1,2].Numerous studies showed that metabolic disorders are closely related to cancer risk and cancer-related deaths[3].According to the reports by the International Agency for Research on Cancer(IARC)and World Cancer Research Fund(WCRF),besides smoking,obesity and alcohol have become the most important risk factors of cancer worldwide[4].展开更多
Comprehensive Summary,Sensing the chirality of molecules is of great importance to fields such as enantioselective synthesis,pharmaceutical industry,and biomedicine.Plasmonic nanoparticles are ideal candidates for mol...Comprehensive Summary,Sensing the chirality of molecules is of great importance to fields such as enantioselective synthesis,pharmaceutical industry,and biomedicine.Plasmonic nanoparticles are ideal candidates for molecular sensing due to their inherent plasmonic properties that significantly enhance their sensitivity to surrounding molecules.Developing plasmonic nanoparticle-molecule complexes for chirality sensing has drawn enormous attention in recent years due to their intriguing properties and potential applications.Thus,in this review,we believe it is timely to circumnavigate the rational design of plasmonic nanoparticle-molecule complexes and widen the scope of their emerging applications in chirality sensing.First,we present different fundamental mechanisms for plasmon-based chirality that are built on the system of plasmonic nanoparticle-molecule complexes.Second,we review the typical applications of plasmonic nanoparticle-molecule complexes in chirality sensing.Third,we discuss the emerging biomedical applications that the plasmon-based chirality has attracted enormous interest.Finally,we provide an outlook on the challenges and opportunities in the field of plasmonic approaches for chirality sensing.展开更多
文摘We described a case of hemiconvulsion-hemiplegia-epilepsy syndrome treated by anatomical hemispherectomy. A 9-year-old boy who suffered from frequent convulsions at 1 month old, left hemiparesis, free of fever, followed by epileptic seizure at 4 years of age, and was diagnosed with hemiconvulsion-hemiplegia-epilepsy syndrome. Clinical manifestations and Wada test results confirmed that the impaired function of the affected cerebral hemisphere had been compensated by the normal hemisphere. The patient was treated by anatomic hemispherectomy. After the operation, the patient was seizure-free, but did not take any anti-epileptic drugs, and the hemiplegia was not aggravated. These findings demonstrated that the cortex controlling sensory and motor function has transferred.
基金the National Natural Science Foundation of China(No.81773170)BeijingNovaProgram(No.Z1511000003150121)Beijing Talents Fund(No.2015000021223ZK23).
文摘Cancer was gradually regarded as a metabolic disease,which might be linked to impairment of mitochondrial function.There are really some essential differences between the mitochondria of normal and cancer cells,which might become promising target for cancer chemotherapy.According to western pharmacology,a known target was needed for drug development.Unfortunately,the number of therapeutic agents relating to the mitochondrion are severely limited because of lacking of knowledge about mitochondrial biology.Unlike the“Western Medicine”,some traditional Chinese herbal medicine(TCHM)might be prone to targeting mitochondria despite the lack of precise molecular mechanisms.If it is the case,we might be able to screen and identify active anti-cancer drugs from traditional Chinese therapeutics by using mitochondrial functional assay.In this review,we would give an overview of the effect of TCHM on the mitochondrion,and the challenges and breakthroughs remaining in cancer treatment.
基金supported by the National Natural Science Foundation of China (22174104 to Q.Z.)the support of the Hubei Provincial Natural Science Foundation of China (2022CFB627)the Fundamental Research Funds for the Central Universities (20422022kf1039)。
文摘Rational design and construction of chiral-achiral hybrid structures are of great importance to realize the multifunctional complex chiral structures toward emerging technological applications. However, significant challenges remain due to the lack of fine control over the heterostructure. Here, we have developed a general bottom-up synthetic strategy for the site-selective growth of Cu nanodomains on intrinsically chiral Au nanocrystals. Chiral AuCu heterostructures with three distinct architectures were achieved by controlling the overgrowth of Cu nanodomains in a site-specific manner. The geometry-dependent plasmonic chirality of the heterostructures was demonstrated experimentally by circular dichroism spectroscopy and theoretically through finite-difference time-domain simulations. The site-specific geometric control of chiral AuCu heterostructures was also extended to employ anisotropic chiral Au nanoplates and nanorods as the building blocks. By virtue of the galvanic replacement reactions between metal ions and Cu atoms, chiral heterostructures with increasing architectural complexity and compositional diversity can be further achieved. The current work not only opens up a promising strategy to synthesize complex chiral hybrid nanostructures but also provides an important knowledge framework that guides the rational design of multifunctional chiral hybrid nanostructures toward chiroptical applications.
基金This work was supported by the grants of the National Natural Science Foundation of China(81772570)the Open Projects of State Key Laboratory of Molecular Oncology(SKL-KF-2019-17)the Program of Introducing Talents of Discipline to Universities(B13026).
文摘Background:The transforming growth factor-β(TGF-β)pathway plays a pivotal role in inducing epithelial-mesenchymal transition(EMT),which is a key step in cancer invasion and metastasis.However,the regulatory mechanism of TGF-βin inducing EMT in colorectal cancer(CRC)has not been fully elucidated.In previous studies,it was found that S100A8 may regulate EMT.This study aimed to clarify the role of S100A8 in TGF-β-induced EMT and explore the underlying mechanism in CRC.Methods:S100A8 and upstream transcription factor 2(USF2)expression was detected by immunohistochemistry in 412 CRC tissues.Kaplan-Meier survival analysis was performed.In vitro,Western blot,and migration and invasion assays were performed to investigate the effects of S100A8 and USF2 on TGF-β-induced EMT.Mouse metastasis models were used to determine in vivo metastasis ability.Luciferase reporter and chromatin immunoprecipitation assay were used to explore the role of USF2 on S100A8 transcription.Results:During TGF-β-induced EMT in CRC cells,S100A8 and the transcription factor USF2 were upregulated.S100A8 promoted cell migration and invasion and EMT.USF2 transcriptionally regulated S100A8 expression by directly binding to its promoter region.Furthermore,TGF-βenhanced the USF2/S100A8 signaling axis of CRC cells whereas extracellular S100A8 inhibited the USF2/S100A8 axis of CRC cells.S100A8 expression in tumor cells was associated with poor overall survival in CRC.USF2 expression was positively related to S100A8 expression in tumor cells but negatively related to S100A8-positive stromal cells.Conclusions:TGF-βwas found to promote EMT and metastasis through the USF2/S100A8 axis in CRC while extracellular S100A8 suppressed the USF2/S100A8 axis.USF2 was identified as an important switch on the intracellular and extracellular S100A8 feedback loop.
基金supported by the National Natural Science Foundation of China (31571321, 31171428)the National Key Research and Develepment Program of China (2016YFE0129200)+1 种基金the Institute of the Fundamental Research Funds of Shandong University (2015JC036)the Open Projects of State Key Laboratory of Molecular Oncology (SKL-KF-2017-17)
文摘When exposing to environmental stress or internal damage,such as genotoxic stress,oxidative stress,and heat stress,cells produce a series of adaptive responses called cellular stress responses[1].The major proteins involved in cellular stress are heat shock proteins(HSPs).HSPs remain in a low expression level and display a diffused distribution in the nucleoplasm and cytoplasm under basal conditions.In response to various stress conditions。
文摘1 INTRODUCTION Association between aberrant metabolism and tumor progression has been discovered and studied for a long period of time,and reprogramming of metabolism has become one of the key characteristics of cancer cells[1,2].Numerous studies showed that metabolic disorders are closely related to cancer risk and cancer-related deaths[3].According to the reports by the International Agency for Research on Cancer(IARC)and World Cancer Research Fund(WCRF),besides smoking,obesity and alcohol have become the most important risk factors of cancer worldwide[4].
基金supported by the National Natural Science Foundation of China(Grant No.22174104 to Q.Z.).L.S.acknowledges the support of the Hubei Provincial Natural Science Foundation of China(Grant No.2022CFB627)the Fundamental Research Funds for the Central Universities(Grant No.20422022kf1039).
文摘Comprehensive Summary,Sensing the chirality of molecules is of great importance to fields such as enantioselective synthesis,pharmaceutical industry,and biomedicine.Plasmonic nanoparticles are ideal candidates for molecular sensing due to their inherent plasmonic properties that significantly enhance their sensitivity to surrounding molecules.Developing plasmonic nanoparticle-molecule complexes for chirality sensing has drawn enormous attention in recent years due to their intriguing properties and potential applications.Thus,in this review,we believe it is timely to circumnavigate the rational design of plasmonic nanoparticle-molecule complexes and widen the scope of their emerging applications in chirality sensing.First,we present different fundamental mechanisms for plasmon-based chirality that are built on the system of plasmonic nanoparticle-molecule complexes.Second,we review the typical applications of plasmonic nanoparticle-molecule complexes in chirality sensing.Third,we discuss the emerging biomedical applications that the plasmon-based chirality has attracted enormous interest.Finally,we provide an outlook on the challenges and opportunities in the field of plasmonic approaches for chirality sensing.
