目的探讨与肝细胞癌(HCC)远处转移相关的DNA拷贝数变异(copy number alteration,CNA)分子标志。方法采用高分辨率Agilent 244K微阵列比较基因组杂交(aCGH)方法检测63例HCC样本基因组DNA的CNA特征。以Log-rank检验、Kaplan-Meier生存分...目的探讨与肝细胞癌(HCC)远处转移相关的DNA拷贝数变异(copy number alteration,CNA)分子标志。方法采用高分辨率Agilent 244K微阵列比较基因组杂交(aCGH)方法检测63例HCC样本基因组DNA的CNA特征。以Log-rank检验、Kaplan-Meier生存分析以及Cox风险比例模型,分析各DNA片段CNA与HCC远处转移的相关性。结果染色体片段12p12.2-13.31丢失是HCC患者远处转移的显著危险因素(P<0.01,Log-rank检验)。与非丢失者相比,12p12.2-13.31丢失HCC患者的远处转移风险比(hazard ratio,HR)为22.98(95%CI=4.29～123.22,P<0.01)。多变量Cox回归分析显示,12p12.2-13.31丢失是HCC远处转移的独立预测因素(HR=7.94,95%CI=1.14～55.61,P<0.05)。结论染色体片段12p12.2-13.31丢失增加HCC远处转移风险,可作为预测HCC远处转移的一个分子标志。展开更多
To facilitate and strengthen collaborations among cancer researchers and physicians in the United States and China,the US Chinese AntiCancer Association(USCACA)and the National Foundation for Cancer Research(NFCR)have...To facilitate and strengthen collaborations among cancer researchers and physicians in the United States and China,the US Chinese AntiCancer Association(USCACA)and the National Foundation for Cancer Research(NFCR)have established the Scholar Excellence Award for the USCACA-NFCR Scholar Exchange and Fellowship Program in Basic,Translational,and Clinical Studies.Since 2010,10 young Chinese researchers and physicians have received the award for their outstanding achievements in cancer research accomplished while in the展开更多
To facilitate and strengthen collaborations among cancer researchers and physicians in the United States and China,the US Chinese AntiCancer Association(USCACA)and the National Foundation for Cancer Research(NFCR)have...To facilitate and strengthen collaborations among cancer researchers and physicians in the United States and China,the US Chinese AntiCancer Association(USCACA)and the National Foundation for Cancer Research(NFCR)have established the Scholar Excellence Award for the USCACA-NFCR Scholar Exchange and Fellowship Program in Basic,Translational,and Clinical Studies.From 2010 to 2013,14 young展开更多
文摘目的探讨与肝细胞癌(HCC)远处转移相关的DNA拷贝数变异(copy number alteration,CNA)分子标志。方法采用高分辨率Agilent 244K微阵列比较基因组杂交(aCGH)方法检测63例HCC样本基因组DNA的CNA特征。以Log-rank检验、Kaplan-Meier生存分析以及Cox风险比例模型,分析各DNA片段CNA与HCC远处转移的相关性。结果染色体片段12p12.2-13.31丢失是HCC患者远处转移的显著危险因素(P<0.01,Log-rank检验)。与非丢失者相比,12p12.2-13.31丢失HCC患者的远处转移风险比(hazard ratio,HR)为22.98(95%CI=4.29～123.22,P<0.01)。多变量Cox回归分析显示,12p12.2-13.31丢失是HCC远处转移的独立预测因素(HR=7.94,95%CI=1.14～55.61,P<0.05)。结论染色体片段12p12.2-13.31丢失增加HCC远处转移风险,可作为预测HCC远处转移的一个分子标志。
文摘To facilitate and strengthen collaborations among cancer researchers and physicians in the United States and China,the US Chinese AntiCancer Association(USCACA)and the National Foundation for Cancer Research(NFCR)have established the Scholar Excellence Award for the USCACA-NFCR Scholar Exchange and Fellowship Program in Basic,Translational,and Clinical Studies.Since 2010,10 young Chinese researchers and physicians have received the award for their outstanding achievements in cancer research accomplished while in the
文摘To facilitate and strengthen collaborations among cancer researchers and physicians in the United States and China,the US Chinese AntiCancer Association(USCACA)and the National Foundation for Cancer Research(NFCR)have established the Scholar Excellence Award for the USCACA-NFCR Scholar Exchange and Fellowship Program in Basic,Translational,and Clinical Studies.From 2010 to 2013,14 young
