Non-small cell lung cancers(NSCLCs)oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors

With the continuous in-depth study of the interaction mechanism between viruses and hosts,the virus has become a promising tool in cancer treatment.In fact,many oncolytic viruses with selectivity and effectiveness have been used in cancer therapy.Human enterovirus is one of the most convenient sources to generate oncolytic viruses,however,the high seroprevalence of some enteroviruses limits its application which urges to exploit more oncolytic enteroviruses.

Advances in COVID-19 mRNA vaccine development

To date,the coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has determined 399,600,607 cases and 5,757,562 deaths worldwide.COVID-19 is a serious threat to human health globally.The World Health Organization(WHO)has declared COVID-19 pandemic a major public health emergency.Vaccination is the most effective and economical intervention for controlling the spread of epidemics,and consequently saving lives and protecting the health of the population.Various techniques have been employed in the development of COVID-19 vaccines.Among these,the COVID-19 messenger RNA(mRNA)vaccine has been drawing increasing attention owing to its great application prospects and advantages,which include short development cycle,easy industrialization,simple production process,flexibility to respond to new variants,and the capacity to induce better immune response.This review summarizes current knowledge on the structural characteristics,antigen design strategies,delivery systems,industrialization potential,quality control,latest clinical trials and real-world data of COVID-19 mRNA vaccines as well as mRNA technology.Current challenges and future directions in the development of preventive mRNA vaccines for major infectious diseases are also discussed.

Rational Quasi-Interpolation Approximation of Scattered Data in R^(3)

This paper is concerned with a piecewise smooth rational quasi-interpolation with algebraic accuracy of degree(n+1)to approximate the scattered data in R 3.We firstly use the modified Taylor expansion to expand the mean value coordinates interpolation with algebraic accuracy of degree one to one with algebraic accuracy of degree(n+1).Then,based on the triangulation of the scattered nodes in R^(2),on each triangle a rational quasi-interpolation function is constructed.The constructed rational quasi-interpolation is a linear combination of three different expanded mean value coordinates interpolations and it has algebraic accuracy of degree(n+1).By comparing accuracy,stability,and efficiency with the C^(1)-Tri-interpolation method of Goodman[16]and the MQ Shepard method,it is observed that our method has some computational advantages.

Construction and verification of an infectious cDNA clone of coxsackievirus B5

Dear Editor,Enteroviruses belonging to the family Picornaviridae are nonenveloped RNA viruses that cause hand-foot-mouth disease(HFMD),which can lead to severe neurological complications.Enteroviruses genomes represent a single open reading frame flanked by 5’-and 3’-untranslated terminal regions(UTRs).