The precise L^(p) norm of a class of Forelli-Rudin type operators on the Siegel upper half space is given in this paper.The main result not only implies the upper L^(p) norm estimate of the Bergman projection,but also...The precise L^(p) norm of a class of Forelli-Rudin type operators on the Siegel upper half space is given in this paper.The main result not only implies the upper L^(p) norm estimate of the Bergman projection,but also implies the precise L^(p) norm of the Berezin transform.展开更多
Summary What is already known about this topic?Prior research has primarily concentrated on occupational health concerns,including injuries and heatstroke,among couriers.Nevertheless,there has been a scarcity of empha...Summary What is already known about this topic?Prior research has primarily concentrated on occupational health concerns,including injuries and heatstroke,among couriers.Nevertheless,there has been a scarcity of emphasis on mental health aspects,with existing studies predominantly addressing the risk factors associated with occupational stress.What is added by this report?The present study demonstrated a significant association between occupational stress and well-being among couriers,with positive coping strategies acting as a mediating factor.Furthermore,the results indicate that implementing a positive coping style may mitigate the impact of occupational stress on well-being.What are the implications for public health practice?Future public policy initiatives should focus on promoting the well-being of couriers by fostering improvements in the workplace environment,reevaluating the organization of work,and delivering support to couriers in managing occupational stress.展开更多
Large scale genomic aberrations including duplication,deletion,translocation,and other structural changes are the cause of a subtype of hereditary genetic disorders and contribute to onset or progress of cancer.The cu...Large scale genomic aberrations including duplication,deletion,translocation,and other structural changes are the cause of a subtype of hereditary genetic disorders and contribute to onset or progress of cancer.The current prime editor,PE2,consisting of Cas9-nickase and reverse transcriptase enables efficient editing of genomic deletion and insertion,however,at small scale.Here,we designed a novel prime editor by fusing reverse transcriptase(RT)to nuclease wild-type Cas9(WT-PE)to edit large genomic fragment.展开更多
Dear Editor,The discovery of base-editing tools sheds new light on both basic biomedical research and clinical therapeutics.1,2 Although showing profound performance in a wide range of applications,current base editor...Dear Editor,The discovery of base-editing tools sheds new light on both basic biomedical research and clinical therapeutics.1,2 Although showing profound performance in a wide range of applications,current base editors have their limitations.In particular,the narrow editing windows of these base editors have significantly limited their targetable sites.In current base editors,the most frequent way to tether deaminase is to fuse it to the N-terminus of the Cas9 protein through flexible peptide linkers.Base editors derived from Streptococcus pyogenes Cas9(SpyCas9)or its variants can efficiently edit desired bases in an~5 nt wide window within the detached,non-target strand(NTS).Maximum editing typically occurs around positions 5–7,counting from the 5′end of the protospacer,which is about 15 nt away from the protospacer adjacent motif(PAM).展开更多
What is already known about this topic?Benzene is harmful to the hematopoietic system and can cause leukemia.However,benzene is still being used in various industries including furniture,rubber,plastic products,and me...What is already known about this topic?Benzene is harmful to the hematopoietic system and can cause leukemia.However,benzene is still being used in various industries including furniture,rubber,plastic products,and metal product manufacturing.What is added by this report?The white blood cell count of workers in general equipment,special equipment,chemical raw materials,and chemical products manufacturing decreased significantly.The enterprises in which benzene concentration exceeded the occupational exposure limit were small enterprises and private enterprises.What are the implications for public health practice?Regular health examinations are necessary for benzeneexposed workers.In addition,the monitoring of benzene concentration in small enterprises and private enterprises should be strengthened.展开更多
基金supported by grants from the National Natural Science Foundation of China (No.81760885,No.81360564)Guangxi Natural Science Foundation (No. 2017GXNSFDA198011)+1 种基金Guangxi Medical Administration Project(No.GZZC14-44)Special Project of TCM Science and Technology of Health and Family Planning Commission of Guangxi Zhuang Autonomous Region(No.GZLC16-34)
基金supported by the National Natural Science Foundation of China(11801172,11771139,12071130)supported by the Natural Science Foundation of Zhejiang Province(LQ21A010002)supported by the Natural Science Foundation of Zhejiang Province(LY20A010007).
文摘The precise L^(p) norm of a class of Forelli-Rudin type operators on the Siegel upper half space is given in this paper.The main result not only implies the upper L^(p) norm estimate of the Bergman projection,but also implies the precise L^(p) norm of the Berezin transform.
文摘Summary What is already known about this topic?Prior research has primarily concentrated on occupational health concerns,including injuries and heatstroke,among couriers.Nevertheless,there has been a scarcity of emphasis on mental health aspects,with existing studies predominantly addressing the risk factors associated with occupational stress.What is added by this report?The present study demonstrated a significant association between occupational stress and well-being among couriers,with positive coping strategies acting as a mediating factor.Furthermore,the results indicate that implementing a positive coping style may mitigate the impact of occupational stress on well-being.What are the implications for public health practice?Future public policy initiatives should focus on promoting the well-being of couriers by fostering improvements in the workplace environment,reevaluating the organization of work,and delivering support to couriers in managing occupational stress.
基金We thank Yang Yang for providing python script for HTS data analysis.This work was supported by National Natural Science Foundation of China.No.U19A2002,No.81771220 and No.81974238.
文摘Large scale genomic aberrations including duplication,deletion,translocation,and other structural changes are the cause of a subtype of hereditary genetic disorders and contribute to onset or progress of cancer.The current prime editor,PE2,consisting of Cas9-nickase and reverse transcriptase enables efficient editing of genomic deletion and insertion,however,at small scale.Here,we designed a novel prime editor by fusing reverse transcriptase(RT)to nuclease wild-type Cas9(WT-PE)to edit large genomic fragment.
基金This work was supported by the Hi-Tech Research&Development(863)Program of China(2015AA020309)National Natural Science Foundation of China(81771220)Salubris Academician Workstation for Innovative Biopharma-ceuticals(no.2017B090904017).
文摘Dear Editor,The discovery of base-editing tools sheds new light on both basic biomedical research and clinical therapeutics.1,2 Although showing profound performance in a wide range of applications,current base editors have their limitations.In particular,the narrow editing windows of these base editors have significantly limited their targetable sites.In current base editors,the most frequent way to tether deaminase is to fuse it to the N-terminus of the Cas9 protein through flexible peptide linkers.Base editors derived from Streptococcus pyogenes Cas9(SpyCas9)or its variants can efficiently edit desired bases in an~5 nt wide window within the detached,non-target strand(NTS).Maximum editing typically occurs around positions 5–7,counting from the 5′end of the protospacer,which is about 15 nt away from the protospacer adjacent motif(PAM).
基金National Key R&D Program of China(2022YFC2503203)the National Natural Science Foundation of China(Project No:82070116).
文摘What is already known about this topic?Benzene is harmful to the hematopoietic system and can cause leukemia.However,benzene is still being used in various industries including furniture,rubber,plastic products,and metal product manufacturing.What is added by this report?The white blood cell count of workers in general equipment,special equipment,chemical raw materials,and chemical products manufacturing decreased significantly.The enterprises in which benzene concentration exceeded the occupational exposure limit were small enterprises and private enterprises.What are the implications for public health practice?Regular health examinations are necessary for benzeneexposed workers.In addition,the monitoring of benzene concentration in small enterprises and private enterprises should be strengthened.
