A distinction of gliomas at cellular and tissue level by surface-enhanced Raman scattering spectroscopy

Glioblastoma multiforme(GBM)is the most common malignant primary brain tumor in adults.The precise identification and distinction of GBM heterogeneity from surrounding brain parenchyma at the cellular level and even at the tissue level are important for GBM therapy.In this study,GBM cells are distinguished from normal astrocytes and non-central nervous system(CNS)tumor cells by surface-enhanced Raman scattering(SERS)based on gold nanoshell(SiO_(2)@Au)particles and support vector machine(SVM)algorithm.In addition,the gold nanoisland(AuNI)SERS substrates are further developed and explored for accurate detection of GBM at the tissue level.The distinction between glioma and trauma tissues,identification of different tumor grades,and IDH mutation are realized with the assistance of orthogonal partial least squares discriminant analysis(OPLS-DA)in a rapid,non-invasive,and convenient method.The results show that the developed SERS-based analytical method has the potential for practical application for the detection of GBM at the single-cell and tissue levels and even for real-time intraoperative diagnosis.

Concept,breakthrough,and future of colonic transendoscopic enteral tubing

Colonic transendoscopic enteral tubing(TET)is an interventional intestine therapeutic procedure.The colonic TET technique represents a novel drug delivery route,interventional diagnosis and therapy,and paradigm for concept validation,showing broad prospects in research and practice.Since its first meeting at the China Gut Conference in 2023,our panel of experts has held a series of discussions on TET’s concept,breakthroughs,and future.We strive to lay the groundwork for further establishing the TET Study Group for designing multicenter studies and developing relevant consensus or guidelines.

Reconfigurable Transmitter Coil Structure for Highly Efficient and Misalignment-insensitive Wireless Power Transfer Systems in Megahertz Range

The structural optimization of coils is a key issue in wireless power transfer(WPT)applications owing to size limitations.In this study,a novel planar-spiral transmitter coil(TX-coil)with an outer-tight and inner-sparse configuration is proposed to achieve a high quality factor(Q-factor)and uniform magnetic field,which ensures high efficiency and improves the misalignment tolerance for several-megahertz WPT systems.Furthermore,a closed-form expression for the Q-factor is provided and analyzed for coil optimization.By using this method,a TX-coil with an outer diameter of 100 mm and a wire diameter of 1.5 mm is designed and tested at 1 MHz.Finite element method simulations and experimental results demonstrate that the Q-factor is increased by about 8%in comparison with evenly spaced planar spiral coils,which is achieved while ensuring a relatively uniform magnetic field.